The multicultural integration in Brazilian music education

A cultura brasileira, uma importante fonte de recursos para a educação musical, proporciona ao ser humano a aprendizagem espontânea vivenciada e enriquecida por múltiplos fatores. As cinco regiões do Brasil: Norte, Sul, Nordeste, Centro-Oeste e Sudeste, apresentam seus estados reunidos com semelhanças nos aspectos físicos, humanos, culturais, sociais e econômicos. As condições climáticas e geográficas diferenciadas contribuem significativamente para que a população adquira e cultive suas peculiaridades assim como as influências culturais de outros países e continentes devido à imigração dos respectivos povos que aqui se estabeleceram. Neste trabalho será abordada a expressão artística característica de alguns estados, destacando a importância da integração pluricultural com ênfase na música, dança e poesia, como recurso fundamental para a educação musical brasileira.Brazilian culture, an important source of funds for music education, provides the human being experienced spontaneous learning and enriched by multiple factors. The five regions of Brazil: North, South, Northeast, Midwest and Southeast, have combined their states with similarities in physical, human, cultural, social and economic. Climatic and geographical conditions differentiated contribute significantly to the population acquire and cultivate their peculiarities as well as cultural influences from other countries and continents due to immigration of their peoples who settled here. This work will be addressed artistic expression characteristic of some states, highlighting the importance of multicultural integration with an emphasis on music, dance and poetry, as a fundamental resource for the Brazilian musical education.info:eu-repo/semantics/publishedVersio

Toxic epidermal necrolysis and Stevens-Johnson syndrome

Toxic epidermal necrolysis (TEN) and Stevens Johnson Syndrome (SJS) are severe adverse cutaneous drug reactions that predominantly involve the skin and mucous membranes. Both are rare, with TEN and SJS affecting approximately 1or 2/1,000,000 annually, and are considered medical emergencies as they are potentially fatal. They are characterized by mucocutaneous tenderness and typically hemorrhagic erosions, erythema and more or less severe epidermal detachment presenting as blisters and areas of denuded skin. Currently, TEN and SJS are considered to be two ends of a spectrum of severe epidermolytic adverse cutaneous drug reactions, differing only by their extent of skin detachment. Drugs are assumed or identified as the main cause of SJS/TEN in most cases, but Mycoplasma pneumoniae and Herpes simplex virus infections are well documented causes alongside rare cases in which the aetiology remains unknown. Several drugs are at "high" risk of inducing TEN/SJS including: Allopurinol, Trimethoprim-sulfamethoxazole and other sulfonamide-antibiotics, aminopenicillins, cephalosporins, quinolones, carbamazepine, phenytoin, phenobarbital and NSAID's of the oxicam-type. Genetic susceptibility to SJS and TEN is likely as exemplified by the strong association observed in Han Chinese between a genetic marker, the human leukocyte antigen HLA-B*1502, and SJS induced by carbamazepine. Diagnosis relies mainly on clinical signs together with the histological analysis of a skin biopsy showing typical full-thickness epidermal necrolysis due to extensive keratinocyte apoptosis. Differential diagnosis includes linear IgA dermatosis and paraneoplastic pemphigus, pemphigus vulgaris and bullous pemphigoid, acute generalized exanthematous pustulosis (AGEP), disseminated fixed bullous drug eruption and staphyloccocal scalded skin syndrome (SSSS). Due to the high risk of mortality, management of patients with SJS/TEN requires rapid diagnosis, evaluation of the prognosis using SCORTEN, identification and interruption of the culprit drug, specialized supportive care ideally in an intensive care unit, and consideration of immunomodulating agents such as high-dose intravenous immunoglobulin therapy. SJS and TEN are severe and life-threatening. The average reported mortality rate of SJS is 1-5%, and of TEN is 25-35%; it can be even higher in elderly patients and those with a large surface area of epidermal detachment. More than 50% of patients surviving TEN suffer from long-term sequelae of the disease

Atrial fibrillation genetic risk differentiates cardioembolic stroke from other stroke subtypes

