2,098 research outputs found
Actes du CongrÚs CollÚges célébrations 92
Ăgalement disponible en version papierTitre de l'Ă©cran-titre (visionnĂ© le 12 aoĂ»t 2009)Notes (part. bibliogr.) au bas des p
Actes du CongrÚs CollÚges célébrations 92
Ăgalement disponible en version papierTitre de l'Ă©cran-titre (visionnĂ© le 12 aoĂ»t 2009)Bibliogr.: p.
The secret in literature and medicine: for an ethics of sharing
LittĂ©rature et mĂ©decine sont deux disciplines entre lâart et la science et les potentialitĂ©s de leur croisement nâest plus Ă mettre en doute, trois dĂ©cennies aprĂšs lâĂ©mergence et lâessor de la MĂ©decine Narrative dans la recherche, la pratique et la formation mĂ©dicales, replaçant la question du sujet, cruciale en Ă©thique, au coeur de la relation thĂ©rapeutique. Face Ă lâhypertechnicitĂ© montante de la mĂ©decine, il importe de poursuivre la rĂ©flexion en interrogeant une notion dâenjeu et complexitĂ©, comme celle du secret, intimement liĂ© aux catĂ©gories de la subjectivitĂ© et de lâintimitĂ©. Lâarticle accompagne son Ă©volution et ses configurations modernes en mĂ©decine et littĂ©rature pour faire dialoguer une Ă©thique mĂ©dicale, concernĂ©e par la perte du colloque singulier et de la rĂ©alitĂ© humaine, et la dĂ©marche littĂ©raire activant des processus langagiers et discursifs par lesquels le secret peut se constituer en maillon dâune dĂ©marche intersubjective de qualitĂ©.info:eu-repo/semantics/publishedVersio
A family of tree-based generators for bubbles in directed graphs
6sĂŹopenBubbles are pairs of internally vertex-disjoint (s, t)-paths in a directed graph. In de Bruijn graphs built from reads of RNA and DNA data, bubbles represent interesting biological events, such as alternative splicing (AS) and allelic differences
(SNPs and indels). However, the set of all bubbles in a de Bruijn graph built from real data is usually too large to be efficiently enumerated and analysed in practice. In particular, despite significant research done in this area, listing bubbles still remains the main bottleneck for tools that detect AS events in a reference-free context. Recently, in the concept of a bubble generator was introduced as a way for obtaining a compact representation of the bubble space of a graph. Although this bubble generator was quite effective in finding AS events, preliminary experiments showed that it is about 5 times slower than state-of-art methods. In this paper we propose a new family of bubble generators which improve substantially on previous work: bubble generators in this new family are about two orders of magnitude faster and are still able to achieve similar precision in identifying AS events. To highlight the practical value of our new bubble generators, we also report some experimental results on real datasets.openAcuña, Vicente; Soares de Lima, Leandro Ishi; Italiano, Giuseppe F.; PepÚ Sciarria, Luca; Sagot, Marie-France; Sinaimeri, BlerinaAcuña, Vicente; Soares de Lima, Leandro Ishi; Italiano, Giuseppe F.; PepÚ Sciarria, Luca; Sagot, Marie-France; Sinaimeri, Blerin
Le lymphome du manteau
peer reviewedLe lymphome du manteau représente 3 à 10% des lymphomes non hodgkiniens (LNH). Il est caractérisé par la translocation chromosomique t(11;14) (q13;32), qui est responsable d'une surexpression de la cycline D1. Cette derniÚre participe à l'oncongenÚse en favorisant la progression du cycle cellulaire. L'ùge médian au moment du diagnostic est compris entre 60 et 70 ans et le pronostic est assez sombre puisque la survie médiane est estimée à 4 ans. Chez la plupart des patients, le diagnostic est posé à un stade avancé de la maladie. Des sites extra-ganglionnaires sont souvent atteints. Le traitement actuel de premiÚre ligne est basé sur de la poly-chimiothérapie suivie, chez les patients jeunes, par une autogreffe de cellules souches hématopoïétiques. L'allogreffe de cellules souches hématopoïétiques aprÚs un conditionnement non-myéloablateur pourrait jouer un rÎle chez les patients en rechute aprÚs autogreffe.Mantle cell lymphoma comprises 3 to 10% of non-Hodgkin's lymphomas. Cyclin D1 expression due to t(11;14) (q13;32) is considered as a hallmark of this lymphoma and plays a pivotal role in the pathophysiology of lymphoma transformation. Median age at diagnosis ranges from 60 to 70 years, and diagnosis is often made at an advances stage with widespread lymphadenopathy and extranodular (particularly bone marrow and gastrointestinal) infiltration. First line treatment consists of combination chemotherapy followed with autologous hematopoietic cell transplantation (HCT) in younger patients, while allogeneic HCT following non-myeloablative conditioning might have a role inpatients relapsing after autologous HCT
Le baron de Vincent (1757-1834), officier et diplomate au service de l'Autriche et la terre de Bioncourt en Lorraine
Donation after Cardiac Death increases the number of liver grafts for liver transplantation
Upregulation of Interleukin 8 by Oxygen-deprived Cells in Glioblastoma Suggests a Role in Leukocyte Activation, Chemotaxis, and Angiogenesis
Leukocyte infiltration and necrosis are two biological phenomena associated with the development of neovascularization during the malignant progression of human astrocytoma. Here, we demonstrate expression of interleukin (IL)-8, a cytokine with chemotactic and angiogenic properties, and of IL-8âbinding receptors in astrocytoma. IL-8 expression is first observed in low grade astrocytoma in perivascular tumor areas expressing inflammatory cytokines. In glioblastoma, it further localizes to oxygen-deprived cells surrounding necrosis. Hypoxic/anoxic insults on glioblastoma cells in vitro using anaerobic chamber systems or within spheroids developing central necrosis induced an increase in IL-8 messenger RNA (mRNA) and protein expression. mRNA for IL-8âbinding chemokine receptors CXCR1, CXCR2, and the Duffy antigen receptor for chemokines (DARC) were found in all astrocytoma grades by reverse transcription/PCR analysis. In situ hybridization and immunohistochemistry localized DARC expression on normal brain and tumor microvascular cells and CXCR1 and CXCR2 expression to infiltrating leukocytes. These results support a model where IL-8 expression is initiated early in astrocytoma development through induction by inflammatory stimuli and later in tumor progression increases due to reduced microenvironmental oxygen pressure. Augmented IL-8 would directly and/or indirectly promote angiogenesis by binding to DARC and by inducing leukocyte infiltration and activation by binding to CXCR1 and CXCR2
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