Devonian Sandstone Lithostratigraphy, Northern Arkansas

Two areas of Devonian sandstone development may be recognized in northern Arkansas. In northwestern Arkansas, the Clifty Formation comprises a massively bedded, super mature quartz arenite of Middle Devonian age overlain by thinner bedded, phosphatic quartz arenite and chert breccia of the Sylamore Sandstone Member, Chattanooga Shale (Upper Devonian). This sequence overlies Ordovician strata (Powell or Everton) and is succeeded by the Chattanooga Shale and strata of Lower Mississippian age. In north-central Arkansas, the Clifty Formation is absent and the Chattanooga Shale may develop sandstone at its base and top. Occasionally the Chattanooga Shale is absent and the entire interval may be Upper Devonian sandstone. These Upper Devonian sandstones are phosphatic, mature quartz arenites referred to the Sylamore Member except where they overlie the Chattanooga Shale. In these cases, the sandstone is recognized as an informal upper member of the Chattanooga. Reports of Lower Mississippian Sylamore Sandstone in north-central Arkansas are regarded as misidentification of the Bachelor Formation (Middle Kinderhookian

COVID-19 revisiting inflammatory pathways of arthritis

Coronavirus disease 2019 (COVID-19) is an infectious disease, caused by severe acute respiratory syndrome coronavirus 2, which predominantly affects the lungs and, under certain circumstances, leads to an excessive or uncontrolled immune activation and cytokine response in alveolar structures. The pattern of pro-inflammatory cytokines induced in COVID-19 has similarities to those targeted in the treatment of rheumatoid arthritis. Several clinical studies are underway that test the effects of inhibiting IL-6, IL-1\u3b2 or TNF or targeting cytokine signalling via Janus kinase inhibition in the treatment of COVID-19. Despite these similarities, COVID-19 and other zoonotic coronavirus-mediated diseases do not induce clinical arthritis, suggesting that a local inflammatory niche develops in alveolar structures and drives the disease process. COVID-19 constitutes a challenge for patients with inflammatory arthritis for several reasons, in particular, the safety of immune interventions during the pandemic. Preliminary data, however, do not suggest that patients with inflammatory arthritis are at increased risk of COVID-19

Synthetic Studies in the Chloramphenicol Series. III. Synthesis of threo-DL-Chloramphenicol from DL-Serine Ethyl Ether

A synthesis of threo-DL-chloramphenicol (I) from a-phthalimido-~-ethoxy-DL-propiophenone (II) is described. The crude ketone II obtained from a-phthalimido-~-ethoxy-DL-propionyl chloride via Friedel-Crafts reaction was reduced with aluminium isopropoxide to give a yield of 17.2 % of the corresponding carbinol III. This carbinol gave in a series of reactions threo -DL-chloramphenicol in an overall yield of 2.4 %

Ignite: More Experience, Less Expense: Meaningful and Budget-Friendly Rewards (Group 1)

For a PBIS acknowledgement system to work effectively, there must be student buy-in, which involves getting student input and implementing incentives that are meaningful and enticing to them. However, this isn’t always easy to do without breaking the bank or losing valuable instructional time! At our elementary school, we decided to focus on monthly incentives that were cost-effective and more of an experience rather than tangible (and often costly) rewards. We made sure to consider multiple factors, including (1) how to implement incentives while still maximizing instructional time for all content areas, (2) making sure all students had opportunities to participate in some way, and (3) modifying our incentives so that we can meet individual students’ needs based on RTI data, behavior plans, etc. This workshop will provide participants with the tools they need to develop student-focused incentives while working within a budget, or even no budget at all

Mechanisms and pathways of Toxoplasma gondii transepithelial migration

Toxoplasma gondii is a ubiquitous parasite and a prevalent food-borne parasitic pathogen. Infection of the host occurs principally through oral consumption of contaminated food and water with the gastrointestinal tract being the primary route for entry into the host. To promote infection, T. gondii has evolved highly specialized strategies for rapid traversal of the single cell thick intestinal epithelial barrier. Parasite transmigration via the paracellular pathway between adjacent cells enables parasite dissemination to secondary sites of infection where chronic infection of muscle and brain tissue is established. It has recently been proposed that parasite interactions with the integral tight junction (TJ) protein occludin influences parasite transmigration of the intestinal epithelium. We review here the emerging mechanisms of T. gondii transmigration of the small intestinal epithelium alongside the developing role played in modulating the wider TJ-associated proteome to rewire host cell regulatory systems for the benefit of the parasite

The echidna Tachyglossus aculeatus combines REM and non-REM aspects in a single sleep state: implications for the evolution of sleep

Placental and marsupial mammals exist in three states of consciousness: waking, non-REM sleep, and REM sleep. We now report that the echidna Tachyglossus aculeatus, a representative of the earliest branch of mammalian evolution (the monotremes), does not have the pattern of neuronal activity of either of the sleep states seen in nonmonotreme mammals. Echidna sleep was characterized by increased brainstem unit discharge variability, as in REM sleep. However, the discharge rate decreased and the EEG was synchronized, as in non-REM sleep. Our results suggest that REM and non-REM sleep evolved as a differentiation of a single, phylogenetically older sleep state. We hypothesize that the physiological changes that occur during postnatal sleep development parallel certain aspects of the changes that have occurred during the evolution of sleep-waking states in mammals

Measurement of fractionated plasma metanephrines for exclusion of pheochromocytoma: Can specificity be improved by adjustment for age?

BACKGROUND: Biochemical testing for pheochromocytoma by measurement of fractionated plasma metanephrines is limited by false positive rates of up to 18% in people without known genetic predisposition to the disease. The plasma normetanephrine fraction is responsible for most false positives and plasma normetanephrine increases with age. The objective of this study was to determine if we could improve the specificity of fractionated plasma measurements, by statistically adjusting for age. METHODS: An age-adjusted metanephrine score was derived using logistic regression from 343 subjects (including 33 people with pheochromocytoma) who underwent fractionated plasma metanephrine measurements as part of investigations for suspected pheochromocytoma at Mayo Clinic Rochester (derivation set). The performance of the age-adjusted score was validated in a dataset of 158 subjects (including patients 23 with pheochromocytoma) that underwent measurements of fractionated plasma metanephrines at Mayo Clinic the following year (validation dataset). None of the participants in the validation dataset had known genetic predisposition to pheochromocytoma. RESULTS: The sensitivity of the age-adjusted metanephrine score was the same as that of traditional interpretation of fractionated plasma metanephrine measurements, yielding a sensitivity of 100% (23/23, 95% confidence interval [CI] 85.7%, 100%). However, the false positive rate with traditional interpretation of fractionated plasma metanephrine measurements was 16.3% (22/135, 95% CI, 11.0%, 23.4%) and that of the age-adjusted score was significantly lower at 3.0% (4/135, 95% CI, 1.2%, 7.4%) (p < 0.001 using McNemar's test). CONCLUSION: An adjustment for age in the interpretation of results of fractionated plasma metanephrines may significantly decrease false positives when using this test to exclude sporadic pheochromocytoma. Such improvements in false positive rate may result in savings of expenditures related to confirmatory imaging