The Success of Sinister Right-Handers in Baseball

Description to be added.Cannot be left empt

First Results of the PixelGEM Central Tracking System for COMPASS

For its physics program with a high-intensity hadron beam of up to 2e7 particles/s, the COMPASS experiment at CERN requires tracking of charged particles scattered by very small angles with respect to the incident beam direction. While good resolution in time and space is mandatory, the challenge is imposed by the high beam intensity, requiring radiation-hard detectors which add very little material to the beam path in order to minimize secondary interactions. To this end, a set of triple-GEM detectors with a hybrid readout structure consisting of pixels in the beam region and 2-D strips in the periphery was designed and built. Successful prototype tests proved the performance of this new detector type, showing both extraordinary high rate capability and detection efficiency. The amplitude information allowed to achieve spatial resolutions about a factor of 10 smaller than the pitch and a time resolution close to the theoretical limit imposed by the layout. The PixelGEM central tracking system consisting of five detectors, slightly improved with respect to the prototype, was completely installed in the COMPASS spectrometer in spring 2008

Timing is Money - Evaluating the Effects of Early Availability of Feature Films via Video on Demand

Based on survey data from 489 German potential Video On Demand users this research explores effects of early movie availability on consumers’ utility, their willingness to pay, and copyright violations. Using a triangulation approach, we employed adaptive conjoint analysis and contingent valuation methodologies. Our results show substantially increased utility levels and greater willingness to pay for Video On Demand services that offer movies simultaneously with or shortly before the first official theatrical release. Our findings bear similarities to results from experiments on hyperbolic discounting, a concept from the field of behavioral economics. Diverging from classic microeconomic theory, immediate consumption seems to be valued irrationally high. This effect is even stronger for copyright violators. Implications both for future academic research and for the motion picture industry are drawn

Bridging the Gap between Security Competencies and Security Threats: Toward a Cyber Security Domain Model

Security incidents are increasing in a wide range of organizational types and sizes worldwide. Although various threat models already exist to classify security threats, they seem to take insufficient account of which organizational assets the threat events are targeting. Therefore, we argue that conducting more job-specific IT security training is necessary to ensure organizational IT security. This requires considering which assets employees use in their daily work and for which threat events employees need to build up IT security competencies. Subsequently, we build a framework-based Cyber Security Domain Model (CSDM) for IT-secure behavior. We follow the Evidence Centered Assessment Design (ECD) to provide a deep- dive analysis of the domain for IT-secure behavior. As the leading result relevant for research and practice, we present our CSDM consisting of 1,087 cyber threat vectors and apply it to five job specifications

Mapping out SU(5) GUTs with non-Abelian discrete flavor symmetries

We construct a class of supersymmetric SU(5) GUT models that produce nearly tribimaximal lepton mixing, the observed quark mixing matrix, and the quark and lepton masses, from discrete non-Abelian flavor symmetries. The SU(5) GUTs are formulated on two five-dimensional throats in the flat limit and the neutrino masses become small due to the type-I seesaw mechanism. The discrete non-Abelian flavor symmetries are given by semi-direct products of cyclic groups that are broken at the infrared branes at the tip of the throats. As a result, we obtain SU(5) GUTs that provide a combined description of non-Abelian flavor symmetries and quark-lepton complementarity.Comment: 5 pages, 3 figures, RevTeX. References and comments added. Final version to appear in Phys. Rev.

PHOSIDA (phosphorylation site database): management, structural and evolutionary investigation, and prediction of phosphosites

PHOSIDA, a phosphorylation site database, integrates thousands of phosphosites identified by proteomics in various species

Defining NASH from a multi-omics systems biology perspective

Non-alcoholic steatohepatitis (NASH) is a chronic liver disease affecting up to 6.5% of the general population. There is no simple definition of NASH, and the molecular mechanism underlying disease pathogenesis remains elusive. Studies applying single omics technologies have enabled a better understanding of the molecular profiles associated with steatosis and hepatic inflammation—the commonly accepted histologic features for diagnosing NASH, as well as the discovery of novel candidate biomarkers. Multi-omics analysis holds great potential to uncover new insights into disease mechanism through integrating multiple layers of molecular information. Despite the technical and computational challenges associated with such efforts, a few pioneering studies have successfully applied multi-omics technologies to investigate NASH. Here, we review the most recent technological developments in mass spectrometry (MS)-based proteomics, metabolomics, and lipidomics. We summarize multi-omics studies and emerging omics biomarkers in NASH and highlight the biological insights gained through these integrated analyses