A bounding surface hysteretic water retention model for deformable soils

The paper presents a soil water retention model that takes into account the effects of void ratio and hydraulic hysteresis on the variation of degree of saturation. Based on a modified form of the van Genuchten equation, the model defines two bounding surfaces, namely a main drying surface and a main wetting surface, which delimit the region of admissible soil states in the space of degree of saturation, suction and void ratio. Suction and void ratio are then combined into a single auxiliary variable, termed scaled suction, and the main surfaces are recast as main curves in the plane of degree of saturation and scaled suction. The effects of both suction and void ratio on the drying/wetting behaviour of the soil are simply incorporated by relating degree of saturation to scaled suction. The soil is dried when the scaled suction is increased and is wetted when the scaled suction is decreased. The model assumes that, inside the region of admissible soil states, the derivative of degree of saturation with respect to the scaled suction depends on the distance of the soil state from the main curves. This assumption ensures a smooth transition of the drying and wetting paths towards their respective main curves. Interestingly, the derivative of degree of saturation with respect to scaled suction can be integrated in a closed form and all wetting and drying paths can therefore be described by two explicit equations (one for drying paths and one for wetting paths), where different wetting or drying paths are characterised by different values of the integration constant. The integration of the model in a closed form facilitates its implementation into numerical codes. The model requires seven parameters, whose values can be obtained from a single drying\u2013wetting test. Predictions are validated against two different data sets published in the literature, which shows the capability of the model to capture the behaviour observed during laboratory tests on fine-grained soils

The role of the integral membrane nucleoporins Ndc1p and Pom152p in nuclear pore complex assembly and function

The nuclear pore complex (NPC) is a large channel that spans the two lipid bilayers of the nuclear envelope and mediates transport events between the cytoplasm and the nucleus. Only a few NPC components are transmembrane proteins, and the role of these proteins in NPC function and assembly remains poorly understood. We investigate the function of the three integral membrane nucleoporins, which are Ndc1p, Pom152p, and Pom34p, in NPC assembly and transport in Saccharomyces cerevisiae. We find that Ndc1p is important for the correct localization of nuclear transport cargoes and of components of the NPC. However, the role of Ndc1p in NPC assembly is partially redundant with Pom152p, as cells lacking both of these proteins show enhanced NPC disruption. Electron microscopy studies reveal that the absence of Ndc1p and Pom152p results in aberrant pores that have enlarged diameters and lack proteinaceous material, leading to an increased diffusion between the cytoplasm and the nucleus

Neoadjuvant therapy for breast cancer

Objective: To evaluate the frequency of neoadjuvant therapy (NT) in women with stage I–III breast cancer in Italy and whether it is influenced by biological characteristics, screening history, and geographic area. Methods: Data from the High Resolution Study conducted in 7 Italian cancer registries were used; they are a representative sample of incident cancers in the study period (2009–2013). Included were 3546 women aged <85 years (groups <50, 50–69, 70–64, and 75+) with stage I–III breast cancer at diagnosis who underwent surgery. Women were classified as receiving NT if they received chemotherapy, target therapy, and/or hormone therapy before the first surgical treatment. Logistic models were built to test the association with biological and contextual variables. Results: Only 8.2% of women (290 cases) underwent NT; the treatment decreases with increasing age (14.5% in age <50 and 2.2% in age 75+), is more frequent in women with negative receptors (14.8%), HER2-positive (15.7%), and triple-negative (15.6%). The multivariable analysis showed the probability of receiving NT is higher in stage III (odds ratio [OR] 3.83; 95% confidence interval [CI] 2.83–5.18), luminal B (OR 1.87; 95% CI 1.27–2.76), triple-negatives (OR 1.88; 95% CI 1.15–3.08), and in symptomatic cancers (OR 1.98; 95% CI 1.13–3.48). Use of NT varied among geographic areas: Reggio Emilia had the highest rates (OR 2.29; 95% CI 1.37–3.82) while Palermo had the lowest (OR 0.41; 95% CI 0.24–0.68). Conclusions: The use of NT in Italy is limited and variable. There are no signs of greater use in hospitals with more advanced care

Resolving data center power bill disputes: the energy-performance trade-offs of consolidation

This is the author accepted manuscript. The final version is available from ACM via http://dx.doi.org/10.1145/2768510.2770933In this paper we challenge the common evaluation practices used for Virtual Machine (VM) consolidation, such as simulation and small testbeds, which fail to capture the fundamental trade-off between energy consumption and performance. We identify a number of over-simplifying assumptions which are typically made about the energy consumption and performance characteristics of modern networked systems. In response, we describe how more accurate models for data-center systems can be designed and used in order to create an evaluation framework that allows the more reliable exploration of the energy-performance trade-off for VM consolidation strategies.This work was jointly supported by by MINECO (grant TEC2014- 55713-R), the EPSRC INTERNET Project EP / H040536/1, and the Defense Advanced Research Projects Agency (DARPA) and the Air Force Research Laboratory (AFRL), under contract FA8750-11-C-0249. The views, opinions, and/or findings contained in this article/presentation are those of the author/presenter and should not be interpreted as representing the official views or policies, either expressed or implied, of the Defense Advanced Research Projects Agency or the Department of Defense

