Hepatitis E Virus Genotype 3 Diversity, France

We characterized 42 hepatitis E virus (HEV) genotype 3 strains from infected patients in France in 3 parts of the genome and sequenced the full-length HEV genotype 3f genome found in Europe. These strains are closely related to swine strains in Europe, which suggests zoonotic transmission of HEV in France

Virus de l'Hépatite E en Midi-Pyrénées (mise au point d'une technique multiplex de dépistage génomique HEV-HAV)

Le virus de l'Hépatite E (HEV) est de plus en plus fréquemment incriminé dans les hépatites aiguës. Dans les pays où l'infection n'est pas endémique, il apparaît maintenant clairement que la transmission est autochtone, vraisemblablement d'origine zoonotique. Le HEV ne doit donc plus être recherché uniquement chez des patients présentant une hépatite au retour d'un pays d'endémie. Parallèlement, dans les pays endémiques, le HEV, avec une transmission cette fois-ci essentiellement hydrique, reste un problème majeur de santé publique en raison de la survenue de nombreuses épidémies. La première partie de ce travail consiste en une revue des connaissances actuelles sur le HEV. La deuxième partie étudie de manière rétrospective les données disponibles sur des patients ayant présenté une hépatite E aiguë en Midi-Pyrénées entre 2003 et 2007. La dernière partie repose sur la description du développement d'une technique de détection conjointe des virus de l'Hépatite A et de l'Hépatite E.TOULOUSE3-BU Santé-Centrale (315552105) / SudocSudocFranceF

Quantifying the impact of public health protection measures on the spread of SARS-CoV-2

International audienceThe new virus, SARS-CoV-2, has probably affected millions of people world-wide since December 2019 and killed thousand. We have designed a model and used it to quantify the effect of local protective measures on the SARS-CoV-2 epidemic, assess their effectiveness and adapt health service strategies in Toulouse, France

Estimating the impact of public health strategies on the spread of SARS‐CoV‐2: Epidemiological modelling for Toulouse, France

International audienceThe spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the resulting disease COVID-19 has killed over 2 million people as of 22 January 2021. We have used a modified susceptible, infected, recovered epidemiological model to predict how the spread of the virus in France will vary depending on the public health strategies adopted, including anti-COVID-19 vaccination. Our prediction model indicates that the French authorities' adoption of a gradual release from lockdown could lead in March 2021 to a virus prevalence similar to that before lockdown. However, a massive vaccination campaign initiated in January 2021 and the continuation of public health measures over several months could curb the spread of virus and thus relieve the load on hospitals

Side effect of a 6 p.m curfew for preventing the spread of SARS-CoV-2: A modeling study from Toulouse, France

International audienceThe spread of SARS-CoV-2 and the resulting disease Covid-19 has killed over 2 million people as of January 22, 2021. We have designed a model and used it to quantify the effect of a 6 p.m curfew on the SARS-CoV-2 epidemic in Toulouse, France. The data show that this measure can lead to the opposite effect from that intended due to larger groups of people on the authorized hours

Divided medium-based model for analyzing the dynamic reorganization of the cytoskeleton during cell deformation

International audienceCell deformability and mechanical responses of living cells depend closely on the dynamic changes in the structural architecture of the cytoskeleton (CSK). To describe the dynamic reorganization and the heterogeneity of the prestressed multi-modular CSK, we developed a two-dimensional model for the CSK which was taken to be a system of tension and compression interactions between the nodes in a divided medium. The model gives the dynamic reorganization of the CSK consisting of fast changes in connectivity between nodes during medium deformation and the resulting mechanical behavior is consistent with the strain-hardening and prestress-induced stiffening observed in cells in vitro. In addition, the interaction force networks which occur and balance to each other in the model can serve to identify the main CSK substructures: cortex, stress fibers, intermediate filaments, microfilaments, microtubules and focal adhesions. Removing any of these substructures results in a loss of integrity in the model and a decrease in the prestress and stiffness, and suggests that the CSK substructures are highly interdependent. The present model may therefore provide a useful tool for understanding the cellular processes involving CSK reorganization, such as mechanotransduction, migration and adhesion processes

Prévalence des co-infections bactériennes et virales dans les gastroentérites infantiles, à Toulouse en 2008-2009

TOULOUSE3-BU Santé-Centrale (315552105) / SudocSudocFranceF