Hemoperfusive Removal of Specific Intoxicants: The Role of the Rabbit in Preclinical Trials

Fjemelse af specifikke giftsloffer ved hemoperfusion Haemoperfusion er den foretrukne metode til direkte detoksifikation af patienter med akutte forgiftninger. Som adsorbant anvendes saedvanligvis kul. Den nyeste forskning indenfor dette omrade beskmftiger Sig med udvikling af specifikke adsorbanter til fjernelse at specitikke antistoffer, immunkomplekser 0g giftstoffer. Der gives en beskrivelse af en dyreeksperimentel model til udvikling af specifik detoksifikation ved anvendelse af haemoperfusion. Som forsagsdyr anvendes kaniner med permanente katetre i v. jugularis og a. carotis. Haemoperfusionssystemet bestfir af en peristaltisk pumpe og en stajle med agaroseperler (0.5—1.0 mm i diameter) indeholdende tusinder af mikrosphaerer (0.2 p. i diameter) koblet til specifikke antigener. Det arterielle blod pumpes fra a. carotis gennem sajlen til V. jugularis. Systemet perfunderes med hepariniseret saltvand (1 enh/ml) far brug, og kaninen hepariniseres med 300 enh heparin pr. kg legemsvaegt. Perfusionshastigheden er 8—15 ml/min, svarende til en perfusionshastighed p5. 20—30 min. I fig. 5 og 6 Vises resultaterne af forsog pa fjernelse af kviksolv og anti bovint serum albumin

Empowerment skills to develope successful entrepreuners in university context

El estudio tuvo como objetivo promover las habilidades requeridas por los estudiantes universitarios para ser emprendedores exitosos. La Investigación fue de tipo descriptivo, no experimental, de campo, con población de 702 estudiantes de diversas universidades de la ciudad de Barranquilla. La técnica de recolección fue un cuestionario integrado por dieciocho (18) ítems. Los resultados indican que los estudiantes deben reforzar el aprendizaje autónomo, el pensamiento crítico, creatividad, identificación y resolución de problemas, toma de decisiones, fomento del trabajo en equipo. Las conclusiones indican que potenciar el emprendimiento es un complemento formativo en el ámbito educativo para forjar iniciativas favorables al desarrollo socio-personal y lograr emprendedores exitosos.The study aimed to promote the skills needed for college students to be successful entrepreneurs. The study was not experimental, descriptive; with a survey of 702 students from the Barranquilla city. The collection technique was a questionnaire composed of eighteen (18) items. The results show that students should strengthen independent learning, critical thinking, creativity, identification and problem solving, decision making, promoting teamwork. The findings indicate that promote entrepreneurship is a complementary training in education to forge friendly initiatives to achieve socio-personal development and successful entrepreneur

Strategic direction of the human talent in the promotion of values in the Venezuelan police forces

This research was aimed at analyzing the strategic direction of human talent to promote values in Venezuelan police forces. The research was supported by Alles (2008), Cortina (2007), Martinelli (2004). The methodology was descriptive, nonexperimental cross-sectional design, the study population consisted of (35) subjects. A survey was applied with 40 items, with application of the Likert scale for interpretation. Data were tabulated according to the reagents and interpreted statistically by absolute and relative frequency, as well by central tendency and standard deviation scores.La Investigación estuvo dirigida a analizar la dirección estratégica del talento humano para fomentar valores en los cuerpos policiales venezolanos. La investigación estuvo sustentada en Alles (2008), Cortina (2007), Martinelli (2004). La metodología fue descriptiva, diseño no experimental transversal, la población estudiada estuvo conformada por (35) sujetos. Se aplicó una encuesta con 40 ítemes, con aplicación de la escala de Likert para su interpretación. Los datos fueron tabulados de acuerdo con los reactivos e interpretados estadísticamente mediante frecuencias absoluta y relativa, y puntajes de tendencia central y desviación estándar

Strategic direction of the human talent in the promotion of values in the Venezuelan police forces

La Investigación estuvo dirigida a analizar la dirección estratégica del talento humano para fomentar valores en los cuerpos policiales venezolanos. La investigación estuvo sustentada en Alles (2008), Cortina (2007), Martinelli (2004). La metodología fue descriptiva, diseño no experimental transversal, la población estudiada estuvo conformada por (35) sujetos. Se aplicó una encuesta con 40 ítemes, con aplicación de la escala de Likert para su interpretación. Los datos fueron tabulados de acuerdo con los reactivos e interpretados estadísticamente mediante frecuencias absoluta y relativa, y puntajes de tendencia central y desviación estándar.This research was aimed at analyzing the strategic direction of human talent to promote values in Venezuelan police forces. The research was supported by Alles (2008), Cortina (2007), Martinelli (2004). The methodology was descriptive, nonexperimental cross-sectional design, the study population consisted of (35) subjects. A survey was applied with 40 items, with application of the Likert scale for interpretation. Data were tabulated according to the reagents and interpreted statistically by absolute and relative frequency, as well by central tendency and standard deviation scores

Iron oxide nanoparticles for neuronal cell applications: uptake study and magnetic manipulations.

