The configuration of Sociology as curricular content and a subject in education

Este artículo tiene el propósito de compartir algunos hallazgos sobre la configuración de las disciplinas de las carreras como espacio o contenido escolar en el sistema educativo de la Provincia de Mendoza, en particular, las modelizaciones pedagógicas de las prácticas de residencia de la cohorte 2006 del profesorado de Sociología. Así, la unidad de indagación fueron nueve Portafolios y sus Memorias en los que se documentaron y narraron dieciocho experiencias de prácticas de residencias desarrolladas durante el ciclo lectivo 2006. Este aporte está organizado en cuatro apartados. En el primero, se describen los dispositivos de trabajo de la cátedra en torno a la organización de las experiencias de residencias de los estudiantes del profesorado (2004-2013). En el segundo, se caracterizan los rasgos de los Portafolios y Memorias de prácticas y cursantes de la cohorte 2006 del Profesorado de Sociología. En el tercer apartado, se ensaya una caracterización de las modelizaciones pedagógicas emergentes, y se presta especial atención a la descripción de sus rasgos. Finalmente, en el cuarto, se proponen una serie de reflexiones en torno a los hallazgos obtenidos y a algunas líneas de indagación emergentes.This article intends to share some findings about the configuration of certain courses’ disciplines as curricular content and subjects within the education system of Mendoza province, more specifically, the kind of pedagogical modeling used in the residence training of the Sociology Teacher Training student group in 2006. Nine Portfolios and their Memoirs were subjected to analysis in which, at the same time, eighteen experiences of residency training practices carried out during the 2006 academic year were documented and narrated. This collective work is organized into four sections. In the first one, we describe the working procedures of the professorship centering on the arrangement of the residency training experiences of the teacher training students (2004-2013). In the second section, we characterize the features of the Portfolios and Memoirs of the practices and students that were part of the teacher training in Sociology in 2006. In the third segment, we perform a characterization of the arising pedagogical modeling while paying particular attention to the description of its features. Finally, in the fourth and last section, we propose a number of considerations regarding the findings and some emerging lines of enquiry.Fil: Elgueta, Martín. Universidad Nacional de Cuyo. Facultad de Ciencias Políticas y SocialesFil: Ficcardi, Marcela. Universidad Nacional de Cuyo. Facultad de Ciencias Políticas y SocialesFil: Lami, Liliana. Universidad Nacional de Cuyo. Facultad de Ciencias Políticas y SocialesFil: Pessino, Patricia. Universidad Nacional de Cuyo. Facultad de Ciencias Políticas y SocialesFil: Raimondi, Cecilia. Universidad Nacional de Cuyo. Facultad de Ciencias Políticas y SocialesFil: Mercado, Graciela. Universidad Nacional de Cuyo. Facultad de Ciencias Políticas y Sociale

Antifungal, phyto, cyto, genotoxic and lipophilic properties of three complexes of sulfadimethoxine (HSDM) with Ag(I). Synthesis and characterization of [Ag3SDM(SCN)2]·H2O and [Ag2(SDM)2o-phenanthroline]·H2O

