Resolución de problemas MaxSAT a través de Evolución Diferencial

[Resumen] En este proyecto se ha desarrollado un algoritmo capaz de resolver el problema MaxSAT empleando un algoritmo evolutivo híbrido o memético, que combina el algoritmo evolutivo de Evolución Diferencial con GSAT y RandomWalk, dos heurísticas de búsqueda local específicas de MaxSAT. El algoritmo desarrollado ha sido empleado para resolver benchmarks recientes de la Evaluación MaxSAT 2020. Se ha comparado el funcionamiento del algoritmo con el de los mejores solvers presentados en la Evaluación MaxSAT 2020, alcanzando el estado del arte tanto en la calidad de las soluciones como en el tiempo de cómputo requerido para obtenerlas.[Abstract]In this project, an algorithm capable of solving the MaxSAT problem has been developed using a hybrid evolutionary or memetic algorithm, which combines the evolutionary algorithm of Differential Evolution with GSAT and RandomWalk, two MaxSAT-specific local search heuristics. The algorithm developed has been used to solve recent benchmarks of the MaxSAT Evaluation 2020. The performance of the algorithm has been compared with that of the best solvers presented in the MaxSAT Evaluation 2020, reaching the state of the art both in the quality of the solutions and in the computing time required to obtain them.Traballo fin de grao. Enxeñaría Informática. Curso 2020/202

Hierarchical Self-Organization from Cyclic Peptide

The 19th International Electronic Conference on Synthetic Organic Chemistry session Polymer and Supramolecular ChemistryOur research group is implicated on the design and synthesis of supramolecular structures based on self-assembling cyclic peptides, particularly alpha,gamma-cyclic peptides (CPs). Most of these structures: dimer, nanotubes, fiber, etc, are based on beta-sheet type interactions. The CPs form structures that have allowed preparing a large variety of structures with applications in ion channels, electron and energy transfer process, molecular tweezers and so on. Here, we present the formation of spheres, hollow spheres, fibers, bars, etc. by a hierarchical supramolecular process from alpha,gamma-cyclic peptides with pyridine derivate ligands attached to one of its side chains, that additionally, are able to coordinate metals (Cu, Pd, etc.), entrap molecules, etc. which give to these structures a great potential for catalysis and drug deliver

Recent Advances in Controlling the Internal and External Properties of Self‐Assembling Cyclic Peptide Nanotubes and Dimers

One of the most powerful strategies for the preparation of nanotubes is based on the stacking of flat-shaped cyclic peptide components. This strategy allows precise control of the nanotube internal diameter, the external properties and, more recently, the structural characterisitics of the internal cavity. The recent advances in these technologies and the applications of the resulting materials are describedThis work was supported by the Spanish Agencia Estatal de Investigación (AEI) and the ERDF (CTQ2013‐43264‐R and CTQ2016‐78423‐R), and by the Xunta de Galicia and the ERDF (EM2014/011 and Centro singular de investigación de Galicia accreditation 2016‐2019, ED431G/09). N. R.‐V. thanks Mineco and the Gil Davila Foundation for her FPU contract and fellowship, respectively. We also thank the ORFEO‐CINCA network and Mineco (CTQ2016‐81797‐REDC)NO

Self‐assembling Venturi‐like peptide nanotubes

We describe the design and synthesis of self-assembling peptide nanotubes that have an internal filter area and whose length and internal diameters, at the entrance and in the constricted area, are precisely controlledThis work was supported by the Spanish Ministry of Economy and Competitivity (Mineco) and the ERDF (CTQ2013‐43264‐R), and by the Xunta de Galicia and the ERDF (EM2014/011). A. F. and H. L. O. thank Mineco for their FPU contracts. We also thank the ORFEO‐CINCA network and Mineco (CTQ2014‐ 51912‐REDC). We very much appreciate Dr. Ignacio Alfonso (IQAC‐CSIC) for his help in designing DOSY experimentsNO

Molecular Plumbing to Bend Self-Assembling Peptide Nanotubes

Light-induced molecular piping of cyclic peptide nanotubes to form bent tubular structures is described. The process is based on the [4+4] photocycloaddition of anthracene moieties, whose structural changes derived from the interdigitated flat disposition of precursors to the corresponding cycloadduct moieties, induced the geometrical modifications in nanotubes packing that provokes their curvature. For this purpose, we designed a new class of cyclic peptide nanotubes formed by β- and α-amino acids. The presence of the former predisposes the peptide to stack in a parallel fashion with the β-residues aligned along the nanotube and the homogeneous distribution of anthracene pendantsThis work was supported by the Spanish Agencia Estatal de Investigación (AEI) (CTQ2016-78423-R and PID2019-111126RB-100), the Xunta de Galicia (ED431C 2017/25 and Centro singular de Investigación de Galicia accreditation 2019–2022, ED431G 2019/03), and the European Union (European Regional Development Fund—ERDF). We also thank the ORFEO-CINCA network and Mineco (CTQ2016-81797-REDC, and RED2018-102331-T)S

