Characterization of qutrit channels in terms of their covariance and symmetry properties

We characterize the completely positive trace-preserving maps on qutrits (qutrit channels) according to their covariance and symmetry properties. Both discrete and continuous groups are considered. It is shown how each symmetry group restricts arbitrariness in the parameters of the channel to a very small set. Although the explicit examples are related to qutrit channels, the formalism is sufficiently general to be applied to qudit channels

Effective detection of quantum discord by using Convolutional Neural Networks

Quantum discord is a form of correlation that is defined as the difference between quantum and classical mutual information of two parties. Due to the optimization involved in the definition of classical mutual information of quantum systems, calculating and distinguishing between discordant and non-discordant states is not a trivial task. Additionally, complete tomography of a quantum state is the prerequisite for the calculation of its quantum discord, and it is indeed resource consuming. Here, by using the relation between the kernels of the convolutional layers of an artificial neural network and the expectation value of operators in quantum mechanical measurements, we design a Convolutional Neural Network (CNN) that uses 16 kernels to completely distinguish between the discordant and non-discordant general two-qubit states. We have also designed a Branching Convolutional Neural Network (BCNN) that can effectively detect quantum discord. Our BCNN achieves an accuracy of around 85% or 99%, by utilizing only 5 or 8 kernels, respectively. Our results show that to detect the existence of quantum discord up to the desired accuracy, instead of complete tomography, one can use suitable quantum circuits to directly measure the expectation values of the kernels, and then a fully connected network will solve the detection problem.Comment: Minor revisions, two references adde

A Case for Inclusion of Genetic Counselors in Cardiac Care

Recent advances in genetic testing for heritable cardiac diseases have led to an increasing involvement of the genetic counselor in cardiology practice. We present a series of cases collected from a nationwide query of genetics professionals regarding issues related to cost and utilization of genetic testing. Three themes emerged across cases: (1) choosing the most appropriate genetic test, (2) choosing the best person to test, and (3) interpreting results accurately. These cases demonstrate that involvement of a genetic counselor throughout the evaluation, diagnosis, and continuing management of individuals and families with inherited cardiovascular conditions helps to promote the efficient use of healthcare dollars

Reduction of Orc6 Expression Sensitizes Human Colon Cancer Cells to 5-Fluorouracil and Cisplatin

Previous studies from our group have shown that the expression levels of Orc6 were highly elevated in colorectal cancer patient specimens and the induction of Orc6 was associated with 5-fluorouracil (5-FU) treatment. The goal of this study was to investigate the molecular and cellular impact of Orc6 in colon cancer. In this study, we use HCT116 (wt-p53) and HCT116 (null-p53) colon cancer cell lines as a model system to investigate the impact of Orc6 on cell proliferation, chemosensitivity and pathways involved with Orc6. We demonstrated that the down regulation of Orc6 sensitizes colon cancer cells to both 5-FU and cisplatin (cis-pt) treatment. Decreased Orc6 expression in HCT-116 (wt-p53) cells by RNA interference triggered cell cycle arrest at G1 phase. Prolonged inhibition of Orc6 expression resulted in multinucleated cells in HCT-116 (wt-p53) cell line. Western immunoblot analysis showed that down regulation of Orc6 induced p21 expression in HCT-116 (wt-p53) cells. The induction of p21 was mediated by increased level of phosphorylated p53 at ser-15. By contrast, there is no elevated expression of p21 in HCT-116 (null-p53) cells. Orc6 down regulation also increased the expression of DNA damaging repair protein GADD45β and reduced the expression level of JNK1. Orc6 may be a potential novel target for future anti cancer therapeutic development in colon cancer

Nicotine exploits a COPI-mediated process for chaperone-mediated up-regulation of its receptors

Chronic exposure to nicotine up-regulates high sensitivity nicotinic acetylcholine receptors (nAChRs) in the brain. This up-regulation partially underlies addiction and may also contribute to protection against Parkinson’s disease. nAChRs containing the α6 subunit (α6* nAChRs) are expressed in neurons in several brain regions, but comparatively little is known about the effect of chronic nicotine on these nAChRs. We report here that nicotine up-regulates α6* nAChRs in several mouse brain regions (substantia nigra pars compacta, ventral tegmental area, medial habenula, and superior colliculus) and in neuroblastoma 2a cells. We present evidence that a coat protein complex I (COPI)-mediated process mediates this up-regulation of α6* or α4* nAChRs but does not participate in basal trafficking. We show that α6β2β3 nAChR up-regulation is prevented by mutating a putative COPI-binding motif in the β3 subunit or by inhibiting COPI. Similarly, a COPI-dependent process is required for up-regulation of α4β2 nAChRs by chronic nicotine but not for basal trafficking. Mutation of the putative COPI-binding motif or inhibition of COPI also results in reduced normalized Förster resonance energy transfer between α6β2β3 nAChRs and εCOP subunits. The discovery that nicotine exploits a COPI-dependent process to chaperone high sensitivity nAChRs is novel and suggests that this may be a common mechanism in the up-regulation of nAChRs in response to chronic nicotine