1,723 research outputs found

    Administración y planeación general de la formación profesional

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    El texto presenta un esquema completo de toda la metodología que se utilizaba para programar la formación profesional en el SENA, con el propósito de dar los elementos, herramientas e ideas generales y específicas que permitieran lograr con éxito la labor del Instructor.The text presents a complete outline of all the methodology that was used to program vocational training at SENA, with the purpose of giving the general and specific elements, tools and ideas that would allow the Instructor's work to be successfully achieved.Introducción -- Objetivo general -- Administración de la Formación Profesional -- Planeación general de la Formación Profesional -- Etapa de planeación -- Etapa de programación -- Etapa de evaluaciónnaDocumento sin fecha, se aproxima fecha a la década39 página

    Overview of progress in European medium sized tokamaks towards an integrated plasma-edge/wall solution

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    Integrating the plasma core performance with an edge and scrape-off layer (SOL) that leads to tolerable heat and particle loads on the wall is a major challenge. The new European medium size tokamak task force (EU-MST) coordinates research on ASDEX Upgrade (AUG), MAST and TCV. This multi-machine approach within EU-MST, covering a wide parameter range, is instrumental to progress in the field, as ITER and DEMO core/pedestal and SOL parameters are not achievable simultaneously in present day devices. A two prong approach is adopted. On the one hand, scenarios with tolerable transient heat and particle loads, including active edge localised mode (ELM) control are developed. On the other hand, divertor solutions including advanced magnetic configurations are studied. Considerable progress has been made on both approaches, in particular in the fields of: ELM control with resonant magnetic perturbations (RMP), small ELM regimes, detachment onset and control, as well as filamentary scrape-off-layer transport. For example full ELM suppression has now been achieved on AUG at low collisionality with n = 2 RMP maintaining good confinement HH(98,y2) 0.95. Advances have been made with respect to detachment onset and control. Studies in advanced divertor configurations (Snowflake, Super-X and X-point target divertor) shed new light on SOL physics. Cross field filamentary transport has been characterised in a wide parameter regime on AUG, MAST and TCV progressing the theoretical and experimental understanding crucial for predicting first wall loads in ITER and DEMO. Conditions in the SOL also play a crucial role for ELM stability and access to small ELM regimes.European Commission (EUROfusion 633053

    Improvement in the Adsorption of Anionic and Cationic Dyes From Aqueous Solutions: A Comparative Study Using Aluminium Pillared Clays and Activated Carbon

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    The aim of this work was to evaluate the adsorption properties of anionic dye Reactive Black 5 (RB5) and cationic dye Methylene Blue (MB) from salted aqueous solution using natural clay, aluminum pillared clay (Al-PILC), and activated carbon. The textural properties of the materials were obtained by N2 adsorption at 77 K and the structural properties of natural and pillared clays were determined by X-ray diffraction. The effect of pH, contact time, initial concentration of dye, and influence of the addition of NaCl were evaluated by batch adsorption. Adsorption isotherms of Al-PILC, in different salt concentration were compared with natural clay and activated carbon. The adsorption isotherms were well fitted by the Langmuir and Langmuir-Freundlich models. The process of pillaring only improved the adsorption of the anionic dye RB5. Depending on the system adsorbent/adsorbate analyzed, the salt concentration can either help or hinder dye adsorption. We found that a special morphology formed during the process of pillaring greatly increased adsorption of the MB cationic dye in the range of high salt concentrations. This unexpected result may help in developing new pillarization strategies to treat effluents with high salt content.Fil: Aguiar, J. E.. Universidade Federal do Ceará. Centro de Tecnologia. Departamento de Engenharia Química. Grupo de Pesquisa em Separações por Adsorção; BrasilFil: Bezerra, B. T. C.. Universidade Federal do Ceará. Centro de Tecnologia. Departamento de Engenharia Química. Grupo de Pesquisa em Separações por Adsorção; BrasilFil: Siqueira, A. C. A.. Universidade Federal do Ceará. Centro de Tecnologia. Departamento de Engenharia Química. Grupo de Pesquisa em Separações por Adsorção; BrasilFil: Barrera Diaz, Deicy Amparo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico San Luis. Instituto de Física Aplicada; ArgentinaFil: Sapag, Manuel Karim. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico San Luis. Instituto de Física Aplicada; ArgentinaFil: Azevedo, D. C. S.. Universidade Federal do Ceará. Centro de Tecnologia. Departamento de Engenharia Química. Grupo de Pesquisa em Separações por Adsorção; BrasilFil: Lucena, S. M. P.. Universidade Federal do Ceará. Centro de Tecnologia. Departamento de Engenharia Química. Grupo de Pesquisa em Separações por Adsorção; BrasilFil: Silva Jr., I. J.. Universidade Federal do Ceará. Centro de Tecnologia. Departamento de Engenharia Química. Grupo de Pesquisa em Separações por Adsorção; Brasi

