La vente du siècle

Si vous voyez la dernière production vidéo de Malcom McLaren, Paris, capital of the XXIst Century, vous en parlerez autour de vous le jour suivant. Comme ceci: Un grand homme à l’air passionné, avec de grosses lunettes à monture noire – une sorte de Buddy Holly français – entre dans un magasin parisien spacieux et lumineux. Apparemment, cette boutique vient juste d’ouvrir ; à l’arrière-plan, on voit un peintre sur une échelle. Le vendeur, du genre Alfred Molina en pull-over violet, sourit : ..

A New Literary History of America.

Contains Title Page, Table of Contentshttps://mavmatrix.uta.edu/english_ctt/1255/thumbnail.jp

O furacão Katrina: Nova Orleans perdida na enchente

Translated by Idelber Avelar, a brief essay by Greil Marcus and Werner Sollors, taken from A New Literary History of America (Harvard University Press, 2009). In the essay, Marcus and Sollors reflect on the political effects of Hurricane Katrina on New Orleans – and on the United States – based on the rereading of literary works that dealt with previous climate catastrophes that befell the region.Em tradução de Idelber Avelar, um breve ensaio de Greil Marcus e Werner Sollors, extraído de A New Literary History of America (Harvard University Press, 2009). No ensaio, Marcus e Sollors refletem acerca dos efeitos políticos do furacão Katrina sobre Nova Orleans – e sobre os Estados Unidos – a partir da releitura de obras literárias que trataram de catástrofes climáticas anteriores que se abateram sobre a região

Exosomes: Potential model for complement-stealth delivery systems

Exosomes are nature's nanocarriers that transport biological information in humans. Their structural properties, origin and functions are making them interesting objects for the diagnosis of diseases, such as cancer, and also, as innovative tools for drug delivery. The interaction of exosomes with the immune system has been one of the focal points of interest; nevertheless their "stealth" properties helping to avoid adverse immune reactions are still not fully understood. In this review, after giving an overview of recent findings on the role of exosomes in disease pathogenesis and physiological functions, we focused on their interaction with the immune system and possibilities for clinical applications. The potential of exosomes of creating stealth nanoparticles that are better tolerated by the immune system than the presently available synthetic drug delivery systems represent a promising new approach in nanomedicine. © 2015 by De Gruyter 2015

Cardiovascular Adverse Reactions During Antidepressant Treatment: A Drug Surveillance Report of German-Speaking Countries Between 1993 and 2010

Background: Antidepressants (ADs) are known to have the potential to cause various cardiovascular adverse drug reactions (ADRs). The tricyclic antidepressants (TCAs) were first revealed to be a possible source of cardiovascular ADRs. In recent years, newer classes of ADs were also suggested to have a higher risk of cardiovascular adverse effects. In particular, the selective serotonin reuptake inhibitors (SSRIs) were suspected to have the potential to induce QTc interval prolongation, and therefore increase the risk of ventricular arrhythmia. This descriptive study is based on the continuous pharmacovigilance program of German-speaking countries (Austria, Germany, and Switzerland), the Arzneimittelsicherheit in der Psychiatrie (AMSP), which assesses severe ADRs occurring in clinical routine situations. Methods: Of 169 278 psychiatric inpatients treated with ADs between 1993 and 2010, 198 cases of cardiovascular ADRs (0.12%) were analyzed. Results: Our study showed that the incidence rates of cardiovascular ADRs were highest during treatment with monoamine oxidase inhibitors (0.27%),TCAs (0.15%), and serotonin noradrenaline reuptake inhibitors (0.14%); the risk of occurring during treatment with SSRIs (0.08%) was significantly lower. The noradrenergic and specific serotonergic AD mirtazapine (0.07%) had a significantly lower risk of cardiovascular ADRs than all other ADs. Severe hypotension was the most frequent ADR, followed by hypertension, arrhythmia, and in some rare cases heart failure. Conclusions: Despite certain limitations due to the AMSP study design, our observations on cardiovascular ADRs can contribute to a better knowledge of the cardiovascular risk profiles of antidepressants in the clinical routine setting. However, prospective studies are needed to verify our findings

Most Networks in Wagner's Model Are Cycling

In this paper we study a model of gene networks introduced by Andreas Wagner in the 1990s that has been used extensively to study the evolution of mutational robustness. We investigate a range of model features and parameters and evaluate the extent to which they influence the probability that a random gene network will produce a fixed point steady state expression pattern. There are many different types of models used in the literature, (discrete/continuous, sparse/dense, small/large network) and we attempt to put some order into this diversity, motivated by the fact that many properties are qualitatively the same in all the models. Our main result is that random networks in all models give rise to cyclic behavior more often than fixed points. And although periodic orbits seem to dominate network dynamics, they are usually considered unstable and not allowed to survive in previous evolutionary studies. Defining stability as the probability of fixed points, we show that the stability distribution of these networks is highly robust to changes in its parameters. We also find sparser networks to be more stable, which may help to explain why they seem to be favored by evolution. We have unified several disconnected previous studies of this class of models under the framework of stability, in a way that had not been systematically explored before