3D printing of a palladium-alumina cermet monolithic catalyst: catalytic evaluation in microwave-assisted cross-coupling reactions

A straightforward manufacture strategy is proposed to obtain an efficient and robust palladium-alumina (Pd0/Al2O3) cermet monolithic catalyst, specifically designed to perform safe microwave assisted organic synthesis (MAOS). In this approach, a cermet catalyst with high surface area, controlled composition and adapted shape and dimensions to a microwave reactor vessel is generated via 3D printing technology and sintering. The resulting catalyst has been explored in heterogeneous Suzuki, Sonogashira, Stille and Heck cross-coupling reactions, in MAOS. The Pd0 catalyst is permanently active, stable, without leaching and can be recycled and reused at least 200 reaction cycles. The generation of hot spots, sparking or hazardous discharges is controlled by the effective immobilization of the palladium in the monolithic structure during the reaction. The palladium content is forming part of both the internal and external structure, providing greater mechanical resistance and catalytic activity with respect to the basic ceramic material (alumina)This work was financially supported by the Consellería de Cultura, Educación e Ordenación Universitaria of the Galician Government: EM2014/022 to A.C., ED431B2016/028 to F.G. The Strategic Grouping AEMAT grant No. ED431E2018/08 and the Spanish Ministry of Science, Innovation and Universities with grant No: MAT2017-90100-C2-1-P "MA thanks Xunta de Galicia and the ERDF (ED431C 2021/21)"S

Adenocarcinoma de colon en la edad pediátrica

The adenocarcinoma of the colon and rectum is rare in children. Most cases occur in the second decade of life. In this case, a patient who presents a low mechanical occlusive syndrome is reported. An exploratory laparotomy was performed. The pathology report indicated a well-differentiated left colon adenocarcinoma, ulcerated and infiltrating to the serosa. The lymph nodes were without metastasis and the section edges were tumor-free. The postoperative progress of the patient was favorable but died on the seventeenth day due to multiple complications.El adenocarcinoma de colon y recto es raro en la edad pediátrica y ocurre, en la mayoría de los casos, en la segunda década de la vida. Se presenta el caso de una paciente que debuta con un síndrome oclusivo mecánico bajo y se decidió la laparotomía exploradora; el informe anatomopatológico fue de adenocarcinoma de colon izquierdo bien diferenciado, ulcerado e infiltrante hasta la serosa, ganglios linfáticos sin metástasis y bordes de sección libres de tumor; evolucionó favorablemente en su postoperatorio, pero falleció a los diecinueve días por múltiples complicaciones

Novel synthesis of platinum complexes and their intracellular delivery to tumor cells by means of magnetic nanoparticles

Platinum-based drugs are popular in clinics as chemotherapeutic agents to treat solid tumors

Apendicitis aguda en el niño, la edad como factor pronóstico

In order to determine the behavior of acute appendicitis and its relationship with age, a retrospective comparative descriptive study was conducted in patients who underwent appendectomy at the José Luis Miranda Pediatric University Hospital in Santa Clara during 2009. The sample consisted of 156 patients, aged between 3 and 15 years. The clinical and laboratory variables were studied, as well as the stage of the appendix at the moment of intervention in 3 different age groups. In patients under 5 years of age, nonspecific signs and symptoms such as generalized pain without Murphy sequence and general distention predominated, as well as complicated forms of the disease. It is in this age group where the major difficulties in diagnosing the disease appeared.Con el objetivo de determinar el comportamiento de la apendicitis aguda y su relación con la edad se realizó un estudio descriptivo comparativo retrospectivo en los pacientes apendicectomizados en el Hospital Pediátrico Provincial Universitario “José Luis Miranda” de Santa Clara en todo el año 2009. La muestra estuvo constituida por 156 pacientes con edades comprendidas entre tres y 15 años, se estudiaron variables clínicas y de laboratorio, así como el estado del apéndice en la intervención en tres grupos de edades diferentes, en los pacientes menores de cinco años predominaron signos y síntomas inespecíficos como el dolor generalizado sin secuencia de Murphy y la  distensión generalizada, así como las formas complicadas de la enfermedad; en este grupo de edad es en el que aparecen mayores dificultades para el diagnóstico de la enfermedad