Synthesis of (−)-Epi-Indolactam V by an Intramolecular Buchwald–Hartwig C–N Coupling Cyclization Reaction

The synthetic efforts toward the concise synthesis of (−)-indolactam V from simple and commercially available starting materials using palladium- and copper-catalyzed intramolecular N-arylation strategy for the elaboration of the requisite nine-membered lactam ring as the key step are described. The incorporation of a turn-inducing structural element along the linear precursor was fundamental to achieve the heterocyclization step as well as obtain the correct regio- and chemoselectivity. The stereoselective nature in the C–N coupling cyclization reaction is interpreted in terms of minimization of allylic strain at the transition state for the palladium-amido complex formation. Meanwhile, the synthesis of the (−)-epi-indolactam V and its enantiomer have been accomplished

Unitarization of the Horocyclic Radon Transform on Homogeneous Trees

Following previous work in the continuous setup, we construct the unitarization of the horocyclic Radon transform on a homogeneous tree X and we show that it intertwines the quasi regular representations of the group of isometries of X on the tree itself and on the space of horocycles.Comment: 16 pages, 3 figure

Idiopathic Eosinophilic Pneumonia with Associated Pulmonary Vasculitis in Horse: A Case Series

Various eosinophilic lesions and their association with diseases have been described in horses. Multisystemic Eosinophilic Epitheliotropic Disease (MEED) characterized by eosinophilic granulomas in various organs represent the most diffuse manifestation. In the present study, we describe the gross and microscopic lesions of idiopathic eosinophilic pneumonia with associated pulmonary vasculitis in 11 horses without systemic involvement. Lungs were enlarged, pale pink, poorly collapsed with white-reddish nodules, randomly distributed throughout the parenchyma. Histologically the lesions ranged from mild eosinophilic bronchointerstitial pneumonia to severe eosinophilic lobular bronchopneumonia associated with eosinophilic necrotizing vasculitis affecting small to medium-size vessels. There was no histologic evidence of parasites within the lesion of any of these horses. Eosinophilic pneumonia with vasculitis and without intralesional parasites have not been previously reported in horses. The current histologic findings are similar to pathologic lung findings observed in Churg-Strauss syndrome of man

Triorchidism: genetic and imaging evaluation in an adult male

We report the results of imaging and cytogenetic studies in a case of tri- orchidism in a 54 years old male without any associated anomaly. A scrotal ultrasonography revealed the presence of two testes within the left hemiscrotum with complete septa- tion and echotexture and vascular flow pattern similar to the vascular flow of the normal right testis. There was no focal abnormal echogenicity suggesting malignancy. Scrotal MRI confirmed two soft-tissue structures in the left hemiscrotum with normal signal intensity at T1w and T2w images. Both testes had a tunica albuginea with low-signal intensity. Cytogenetic analysis resulted in normal male karyotype 46XY. Array-CGH analysis detected the presence of two interstitial rearrangements: a ~120 Kb deletion of chro- mosome 1 and a ~140 Kb deletion of chromosome 16. Currently there are little details on the functions of both genes

Unitarization and Inversion Formulae for the Radon Transform Between Dual Pairs

We consider the Radon transform associated to dual pairs (X,\u39e) in the sense of Helgason, with X = G/K and \u39e = G/H, where G is a locally compact group and K and H are closed subgroups of G. Under some technical assumptions, we prove that if the quasi-regular representations of G acting on L2(X) and L2(\u39e) are irreducible, then the Radon transform admits a unitarization intertwining the two representations. If, in addition, the representations are square- integrable, we provide an inversion formula for the Radon transform based on the voice transform associated to these representations

The Transnational and the Text-Searchable: Digitized Sources and the Shadows They Cast

This working paper explores the consequences for historians' research practice of the twinned transnational and digital turns. The accelerating digitization of historians' sources (scholarly, periodical, and archival) and the radical shift in the granularity of access to information within them has radically changes historians' research practice. Yet this has incited remarkably little reflection regarding the consequences for individual projects or collective knowledge generation. What are the implications for international research in particular? This essay heralds the new kinds of historical knowledge-generation made possible by web access to digitized, text-searchable sources. It also attempts an accounting of all that we formerly, unwittingly, gained from the frictions inherent to international research in an analog world. What are the intellectual and political consequences of that which has been lost