Lunar Propellant Factory Mission Design To Sustain Future Human Exploration

The International Space Exploration Coordination Group (ISECG) Global Exploration Roadmap (GER) is the standard document reflecting the current focus of the leading space agencies that envision space exploration missions beyond Low Earth Orbit (LEO), returning to the Moon and going to Mars in the upcoming years. The roadmap showcases the Moon as a stepping-stone for further human space exploration, by setting up a sustainable space infrastructure on its surface an orbit. Inspired from this vision, we present the result of a phase A study about a lunar propellant factory near the Shackleton south-pole crater relying on In-Situ Resources Utilization (ISRU) to produce and sell Liquid Oxygen (LOX) on the moon surface and in orbit. The overall timeline of the mission is in line with the ISECG exploration roadmap Moon phase, based on realistic technologies of advanced-enough Technology Readiness Levels (TRL). It is a second iteration on the Lunar Propellant Outpost (LUPO) mission architecture, presented during IAC 2018. We preserved and reviewed the original building blocks (Habitats, Crew Mobility Elements, ISRU Facilities, and Lunar Spaceport) of the LUPO mission architecture, and further improved the mission design, supported by trade-off analysis on different mission scenarios. An extensive analysis and optimisation have been performed on ISRU processes and surface electrical power management, the core of our infrastructure. The mission architecture also includes crew on the lunar surface, so life support systems and habitat, as well as operations concepts, have been studied in-depth, and a synthesis of all results is presented. The main aim of this iteration was to improve and refine the baseline infrastructural and technological design architecture of LUPO and reflect on missions going beyond the Moon by providing refuelling services, with sustainability and economic viability in mind

Sense of smell in chronic rhinosinusitis: A multicentric study on 811 patients

Introduction: The impairment of the sense of smell is often related to chronic rhinosinusitis (CRS) with or without nasal polyps (CRSwNP, CRSsNP). CRSwNP is a frequent condition that drastically worsens the quality of life of those affected; it has a higher prevalence than CRSsNP. CRSwNP patients experience severe loss of smell with earlier presentation and are more likely to experience recurrence of their symptoms, often requiring revision surgery. Methods: The present study performed a multicentric data collection, enrolling 811 patients with CRS divided according to the inflammatory endotype (Type 2 and non-Type 2). All patients were referred for nasal endoscopy for the assessment of nasal polyposis using nasal polyp score (NPS); Sniffin' Sticks olfactory test were performed to measure olfactory function, and SNOT-22 (22-item sinonasal outcome test) questionnaire was used to assess patients' quality of life; allergic status was evaluated with skin prick test and nasal cytology completed the evaluation when available. Results: Data showed that Type 2 inflammation is more common than non-type 2 (656 patients versus 155) and patients suffer from worse quality of life and nasal polyp score. Moreover, 86.1% of patients with Type 2 CRSwNP were affected by a dysfunction of the sense of smell while it involved a lesser percentage of non-Type 2 patients. Indeed, these data give us new information about type-2 inflammation patients' characteristics. Discussion: The present study confirms that olfactory function weights on patients' QoL and it represents an important therapeutic goal that can also improve patients' compliance when achieved. In a future - and present - perspective of rhinological precision medicine, an impairment of the sense of smell could help the clinician to characterize patients better and to choose the best treatment available

Next Generation Molecular Diagnosis of Hereditary Spastic Paraplegias: An Italian Cross-Sectional Study