    Niveles inmunitarios contra fiebre aftosa en bovinos del Urabá antioqueño 1978 - 1985

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    This paper discribes the results of the protection status of cattle against Foot-and- Mouth Disease (FMD) found during the 1978 to 1985 period. One of the vaccination cycles was considered for each year, and a statistical representative random sample was calculated for both, young and adult cattle. Animals were bled at day 90 postvaccination and neutralizing antibody titers against FMD types A and 0 were assayed by neutralization test in microtiter plates, using BHK21 cells. The value of 1.5 log was considered to discriminate protected from unprotected cattle. During the analyzed period, in young cattle, the percentages of protection against the virus type A ranged from 25.6 to 64.4%, and against the type 0 from 27.9 to 74.2%. The estimated percentages of protection in adult cattle, ranged from 23.1 to 87.7% against the virus type A and from 42.8 to 88.8% against the type 0. The estimated percentages of protection found in adult cattle were, in most of the years, higher (P < 0.05) than those found in young cattle. In the latter category, the inmune response against the virus type 0 was higher than that against the type A. These differences were statistically significant (P < 0.05) in 1979, 1980, 1981 and 1982. From the above results a satisfactory protection status against FMD was deduced, specially since 1980 which has been reflected in a remarkable reduction of FMD outbreaks in this region. Besides, it was confirmed the efficacy of massive and systematic vaccination procedures, complemented by other actions such as control of cattle movement and severe epidemiologic surveillance.Se describen los resultados de la evaluación continuada del estado de protección contra fiebre aftosa (F.A.) en la población bovina del Urabá antioqueño, durante 1978 a 1985. Para cada año se consideró uno de los ciclos de vacunación y se determinó una muestra estadísticamente representativa de bovinos jóvenes y adultos. Estos fueron sangrados a los 90 días post-vacunación y sus títulos de anticuerpos contra los virus tipos A y O evaluados mediante la técnica de seroneutralización en placa, utilizando células BHK sub 21. Se consideró el valor 1.5 log como título discriminante entre protección y no protección. Durante el período analizado, en los bovinos jóvenes los valores estimados de protección contra el virus tipo A oscilaron entre 25.6 y 64.4 por ciento y contra el tipo O, entre 27.9 y 74.2 por ciento. En los adultos, los valores estimados de protección fluctuaron entre 23.1 y 87.7 por ciento para el virus tipo A y entre 42.8 y 88.8 por ciento para el virus tipo O. El procentaje estimado de bovinos adultos protegidos contra F.A. fue en la mayoría de los años superior (P menor que 0.05) al encontrado en los jóvenes, en los cuales la respuesta inmune fue mayor para el virus tipo O que para el tipo A, siendo la diferencia estadísticamente significativa (P menor que 0.05) en los años 1979, 1980, 1981 y 1982. De los resultados se dedujo que la protección contra F.A. fue satisfactoria, especialmente a partir de 1980, reflejada en una disminución notoria del número de focos en la región, lo cual confirma la eficacia de los programas masivos y sistemáticos de vacunación, complementados con medidas de control de movilización de animales y una drástica vigilancia epidemiológica.Ganado de leche-Ganadería lech

    Participation of Actin on Giardia lamblia Growth and Encystation

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    BACKGROUND:Microfilaments play a determinant role in different cell processes such as: motility, cell division, phagocytosis and intracellular transport; however, these structures are poorly understood in the parasite Giardia lamblia. METHODOLOGY AND PRINCIPAL FINDINGS:By confocal microscopy using TRITC-phalloidin, we found structured actin distributed in the entire trophozoite, the label stand out at the ventral disc, median body, flagella and around the nuclei. During Giardia encystation, a sequence of morphological changes concurrent to modifications on the distribution of structured actin and in the expression of actin mRNA were observed. To elucidate whether actin participates actively on growth and encystation, cells were treated with Cytochalasin D, Latrunculin A and Jasplakinolide and analyzed by confocal and scanning electron microscopy. All drugs caused a growth reduction (27 to 45%) and changes on the distribution of actin. Besides, 60 to 80% of trophozoites treated with the drugs, exhibited damage at the caudal region, alterations in the flagella and wrinkles-like on the plasma membrane. The drugs also altered the cyst-yield and the morphology, scanning electron microscopy revealed diminished cytokinesis, cysts with damages in the wall and alterations in the size and on the intermembranal space. Furthermore, the drugs caused a significant reduction of the intensity of fluorescence-labeled CWP1 on ESV and on cyst wall, this was coincident with a reduction of CWP1 gene expression (34%). CONCLUSIONS AND SIGNIFICANCE:All our results, indicated an important role of actin in the morphology, growth and encystation and indirectly suggested an actin role in gene expression

