1,318 research outputs found

    Necessidades (de saúde) de adolescentes do D.A. Raposo Tavares, SP, referidas à família, escola e bairro

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    Este estudo, de natureza epidemiológica descritiva, objetiva caracterizar as necessidades de saúde dos adolescentes do Distrito Administrativo Raposo Tavares - município de São Paulo, que apresenta diversas situações de vulnerabilidade social. Foram estudados 133 adolescentes e suas famílias, inscritos em 1 2 escolas públicas e I Centro de Juventude, buscando localizar as suas necessidades de saúde a partir das suas formas de inserção social (plenamente incluidos, precariamente incluidos e excluidos). Os resultados indicam que às formas de reprodução evidenciadas na amostra estudada se associavam necessidades diferenciados, seja do ponto de vista quantitativo, seja do ponto de vista qualitativo, relacionadas às agências e ao espaço de socialização: família, escola e bairro. São necessárias ações intersetoriais, não só de incremento das políticas sociais públicas, mas de capacitação dos adolescentes para que exerçam seus direitos sociais e possam dispor de processos de socialização acolhedores e protetores.This is an epidemiological descriptive study which has lhe objective of characterizing lhe health needs of adolescente who tive in a social vulnerable neighborhood of lhe city of SãoPaulo (Raposo Tavares). A questionnaire and a form were utilized to collect data Dom a sample of 133 adolescente from lhe 12 public schools and lhe Youth Center of lhe community. Data Dom social reproduction indicators were organized to socially classify the adolescents’ families in three social groups. The results indicated that 16.5% of them were in a socially included group, 51.1%, in a precariously included group and, finally, ~2.3% of the adolescents were considered being in a socially excluded group. There were some significant quantitative and qualitative differences in the health needs felt by the adolescents when they refer to family, school and neighborhood. To satisfy these needs, it is necessary to improve social public policies and to empower youngsters to exercise their rights in order to guarantee care and protectionduring their socialization processes

    Biomolecular insights into North African-related ancestry, mobility and diet in eleventh-century Al-Andalus

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    Historical records document medieval immigration from North Africa to Iberia to create Islamic al-Andalus. Here, we present a low-coverage genome of an eleventh century CE man buried in an Islamic necropolis in Segorbe, near Valencia, Spain. Uniparental lineages indicate North African ancestry, but at the autosomal level he displays a mosaic of North African and European-like ancestries, distinct from any present-day population. Altogether, the genome-wide evidence, stable isotope results and the age of the burial indicate that his ancestry was ultimately a result of admixture between recently arrived Amazigh people (Berbers) and the population inhabiting the Peninsula prior to the Islamic conquest. We detect differences between our sample and a previously published group of contemporary individuals from Valencia, exemplifying how detailed, small-scale aDNA studies can illuminate fine-grained regional and temporal differences. His genome demonstrates how ancient DNA studies can capture portraits of past genetic variation that have been erased by later demographic shifts-in this case, most likely the seventeenth century CE expulsion of formerly Islamic communities as tolerance dissipated following the Reconquista by the Catholic kingdoms of the north

    A genetic chronology for the Indian Subcontinent points to heavily sex-biased dispersals

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    Background India is a patchwork of tribal and non-tribal populations that speak many different languages from various language families. Indo-European, spoken across northern and central India, and also in Pakistan and Bangladesh, has been frequently connected to the so-called “Indo-Aryan invasions” from Central Asia ~3.5 ka and the establishment of the caste system, but the extent of immigration at this time remains extremely controversial. South India, on the other hand, is dominated by Dravidian languages. India displays a high level of endogamy due to its strict social boundaries, and high genetic drift as a result of long-term isolation which, together with a very complex history, makes the genetic study of Indian populations challenging. Results We have combined a detailed, high-resolution mitogenome analysis with summaries of autosomal data and Y-chromosome lineages to establish a settlement chronology for the Indian Subcontinent. Maternal lineages document the earliest settlement ~55–65 ka (thousand years ago), and major population shifts in the later Pleistocene that explain previous dating discrepancies and neutrality violation. Whilst current genome-wide analyses conflate all dispersals from Southwest and Central Asia, we were able to tease out from the mitogenome data distinct dispersal episodes dating from between the Last Glacial Maximum to the Bronze Age. Moreover, we found an extremely marked sex bias by comparing the different genetic systems. Conclusions Maternal lineages primarily reflect earlier, pre-Holocene processes, and paternal lineages predominantly episodes within the last 10 ka. In particular, genetic influx from Central Asia in the Bronze Age was strongly male-driven, consistent with the patriarchal, patrilocal and patrilineal social structure attributed to the inferred pastoralist early Indo-European society. This was part of a much wider process of Indo-European expansion, with an ultimate source in the Pontic-Caspian region, which carried closely related Y-chromosome lineages, a smaller fraction of autosomal genome-wide variation and an even smaller fraction of mitogenomes across a vast swathe of Eurasia between 5 and 3.5 ka

    Digital cranial endocast of Riograndia guaibensis (Late Triassic, Brazil) sheds light on the evolution of the brain in non-mammalian cynodonts

