Prevalence, associated factors and outcomes of pressure injuries in adult intensive care unit patients: the DecubICUs study

Funder: European Society of Intensive Care Medicine; doi: http://dx.doi.org/10.13039/501100013347Funder: Flemish Society for Critical Care NursesAbstract: Purpose: Intensive care unit (ICU) patients are particularly susceptible to developing pressure injuries. Epidemiologic data is however unavailable. We aimed to provide an international picture of the extent of pressure injuries and factors associated with ICU-acquired pressure injuries in adult ICU patients. Methods: International 1-day point-prevalence study; follow-up for outcome assessment until hospital discharge (maximum 12 weeks). Factors associated with ICU-acquired pressure injury and hospital mortality were assessed by generalised linear mixed-effects regression analysis. Results: Data from 13,254 patients in 1117 ICUs (90 countries) revealed 6747 pressure injuries; 3997 (59.2%) were ICU-acquired. Overall prevalence was 26.6% (95% confidence interval [CI] 25.9–27.3). ICU-acquired prevalence was 16.2% (95% CI 15.6–16.8). Sacrum (37%) and heels (19.5%) were most affected. Factors independently associated with ICU-acquired pressure injuries were older age, male sex, being underweight, emergency surgery, higher Simplified Acute Physiology Score II, Braden score 3 days, comorbidities (chronic obstructive pulmonary disease, immunodeficiency), organ support (renal replacement, mechanical ventilation on ICU admission), and being in a low or lower-middle income-economy. Gradually increasing associations with mortality were identified for increasing severity of pressure injury: stage I (odds ratio [OR] 1.5; 95% CI 1.2–1.8), stage II (OR 1.6; 95% CI 1.4–1.9), and stage III or worse (OR 2.8; 95% CI 2.3–3.3). Conclusion: Pressure injuries are common in adult ICU patients. ICU-acquired pressure injuries are associated with mainly intrinsic factors and mortality. Optimal care standards, increased awareness, appropriate resource allocation, and further research into optimal prevention are pivotal to tackle this important patient safety threat

Correction to: Prevalence, associated factors and outcomes of pressure injuries in adult intensive care unit patients: the DecubICUs study

The original version of this article unfortunately contained a mistake

Prevalence, associated factors and outcomes of pressure injuries in adult intensive care unit patients: the DecubICUs study

Funder: European Society of Intensive Care Medicine; doi: http://dx.doi.org/10.13039/501100013347Funder: Flemish Society for Critical Care NursesAbstract: Purpose: Intensive care unit (ICU) patients are particularly susceptible to developing pressure injuries. Epidemiologic data is however unavailable. We aimed to provide an international picture of the extent of pressure injuries and factors associated with ICU-acquired pressure injuries in adult ICU patients. Methods: International 1-day point-prevalence study; follow-up for outcome assessment until hospital discharge (maximum 12 weeks). Factors associated with ICU-acquired pressure injury and hospital mortality were assessed by generalised linear mixed-effects regression analysis. Results: Data from 13,254 patients in 1117 ICUs (90 countries) revealed 6747 pressure injuries; 3997 (59.2%) were ICU-acquired. Overall prevalence was 26.6% (95% confidence interval [CI] 25.9–27.3). ICU-acquired prevalence was 16.2% (95% CI 15.6–16.8). Sacrum (37%) and heels (19.5%) were most affected. Factors independently associated with ICU-acquired pressure injuries were older age, male sex, being underweight, emergency surgery, higher Simplified Acute Physiology Score II, Braden score 3 days, comorbidities (chronic obstructive pulmonary disease, immunodeficiency), organ support (renal replacement, mechanical ventilation on ICU admission), and being in a low or lower-middle income-economy. Gradually increasing associations with mortality were identified for increasing severity of pressure injury: stage I (odds ratio [OR] 1.5; 95% CI 1.2–1.8), stage II (OR 1.6; 95% CI 1.4–1.9), and stage III or worse (OR 2.8; 95% CI 2.3–3.3). Conclusion: Pressure injuries are common in adult ICU patients. ICU-acquired pressure injuries are associated with mainly intrinsic factors and mortality. Optimal care standards, increased awareness, appropriate resource allocation, and further research into optimal prevention are pivotal to tackle this important patient safety threat

Application of Modern Digital Systems and Approaches to Business Process Management

In order to adapt to ever-changing customer needs and satisfy them, good Business Process Management (BPM) in Small and Medium-sized Enterprises (SMEs) is crucial. The target group of this research is production SMEs whose BPM can be monitored respecting the values of key performance indicators (KPIs). This paper shows how improving the performance of the observed business processes can improve the level of customer satisfaction. This improvement should lead to the sustainability of SMEs in the market. In this paper, evaluation of business processes performance is defined as a multi-criteria decision problem. The relative importance of considered KPIs and their imprecise values are described by linguistic expressions, which are then modeled by triangular intuitionistic fuzzy numbers (TIFNs). Calculation of KPI weights is done by using the fuzzy analytic hierarchy process (FAHP). Evaluation of BPM success is conducted respecting the obtained KPI weights and KPI values. An optimal solution for BPM success improvement, respecting customer satisfaction indicators, is calculated using the Artificial Neural Network (ANN) and Genetic Algorithm (GA) approaches. By applying the proposed model, managers of production SMEs can determine the management initiatives that will improve their business and the sustainability of their companies

