74 research outputs found
Meeting the needs of students with disabilities experiencing homelessness: Federal, community, and educator roles
Homelessness is a complex and multifaceted condition that affects 2.5 million, or one in every 30, children annually. Based on these numbers, it is likely that at least one student has experienced or is experiencing homelessness in most public school classrooms. Sixteen percent of students experiencing homelessness also received services under IDEA in 2014. Authors describe how homelessness impacts the outcomes of students-particularly those with disabilities, what federal policies and protections exist, and how communities lend support. One hallmark of special education, and an essential strategy for serving students experiencing homelessness, is a team approach. Thus, the authors conclude with five practical, team-based tips for school personnel, based on the acronym HOMES, to help ensure they are providing the supports and services these students need
Transverse momentum and centrality dependence of dihadron correlations in Au+Au collisions at sqrt(s_NN)=200 GeV: Jet-quenching and the response of partonic matter
Azimuthal angle \Delta\phi correlations are presented for charged hadrons
from dijets for 0.4 < p_T < 10 GeV/c in Au+Au collisions at sqrt(s_NN) = 200
GeV. With increasing p_T, the away-side distribution evolves from a broad to a
concave shape, then to a convex shape. Comparisons to p+p data suggest that the
away-side can be divided into a partially suppressed "head" region centered at
Delta\phi ~ \pi, and an enhanced "shoulder" region centered at Delta\phi ~ \pi
+/- 1.1. The p_T spectrum for the "head" region softens toward central
collisions, consistent with the onset of jet quenching. The spectral slope for
the "shoulder" region is independent of centrality and trigger p_T, which
offers constraints on energy transport mechanisms and suggests that the
"shoulder" region contains the medium response to energetic jets.Comment: 420 authors from 58 institutions, 6 pages, 4 figures. Submitted to
Physical Review Letters. Plain text data tables for the points plotted in
figures for this and previous PHENIX publications are (or will be) publicly
available at http://www.phenix.bnl.gov/papers.htm
Particle-species dependent modification of jet-induced correlations in Au+Au collisions at sqrt(s_NN) = 200 GeV
We report PHENIX measurements of the correlation of a trigger hadron at
intermediate transverse momentum (2.5<p_{T,trig}<4 GeV/c), with associated
mesons or baryons at lower p_{T,assoc}, in Au+Au collisions at sqrt(s_NN) = 200
GeV. The jet correlations for both baryons and mesons show similar shape
alterations as a function of centrality, characteristic of strong modification
of the away-side jet. The ratio of jet-associated baryons to mesons for this
jet increases with centrality and p_{T,assoc} and, in the most central
collisions, reaches a value similar to that for inclusive measurements. This
trend is incompatible with in-vacuum fragmentation, but could be due to
jet-like contributions from correlated soft partons which recombine upon
hadronization.Comment: 344 authors, 4 pages text, RevTeX, 4 figures. Submitted to Physical
Review Letters. Plain text data tables for the points plotted in figures for
this and previous PHENIX publications are (or will be) publicly available at
http://www.phenix.bnl.gov/papers.htm
Genome-Wide Association Studies in an Isolated Founder Population from the Pacific Island of Kosrae
It has been argued that the limited genetic diversity and reduced allelic heterogeneity observed in isolated founder populations facilitates discovery of loci contributing to both Mendelian and complex disease. A strong founder effect, severe isolation, and substantial inbreeding have dramatically reduced genetic diversity in natives from the island of Kosrae, Federated States of Micronesia, who exhibit a high prevalence of obesity and other metabolic disorders. We hypothesized that genetic drift and possibly natural selection on Kosrae might have increased the frequency of previously rare genetic variants with relatively large effects, making these alleles readily detectable in genome-wide association analysis. However, mapping in large, inbred cohorts introduces analytic challenges, as extensive relatedness between subjects violates the assumptions of independence upon which traditional association test statistics are based. We performed genome-wide association analysis for 15 quantitative traits in 2,906 members of the Kosrae population, using novel approaches to manage the extreme relatedness in the sample. As positive controls, we observe association to known loci for plasma cholesterol, triglycerides, and C-reactive protein and to a compelling candidate loci for thyroid stimulating hormone and fasting plasma glucose. We show that our study is well powered to detect common alleles explaining ≥5% phenotypic variance. However, no such large effects were observed with genome-wide significance, arguing that even in such a severely inbred population, common alleles typically have modest effects. Finally, we show that a majority of common variants discovered in Caucasians have indistinguishable effect sizes on Kosrae, despite the major differences in population genetics and environment
Suppression pattern of neutral pions at high transverse momentum in Au+Au collisions at sqrt(s_NN) = 200 GeV and constraints on medium transport coefficients
For Au + Au collisions at 200 GeV we measure neutral pion production with
good statistics for transverse momentum, p_T, up to 20 GeV/c. A fivefold
suppression is found, which is essentially constant for 5 < p_T < 20 GeV/c.
