Impact of the Minneapolis Neighborhood Revitalization Program on Neighborhood Organizations.

The inauguration of the Minneapolis Neighborhood Revitalization Program in 1991 and the unprecedented level of funding it provides to neighborhood groups gives the program the potential to significantly affect neighborhoods and their organizations. This study looks at the impact of NRP on three neighborhood organizations: the Whittier Alliance, the Stevens Square Community Organization, and the Jordan Area Community Council. Intensive in-person interviews with neighborhood activists and city staff members revealed the changes each neighborhood group went through as they prepared their NRP plan. The study concludes that NRP in deepening the bias toward middle class, white property owners and that in two of the neighborhoods it has increased factionalism. A summary of the study appeared in the June 1994 CURA Reporter

Finishing the euchromatic sequence of the human genome

The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead

Handbook Analisis Kebijakan Publik : Teori, Politik dan Metode

Studi tentang kebijakan publik, termasuk metode analisis kebijakan, telah menjadi salah satu bidang yang berkembang pesat dalam ilmu sosial selama beberapa dekade terakhir. Analisis kebijakan publik adalah suatu disiplin ilmu sosial terapan yang menggunakan beberapa metode penyelidikan dan argumen untuk menghasilkan dan menyebarkan informasi terkait kebijakan yang dapat digunakan dalam ranah politi

Handbook analisis kebijakan kebijakan publik : teori, politik dan metode

xxxii, 904 hlm.; 24 cm

Handbook Analisis Kebijakan Publik : Teori, Politik, dan Metode

Studi tentang kebijakan publik, termasuk metode analisis kebijakan, telah menjadi salah satu bidang yang berkembang pesat dalam ilmu sosial selama beberapa dekade terakhir. Analisis kebijakan publik adalah suatu disiplin ilmu sosial terapan yang menggunakan beberapa metode penyelidikan dan argumen untuk menghasilkan dan menyebarkan informasi terkait kebijakan yang dapat digunakan dalam ranah politikxxxi+904hlm.;16x24c

SLCO1A2, SLCO1B1 and SLCO2B1 polymorphisms influences chloroquine and primaquine treatment in Plasmodium vivax malaria

Financial support was provided by Conselho Nacional de Desenvolvimento Cient´ıfico e Tecnologico (CNPq, Brazil)Universidade Federal do Rio Grande do Sul. Departamento de Genética. Porto Alegre, RS, Brazil.Universidade Federal do Rio Grande do Sul. Departamento de Genética. Porto Alegre, RS, Brazil.Universidade Federal do Para. Laboratório de Microbiologia e Imunologia. Belém, PA, Brazil.Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Programa de Ensaios Clínicos em Malária. Ananindeua, PA, Brasil.Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Programa de Ensaios Clínicos em Malária. Ananindeua, PA, Brasil.Universidade Federal do Pará. Laboratório de Genética Humana e Médica. Belém, PA, Brazil.Universidade Federal do Pará. Laboratório de Genética Humana e Médica. Belém, PA, Brazil.Hospital de Clínicas de Porto Alegre. Unidade de Bioestatística. Grupo de Pesquisa e Pós Graduação. Porto Alegre, RS, Brazil.Universidade Federal do Rio Grande do Sul. Departamento de Genética. Porto Alegre, RS, Brazil.Aim: The association of transporters gene polymorphisms with chloroquine/primaquine malaria treatment response was investigated in a Brazilian population. Patients & methods: Totally, 164 Plasmodium vivax malaria infected patients were included. Generalized estimating equations were performed to determine gene influences on parasitemia and/or gametocytemia clearance over treatment time. Results: Significant interaction between SLCO2B1 genotypes and treatment over time for parasitemia clearance rate on day 2 were observed (p FDR = 0.002). SLCO1A2 and SLCO1B1 gene treatment over time interactions were associated with gametocytemia clearance rate (p FDR = 0.018 and p FDR = 0.024). ABCB1, ABCC4 and SLCO1B3 were not associated with treatment response. Conclusion: The present work presents the first pharmacogenetic report of an association between chloroquine/primaquine responses with OATP transporters