Hereditary spastic paraplegia (HSP) refers to a group of genetically heterogeneous neurodegenerative motor neuron disorders characterized by progressive age-dependent loss of corticospinal motor tract function, lower limb spasticity, and weakness. Recent clinical use of next generation sequencing (NGS) methodologies suggests that they facilitate the diagnostic approach to HSP, but the power of NGS as a first-tier diagnostic procedure is unclear. The larger-than-expected genetic heterogeneity-there are over 80 potential disease-associated genes-and frequent overlap with other clinical conditions affecting the motor system make a molecular diagnosis in HSP cumbersome and time consuming. In a single-center, cross-sectional study, spanning 4 years, 239 subjects with a clinical diagnosis of HSP underwent molecular screening of a large set of genes, using two different customized NGS panels. The latest version of our targeted sequencing panel (SpastiSure3.0) comprises 118 genes known to be associated with HSP. Using an in-house validated bioinformatics pipeline and several in silico tools to predict mutation pathogenicity, we obtained a positive diagnostic yield of 29% (70/239), whereas variants of unknown significance (VUS) were found in 86 patients (36%), and 83 cases remained unsolved. This study is among the largest screenings of consecutive HSP index cases enrolled in real-life clinical-diagnostic settings. Its results corroborate NGS as a modern, first-step procedure for molecular diagnosis of HSP. It also disclosed a significant number of new mutations in ultra-rare genes, expanding the clinical spectrum, and genetic landscape of HSP, at least in Italy

Search for Eccentric Black Hole Coalescences during the Third Observing Run of LIGO and Virgo

Despite the growing number of confident binary black hole coalescences observed through gravitational waves so far, the astrophysical origin of these binaries remains uncertain. Orbital eccentricity is one of the clearest tracers of binary formation channels. Identifying binary eccentricity, however, remains challenging due to the limited availability of gravitational waveforms that include effects of eccentricity. Here, we present observational results for a waveform-independent search sensitive to eccentric black hole coalescences, covering the third observing run (O3) of the LIGO and Virgo detectors. We identified no new high-significance candidates beyond those that were already identified with searches focusing on quasi-circular binaries. We determine the sensitivity of our search to high-mass (total mass $M>70$ $M_\odot$) binaries covering eccentricities up to 0.3 at 15 Hz orbital frequency, and use this to compare model predictions to search results. Assuming all detections are indeed quasi-circular, for our fiducial population model, we place an upper limit for the merger rate density of high-mass binaries with eccentricities $0 < e \leq 0.3$ at $0.33$ Gpc$^{-3}$ yr$^{-1}$ at 90\% confidence level.Comment: 24 pages, 5 figure

Search for eccentric black hole coalescences during the third observing run of LIGO and Virgo

Despite the growing number of confident binary black hole coalescences observed through gravitational waves so far, the astrophysical origin of these binaries remains uncertain. Orbital eccentricity is one of the clearest tracers of binary formation channels. Identifying binary eccentricity, however, remains challenging due to the limited availability of gravitational waveforms that include effects of eccentricity. Here, we present observational results for a waveform-independent search sensitive to eccentric black hole coalescences, covering the third observing run (O3) of the LIGO and Virgo detectors. We identified no new high-significance candidates beyond those that were already identified with searches focusing on quasi-circular binaries. We determine the sensitivity of our search to high-mass (total mass M&gt;70 M⊙) binaries covering eccentricities up to 0.3 at 15 Hz orbital frequency, and use this to compare model predictions to search results. Assuming all detections are indeed quasi-circular, for our fiducial population model, we place an upper limit for the merger rate density of high-mass binaries with eccentricities 0&lt;e≤0.3 at 0.33 Gpc−3 yr−1 at 90\% confidence level

Search for gravitational-lensing signatures in the full third observing run of the LIGO-Virgo network

Gravitational lensing by massive objects along the line of sight to the source causes distortions of gravitational wave-signals; such distortions may reveal information about fundamental physics, cosmology and astrophysics. In this work, we have extended the search for lensing signatures to all binary black hole events from the third observing run of the LIGO--Virgo network. We search for repeated signals from strong lensing by 1) performing targeted searches for subthreshold signals, 2) calculating the degree of overlap amongst the intrinsic parameters and sky location of pairs of signals, 3) comparing the similarities of the spectrograms amongst pairs of signals, and 4) performing dual-signal Bayesian analysis that takes into account selection effects and astrophysical knowledge. We also search for distortions to the gravitational waveform caused by 1) frequency-independent phase shifts in strongly lensed images, and 2) frequency-dependent modulation of the amplitude and phase due to point masses. None of these searches yields significant evidence for lensing. Finally, we use the non-detection of gravitational-wave lensing to constrain the lensing rate based on the latest merger-rate estimates and the fraction of dark matter composed of compact objects

LA PARTECIPAZIONE (IM)-POSSIBILE? La democrazia e i suoi percorsi evolutivi.

