A Parafermionic Generalization of the Jaynes Cummings Model

We introduce a parafermionic version of the Jaynes Cummings Hamiltonian, by coupling $k$ Fock parafermions (nilpotent of order $F$) to a 1D harmonic oscillator, representing the interaction with a single mode of the electromagnetic field. We argue that for $k=1$ and $F\leq 3$ there is no difference between Fock parafermions and quantum spins $s=\frac{F-1}{2}$. We also derive a semiclassical approximation of the canonical partition function of the model by assuming $\hbar$ to be small in the regime of large enough total number of excitations $n$, where the dimension of the Hilbert space of the problem becomes constant as a function of $n$. We observe in this case an interesting behaviour of the average of the bosonic number operator showing a single crossover between regimes with different integer values of this observable. These features persist when we generalize the parafermionic Hamiltonian by deforming the bosonic oscillator with a generic function $\Phi(x)$; the $q-$deformed bosonic oscillator corresponds to a specific choice of the deformation function $\Phi$. In this particular case, we observe at most $k(F-1)$ crossovers in the behavior of the mean bosonic number operator, suggesting a phenomenology of superradiance similar to the $k-$atoms Jaynes Cummings model.Comment: to appear on J.Phys.

Cortical and subcortical neuronal substrates of social behavior

Social behavior is one of the most important properties of animal life and it plays a critical role in biological adaptations. However, the neural substrates of social cognitive processing are complex and largely unknown. The \u201csocial brain\u201d network, involving a range of cortical and subcortical regions and connective pathways, varies depending on task demands. The aim of this thesis was to clarify the implication of different brain pathways and systems in different aspects of mice social behavior. The work presented in the first two chapters of the thesis was to develop and validated a new behavioral test to assess the ability to discriminate unfamiliar conspecific based on their emotional state. The results provide significant new insights on the role of the PVN-CeA oxytocin pathway and the implication of an excitatory and inhibitory imbalance in mPFC as core behavioral dysfunctions in social cognitive deficits. The last part of the thesis was focused more on the investigation of the behavioral and physiological effects produced by pharmacological treatment (oxytocin). In particular, taking advantage of the effects oxytocin produced in a mouse model of genetic liability, we investigated the physiological mechanisms of exogenous oxytocin action in the mPFC. All the results presented in this thesis indicate mixed molecular factors for the different social and brain response in mice that may be crucial in the aetiology of the social disease

The impact of land use characteristics for sustainable mobility: the case study of Rome

Sustainable mobility requires actions to reduce the need for travel, to promote modal shift, to reduce trip lengths and to increase efficiency of transport system. Public transport could play an important role to solve part of the needs previously reported. Starting from these remarks, the present paper analyse the role, the importance and the impact of land use characteristics to develop services able to compete with automobile use. This analysis is carried out by studying the real world case of the city of Rome in Italy. The results of the test carried out highlight the importance of density of residences and activities, the need for a good quality access system to the transit services stops and the importance of the configuration of the transit network, identifying the best way to connect the different districts of the urban area. However, single actions are not sufficient to achieve a sustainable transport system: these actions can be successful only if they are planned in a complex unique system that helps the synergic development of the effects of the single actions proposed

Young at Heart: Pioneering Approaches to Model Nonischaemic Cardiomyopathy with Induced Pluripotent Stem Cells

A mere 9 years have passed since the revolutionary report describing the derivation of induced pluripotent stem cells from human fibroblasts and the first in-patient translational use of cells obtained from these stem cells has already been achieved. From the perspectives of clinicians and researchers alike, the promise of induced pluripotent stem cells is alluring if somewhat beguiling. It is now evident that this technology is nascent and many areas for refinement have been identified and need to be considered before induced pluripotent stem cells can be routinely used to stratify, treat and cure patients, and to faithfully model diseases for drug screening purposes. This review specifically addresses the pioneering approaches to improve induced pluripotent stem cell based models of nonischaemic cardiomyopathy

Identification of an intragenic deletion in the SGCB gene through a re-evaluation of negative next generation sequencing results