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    A digital cranial endocast of the specimen UFRGS-PV-596-T of Riograndia guaibensis was obtained from μCT scan images. This is a small cynodont, closely related to mammaliaforms, from the Late Triassic of Brazil. Riograndia has large olfactory bulb casts and the cerebral hemispheres region is relatively wider than in other non-mammaliaform cynodonts. Impressions of vessels were observed and a conspicuous mark on the dorsal surface was interpreted as the transverse sinus. The calculated encephalization quotient is greater than the range seen in most other non-mammaliaform cynodonts. The ratios between linear and area measurements of the dorsal surface suggest four evolutionary changes from a basal eucynodont morphology to mammaliaforms, involving an evolutionary increase of the relative size of the olfactory bulbs and the width of the cerebral hemispheres and cerebellum. The data supports the hypothesis of the neurological evolution of the mammalian lineage starting with a trend for an increase of the olfactory bulbs, which is associated with adaptations in the nasal cavity. This trend is suggested to be linked to the selective pressures for small-sized faunivorous, and probably nocturnal, animals, and represents an initial improvement of the sensory receptor system, subsequently leading to further development of the ‘superior’ structures for sensorial processing and integration.Fil: Rodrigues, Pablo Gusmão. Universidade Federal do Rio Grande do Sul; BrasilFil: Martinelli, Agustín Guillermo. Universidade Federal do Rio Grande do Sul; Brasil. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Museo Argentino de Ciencias Naturales "Bernardino Rivadavia"; ArgentinaFil: Schultz, Cesar Leandro. Universidade Federal do Rio Grande do Sul; BrasilFil: Corfe, Ian J.. University of Helsinki; FinlandiaFil: Gill, Pamela G.. University of Bristol; Reino UnidoFil: Soares, Marina. Universidade Federal do Rio Grande do Sul; BrasilFil: Rayfield, Emily J.. University of Bristol; Reino Unid

    A Population of Dipper Stars from the Transiting Exoplanet Survey Satellite Mission

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    Dipper stars are a classification of young stellar objects that exhibit dimming variability in their light curves, dropping in brightness by 10-50%, likely induced by occultations due to circumstellar disk material. This variability can be periodic, quasi-periodic, or aperiodic. Dipper stars have been discovered in young stellar associations via ground-based and space-based photometric surveys. We present the detection and characterization of the largest collection of dipper stars to date: 293 dipper stars, including 234 new dipper candidates. We have produced a catalog of these targets, which also includes young stellar variables that exhibit predominately bursting-like variability and symmetric variability (equal parts bursting and dipping). The total number of catalog sources is 414. These variable sources were found in a visual survey of TESS light curves, where dipping-like variability was observed. We found a typical age among our dipper sources of <5 Myr, with the age distribution peaking at ~2 Myr, and a tail of the distribution extending to ages older than 20 Myr. Regardless of the age, our dipper candidates tend to exhibit infrared excess, which is indicative of the presence of disks. TESS is now observing the ecliptic plane, which is rich in young stellar associations, so we anticipate many more discoveries in the TESS dataset. A larger sample of dipper stars would enhance the census statistics of light curve morphologies and dipper ages.Comment: 19 pages, 11 figures, 1 table (included in latex source), accepted for publication in ApJ

    Bartonella Clarridgeiae Bacteremia Detected In An Asymptomatic Blood Donor.

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    Human exposure to Bartonella clarridgeiae has been reported only on the basis of antibody detection. We report for the first time an asymptomatic human blood donor infected with B. clarridgeiae, as documented by enrichment blood culture, PCR, and DNA sequencing.53352-

    Differences in Immunoglobulin Light Chain Species Found in Urinary Exosomes in Light Chain Amyloidosis (AL)

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    Renal involvement is a frequent consequence of plasma cell dyscrasias. The most common entities are light chain amyloidosis, monoclonal immunoglobulin deposition disease and myeloma cast nephropathy. Despite a common origin, each condition has its own unique histologic and pathophysiologic characteristic which requires a renal biopsy to distinguish. Recent studies have shown urinary exosomes containing kidney-derived membrane and cytosolic proteins that can be used to probe the proteomics of the entire urinary system from the glomerulus to the bladder. In this study, we analyzed urine exosomes to determine the differences between exosomes from patients with light chain amyloidosis, multiple myeloma, monoclonal gammopathy of undetermined significance, and non-paraproteinemia related kidney disease controls. In patients with light chain amyloidosis, multiple myeloma and monoclonal gammopathy of undetermined significance, immunoreactive proteins corresponding to monomeric light chains were found in exosomes by western blot. In all of the amyloidosis samples with active disease, high molecular weight immunoreactive species corresponding to a decamer were found which were not found in exosomes from the other diseases or in amyloidosis exosomes from patients in remission. Few or no light chains monomeric bands were found in non-paraproteinemia related kidney disease controls. Our results showed that urinary exosomes may have tremendous potential in furthering our understanding of the pathophysiology and diagnosis of plasma cell dyscrasia related kidney diseases
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