Fungal infections are still a major problem. Some limitations of current antifungals (toxicity, fungal resistance) require the search for new drugs. The interest in metal–sulfanilamide derivatives was stimulated by the successful introduction of a silver-sulfadiazine complex, yet in current use, to prevent microbial infections during burn treatment of both humans and animals. Sulfadimethoxine (HSDM) is used in medicine, most frequently veterinary, to treat many infections, such as respiratory, urinary, etc. In this work we report the synthesis, characterization by elemental analysis, FTIR, 1H NMR and 13C NMR spectra of the heteroleptic complexes [Ag3SDM(SCN)2]·H2O and [Ag2(SDM)2o-phenanthroline]·H2O, named as AgSDM-SCN and AgSDM-phen, respectively, and the biological properties (lipophilicity, antifungal, phyto, cyto and genotoxicity) of AgSDM-SCN, AgSDM-phen and the homoleptic one: AgSDM. 1H NMR spectra show that the sulfonamide moiety loses its acidic proton in both complexes, in agreement with the FTIR results. The three complexes showed a moderate antifungal activity, mainly against the yeasts Candida albicans, C. tropicalis and Cryptococcus neoformans. None of the tested fungi was inhibited by the free ligand. Lipophilicity: log Koctanol/water values were 0.80, 0.84, 0.85, 0.94 and 0.43 for HSDM, NaSDM, AgSDM, AgSDM-SCN and AgSDM-phen respectively, similarly to another sulfa-metal complexes. No genotoxicity or cytotoxicity were observed for AgSDM and AgSDM-SCN in the Allium cepa test, different from AgSDM-phen. Given these results, the studied complexes could be good candidates for further pharmaceutical studies.Fil: Mosconi, Natalia Ester. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas; ArgentinaFil: Monti, Laura Lucía. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; Argentina. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas; ArgentinaFil: Giulidori, Cecilia María del Luján. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas; ArgentinaFil: Williams, Patricia Ana María. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Química Inorgánica "Dr. Pedro J. Aymonino". Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Química Inorgánica "Dr. Pedro J. Aymonino"; ArgentinaFil: Raimondi, Marcela Patricia. Universidad Nacional de Rosario. Facultad de Ciencias Médicas; ArgentinaFil: Bellú, Sebastián Eduardo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Química Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Química Rosario; ArgentinaFil: Rizzotto, Marcela Adriana. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas; Argentin

SARS-CoV-2 susceptibility and COVID-19 disease severity are associated with genetic variants affecting gene expression in a variety of tissues

Variability in SARS-CoV-2 susceptibility and COVID-19 disease severity between individuals is partly due to genetic factors. Here, we identify 4 genomic loci with suggestive associations for SARS-CoV-2 susceptibility and 19 for COVID-19 disease severity. Four of these 23 loci likely have an ethnicity-specific component. Genome-wide association study (GWAS) signals in 11 loci colocalize with expression quantitative trait loci (eQTLs) associated with the expression of 20 genes in 62 tissues/cell types (range: 1:43 tissues/gene), including lung, brain, heart, muscle, and skin as well as the digestive system and immune system. We perform genetic fine mapping to compute 99% credible SNP sets, which identify 10 GWAS loci that have eight or fewer SNPs in the credible set, including three loci with one single likely causal SNP. Our study suggests that the diverse symptoms and disease severity of COVID-19 observed between individuals is associated with variants across the genome, affecting gene expression levels in a wide variety of tissue types

Impact of COVID-19 on cardiovascular testing in the United States versus the rest of the world

Objectives: This study sought to quantify and compare the decline in volumes of cardiovascular procedures between the United States and non-US institutions during the early phase of the coronavirus disease-2019 (COVID-19) pandemic. Background: The COVID-19 pandemic has disrupted the care of many non-COVID-19 illnesses. Reductions in diagnostic cardiovascular testing around the world have led to concerns over the implications of reduced testing for cardiovascular disease (CVD) morbidity and mortality. Methods: Data were submitted to the INCAPS-COVID (International Atomic Energy Agency Non-Invasive Cardiology Protocols Study of COVID-19), a multinational registry comprising 909 institutions in 108 countries (including 155 facilities in 40 U.S. states), assessing the impact of the COVID-19 pandemic on volumes of diagnostic cardiovascular procedures. Data were obtained for April 2020 and compared with volumes of baseline procedures from March 2019. We compared laboratory characteristics, practices, and procedure volumes between U.S. and non-U.S. facilities and between U.S. geographic regions and identified factors associated with volume reduction in the United States. Results: Reductions in the volumes of procedures in the United States were similar to those in non-U.S. facilities (68% vs. 63%, respectively; p = 0.237), although U.S. facilities reported greater reductions in invasive coronary angiography (69% vs. 53%, respectively; p < 0.001). Significantly more U.S. facilities reported increased use of telehealth and patient screening measures than non-U.S. facilities, such as temperature checks, symptom screenings, and COVID-19 testing. Reductions in volumes of procedures differed between U.S. regions, with larger declines observed in the Northeast (76%) and Midwest (74%) than in the South (62%) and West (44%). Prevalence of COVID-19, staff redeployments, outpatient centers, and urban centers were associated with greater reductions in volume in U.S. facilities in a multivariable analysis. Conclusions: We observed marked reductions in U.S. cardiovascular testing in the early phase of the pandemic and significant variability between U.S. regions. The association between reductions of volumes and COVID-19 prevalence in the United States highlighted the need for proactive efforts to maintain access to cardiovascular testing in areas most affected by outbreaks of COVID-19 infection