BACKGROUND: The ability to direct and manipulate neuronal cells has important potential in therapeutics and neural network studies. An emerging approach for remotely guiding cells is by incorporating magnetic nanoparticles (MNPs) into cells and transferring the cells into magnetic sensitive units. Recent developments offer exciting possibilities of magnetic manipulations of MNPs-loaded cells by external magnetic fields. In the present study, we evaluated and characterized uptake properties for optimal loading of cells by MNPs. We examined the interactions between MNPs of different cores and coatings, with primary neurons and neuron-like cells. RESULTS: We found that uncoated-maghemite iron oxide nanoparticles maximally interact and penetrate into cells with no cytotoxic effect. We observed that the cellular uptake of the MNPs depends on the time of incubation and the concentration of nanoparticles in the medium. The morphology patterns of the neuronal cells were not affected by MNPs uptake and neurons remained electrically active. We theoretically modeled magnetic fluxes and demonstrated experimentally the response of MNP-loaded cells to the magnetic fields affecting cell motility. Furthermore, we successfully directed neurite growth orientation along regeneration. CONCLUSIONS: Applying mechanical forces via magnetic mediators is a useful approach for biomedical applications. We have examined several types of MNPs and studied the uptake behavior optimized for magnetic neuronal manipulations.MM gratefully acknowledges the BINA Scholarship for Outstanding Graduate Students. The authors thank Michelle Katz for her help with the morphology measurements

Challenging the Science Curriculum Paradigm: TeachingPrimary Children Atomic-Molecular Theory

Solutions to global issues demand the involvement of scientists, yet concern exists about retention rates in science as students pass through school into University. Young children are curious about science, yet are considered incapable of grappling with abstract and microscopic concepts such as atoms, sub-atomic particles, molecules and DNA. School curricula for primary (elementary) aged children reflect this by their limitation to examining only what phenomena are without providing any explanatory frameworks for how or why they occur. This research challenges the assumption that atomic-molecular theory is too difficult for young children, examining new ways of introducing atomic theory to 9 year olds and seeks to verify their efficacy in producing genuine learning in the participants. Early results in three cases in different schools indicate these novel methods fostered further interest in science, allowed diverse children to engage and learn aspects of atomic theory, and satisfied the children’s desire for intellectual challenge. Learning exceeded expectations as demonstrated in the post-interview findings. Learning was also remarkably robust, as demonstrated in two schools eight weeks after the intervention, and in one school, one year after their first exposure to ideas about atoms, elements and molecules

Nocturia, Sleep-Disordered Breathing, and Cardiovascular Morbidity in a Community-Based Cohort

Background: Nocturia has been independently associated with cardiovascular morbidity and all-cause mortality, but such studies did not adjust for sleep-disordered breathing (SDB), which may have mediated such a relationship. Our aims were to determine whether an association between nocturia and cardiovascular morbidity exists that is independent of SDB. We also determined whether nocturia is independently associated with SDB. Methodology/Principal Findings: In order to accomplish these aims we performed a cross-sectional analysis of the Sleep Heart Health Study that contained information regarding SDB, nocturia, and cardiovascular morbidity in a middle-age to elderly community-based population. In 6342 participants (age 63±11 [SD] years, 53% women), after adjusting for known confounders such as age, body mass index, diuretic use, diabetes mellitus, alpha-blocker use, nocturia was independently associated with SDB (measured as Apnea Hypopnea index >15 per hour; OR 1.3; 95%CI, 1.2-1.5). After adjusting for SDB and other known confounders, nocturia was independently associated with prevalent hypertension (OR 1.23; 95%CI 1.08-1.40; P = 0.002), cardiovascular disease (OR 1.26; 95%CI 1.05-1.52; P = 0.02) and stroke (OR 1.62; 95%CI 1.14-2.30; P = 0.007). Moreover, nocturia was also associated with adverse objective alterations of sleep as measured by polysomnography and self-reported excessive daytime sleepiness (P<0.05). Conclusions/Significance: Nocturia is independently associated with sleep-disordered breathing. After adjusting for SDB, there remained an association between nocturia and cardiovascular morbidity. Such results support screening for SDB in patients with nocturia, but the mechanisms underlying the relationship between nocturia and cardiovascular morbidity requires further study. MeSH terms: Nocturia, sleep-disordered breathing, obstructive sleep apnea, sleep apnea, polysomnography, hypertension