Detection of non-Hodgkin's lymphoma liver disease in cirrhotic patients

Computer tomography (CT) scan and ultrasound scan (US) are the preferred methods for staging subdiaphragmatic non-Hodgkin’s lymphoma (NHL),1 but their sensitivity in detecting focal lesions in the liver may be reduced if fibrosis is present. We investigated 6 NHL patients who also had a viral liver disease (chronic active hepatitis or cirrhosis) by US and CT liver scans and liver biopsy. US was performed using a Spazio-Hitachi instrument with a 3.5 MHz probe. With the exception of two patients, who underwent laparotomy as a diagnostic procedure, liver biopsy was performed under US guidance using a Menghini fine needle with automatic aspiration (1.2 mm in diameter x 150 mm in length), or a Chiba fine needle (0.7 mm x 150 mm)

A case of the management of Heterotopic ossification as the result of acetabular fracture in a patient with traumatic brain injury

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Animal models for COVID-19

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the aetiological agent of coronavirus disease 2019 (COVID-19), an emerging respiratory infection caused by the introduction of a novel coronavirus into humans late in 2019 (frst detected in Hubei province, China). As of 18 September 2020, SARS-CoV-2 has spread to 215 countries, has infected more than 30 million people and has caused more than 950,000 deaths. As humans do not have pre-existing immunity to SARS-CoV-2, there is an urgent need to develop therapeutic agents and vaccines to mitigate the current pandemic and to prevent the re-emergence of COVID-19. In February 2020, the World Health Organization (WHO) assembled an international panel to develop animal models for COVID-19 to accelerate the testing of vaccines and therapeutic agents. Here we summarize the fndings to date and provides relevant information for preclinical testing of vaccine candidates and therapeutic agents for COVID-19.info:eu-repo/semantics/acceptedVersio

Propensity to spending of an average consumer over a brief period

Understanding consumption dynamics and its impact on the whole economy and welfare within the present economic crisis is not an easy task. Indeed the level of consumer demand for different goods varies with the prices, consumer incomes and demographic factors. Furthermore crisis may trigger different behaviors which result in distortions and amplification effects. In the present work we propose a simple model to quantitatively describe the time evolution over a brief period of the amount of money an average consumer decides to spend, depending on his/her available budget. A simple hydrodynamical analog of the model is discussed. Finally, perspectives of this work are briefly outlined

An Approach to T&E of Military SDR Platforms and Waveforms: the LANCERS Lab

Software Defined Radio (SDR) is currently one of the main topics of interest in military communications, as well as in civil ones. Since 2002, the Italian Ministry of Defense (MoD) has identified the SDR technology as a strategic capability. In this respect, Italy has become part of the major multinational programs related to military SDR and waveforms, such as ESSOR (European Secure Software Radio) and COALWNW (COALition Wideband Networking Waveform). In addition, the Italian national SDR program (SDR-N) aims at developing a complete family of SDR products, part of which are already available for fielding. In order to develop a governmental capability of Test and Evaluation (T&E) for future SDR, minimizing the risks related to the fielding of this new technology, a dedicated laboratory, called LANCERS lab, has been established in the premises of CSSN ITE (Centro Supporto e Sperimentazione Navale Istituto per le Telecomunicazioni e lElettronica), a research center of the Italian Navy. LANCERS lab gathers the expertise of military technical personnel and University researchers, to provide a twofold capability: developing T&E strategies and procedures for the new tactical communications based on SDR and maintaining knowledge about the state of the art of SDR, fostering new research and development. In this paper we describe the LANCERS lab in all the following aspects: plan of development, organization, current activities, and future perspectives

IS BASELINE STRAIN INDEX A PROGNOSTIC FACTOR FOR SMALL UNILATERAL SUPRASPINATUS TENDON TEARS? A PROSPECTIVE STUDY

Purpose. From prospectively report the 2-year follow-up clinical and real-time sonoelastography (RTSE) outcomes of a group of patients affected by small unilateral supraspinatus tendon tears. Our hypothesis was that patients with lower baseline strain indexes would have worst outcomes at follow-up. Methods. We recruited patients suffering by a unilateral rotator cuff tear. All patients have prospectively scrutinized. Patients were initially managed non-operatively, after at least 3 months of failed conservative treatment patients went under surgery. Our clinical evaluation and follow up was done by: complete physical examination; VAS for pain; Quick DASH; Constant–Murley score; Simple Shoulder Test; ASES score and UCLA score. The mechanical properties of tissues were evalutated by Conventional ultrasounds and RTSE and they were estimated uging the Strain index. Results. Forty-three patients were available for evaluation at 2 years. Fifteen had undergone surgery (operative group), while 28 recovered from pain and dysfunction with conservative management andhad not required surgery (non-operative group). Patients in both groups significantly improved at follow-up, and no differences were found in all considered clinical outcomes. The biomechanical properties of repaired tendons were maintained, while non-operatively treated tendons softened over time. Baseline and follow-up strain indexes were linearly correlated with clinical outcomes at 2 years. Conclusions. Baselinestrain index could be associated with post-operative functional outcomes at 2-year follow-up. The biomechanical properties of surgically repaired tendons were maintained, while non-operatively treated tendons softened over time. At least in this cohort of patients, baseline strain index did not suggest who could be managed conservatively and who will need surgery

Small bowel metastases from renal cell carcinoma: a rare cause of intestinal intussusception.

Small bowel metastases from renal cell carcinoma (RCC) are very rare. Clinical presentation includes obstruction, bleeding, intussusception and rarely perforation. We report a case of a 48-year-old female presenting a jejunal intussusception due to intestinal metastasis from RCC. To our knowledge, there are only a few such cases reported in the literature (seven cases). However, if considered in the total summary of reported cases with small bowel metastases from RCC, intussusception is a probable cause

Diastereoselective Synthesis of 1,3,5-Trisubstituted 4-Nitropyrrolidin-2-ones via a Nitro-Mannich/Lactamization Cascade

A versatile one-pot nitro-Mannich/lactamization cascade for the direct synthesis of 1,3,5-trisubstituted 4-nitropyrrolidin-2-ones has been developed. The reaction is easy to perform and broad in scope, and high levels of diastereoselectivity can be achieved