SPORTS PRACTICE AS THERAPEUTIC METHOD IN PHYSICAL REHABILITATION PROGRAMS FOR CHILDREN WITH SPECIAL EDUCATION NEEDS

Our main concern consists in offering an optimal physical development rehabilitation program for children with special educational needs. The therapeutic programs we approach in special schools is based on the diversity of physiotherapy methods and playful physical activity. To increase pupil’s interest in physiotherapy sessions and to make this therapy more pleasant for these children, we introduced key elements from regular sport activities in their individual therapeutic intervention programs (e.g. basketball- played at a larger and lower positioned basket, football- played with a lighter ball in a small field, bocce- played with lightweight balls on a smaller field). These programs have been well received, no special needs child was yet to refuse playing any adapted sport for their condition. By introducing regular sports in the physiotherapy programs applied for children in our school, we succeeded to forward socialization, team-work, improving gross and fine motor skills, developing high receptivity towards sports. In order to bring out the best of their abilities, each and every child is given the opportunity and is encouraged to compete in local sports competitions organized for children with special needs. There are connections between mental and physical wellness. Maintaining physical health can also support mental well-being. In this way, everyone can use athletics as a form of treatment. This review will go into great detail on the therapeutic benefits of sport for kids, including how it can help them individually achieve better physical and emotional results and facilitate social integration. For the diversity of the therapeutic program and the healthy development of these children, as well as for the increase of their quality of life, it is necessary to integrate mainstream sports in the curriculum of special schools, as long as they are adapted to the needs of children with disabilities

CONSERVATING THE TRADITIONAL CELLARS OF SALACEA, BIHOR COUNTY, ROMANIA

This paper argues for the enhanced utilization of the built heritage in the case of the unique cellars of Salacea, Bihor Country which is called „the village of 1000 cellars„. The research analysis of the cellars includes field investigations, study of existing bibliography, air-photo interpretation. For examining the architectureal plans, facades and volumes use was made of software such as: Archicad 22 R1 INT version 22.0.0.3006, Artlantis (2017) 6.5 version 6.5.2.14, Adobe Illustrator CC (2017) version 21.1.0 and Adobe Photoshop CC (2015) version 16.1, and for processing the photos Adobe Lightroom version 6.12. Cartographic materials have been processed in 3D Studio Max, Corel Draw and Corel Photopaint. The use of spatial data allowed identification and analysis of important aspect for understanding the territorial reality. The study identifies two authentic models of cellars that could be exploited for their heritage potential for tourism development and a source of income for the local area

Управление затратами предприятия

Объектом исследования является УМП "Комбинат спецобслуживания". Целью работы является разработка мероприятий по совершенствованию системы управления затратами УМП "Комбинат спецослуживания". В процессе исследования проводился анализ деятельности предприятия и разработка мероприятий по совершенствованию системы управления затратами предприятия. Результаты анализа деятельности предприятия и разработанные мероприятия по совершенствованию системы управления затратами УМП "Комбинат спецобслуживания" могут быть использованы для разработки новой методологии управления затратами и внедрены в систему управления затратами на предприятии на примере метода АВС. Проведен анализ деятельности предприятия, а также разработаны новые системы управления затратами предприятия на примере метода АВС.The object of the study is the UMP "Combinat specobsluzhvaniya". The purpose of the work is to develop measures to improve the cost management system of the " Combinat specobsluzhvaniya ". In the process of the study, an analysis of the enterprise's activities and development of measures to improve the enterprise cost management system was conducted. The results of the enterprise activity analysis and the developed measures to improve the cost management system of the " Combinat specobsluzhvaniya " can be used to develop a new methodology for cost management and implemented in the enterprise cost management system using the ABC method as an example. The enterprise activity analysis is carried out, and new enterprise cost management systems are developed using the ABC method as an example

TOURIST PERCEPTION OF THE „NIGHT OF THE MUSEUMS” EVENT. CASE STUDY IN ORADEA MUNICIPALITY, ROMANIA

Cultural events have a significant influence on the local economy. Cultural festivals can attract tourists, extend the tourist season and add vitality to a city. However, there is relatively little research on how festivals influence a destinat ion's tourist experience or outcomes, such as satisfaction. The main objective of this study is to evaluate the tourist perception of the participants on the Night of the Museums event held in Oradea municipality, Bihor County, Romania, assuming that a good tourist perception among the population can represent an element of identity for a destination, thus contributing to the increase of its capacity to attract tourists. The results emphasize the positive effects at the socio-cultural level. The festival provides multiple possibilities to spend free time in a pleasant way, it sustains the development of cultural life, a nd it improves the educational and the cultural level of community