A first update on mapping the human genetic architecture of COVID-19

peer reviewe

Synthesis, Antifungal and Antitumor Activity of Novel (Z)-5-Hetarylmethylidene-1,3-thiazol-4-ones and (Z)-5-Ethylidene-1,3-thiazol-4-ones

New hetaryl- and alkylidenerhodanine derivatives 3a-d, 3e, and 4a-d were prepared from heterocyclic aldehydes 1a-d or acetaldehyde 1e. The treatment of several rhodanine derivatives 3a-d and 3e with piperidine or morpholine in THF under reflux, afforded (Z)-5-(hetarylmethylidene)-2-(piperidin-1-yl) thiazol-4(5H)-ones and 2-morpholinothiazol-4(5H)-ones 5a-d, 6a-d, and (Z)-5-ethylidene-2-morpholinothiazol-4(5H)-one (5e), respectively, in good yields. Structures of all compounds were determined by IR, 1D and 2D NMR and mass spectrometry. Several of these compounds were screened by the U.S. National Cancer Institute (NCI) to assess their antitumor activity against 60 different human tumor cell lines. Compound 3c showed high activity against HOP-92 (Non-Small Cell Lung Cancer), which was the most sensitive cell line, with GI(50) = 0.62 mu M and LC50 > 100 mu M from the in vitro assays. In vitro antifungal activity of these compounds was also determined against 10 fungal strains. Compound 3e showed activity against all fungal strains tested, but showed high activity against Saccharomyces cerevisiae (MIC 3.9 mu g/mL)

Antimicrobial, anti-inflammatory and antioxidant activities of polyoxygenated chalcones

It was synthesized nine polyoxygenated chalcones with a potential and safe use as antioxidant, antimicrobial and anti-inflammatory therapies. Chalcones obtained by Claisen-Schmidt condensation were studied as antioxidant, inhibitors of human 5-lipoxygenase, antifungal, antibacterial and antibiotic resistance modifiers. Two chalcones with catecholic moieties were able to strongly decrease the minimum inhibitory concentration (MIC) of methicillin against methicillin-resistant Staphylococcus aureus, increase the antiradical activity and significantly inhibit the human 5-lipoxygenase. Only one of these chalcones was active synergistically with methicillin. Chalcones with methoxyl substituents at different positions displayed the best activities against Cryptococcus neoformans. Only one chalcone showed good activity against the plant pathogenic bacteria Pseudomonas syringae whose half maximal inhibitory concentration (IC50) value (2.5 µg mL-1) was similar to that observed with the antibiotic streptomycin (2.9 µg mL-1). These simple chalcones have safe potential uses in antioxidant, antimicrobial and anti-inflammatory therapies.Fil: Vásquez-Martínez, Yesseny A. Universidad de Santiago de Chile. Facultad de Ciencias Médicas. Programa Centro de Investigaciones Biomédicas Aplicadas; Chile.Fil: Osorio, Mauricio E. Universidad Técnica Federico Santa María. Departamento de Química. Laboratorio de Productos Naturales; Chile.Fil: San Martín, Diego A. Universidad Técnica Federico Santa María. Departamento de Química. Laboratorio de Productos Naturales; Chile.Fil: Carvajal, Marcela A. Universidad Técnica Federico Santa María. Centro de Biotecnología (CB-DAL); Chile.Fil: Vergara, Alejandra P. Universidad Técnica Federico Santa María. Centro de Biotecnología (CB-DAL); Chile.Fil: Sanchez, Elizabeth. Universidad Técnica Federico Santa María. Centro de Biotecnología (CB-DAL); Chile.Fil: Raimondi, Marcela. Universidad Nacional de Rosario. Facultad de Farmacia y Bioquímica. Área Farmacognosia; Argentina.Fil: Zacchino, Susana. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Área Farmacognosia; Argentina.Fil: Mascayano, Carolina. Universidad de Santiago de Chile. Facultad de Química y Biología. Departamento de Ciencias del Ambiente; Chile.Fil: Torrent, Claudia. Universidad de Santiago de Chile. Facultad de Química y Biología. Departamento de Ciencias del Ambiente; Chile.Fil: Cabezas, Francisco. Universidad de Santiago de Chile. Facultad de Química y Biología. Departamento de Ciencias del Ambiente; Chile.Fil: Mejias, Sophia. Universidad de Santiago de Chile. Facultad de Química y Biología. Departamento de Biología; Chile.Fil: Montoya, Margarita. Universidad de Santiago de Chile. Facultad de Química y Biología. Departamento de Biología; Chile.Fil: Cortez-San Martín, Marcelo. Universidad de Santiago de Chile. Facultad de Química y Biología. Departamento de Biología; Chile