    Trends in incidence and outcomes of revision total hip arthroplasty in Spain: A population based study

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    <p>Abstract</p> <p>Background</p> <p>To analyze changes in incidence and outcomes of patients undergoing revision total hip arthroplasty (RTHA) over an 8-year study period in Spain.</p> <p>Methods</p> <p>We selected all surgical admissions in individuals aged ≥ 40 years who underwent RTHA (ICD-9-CM procedure code 81.53) between 2001 and 2008 from the Spanish National Hospital Discharge Database. Age- and sex-specific incidence rates, Charlson co-morbidity index, length of stay (LOS), costs and in-hospital mortality (IHM) were estimated for each year. Multivariate analyses were conducted to asses time trends.</p> <p>Results</p> <p>32, 280 discharges of patients (13, 391 men/18, 889 women) having undergone RTHA were identified. Overall crude incidence showed a small but significant increase from 20.2 to 21.8 RTHA per 100, 000 inhabitants from 2001 to 2008 (p < 0.01).</p> <p>The incidence increased for men (17.7 to 19.8 in 2008) but did not vary for women (22.3 in 2001 and 22.2 in 2008). Greater increments were observed in patients older than 84 years and in the age group 75-84. In 2001, 19% of RTHA patients had a Charlson Index ≥ 1 and this proportion rose to 24.6% in 2008 (p < 0.001). The ratio RTHA/THA remained stable and around 20% in Spain along the entire period</p> <p>The crude overall in-hospital mortality (IHM) increased from 1.16% in 2001 to 1.77% (p = 0.025) in 2008. For both sexes the risk of death was higher with age, with the highest mortality rates found among those aged 85 or over. After multivariate analysis no change was observed in IHM over time. The mean inflation adjusted cost per patient increased by 78.3%, from 9, 375 to 16, 715 Euros from 2001 to 2008.</p> <p>After controlling for possible confounders using Poisson regression models, we observed that the incidence of RTHA hospitalizations significantly increased for men and women over the period 2001 to 2008 (IRR 1.10, 95% CI 1.03-1.18 and 1.08, 95% CI 1.02-1.14 respectively).</p> <p>Conclusions</p> <p>The crude incidence of RTHA in Spain showed a small but significant increase from 2001 to 2008 with concomitant reductions in LOS, significant increase in co-morbidities and cost per patient.</p

    MASTREE+ : time-series of plant reproductive effort from six continents

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    Significant gaps remain in understanding the response of plant reproduction to environmental change. This is partly because measuring reproduction in long-lived plants requires direct observation over many years and such datasets have rarely been made publicly available. Here we introduce MASTREE+, a data set that collates reproductive time-series data from across the globe and makes these data freely available to the community. MASTREE+ includes 73,828 georeferenced observations of annual reproduction (e.g. seed and fruit counts) in perennial plant populations worldwide. These observations consist of 5971 population-level time-series from 974 species in 66 countries. The mean and median time-series length is 12.4 and 10 years respectively, and the data set includes 1122 series that extend over at least two decades (≥20 years of observations). For a subset of well-studied species, MASTREE+ includes extensive replication of time-series across geographical and climatic gradients. Here we describe the open-access data set, available as a.csv file, and we introduce an associated web-based app for data exploration. MASTREE+ will provide the basis for improved understanding of the response of long-lived plant reproduction to environmental change. Additionally, MASTREE+ will enable investigation of the ecology and evolution of reproductive strategies in perennial plants, and the role of plant reproduction as a driver of ecosystem dynamics

    Alternative molecular mechanisms for force transmission at adherens junctions via β-catenin-vinculin interaction

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    Force transmission through adherens junctions (AJs) is crucial for multicellular organization, wound healing and tissue regeneration. Recent studies shed light on the molecular mechanisms of mechanotransduction at the AJs. However, the canonical model fails to explain force transmission when essential proteins of the mechanotransduction module are mutated or missing. Here, we demonstrate that, in absence of α-catenin, β-catenin can directly and functionally interact with vinculin in its open conformation, bearing physiological forces. Furthermore, we found that β-catenin can prevent vinculin autoinhibition in the presence of α-catenin by occupying vinculin´s head-tail interaction site, thus preserving force transmission capability. Taken together, our findings suggest a multi-step force transmission process at AJs, where α-catenin and β-catenin can alternatively and cooperatively interact with vinculin. This can explain the graded responses needed to maintain tissue mechanical homeostasis and, importantly, unveils a force-bearing mechanism involving β-catenin and extended vinculin that can potentially explain the underlying process enabling collective invasion of metastatic cells lacking α-catenin
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