Strata: Deserts Past, Present and Future

This book documents a collaborative, environmental art project on Puritjarra, a rock shelter in the Cleland Hills in western central Australia. The project incorporates the perspectives of scholars of archaeology, ecology, environmental history and the history of science as well as those of contemporary artists drawing upon the heritage of Indigenous peoples and settlers. It explores diverse ways of representing and understanding a place where desert oaks may well have been a continuous feature of the landscape for the last 100,000 years, while plant and animal species introduced more recently have caused significant change within the span of a single human lifetime. Recurring themes include water, food, shelter and spiritual renewal. The aim of the project: “co-understanding… valuing the different ways each of us sees a single place that is significant, but differently so, for each perspective.

The role of self-disclosure in buffering negative feelings within adolescent friendships

Friendship serves a variety of functions throughout development and can buffer the effects of negative experiences through self-disclosure, the communication of emotions. Participants were 140 adolescents (51% male, M =12.95 years old) that completed surveys examining the buffering of negative life events, global self-worth, and relationships with their best friend in a correlational design. It was hypothesized that buffered feelings from negative experiences would mediate the relationship between self-disclosure and global self-worth, particularly for girls. Findings indicated levels of self-disclosure and buffered feelings from negative experiences were not associated with increased global self-worth. Gender differences were found between ratings of friendship and buffered feelings of different types of negative experiences, favoring girls. In addition, the overall model of self-disclosure and buffering of negative experiences together affected global self-worth for boys. Challenges in measurement of buffered feelings from negative experiences and global self-worth are discussed

The development of a measure of social care outcome for older people. Funded/commissioned by: Department of Health

An essential element of identifying Best Value and monitoring cost-effective care is to be able to identify the outcomes of care. In the field of health services, use of utility-based health related quality of life measures has become widespread, indeed even required. If, in the new era of partnerships, social care outcomes are to be valued and included we need to develop measures that reflect utility or welfare gain from social care interventions. This paper reports on a study, commissioned as part of the Department of Health’s Outcomes of Social Care for Adults Initiative, that developed an instrument and associated utility indexes that provide a tool for evaluating social care interventions in both a research and service setting. Discrete choice conjoint analysis used to derive utility weights provided us with new insights into the relative importance of the core domains of social care to older people. Whilst discrete choice conjoint analysis is being increasingly used in health economics, this is the first study that has attempted to use it to derive a measure of outcome

The European Commission’s Green Deal is an opportunity to rethink harmful practices of research and innovation policy

The European Union’s Green Deal and associated policies, aspiring to long-term environmental sustainability, now require economic activities to ‘do no significant harm’ to EU environmental objectives. The way the European Commission is enacting the do no significant harm principle relies on quantitative tools that try to identify harm and adjudicate its significance. A reliance on established technical approaches to assessing such questions ignores the high levels of imprecision, ambiguity, and uncertainty—levels often in flux—characterizing the social contexts in which harms emerge. Indeed, harm, and its significance, are relational, not absolute. A better approach would thus be to acknowledge the relational nature of harm and develop broad capabilities to engage and ‘stay with’ the harm. We use the case of European research and innovation activities to expose the relational nature of harm, and explore an alternative and potentially more productive approach that departs from attempts to unilaterally or uniformly claim to know or adjudicate what is or is not significantly harmful. In closing, we outline three ways research and innovation policy-makers might experiment with reconfiguring scientific and technological systems and practices to better address the significant harms borne by people, other-than-human beings, and ecosystems

Atomic Resolution Structure of the Oncolytic Parvovirus LuIII by Electron Microscopy and 3D Image Reconstruction.

LuIII, a protoparvovirus pathogenic to rodents, replicates in human mitotic cells, making it applicable for use to kill cancer cells. This virus group includes H-1 parvovirus (H-1PV) and minute virus of mice (MVM). However, LuIII displays enhanced oncolysis compared to H-1PV and MVM, a phenotype mapped to the major capsid viral protein 2 (VP2). This suggests that within LuIII VP2 are determinants for improved tumor lysis. To investigate this, the structure of the LuIII virus-like-particle was determined using single particle cryo-electron microscopy and image reconstruction to 3.17 Å resolution, and compared to the H-1PV and MVM structures. The LuIII VP2 structure, ordered from residue 37 to 587 (C-terminal), had the conserved VP topology and capsid morphology previously reported for other protoparvoviruses. This includes a core β-barrel and α-helix A, a depression at the icosahedral 2-fold and surrounding the 5-fold axes, and a single protrusion at the 3-fold axes. Comparative analysis identified surface loop differences among LuIII, H-1PV, and MVM at or close to the capsid 2- and 5-fold symmetry axes, and the shoulder of the 3-fold protrusions. The 2-fold differences cluster near the previously identified MVM sialic acid receptor binding pocket, and revealed potential determinants of protoparvovirus tumor tropism