Experimental uncertainties are small enough to constrain any model-dependent
parameterization for the transport coefficient of the medium, e.g. \mean(q^hat)
in the parton quenching model. The spectral shape is similar for all collision
classes, and the suppression does not saturate in Au+Au collisions; instead, it
increases proportional to the number of participating nucleons, as N_part^2/3.Comment: 422 authors, 6 pages text, RevTeX-4, 4 figures, 1 Table. Submitted to
Physical Review Letters. Plain text data tables for the points plotted in
figures for this and previous PHENIX publications are (or will be) publicly
available at http://www.phenix.bnl.gov/papers.htm
Immunometabolism at the crossroads of obesity and cancer-a Keystone Symposia report.
peer reviewedImmunometabolism considers the relationship between metabolism and immunity. Typically, researchers focus on either the metabolic pathways within immune cells that affect their function or the impact of immune cells on systemic metabolism. A more holistic approach that considers both these viewpoints is needed. On September 5-8, 2022, experts in the field of immunometabolism met for the Keystone symposium "Immunometabolism at the Crossroads of Obesity and Cancer" to present recent research across the field of immunometabolism, with the setting of obesity and cancer as an ideal example of the complex interplay between metabolism, immunity, and cancer. Speakers highlighted new insights on the metabolic links between tumor cells and immune cells, with a focus on leveraging unique metabolic vulnerabilities of different cell types in the tumor microenvironment as therapeutic targets and demonstrated the effects of diet, the microbiome, and obesity on immune system function and cancer pathogenesis and therapy. Finally, speakers presented new technologies to interrogate the immune system and uncover novel metabolic pathways important for immunity
The James Webb Space Telescope Mission
Twenty-six years ago a small committee report, building on earlier studies,
expounded a compelling and poetic vision for the future of astronomy, calling
for an infrared-optimized space telescope with an aperture of at least .
With the support of their governments in the US, Europe, and Canada, 20,000
people realized that vision as the James Webb Space Telescope. A
generation of astronomers will celebrate their accomplishments for the life of
the mission, potentially as long as 20 years, and beyond. This report and the
scientific discoveries that follow are extended thank-you notes to the 20,000
team members. The telescope is working perfectly, with much better image
quality than expected. In this and accompanying papers, we give a brief
history, describe the observatory, outline its objectives and current observing
program, and discuss the inventions and people who made it possible. We cite
detailed reports on the design and the measured performance on orbit.Comment: Accepted by PASP for the special issue on The James Webb Space
Telescope Overview, 29 pages, 4 figure
Improving robotic stroke rehabilitation by incorporating neural intent detection: Preliminary results from a clinical trial
This paper presents the preliminary findings of a multi-year clinical study evaluating the effectiveness of adding a brain-machine interface (BMI) to the MAHI-Exo II, a robotic upper limb exoskeleton, for elbow flexion/extension rehabilitation in chronic stroke survivors. The BMI was used to trigger robot motion when movement intention was detected from subjects' neural signals, thus requiring that subjects be mentally engaged during robotic therapy. The first six subjects to complete the program have shown improvements in both Fugl-Meyer Upper-Extremity scores as well as in kinematic movement quality measures that relate to movement planning, coordination, and control. These results are encouraging and suggest that increasing subject engagement during therapy through the addition of an intent-detecting BMI enhances the effectiveness of standard robotic rehabilitation
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