The influence of surface finishing methods on touch-sensitive reactions

This paper describes the modern technological development trends in jewelry design. In the jewelry industry, new trends, associated with the introduction of updated non-traditional materials and finishing techniques, are appearing. The existing information-oriented society enhances the visual aesthetics of new jewelry forms, decoration techniques (depth and surface), synthesis of different materials, which, all in all, reveal a bias towards positive effects of visual design. Today, the jewelry industry includes not only traditional techniques, but also such improved techniques as computer-assisted design, 3D-prototyping and other alternatives to produce an updated level of jewelry material processing. The authors present the specific features of ornamental pattern designing, decoration types (depth and surface) and comparative analysis of different approaches in surface finishing. Identifying the appearance or the effect of jewelry is based on proposed evaluation criteria, providing an advanced visual aesthetics basis is predicated on touch-sensitive responses

Antiradical and Oxidative Stress Release Properties of Trifolium pratense L. extract

Low adaptive capacity and oxidative stress are the factors leading to cellular dysfunction, protein and lipid peroxidation, and the development of diseases. In recent decades, there has been a trend toward the active use of plant-based antioxidants. Trifolium pratense L. is a promising plant for the pharmaceutical and food industry and has anti-radical properties. This work is devoted to studying the antiradical and oxidative stress-released properties of T. pratense in Caenorhabditis elegans under oxidative and temperature stress. The objective of this research was to evaluate the anti-radical properties of the T. pratense extracts and individual BAS (chlorogenic acid, ononin, biochanin A, genistein) and analysis their influences on the oxidative stress of Caenorhabditis elegans in the presence of paraquat. Analysis of the antiradical properties revealed that chlorogenic acid has the maximum ability to neutralize the free radical (35.49µmol). A separate analysis of oxidative stress revealed high ononin activity at concentrations of 10, 50, and 100 µmol at 48 hours of cultivation.  Biochanin A increases survival by 13.1% compared to the control. The use of the extract (500µmol) contributed to an increase in survival on day 1 of incubation. Under conditions of thermal stress, ononin (50 and 200 µmol) has a positive effect on the viability of C. elegans.  The extract and BAS of T. pratense are characterized by high antiradical activity. In addition, the ability to influence the viability of C. elegans was revealed. Therefore, it is worthwhile to further study the biological properties of T. pratense for use in geroprotective therapy

Specialties of Blood Serum Structurization Under Some Physiological Conditions

Background: it is well-known that physiological stress agents can to produce a significant response of regulatory systems. At the same time, the nature of metabolic shifts in the organism during significant physical exertion and emotional stress has been insufficiently studied in detail. Aim: The aim of this investigation is study of modification of crystallogenic properties of human blood serum action under physical exertion and psychoemotional stress. Results: it is stated that physical exertion and psychoemotional stress causes increasing of crystallogenic activity of human blood serum. This trend is more pronounced for the first impact. This is confirmed by the results of vizuametric analysis of blood serum facias and its spectrometric testing. Conclusion: we show that crystalloscopic picture of blood serum is an informative criterion of different physiological conditions, including physical exertion and psychoemotional stress. It realized in the shifts of structure of biological fluid facias

Review of effective methods of teaching a foreign language to university students in the framework of online distance learning: international experience

The research goal is to analyze the existing and most frequently used methods and competency-based approaches to distance learning of a foreign language. The tasks are formulated to achieve the goal. They involve classifying the methods of foreign language teaching based on the competency approach and identifying the effective methods. The methodological basis of this research includes methods of analyzing the practical experience of foreign language teaching based on a competency-based approach, synthesis of national and international experience, comparison of national models of the language environment, and generalization of sociological data. As a result of the conducted research, it has been revealed that among various methods, approaches related to information and communication technologies [ICT] are utilized most often. We believe that when teachers conduct courses using synchronous computer-mediated communication [SCMC] tools or platforms, students should be given opportunities to express their opinions. Most teachers recognize the creation of instructional videos as the most effective. According to the students, this type of activity also has the greatest learning effect and stimulates creativity. The scientific novelty of the research is the study of foreign language teaching methods based on a competency-based approach within the framework of online distance learning and the relationship of all interested parties, in other words, teachers, students, and educational institutions