Synthesis of novel thiazole-based 8,9-dihydro-7H-pyrimido[4,5-b][1,4]diazepines as potential antitumor and antifungal agents

A new series of novel thiazole-based 8,9-dihydro-7H-pyrimido[4,5-b][1,4]diazepines 6a–g and 7a–g were obtained with high regioselectivity from the reaction of triamino- or tetraaminopyrimidines 4 and 5 with α,β-unsaturated carbonyl compounds 3a–g based on 2,4-dichlorothiazol-5-carbaldehyde 1. Twelve of the synthesized compounds were selected and tested by US National Cancer Institute (NCI) for their antitumor activity against 60 different human tumor cell lines. Compounds 7d and 7g showed important GI50 ranges of 1.28–2.98 μM and 0.35–2.78 μM respectively under in vitro assays. In addition, 6a–g and 7a–g were tested for antifungal properties against the clinical important fungi Candida albicans and Cryptococcus neoformans. Although these compounds showed moderate activities against C. albicans, the 2-amino derivatives 7a–g and mainly 7a and 7b, showed high activity against standardized and clinical isolates of C. neoformans with MIC50 = 7.8–31.2 μg/mL, MIC80 = 15.6–31.2 μg/mL and MIC100 = 15.6–62.5 μg/mL. In addition, since both compounds were fungicide rather than fungistatic these thiazole-based 8,9-dihydro-7H-pyrimido[4,5-b][1,4]diazepines appear as good candidates for further development not only as antifungal but also as antitumor drugs.Fil: Ramírez, Juan. Universidad del Valle. Departamento de Química; ColombiaFil: Svetaz, Laura Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Cientifico Tecnológico Rosario; Argentina. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Departamento de Química Orgánica. Area Farmacognosia; ArgentinaFil: Quiroga, Jairo. Universidad del Valle. Departamento de Química; ColombiaFil: Abonia, Rodrigo. Universidad del Valle. Departamento de Química; ColombiaFil: Raimondi, Marcela. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Departamento de Química Orgánica. Area Farmacognosia; ArgentinaFil: Zacchino, Susana. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Departamento de Química Orgánica. Area Farmacognosia; ArgentinaFil: Insuasty, Braulio. Universidad del Valle. Departamento de Química; Colombi

Heteroleptic complexes of antifungal drugs with the silver ion

In spite of a large number of antibiotics and chemotherapeutics available for medical use, the emergence of old and new antibiotic resistance in the last decades revealed a substantial medical need for new classes of antimicrobial agents. In this paper we report the synthesis, characterization by elemental analysis, Fourier transform infrared and Nuclear magnetic resonance spectroscopies, and antifungal properties of two heteroleptic complexes of albendazole (albz) with Ag(I), using KSCN and o-phenanthroline (phen) as the second ligand, respectively. Both complexes showed a moderate antifungal activity with all the assayed fungi, mainly Candida albicans and Candida tropicalis, that showed no activity against albendazole. Copyright © 2016 John Wiley & Sons, Ltd.Fil: Giulidori, Cecilia María del Luján. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas; ArgentinaFil: Mosconi, Natalia. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas; ArgentinaFil: Toplikar, Brenda. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas; ArgentinaFil: Vega, Marisa. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas; ArgentinaFil: Williams, Patricia Ana María. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Química Inorgánica "Dr. Pedro J. Aymonino". Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Química Inorgánica "Dr. Pedro J. Aymonino"; ArgentinaFil: Svetaz, Laura Andrea. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas; ArgentinaFil: Raimondi, Marcela. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas; ArgentinaFil: Rizzotto, Marcela Adriana. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Química Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Química Rosario; Argentin