De Novo

The crystal structure of form 4 of the drug 4-[4-(2-adamantylcarbamoyl)-5-tert-butyl-pyrazol-1-yl]benzoic acid is determined using a protocol for NMR powder crystallography at natural isotopic abundance combining solid-state 1H NMR spectroscopy, crystal structure prediction, and density functional theory chemical shift calculations. This is the first example of NMR crystal structure determination for a molecular compound of previously unknown structure, and at 422 g/mol this is the largest compound to which this method has been applied so far

Genetic modifiers of radon-induced lung cancer risk: a genome-wide interaction study in former uranium miners

PURPOSE: Radon is a risk factor for lung cancer and uranium miners are more exposed than the general population. A genome-wide interaction analysis was carried out to identify genomic loci, genes or gene sets that modify the susceptibility to lung cancer given occupational exposure to the radioactive gas radon. METHODS: Samples from 28 studies provided by the International Lung Cancer Consortium were pooled with samples of former uranium miners collected by the German Federal Office of Radiation Protection. In total, 15,077 cases and 13,522 controls, all of European ancestries, comprising 463 uranium miners were compared. The DNA of all participants was genotyped with the OncoArray. We fitted single-marker and in multi-marker models and performed an exploratory gene-set analysis to detect cumulative enrichment of significance in sets of genes. RESULTS: We discovered a genome-wide significant interaction of the marker rs12440014 within the gene CHRNB4 (OR = 0.26, 95% CI 0.11-0.60, p = 0.0386 corrected for multiple testing). At least suggestive significant interaction of linkage disequilibrium blocks was observed at the chromosomal regions 18q21.23 (p = 1.2 × 10-6), 5q23.2 (p = 2.5 × 10-6), 1q21.3 (p = 3.2 × 10-6), 10p13 (p = 1.3 × 10-5) and 12p12.1 (p = 7.1 × 10-5). Genes belonging to the Gene Ontology term "DNA dealkylation involved in DNA repair" (GO:0006307; p = 0.0139) or the gene family HGNC:476 "microRNAs" (p = 0.0159) were enriched with LD-blockwise significance. CONCLUSION: The well-established association of the genomic region 15q25 to lung cancer might be influenced by exposure to radon among uranium miners. Furthermore, lung cancer susceptibility is related to the functional capability of DNA damage signaling via ubiquitination processes and repair of radiation-induced double-strand breaks by the single-strand annealing mechanism

Science and history explored by nuclear magnetic resonance

Nuclear Magnetic Resonance was chosen as the main tool for investigating different biological and chemical systems, as it is unique in providing the information details about the morphology and molecular structures and conformations by which the fundamental properties of these biological and chemical systems can be understood. Proton spin-diffusion experiments combined with 13C CPMAS spectroscopy were successfully applied to characterize the changes that occur during the thermal denaturation of keratin fibers from wool and hair. A model describing both the effect of thermal denaturation and the effect of different chemical treatments on keratin fibers is presented. Proton NMR spectroscopy was used for studying the proton exchange in Sulfonated Polyether Ether Ketone proton exchange membranes revealing that the water exchange processes in hydrated SPEEK-silica membranes are more efficient when low concentrations of polyethoxysiloxane (PEOS) are used for the membrane preparation. Proton 1D exchange spectroscopy combined with transverse relaxation measurements offered good insight in the state of water in hydrated SPEEK/SiO2 membranes revealing that concentrations of 5%-10% wt. PEOS could enhance the electrical conductivity of PEM. Hyperpolarized 129Xe NMR spectroscopy was successfully applied for monitoring the free radical polymerization reactions of methyl methacrylate, methyl acrylate and the copolymerization of methyl methacrylate and methyl acrylate. The observation of Xe chemical shift and linewidths during the reactions reveal information about the polymer chain growths during the polymerizations. The successful application of the NMR-MOUSE to visualise the different anatomical layers with varying proton densities opens the possibility of its use in clinical studies such as osteoporosis for bone density measurements. The NMR-MOUSE was also successfully applied for the analysis of violins and bows and a classification of the violins and bows as a function of the fabrication year was achieved