A large mutation screening of 504 patients with muscular dystrophy or myopathy has been performed by next generation sequencing (NGS). Among this cohort of patients, we report a case with a severe form of muscular dystrophy with a proximal weakness in the limb-girdle muscles. Her biopsy revealed typical dystrophic features and immunohistochemistry for α- and γ-sarcoglycans showed an absent reaction, addressing the clinical diagnosis toward a sarcoglycanopathy. Considering that no causative point mutation was detected in any of the four sarcoglycan genes, we re-evaluated the NGS data by careful quantitative analysis of the specific reads mapping on the four sarcoglycan genes. A complete absence of reads from the sixth exon of the β-sarcoglycan gene was found. Subsequent array comparative genomic hybridization (CGH) analysis confirmed the result with the identification of a novel 3.3 kb intragenic deletion in the SGCB gene. This case illustrates the importance of a multidisciplinary approach involving clinicians and molecular geneticists and the need for a careful re-evaluation of NGS data

Bi-Allelic DES Gene Variants Causing Autosomal Recessive Myofibrillar Myopathies Affecting Both Skeletal Muscles and Cardiac Function

Mutations in the human desmin gene (DES) may cause both autosomal dominant and recessive cardiomyopathies leading to heart failure, arrhythmias and atrio-ventricular blocks, or progressive myopathies. Cardiac conduction disorders, arrhythmias and cardiomyopathies usually associated with progressive myopathy are the main manifestations of autosomal dominant desminopathies, due to mono-allelic pathogenic variants. The recessive forms, due to bi-allelic variants, are very rare and exhibit variable phenotypes in which premature sudden cardiac death could also occur in the first or second decade of life. We describe a further case of autosomal recessive desminopathy in an Italian boy born of consanguineous parents, who developed progressive myopathy at age 12, and dilated cardiomyopathy four years later and died of intractable heart failure at age 17. Next Generation Sequencing (NGS) analysis identified the homozygous loss-of-function variant c.634C>T; p.Arg212*, which was likely inherited from both parents. Furthermore, we performed a comparison of clinical and genetic results observed in our patient with those of cases so far reported in the literature

Investigating plant micro‐remains embedded in dental calculus of the Phoenician inhabitants of Motya (Sicily, Italy)

Plant records reveal remarkable evidence about past environments and human cultures. Exploiting dental calculus analysis and using a combined approach of microscopy and gas chromatography mass spectrometry, our research outlines dietary ecology and phytomedicinal practices of the ancient community of Motya (Sicily, eight to sixth century BC), one of the most important Phoenician settlements in the Mediterranean basin. Micro‐remains suggest use or consumption of Triticeae cereals, and animal‐derived sources (e.g., milk and aquatic birds). Markers of grape (or wine), herbs, and rhizomes, endemic of Mediterranean latitudes and the East, provide insight into the subsistence of this colony, in terms of foodstuffs and phytotherapeutic products. The application of resins and wood of Gymnosperms for social and cultural purposes is hypothesized through the identification of Pinaceae secondary metabolites and pollen grains. The information hidden in dental calculus discloses the strong human‐plant interaction in Motya’s Phoenician community, in terms of cultural traditions and land use

Khirbet Al-Batrawy in North-Central Jordan: New discoveries in the Early Bronze Age Palace, 2018-2020

After 16 seasons (2005-2020) of excavations and restorations at Khirbet al-Batrawy in north-central Jordan, a clear picture of the history of the site and its major monuments has been obtained. In the last three seasons, works by Sapienza University of Rome and the Department of Antiquities of the Hashemite Kingdom of Jordan resumed the exploration of the “Palace of the Copper Axes”, leading to the discovery of a monumental entrance hall and a further western wing. Many finds, including several imports from Egypt, Syria, Anatolia and farther east, allow us to understand the functioning and socio-economic role of the palace in the southern Levantine scenario of the Early Bronze Age, and contribute to a better definition of urbanism in this region of the ancient Near East