AbstractObjectiveWe sought to assess whether genetic risk factors for atrial fibrillation can explain cardioembolic stroke risk.MethodsWe evaluated genetic correlations between a prior genetic study of AF and AF in the presence of cardioembolic stroke using genome-wide genotypes from the Stroke Genetics Network (N = 3,190 AF cases, 3,000 cardioembolic stroke cases, and 28,026 referents). We tested whether a previously-validated AF polygenic risk score (PRS) associated with cardioembolic and other stroke subtypes after accounting for AF clinical risk factors.ResultsWe observed strong correlation between previously reported genetic risk for AF, AF in the presence of stroke, and cardioembolic stroke (Pearson’s r=0.77 and 0.76, respectively, across SNPs with p &lt; 4.4 × 10−4 in the prior AF meta-analysis). An AF PRS, adjusted for clinical AF risk factors, was associated with cardioembolic stroke (odds ratio (OR) per standard deviation (sd) = 1.40, p = 1.45×10−48), explaining ∼20% of the heritable component of cardioembolic stroke risk. The AF PRS was also associated with stroke of undetermined cause (OR per sd = 1.07, p = 0.004), but no other primary stroke subtypes (all p &gt; 0.1).ConclusionsGenetic risk for AF is associated with cardioembolic stroke, independent of clinical risk factors. Studies are warranted to determine whether AF genetic risk can serve as a biomarker for strokes caused by AF.</jats:sec

A integração pluricultural na educação musical brasileira

Brazilian culture, an important source of funds for music education, provides the human being experienced spontaneous learning and enriched by multiple factors. The five regions of Brazil: North, South, Northeast, Midwest and Southeast, have combined their states with similarities in physical, human, cultural, social and economic. Climatic and geographical conditions differentiated contribute significantly to the population acquire and cultivate their peculiarities as well as cultural influences from other countries and continents due to immigration of their peoples who settled here. This work will be addressed artistic expression characteristic of some states, highlighting the importance of multicultural integration with an emphasis on music, dance and poetry, as a fundamental resource for the Brazilian musical education.A cultura brasileira, uma importante fonte de recursos para a educação musical, proporciona ao ser humano a aprendizagem espontânea vivenciada e enriquecida por múltiplos fatores. As cinco regiões do Brasil: Norte, Sul, Nordeste, Centro-Oeste e Sudeste, apresentam seus estados reunidos com semelhanças nos aspectos físicos, humanos, culturais, sociais e econômicos. As condições climáticas e geográficas diferenciadas contribuem significativamente para que a população adquira e cultive suas peculiaridades assim como as influências culturais de outros países e continentes devido à imigração dos respectivos povos que aqui se estabeleceram. Neste trabalho será abordada a expressão artística característica de alguns estados, destacando a importância da integração pluricultural com ênfase na música, dança e poesia, como recurso fundamental para a educação musical brasileira

Construction and comparative analyses of highly dense linkage maps of two sweet cherry intra-specific progenies of commercial cultivars

Despite the agronomical importance and high synteny with other Prunus species, breeding improvements for cherry have been slow compared to other temperate fruits, such as apple or peach. However, the recent release of the peach genome v1.0 by the International Peach Genome Initiative and the sequencing of cherry accessions to identify Single Nucleotide Polymorphisms (SNPs) provide an excellent basis for the advancement of cherry genetic and genomic studies. The availability of dense genetic linkage maps in phenotyped segregating progenies would be a valuable tool for breeders and geneticists. Using two sweet cherry (Prunus avium L.) intra-specific progenies derived from crosses between 'Black Tartarian' * 'Kordia' (BT*K) and 'Regina' * 'Lapins'(R*L), high-density genetic maps of the four parental lines and the two segregating populations were constructed. For BT*K and R*L, 89 and 121 F(1) plants were used for linkage mapping, respectively. A total of 5,696 SNP markers were tested in each progeny. As a result of these analyses, 723 and 687 markers were mapped into eight linkage groups (LGs) in BT*K and R*L, respectively. The resulting maps spanned 752.9 and 639.9 cM with an average distance of 1.1 and 0.9 cM between adjacent markers in BT*K and R*L, respectively. The maps displayed high synteny and co-linearity between each other, with the Prunus bin map, and with the peach genome v1.0 for all eight LGs (LG1-LG8). These maps provide a useful tool for investigating traits of interest in sweet cherry and represent a qualitative advance in the understanding of the cherry genome and its synteny with other members of the Rosaceae family

Sweet cherry SNP RosBREED markers located in different LGs within the sweet cherry high density linkage maps in comparison with the peach genome v1.0.

<p>Sweet cherry SNP RosBREED markers located in different LGs within the sweet cherry high density linkage maps in comparison with the peach genome v1.0.</p