Czynniki warunkujące wypoczynek nocny i jakość opieki pielęgniarskiej pacjenta oddziału neurologicznego

Introduction. The duration of hospitalization in a neurological ward depends on the medical diagnosis and the patient’s state of health. Because of the variety of symptoms from the nervous system, nurse practitioners provide 24 hours care for their patients, fulfilling their professional duties. The family is also included in the care of the patient during the day. At night, the patient is mainly under the care of a nurse, which on the one hand, is a period of sleep and rest, and on the other hand, the risk of health deficiencies is increased.Aim. The purpose of this paper is to present the patient’s opinion about the factors determining night rest in the ward and the quality of nursing care provided at night.Material and Methods. A diagnostic survey was the research method, and the survey was the technique applied. The tools applied consisted of: Author Survey Questionnaire and Care Satisfaction Scale (Newcastle). The study was performed in a group of 98 patients of the clinical neurological Clinic in Rzeszów. The study covered the factors negatively affecting the patient’s night time rest in hospital and the nurse’s assessment of nursing and therapeutic tasks performed during the night. Patients with the score exceeding 6 in the Hodgkinson test 6 were included in the study.Results. The factors hindering/disrupting the night rest were listed by the patients in the following order: snoring of other patients, pain, uncomfortable bed, morning temperature measurements, medical acts and others. The least disturbing factor was the staff’s talks. In assessing the quality of nursing care provided during the night, the highest scores were obtained by the following activities performed by nurses: satisfying needs to create a sense of security, providing medical care at scheduled time and satisfying the need for sleep and rest at night or the opportunity to talk to a nurse.Conclusions. 1) The discomfort caused by factors affecting the night rest in the assessment of the patient is on the average level. 2) Overall assessment of nursing care by patients in both aspects the “experience” of nursing care and “satisfaction” was high. (JNNN 2017;6(4):143–149)Wstęp. Czasookres hospitalizacji w oddziale neurologicznym jest uzależniony od rozpoznania lekarskiego oraz stanu zdrowia pacjenta. Ze względu na różnorodność objawów ze strony układu nerwowego pielęgniarki sprawując całodobową opiekę nad pacjentem realizują zadania wynikające z roli zawodowej. W ciągu dnia do opieki nad pacjentem włącza się także rodzina. W porze nocnej pacjent pozostaje głównie pod opieką pielęgniarki, stąd też jest to z jednej strony czas snu i wypoczynku, a z drugiej strony pora zwiększonego ryzyka wystąpienia deficytów w zdrowiu.Cel. Celem niniejszej pracy jest ukazanie opinii pacjenta na temat czynników warunkujących wypoczynek nocny w oddziale i ocena jakości opieki pielęgniarskiej świadczonej w porze nocnej.Materiał i metody. Metodą badawczą był sondaż diagnostyczny, techniką ankieta. Narzędziem wykorzystanym w pracy były: Autorski Kwestionariusz Ankiety oraz Skala Zadowolenia z Pielęgnacji (Newcastle). Badanie przeprowadzono w grupie 98 pacjentów klinik neurologicznych Szpitali Klinicznych miasta Rzeszowa. Przedmiotem badań były czynniki negatywnie wpływające na wypoczynek nocny pacjenta w szpitalu oraz ocena realizacji zadań opiekuńczych i terapeutycznych realizowanych w porze nocnej przez pielęgniarki. Do badań zakwalifikowano pacjentów, którzy w teście Hodgkinsona uzyskali powyżej 6.Wyniki. Wśród czynników utrudniających/zakłócających wypoczynek nocny pacjenci wymieniali w kolejności: chrapanie innych pacjentów, dolegliwości bólowe, niewygodne łóżko, poranny pomiar temperatury, czynności medyczne i inne. Najmniej zakłócającym czynnikiem były rozmowy personelu. W ocenie jakości opieki pielęgniarskiej świadczonej w porze nocnej najwyższe oceny uzyskały takie świadczenia pielęgniarskie jak: zaspokajanie potrzeb w zakresie jedzenia i picia, stworzenie poczucia bezpieczeństwa, realizacja opieki medycznej w zaplanowanym czasie, nocnego zaspokajanie potrzeby snu i wypoczynku nocnego czy też możliwości rozmowy z pielęgniarką.Wnioski. 1) Uciążliwość czynników wpływających negatywnie na wypoczynek nocny w ocenie pacjenta jest na poziomie średnim. 2) Całościowa ocena opieki pielęgniarskiej przez pacjentów zarówno w aspekcie „doświadczeń” z opieki pielęgniarskiej jak i „satysfakcji” była wysoka. (PNN 2017;6(4):143–149

Bioorganic Chemistry: Current and Future Perspectives

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Selenides and Diselenides: A Review of Their Anticancer and Chemopreventive Activity

Selenium and selenocompounds have attracted the attention and the efforts of scientists worldwide due to their promising potential applications in cancer prevention and/or treatment. Different organic selenocompounds, with diverse functional groups that contain selenium, have been reported to exhibit anticancer and/or chemopreventive activity. Among them, selenocyanates, selenoureas, selenoesters, selenium-containing heterocycles, selenium nanoparticles, selenides and diselenides have been considered in the search for efficiency in prevention and treatment of cancer and other related diseases. In this review, we focus our attention on the potential applications of selenides and diselenides in cancer prevention and treatment that have been reported so far. The around 80 selenides and diselenides selected herein as representative compounds include promising antioxidant, prooxidant, redox-modulating, chemopreventive, anticancer, cytotoxic and radioprotective compounds, among other activities. The aim of this work is to highlight the possibilities that these novel organic selenocompounds can offer in an effort to contribute to inspire medicinal chemists in their search of new promising derivatives