Effect of low temperature on rooting rate and carbohydrate content of Fritillaria meleagris bulbs formed in culture in vitro

Projekat ministarstva br. 143026

The current status of conservation of plant genetic resources in IBISS and related cryopreservation activities

The presentation has two parts: to describe the current status of genetic resources stored in plant tissue culture at Institute for Biological Research Sinisa Stankovic (IBISS), Belgrade, Serbia and to present some results on fundamental aspects of cryopreservation research. The IBISS represents the largest and the most complete research institution in the field of biological sciences in Serbia. The researchers at the IBISS are primarily focused on fundamental studies in biology and are included in projects supported by Ministry of Science of Republic of Serbia. The IBISS is organized on the basis of research teams working within specific departments. The profile of researches performed at Department of Plant Physiology is characterized by basic lines of developmental plant physiology (photomorphogenesis, in vitro morphogenesis and cytodifferentiation) as well as of experimental plant biology (genetic engineering, secondary metabolite production, fungal growth and development). The IBISS has a specialized unit for experiments on in vitro plant cultures (160 m2) and developed protocols for micropropagation of more than 50 plant species. The summary of endemic, endangered and pharmaceuticaly valuable plant species kept as in vitro cultures in IBISS will be presented. Cryopreservation is a valuable alternative to the in vitro collection for conserving different types of the plant material which is planed to develop in future. Second part of presentation is some fundamental aspects of cryoprotection. This study investigated the effects of one month acclimation on the accumulation of soluble sugars (sucrose, fructose and glucose) and polyols in Fritallaria meleagris bulbs formed in culture in vitro. Analysis of carbohydrate content revealed that sucrose was the dominant soluble carbohydrate in bulblets of F. meleagris. There was no high increase of sucrose accumulation in bulblets after low temperature storage. Monosacharides (glucose and fructose) are present at significantly lower content than sucrose at standard conditions. The significantly increased accumulation of glucose and fructose in bulblets was observed after low temperature treatment but the magnitude of change was much less for glucose than for fructose. The analyses of polyol content in bulblets of F. meleagris revealed more than twice higher accumulation of sugar alcohols after low temperature treatment (Table 1). Also the SOD activity during and after acclimation will be presented.vokMyynti MTT, Tietopalvelut 31600 Jokioine

Antioxidant and antimicrobial activity of two Asplenium species

Extracts of the aerial (fronds) and underground parts (rhizome and roots) of Asplenium adiantum-nigrum L. and Asplenium ruta-muraria L. were analyzed for their phenolic composition and antioxidant properties (scavenging capacities against DPPH center dot and ABTS(center dot+)), and were comparatively assayed for antimicrobial and antibiofilm activity. Total of the 17 phenolic compounds, belonging to the classes of phenolic acids (hydroxybenzoic and hydroxycinnamic acids), flavonoids (flavan-3-ols, flavonols), and xanthones were identified and quantified using UHPLC/DAD/(-)HESI-MS/MS analysis. The present study shows that two analyzed ferns are significantly diverse in terms of their phenolic profile. Flavonoids considerably contribute to the total phenolic content of A. ruta-muraria, ranging from 47% in roots to around 75% in rhizome and fronds, while A. adiantum-nigrum preferably accumulates xanthones. Antioxidant activity of fern methanol extracts was ascribed to their phenolics content. Extracts of rhizomes of both Asplenium ferns exhibited the highest antimicrobial activity, while frond extracts were more efficient in inhibition of Candida albicans biofilm formation. The present study provides experimental evidence that methanol extracts from two analyzed Asplenium fern species exhibit strong antibacterial effect against Gram-negative bacteria which candidate them as a potentially useful natural antimicrobial agents

Influence of sodium salicylate on rosmarinic acid, carnosol and carnosic acid accumulation by Salvia officinalis L. shoots grown in vitro

To evaluate sodium salicylate (NaSA) as an elicitor of rosmarinic acid (RA) and phenolic diterpenes, carnosol (C) and carnosic acid (CA) production, in a culture of Salvia officinalis shoots. In sage shoots grown in vitro, 28 polyphenolic compounds (phenolic acids, flavonoids, and phenolic diterpenes) were identified. In shoots treated for 1 week with increasing NaSA concentrations, the content of C increased from 2.3 in control to 5.7 mg g(-1) DW in shoots treated with 500 A mu M NaSA. In shoots that were recovered on basal medium for 3 weeks, the maximal amount of C (14 mg/g(-1) DW) was with 150 A mu M NaSA treatment. In treated and recovered shoots, the increase in C was accompanied with a decrease in CA, resulting in 1.9-fold increase in the C/CA ratio. Accumulation of RA was not affected by the NaSA treatment. However, elicitation by NaSA was accompanied with growth retardation. NaSA can improve C production in sage shoot culture, probably by stimulating the conversion of CA to C.European Union Seventh Framework Program {[}227448]; Ministry of Education, Science and Technological Development of the Republic of Serbia {[}173024