Indicación de búsqueda de donante emparentado para el transplante de médula ósea

En el trasplante de progenitores hematopoyéticos si no hay un hermano HLA idéntico es mejor opción iniciar una búsqueda familiar ampliada que en los registros internacionales. Sin embargo, ésta no es posible sin conocer la frecuencia de los alelos y haplotipos HLA en las diferentes áreas geográficas. Por tanto nos planteamos su estudio para establecer las indicaciones precisas del inicio de búsqueda de donante no emparentado en nuestra área. Se realizó tipaje HLA por alta resolución de 192 familias de pacientes hematológicos y se asignaron 548 haplotipos por segregación familiar. Los alelos que indicarían esta búsqueda por su alta frecuencia fueron: HLA-A*01:01, *02:01, *03:01, *11:01, *24:02, *29:02, HLA-B*07:02, 08:01, *18:01, *44:02, *44:03, *51:01, *14:02, HLA-C*04:01, *05:01, *06:02, *07:01, *07:02, *08:02, *12:03 y *16:01, HLA-DRB1*07:01, *03:01 * 15:01, *13:01 *01:01, *11:04 y los haplotipos A*2902-B*4403-C*1601-DRB1*0701, A*0101-C*0701-B*0801-DRB1*0301, A*3301-C*0802-B* 1402-DRB1*0102, A*3002-C*0501-B*1801-DRB1*0301 y A*0201-C*0702-B* 0702-DRB1*1501. Por el contrario, no se recomienda en los casos de alelos o haplotipos raros y para aquellos HLA-B con múltiples asociaciones a HLA-C

Cyclopropyl and cyclobutylboronates and silanes: A stereo­selective approach

Chiral cyclopropyl- and cyclobutylboronic esters and -silanes have become attractive intermediates for the preparation of functionalized small rings. This review highlights the stereoselective methods developed for their preparation, including both diastereo- and enantio­selective approaches. 1 Introduction 2 Stereoselective Synthesis of Cyclopropyl- and Cyclobutylboronates and -silanes 2.1 Diastereoselective Synthesis of Cyclopropyl- and Cyclobutylboronates and -silanes 2.2 Asymmetric Synthesis of Cyclopropyl- and Cyclobutylboronates and -silanes 3 ConclusionsWe thank the European Research Council (ERC-337776) and MINECO (CTQ2016-78779-R) for financial support. M.T. thanks MICINN for a RyC contrac

Regio- and stereospecific copper-catalyzed substitution reaction of propargylic ammonium salts with aryl Grignard reagents

This document is the unedited Author’s version of a Submitted Work that was subsequently accepted for publication in Journal of the American Chemical Society, copyright © American Chemical Society after peer review. To access the final edited and published work see http://doi.org/10.1021/jacs.7b05273We have developed a copper-catalyzed substitution reaction of propargylic ammonium salts with aryl Grignard reagents. The reaction is stereospecific and α-regioselective and proceeds with exceptional functional group tolerance. Conveniently, a stable, inexpensive, and commercially available copper salt is used and no added ligand is requiredWe thank the European Research Council (ERC-337776) and MINECO (CTQ2016-78779-R) for financial support. M.T. thanks MICINN for a RyC contrac

Enantioselective synthesis of cyclobutylboronates via a copper-catalyzed desymmetrization approach

This is the peer reviewed version of the following article: Guisán-Ceinos, M., Parra, A., Martín-Heras, V. and Tortosa, M. (2016), Enantioselective Synthesis of Cyclobutylboronates via a Copper-Catalyzed Desymmetrization Approach. Angew. Chem., which has been published in final form at http://dx.doi.org/10.1002/ange.201601976. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.In this report, the first catalytic enantioselective synthesis of cyclobutylboronates, using a chiral copper(I) complex, is disclosed. A broad variety of cyclobutanes have been prepared with consistently high levels of diastereo- and enantiocontrol. Moreover, this method constitutes the first report of an enantioselective desymmetrization of meso-cyclobutenes to prepare chiral cyclobutanesWe thank the European Research Council (ERC-337776) and MINECO (CTQ2012-35957) for financial support. M. T. and A. P. thank MICINN for RyC and JdC contract

Using Eye Tracking Technology to Analyse Cognitive Load in Multichannel Activities in University Students

Monitoring through the use of eye-tracking technology helps in understanding the cognitive load learners experience when doing tasks. This data gives the teacher and the student important information for improving learning outcomes. This study examined whether students’ participation in a learning virtual laboratory, with a self-regulated video monitored with eye-tracking, would influence their learning outcomes. It also examined whether students’ prior knowledge affected their learning outcomes. Lastly, the study identified clusters related to cognitive load in relevant Areas of Interest vs. non-relevant Areas of Interest. The sample comprised 42 university students of health sciences. The results indicate that participation in the virtual laboratory was related to better learning outcomes. In addition, prior knowledge did not affect cognitive load. A number of different clusters were found related to indicators of cognitive load in relevant and non-relevant AOIs. More applied studies are needed about the effects of monitoring on learning outcomes and on what it means for individualization of learning.his work was supported by the Ministerio de Ciencia e Innovación de España. Proyectos de I + D+i-RTI Tipo B under Grant number [PID2020-117111RB-I00]

Copper-catalysed cross-coupling of alkyl Grignard reagents and propargylic ammonium salts: Stereospecific synthesis of allenes