Application of molecularly imprinted polymers in an analytical chiral separation and analysis

Over the last two decades the process of development and application of a new types of molecular imprinted polymer (MIP) sorbents in the field of analytical chemistry have been widely described in the literature. One of the new trends in analytical chemistry practice is the use of new types of MIP sorbents as specific sorption materials constituting the stationary phase in advanced separation techniques. The following review paper contains comprehensive information about the application of a specific and well defined MIP sorbents (with the data base in the paper about the reagents used in MIP preparation process) as stationary phases in separation techniques including high performance liquid chromatography and capillary electrochromatography. Coverage includes newly created types of stationary phases (MIP sorbents) used for chiral recognition, with the focus on applications in enantioselective separation

The 1,3,5-triazine derivatives as innovative chemical family of 5-HT6 serotonin receptor agents with therapeutic perspectives for cognitive impairment

Among serotonin receptors, the 5-HT6 subtype is the most controversial and the least known in the field of molecular mechanisms. The 5-HT6R ligands can be pivotal for innovative treatment of cognitive impairment, but none has reached pharmacological market, predominantly, due to insufficient “druglikeness” properties. Recently, 1,3,5-triazine-piperazine derivatives were identified as a new chemical family of potent 5-HT6R ligands. For the most active triazine 5-HT6R agents found (1-4), a wider binding profile and comprehensive in vitro evaluation of their drug-like parameters as well as behavioral studies and an influence on body mass in vivo were investigated within this work. Results indicated the most promising pharmacological/druglikeness profiles for 4-((1H-indol-3-yl)methyl)-6-(4-methylpiperazin-1-yl)-1,3,5-triazin-2-amine (3) and 4-((2-isopropyl-5-methylphenoxy)methyl)-6-(4-methylpiperazin-1-yl)-1,3,5-triazin-2-amine (4), which displayed a significant procognitive action and specific anxiolytic-like effects in the behavioral tests in vivo together with satisfied pharmaceutical and safety profiles in vitro. The thymol derivative (4) seems to be of higher importance as a new lead candidate, due to the innovative, non-indole and non-sulfone structure with the best 5-HT6R binding properties

Antiviral, antimicrobial and antibiofilm activity of selenoesters and selenoanhydrides

Selenoesters and the selenium isostere of phthalic anhydride are bioactive selenium compounds with a reported promising activity in cancer, both due to their cytotoxicity and capacity to reverse multidrug resistance. Herein we evaluate the antiviral, the biofilm inhibitory, the antibacterial and the antifungal activities of these compounds. The selenoanhydride and 7 out of the 10 selenoesters were especially potent antiviral agents in Vero cells infected with herpes simplex virus-2 (HSV-2). In addition, the tested selenium derivatives showed interesting antibiofilm activity against Staphylococcus aureus and Salmonella enterica serovar Typhimurium, as well as a moderate antifungal activity in resistant strains of Candida spp. They were inactive against anaerobes, which may indicate that the mechanism of action of these derivatives depends on the presence of oxygen. The capacity to inhibit the bacterial biofilm can be of particular interest in the treatment of nosocomial infections and in the coating of surfaces of prostheses. Finally, the potent antiviral activity observed converts these selenium derivatives into promising antiviral agents with potential medical applications.The study was supported by the project SZTE ÁOK-KKA 2018/270-62-2 of the University of Szeged, Faculty of Medicine. Gabriella Spengler was also supported by the János Bolyai Research Scholarship of the Hungarian Academy of Sciences. The authors of this paper received funding from the Márton Áron Research Programme financed by the Hungarian Ministry of Foreign Aairs and Trade. AK was supported by the New National Excellence Program (ÚNKP-18-3) of the Ministry of Human Capacities of Hungary and by the Campus mundi short-study program of the Tempus Public Foundation. EDA was supported by the Spanish “Consejo Superior de Investigaciones Científicas” (201780I027) (CSIC, Spanish National Research Council). CSM wishes to express gratitude to UNED-Pamplona, Fundación Bancaria “La Caixa”, and “Fundación Caja Navarra” for financial support for the project. JMAB and HEM are supported by a BBSRC David Phillips Fellowship to JMAB (BB/M02623X/1)

Antimicrobial, Anticancer and Multidrug-Resistant Reversing Activity of Novel Oxygen-, Sulfur- and Selenoflavones and Bioisosteric Analogues

Multidrug resistance of cancer cells to cytotoxic drugs still remains a major obstacle to the success of chemotherapy in cancer treatment. The development of new drug candidates which may serve as P-glycoprotein (P-gp) efflux pump inhibitors is a promising strategy. Selenium analogues of natural products, such as flavonoids, offer an interesting motif from the perspective of drug design. Herein, we report the biological evaluation of novel hybrid compounds, bearing both the flavone core (compounds 1–3) or a bioisosteric analogue core (compounds 4–6) and the triflyl functional group against Gram-positive and Gram-negative bacteria, yeasts, nematodes, and human colonic adenocarcinoma cells. Results show that these flavones and analogues of flavones inhibited the activity of multidrug resistance (MDR) efflux pump ABCB1 (P-glycoprotein, P-gp). Moreover, the results of the rhodamine 123 accumulation assay demonstrated a dose-dependent inhibition of the abovementioned efflux pump. Three compounds (4, 5, and 6) exhibited potent inhibitory activity, much stronger than the positive control, verapamil. Thus, these chalcogen bioisosteric analogues of flavones become an interesting class of compounds which could be considered as P-gp efflux pump inhibitors in the therapy of MDR cancer. Moreover, all the compounds served as promising adjuvants in the cancer treatment, since they exhibited the P-gp efflux pump modulating activity