Perché ancora un convegno su democrazia e partecipazione? In questo sfondo epocale di criticità della politica e nuove istanze dal basso, il compito che ci siamo proposti con questo secondo incontro di studi è quello di interrogare la realtà che ci circonda. In tale sforzo condiviso, si delinea una linea di continuità con il precedente Convegno, svoltosi sempre presso la Facoltà di Scienze Politiche dell’Università di Teramo il 25 novembre 2011, ma anche la ricerca di nuove chiavi di lettura sul tema della democrazia partecipativa. E non solo per descriverne i fenomeni e i nuovi processi in atto, ma soprattutto per sollevare domande coraggiose e penetranti su quali possano essere i nuovi strumenti (etici, logici, argomentativi, giuridici, sociologici, ecc.) per interpretare e governare i cambiamenti in atto, e per comprendere le contraddizioni tra il vecchio che persiste e il nuovo che emerge

Executive Functions and Rapid Automatized Naming: A New Tele-Rehabilitation Approach in Children with Language and Learning Disorders

Executive function deficits are documented in many neurodevelopmental disorders and may contribute to clinical complexity or rehabilitation resilience. The present research was primarily aimed at presenting and evaluating the feasibility and effectiveness of a telerehabilitation program used during the pandemic period. MemoRAN (Anastasis), a computerised cognitive training to improve executive control during visual-verbal integration tasks was used in a sample of 42 children (5&ndash;11 years old) with specific learning or language disorders. The MemoRAN training was based on exercises of inhibition, cognitive flexibility and updating in working memory for three months, with a frequency of approximately three sessions per week. Afterwards, a comparison between a subgroup of children using Memo-RAN and an active control group, using a tele-rehabilitation program directed on reading was conducted. Effect size analysis in pre-post measurements suggests an average effect of MemoRAN in measurements that require control processes, such as accuracy in dictation, reading, inhibition and working memory testing. Comparison with the active control group and the clinical utility implications of these types of treatment will be discussed

1.6-W self-referenced frequency comb at 2.06 mu m using a Ho:YLF multipass amplifier

A high-power optical frequency comb at 2.06 mu m has been generated using a Ho:YLF multipass amplifier seeded by the long wavelength supercontinuum tail of an octave-spanning Er: fiber comb source. The Ho:YLF amplifier showed a net gain larger than 30 dB from 2048 to 2068 nm, allowing the generation of a 20 nm bandwidth comb with a mode spacing of 100 MHz and a power per mode ranging from 20 to 370 mu W. In the time domain, the amplified comb corresponds to a pulse train with 1.6 W total power and 508 fs transform-limited pulse duration. Using a self-referencing f - 2f interferometer and a phase-locking loop, spectral narrowing of the offset frequency down to less than 17 Hz has been achieved. (c) 2011 Optical Society of Americ

The 2019 Eruptive Activity at Stromboli Volcano: A Multidisciplinary Approach to Reveal Hidden Features of the “Unexpected” 3 July Paroxysm

In July and August 2019, Stromboli volcano underwent two dangerous paroxysms previously considered “unexpected” because of the absence of significant changes in usually monitored parameters. We applied a multidisciplinary approach to search for signals able to indicate the possibility of larger explosive activity and to devise a model to explain the observed variations. We analysed geodetic data, satellite thermal data, images from remote cameras and seismic data in a timespan crossing the eruptive period of 2019 to identify precursors of the two paroxysms on a medium-term time span (months) and to perform an in-depth analysis of the signals recorded on a short time scale (hours, minutes) before the paroxysm. We developed a model that explains the observations. We call the model “push and go” where the uppermost feeding system of Stromboli is made up of a lower section occupied by a low viscosity, low density magma that is largely composed of gases and a shallower section occupied by the accumulated melt. We hypothesize that the paroxysms are triggered when an overpressure in the lower section is built up; the explosion will occur at the very moment such overpressure overcomes the confining pressure of the highly viscous magma above it