The Journey of the Mute Frankenstein of Thomas Potter Cooke. Towards a language for a new science

In 1923 at the Royal Theatre English Opera House of London started the journey of the mute Frankenstein of Thomas Potter Cook. On that stage the creature born from the encounter between science and romantic genius definitively lost his voice to progressively assume more and more the appearance of a body that speaks for itself, beyond literary fact, and above all beyond verbal language. If in the novel by Mary Shelley the acquisition of a language is the main tool of identity emancipation for the indefinable 'product' of contemporary scientific culture, on stage the actor Cooke, who played that silent character 365 times, laid the foundations of one of the myths of modernity. The article questions the way in which the creature of Dr. Victor Frankenstein came into the midst of 1820s European popular culture, contributing on the one hand to preparing public imagination for the debate on Darwinism that would take place forty years later; revealing on the other a new fundamental aesthetic perception, because the discoveries of the new sciences (chemistry, physics, physiology, etc.) became a common experience that can be found empirically

Pornografia di Gombrowicz per Luca Ronconi. I limiti della regia e la ricerca di un teatro infinito

Luca Ronconi used to say that every text is representable. Even though his work is the best demonstration of a theatre without borders, it often contained an implicit reflection on the limit of the staging and on the identity of the director. Especially in Pornografia, a spectacle of the 2013 adapted from the novel by W. Gombrowicz, Ronconi questions the director’s gaze, his manipulative and performative power. The analysis of the discursivity of this show will give us the opportunity to investigate the aesthetic issues triggered by his way of thinking and practicing the staging

Cristo '63 di Carmelo Bene. Omaggio a Joyce

In queste pagine si cerca innanzitutto di ricostruire una delle serate più scandalose della scena italiana degli anni '60 con l'intenzione di mostrare la relazione tra la scrittura scenica beniana e il linguaggio dei romanzi di J. Joyce. Cristo '63 infatti si presenta nella sua unicità come una possibilità per capire “l’applicazione” che Bene fece dell’Ulisse in scena

Regia e romanzo. Una questione storiografica alla prova dei fatti

This essay discusses the historiographic assumption put forward by Jean-Pierre Sarrazac in a 2005 study, which considers the appearance of the modern director as ensuing from a common novel and theater culture. Starting from the theoretical- methodological approach proposed by the French scholar, we aim at assessing its developments outside of the case study in hand, by measuring its procedural scope and its evolution over time. We will try to understand if André Antoine’s statement, explaining in 1903 that the director's work matched the describing of the novelist, was still valid a few years later when, also in Paris, Jacques Copeau worked on Dostoevsky's Brothers Karamazov

Regia e romanzo tra XX e XXI secolo. Due sguardi (per un’introduzione)

Questo saggio introduttivo si concentra sui possibili esiti della ricerca sui rapporti tra il teatro e il romanzo in un secolo dominato dalla figura del regista. Prima di introdurre i saggi, i curatori presentano due prospettive differenti ma complementari: la prima si concentra sull'autorialità del regista , la seconda propone un'analisi del recente fenomeno della romanzizzazione della drammaturgia contemporane

Flows of Energy and matter cycles in the ecosystems : a conceptual tool to deal with issues of global sustainability

Preprin

Metabolic response of Insulinoma 1E cells to glucose stimulation studied by fluorescence lifetime imaging

A cascade of highly regulated biochemical processes connects glucose stimulation to insulin secretion in specialized cells of mammalian pancreas, the β-cells. Given the importance of this process for systemic glucose homeostasis, noninvasive and fast strategies capable to monitor the response to glucose in living cells are highly desirable. Here, we use the phasor-based approach to Fluorescence Lifetime IMaging (FLIM) microscopy to quantify the ratio between protein-bound and free Nicotinamide adenine dinucleotide (phosphate) species in their reduced form (NAD(P)H), and the Insulinoma cell line INS-1E as a β-like cellular model. Phasor-FLIM analysis shows that the bound/free ratio of NAD(P)H species increases upon pulsed glucose stimulation. Such response is impaired by 48-hours preincubation of cells under hyperglycemic conditions. Phasor-FLIM concomitantly monitors the appearance of long-lifetime species (LLS) as characteristic products of hyperglycemia-induced oxidative stress

Foetal exposure to maternal stressful events increases the risk of having asthma and atopic diseases in childhood

Background:The natural history of asthma and atopic diseases beginsin utero.Studies investigating the influence of foetal exposure to maternal stressful life eventsduring pregnancy (SLEP) on asthma and atopic diseases are lacking.Aim:To test whether the children of mothers who had experienced SLEP are at anincreased risk for asthma, atopic eczema and allergic rhinitis.Methods:The association between maternal SLEP (at least one among: divorce,mourning or loss of the job) and the occurrence of asthma and atopic diseases inchildhood was studied in a population (n = 3854) of children, aged 3–14 yrs, livingin Northern Italy. The parents filled in a standardized questionnaire about the chil-dren’s health and the events occurred to their mothers during pregnancy.Results:Three hundred and thirty-three (9%) of the mothers experienced SLEP.Their children had a statistically significantly higher lifetime prevalence of wheezing(31.6% vs. 23.1%), asthma (8.9% vs. 5.6%), allergic rhinitis (10.9% vs. 7.3%) andatopic eczema (29.7% vs. 21.1%) than those of mothers without SLEP. Afteradjusting for potential confounders, the foetal exposure to SLEP was positivelyassociated with wheezing (OR: 1.41, 95% CI: 1.03–1.94), asthma (OR: 1.71, 95%CI: 1.02–2.89), allergic rhinitis (OR: 1.75, 95% CI: 1.08–2.84) and atopic eczema(OR: 1.53, 95% CI: 1.11–2.10).Conclusion:The children of mothers who had experienced SLEP were at a moder-ately increased risk of having wheezing, asthma, eczema and allergic rhinitis duringtheir childhood. Maternal stress during pregnancy might enhance the expression ofasthma and atopic phenotypes in children.Pediatric Allergy and Immunology724Pediatric Allergy and Immunology23(2012) 724–729ª2012 John Wiley & Sons A/S. Published by Blackwell Publishing Lt