Herein we describe a robust and practical method to prepare enantiomerically enriched trisubstituted allenes using alkyl Grignard reagents and bench stable propargylic ammonium salts. Excellent yields as well as regio- and stereoselectivities are observed. Our conditions provide a solution to the allene racemization, which has been a long-standing problem when using Grignard reagents

Lime-Crusted Rammed Earth: Materials Study

This study analyses the durability of rammed-earth wall construction techniques. The analysis focuses on three medieval masonry types from the Castle of Villavieja (Castellón, Spain) using two variations of lime-reinforced rammed earth in its walls: lime-crusted rammed earth and brick-reinforced rammed earth. Materials analysis reveals the good properties of the materials used in the outer wall facing despite its age. It also clearly shows how deterioration depends more on the construction technique (construction of the wall with a base, cornice, facings, core; on-site installation, bonds, etc.) than on the material itself. These two types of lime-reinforced rammed earth (lime-crusted rammed earth and brick-reinforced rammed earth) are the most common kinds of fortified architecture in the Iberian Peninsula as well as in northern Africa and the Middle East. The case presented herein is therefore highly relevant as it advances our knowledge of the behaviour of the materials comprising these walls and lays the foundations for suitable future conservation works of a vast array of architectural heritage.Mileto, C.; Vegas López-Manzanares, F.; Alejandre, FJ.; Martín, JJ.; Garcia Soriano, L. (2013). Lime-Crusted Rammed Earth: Materials Study. Advanced Materials Research. 831:9-13. doi:10.4028/www.scientific.net/AMR.831.9S913831C. Mileto, F. Vegas, V. Cristini: Refuerzos y mejoras: variantes constructivas de la tapia en España. Actas de XI Terra 2012 Int. Conference (in press, Lima 2013).C. Mileto et al.: The restoration of rammed earth architecture in the Iberian Peninsula – criteria, techniques, results and perspectives. LEHM 2012. (Dachverband Lehm, Weimar 2012).C. Mileto, F. Vegas, V. Cristini, L. García: Restoration of rammed earth architecture in the Iberian Peninsula: ongoing research. Rammed Earth Conservation, (CRC-Balkema, Londres 2012).J.A. Vicent: Arqueología. La Villavella – Estudio Arqueológico e Histórico (Valencia 1977).J.M. García, I. Moraño: El Castell de Nules (La Vilavella) (inédito, Valencia 2010).UNE 103. 200. Determinación del contenido de carbonatos en los suelos (Madrid 1993).J.J. Martín et al. Hormigones de Cal Islámicos: Altas Resistencias en los Tapiales del Sector Oriental de la Muralla de Sevilla España. Actas IX CICOP. (Sevilla, 2008).G. Brown, G.W. Brindley. The X-ray identification and crystal structures of clay min-erals. G.W. Brindley and G. Brown (ed. ). Mineralogical Society (London 1961).F.H. Chung. Quantitative interpretation of x-ray diffraction patterns. I. Matrix-fluxing method of quantitative analysis of mixtures. Journal of Applied Crystallography, 8, 17-19, (1974).UNE-EN1936. Métodos de ensayo para piedra natural. Determinación de la densidad real y aparente y de la porosidad abierta y total (Madrid 2007).UNE-EN 1015-11. Métodos de ensayo de los morteros para albañilería. Parte 11: Determinación de la resistencia a flexión y a compresión del mortero endurecido (Madrid 2000)

Learning veterinary anatomy playing cards

Gamification is a dynamic tool for educational transformation useful to encourage student interest and enhance learning. Here we present a study conducted to investigate the effectiveness of an educational card game developed by us in veterinary anatomy practicals to reinforce knowledge acquisition in veterinary students. A total of four sets of cards were designed, each one with different anatomical topics (structure identification, articulation and positioning, clinical anatomy, and comparative anatomy); students were arranged in small groups (7–10 students per group) and played the game at the end of each anatomy practical session, discussing the corresponding questions, randomly chosen, as a team. This activity was highly valued by students, most of whom (>80%) expressed that the game was enjoyable, challenging, helpful to improve their knowledge and understanding in clinical anatomy, and effective for anatomy exam preparation. Thus, the use of educational games in practical sessions seems to improve student engagement in the learning process individually and as a team.NEW & NOTEWORTHY The development and implementation of a card game as a training resource that allows learning veterinary anatomy in a motivating and cooperative environment, promoting teamwork, relationships, and trust and communication between colleagues, is described. Stimulating the ability to solve problems as a team has provided help to students preparing for their exams in a more dynamic and enjoyable way.The authors are supported by Universidad CEU CardenalHerrera (PI83A-VV-19)Veterinari

Calculation of Response matrix of a BSS with 6LiI scintillator

The response matrix of a Bonner sphere spectrometer was calculated using MCNP 4C and MCNPX 2.4.0 codes. As thermal neutron detector a 0.4 cm £; 0.4 cm 6LiI which is located at the center of a set of polyethylene spheres. The response was calculated for 0, 2, 3, 5, 8, 10, and 12 inches-diameter polyethylene spheres for neutrons whose energy goes from 2.50E(-8) to 100 MeV. The response matrix was calculated for 23 neutron energies, the response functions were energy-interpolated to 51 neutron energies and were compared with a matrix response reported in the literature, in this comparison both response matrices are in agreement. The main differences were found in the bare detector and are attributed to the irradiation conditions and cross sections, for the other detectors the differences are due to the cross sections libraries