Relations between bedtime parenting behaviors and temperament across 14 cultures

ObjectivesThe present study examined parental sleep-supporting practices during toddlerhood in relation to temperament across 14 cultures. We hypothesized that passive sleep-supporting techniques (e.g., talking, cuddling), but not active techniques (e.g., walking, doing an activity together), would be associated with less challenging temperament profiles: higher Surgency (SUR) and Effortful Control (EC) and lower Negative Emotionality (NE), with fine-grained dimensions exhibiting relationships consistent with their overarching factors (e.g., parallel passive sleep-supporting approach effects for dimensions of NE). MethodsCaregivers (N = 841) across 14 cultures (M = 61 families per site) reported toddler (between 17 and 40 months of age; 52% male) temperament and sleep-supporting activities. Utilizing linear multilevel regression models and group-mean centering procedures, we assessed the role of between- and within-cultural variance in sleep-supporting practices in relation to temperament. ResultsBoth within-and between-culture differences in passive sleep-supporting techniques were associated with temperament attributes, (e.g., lower NE at the between-culture level; higher within-culture EC). For active techniques only within-culture effects were significant (e.g., demonstrating a positive association with NE). Adding sleep-supporting behaviors to the regression models accounted for significantly more between-culture temperament variance than child age and gender alone. ConclusionHypotheses were largely supported. Findings suggest parental sleep practices could be potential targets for interventions to mitigate risk posed by challenging temperament profiles (e.g., reducing active techniques that are associated with greater distress proneness and NE).Peer reviewe

Microbial interactions in the mosquito gut determineSerratiacolonization and blood-feeding propensity

How microbe–microbe interactions dictate microbial complexity in the mosquito gut is unclear. Previously we found that, Serratia, a gut symbiont that alters vector competence and is being considered for vector control, poorly colonized Aedes aegypti yet was abundant in Culex quinquefasciatus reared under identical conditions. To investigate the incompatibility between Serratia and Ae. aegypti, we characterized two distinct strains of Serratia marcescens from Cx. quinquefasciatus and examined their ability to infect Ae. aegypti. Both Serratia strains poorly infected Ae. aegypti, but when microbiome homeostasis was disrupted, the prevalence and titers of Serratia were similar to the infection in its native host. Examination of multiple genetically diverse Ae. aegypti lines found microbial interference to S. marcescens was commonplace, however, one line of Ae. aegypti was susceptible to infection. Microbiome analysis of resistant and susceptible lines indicated an inverse correlation between Enterobacteriaceae bacteria and Serratia, and experimental co-infections in a gnotobiotic system recapitulated the interference phenotype. Furthermore, we observed an effect on host behavior; Serratia exposure to Ae. aegypti disrupted their feeding behavior, and this phenotype was also reliant on interactions with their native microbiota. Our work highlights the complexity of host–microbe interactions and provides evidence that microbial interactions influence mosquito behavior

Links between television exposure and toddler dysregulation : Does culture matter?

Television exposure in early childhood has increased, with concerns raised regarding adverse effects on social-emotional development, and emerging self-regulation in particular. The present study addressed television exposure (i.e., amount of time watching TV) and its associations with toddler behavioral/emotional dysregulation, examining potential differences across 14 cultures. The sample consisted of an average of 60 toddlers from each of the 14 countries from the Joint Effort Toddler Temperament Consortium (JETTC; Gartstein & Putnam, 2018). Analyses were conducted relying on the multi-level modeling framework (MLM), accounting for between- and within-culture variability, and examining the extent to which TV exposure contributions were universal vs. variable across sites. Effects of time watching TV were evaluated in relation to temperament reactivity and regulation, as well as measures of emotional reactivity, attention difficulties, and aggression. Results indicated that more time spent watching TV was associated with higher ratings on Negative Emotionality, emotional reactivity, aggression, and attention problems, as well as lower levels of soothability. However, links between TV exposure and both attention problems and soothability varied significantly between cultures. Taken together, results demonstrate that increased time spent watching television was generally associated with dysregulation, although effects were not consistently uniform, but rather varied as a function of culturally-dependent contextual factors.acceptedVersionPeer reviewe

Identification of eight novel proteasome variants in five unrelated cases of proteasome-associated autoinflammatory syndromes (PRAAS)

Mutations in genes coding for proteasome subunits and/or proteasome assembly helpers typically cause recurring autoinflammation referred to as chronic atypical neutrophilic dermatosis with lipodystrophy and elevated temperatures (CANDLE) or proteasome-associated autoinflammatory syndrome (PRAAS). Patients with CANDLE/PRAAS present with mostly chronically elevated type I interferon scores that emerge as a consequence of increased proteotoxic stress by mechanisms that are not fully understood. Here, we report on five unrelated patients with CANDLE/PRAAS carrying novel inherited proteasome missense and/or nonsense variants. Four patients were compound heterozygous for novel pathogenic variants in the known CANDLE/PRAAS associated genes, PSMB8 and PSMB10, whereas one patient showed additive loss-of-function mutations in PSMB8. Variants in two previously not associated proteasome genes, PSMA5 and PSMC5, were found in a patient who also carried the PSMB8 founder mutation, p.T75M. All newly identified mutations substantially impact the steady-state expression of the affected proteasome subunits and/or their incorporation into mature 26S proteasomes. Our observations expand the spectrum of PRAAS-associated genetic variants and improve a molecular diagnosis and genetic counseling of patients with sterile autoinflammation