The ν\nu-cleus experiment: A gram-scale fiducial-volume cryogenic detector for the first detection of coherent neutrino-nucleus scattering

We discuss a small-scale experiment, called $\nu$-cleus, for the first detection of coherent neutrino-nucleus scattering by probing nuclear-recoil energies down to the 10 eV-regime. The detector consists of low-threshold CaWO$_4$ and Al$_2$O$_3$ calorimeter arrays with a total mass of about 10 g and several cryogenic veto detectors operated at millikelvin temperatures. Realizing a fiducial volume and a multi-element target, the detector enables active discrimination of $\gamma$, neutron and surface backgrounds. A first prototype Al$_2$O$_3$ device, operated above ground in a setup without shielding, has achieved an energy threshold of ${\sim20}$ eV and further improvements are in reach. A sensitivity study for the detection of coherent neutrino scattering at nuclear power plants shows a unique discovery potential (5$\sigma$) within a measuring time of ${\lesssim2}$ weeks. Furthermore, a site at a thermal research reactor and the use of a radioactive neutrino source are investigated. With this technology, real-time monitoring of nuclear power plants is feasible.Comment: 14 pages, 19 figure

Modeling the ecosystem services related to phytoextraction: Carbon sequestration potential using willow and poplar

Poplar and willow demonstrate great potential for the phytoextraction of trace elements (TEs) from soils. In most cases, these species are managed as short-rotation coppice, producing high woody biomass yields, which could provide a valuable contribution toward reducing greenhouse gas emissions in the atmosphere. In the current study, we compared the TE extraction and CO2 sequestration rates in a four-year field trial in Southern Italy of two arboreal species (willow and poplar). The results show that, once established in the study area, willow extracted more Cd and Cu and less Pb than poplar. The two species demonstrated the same average Ni and Zn extraction rates. Greater biomass yields in poplar suggest that this species was able to fix greater amounts of CO2 (28.7 Mg ha−1 yr−1) than willow (24.9 Mg ha−1 yr−1). We argue that the choice of the species to be used in phytoextraction should first be made considering the TE-specific affinity and phytoextraction rates. For TEs whose extraction rates were the same (i.e., Ni and Zn), poplar is to be preferred because of its ability to fix greater amounts of CO2 than willow

Cardiac myocyte-specific knock-out of calcium-independent phospholipase A2γ (iPLA2γ) decreases oxidized fatty acids during ischemia/reperfusion and reduces infarct size

Calcium-independent phospholipase A(2)γ (iPLA(2)γ) is a mitochondrial enzyme that produces lipid second messengers that facilitate opening of the mitochondrial permeability transition pore (mPTP) and contribute to the production of oxidized fatty acids in myocardium. To specifically identify the roles of iPLA(2)γ in cardiac myocytes, we generated cardiac myocyte-specific iPLA(2)γ knock-out (CMiPLA(2)γKO) mice by removing the exon encoding the active site serine (Ser-477). Hearts of CMiPLA(2)γKO mice exhibited normal hemodynamic function, glycerophospholipid molecular species composition, and normal rates of mitochondrial respiration and ATP production. In contrast, CMiPLA(2)γKO mice demonstrated attenuated Ca(2+)-induced mPTP opening that could be rapidly restored by the addition of palmitate and substantially reduced production of oxidized polyunsaturated fatty acids (PUFAs). Furthermore, myocardial ischemia/reperfusion (I/R) in CMiPLA(2)γKO mice (30 min of ischemia followed by 30 min of reperfusion in vivo) dramatically decreased oxidized fatty acid production in the ischemic border zones. Moreover, CMiPLA(2)γKO mice subjected to 30 min of ischemia followed by 24 h of reperfusion in vivo developed substantially less cardiac necrosis in the area-at-risk in comparison with their WT littermates. Furthermore, we found that membrane depolarization in murine heart mitochondria was sensitized to Ca(2+) by the presence of oxidized PUFAs. Because mitochondrial membrane depolarization and calcium are known to activate iPLA(2)γ, these results are consistent with salvage of myocardium after I/R by iPLA(2)γ loss of function through decreasing mPTP opening, diminishing production of proinflammatory oxidized fatty acids, and attenuating the deleterious effects of abrupt increases in calcium ion on membrane potential during reperfusion

Comportamiento de vacas lecheras primíparas y sus cruzas en un sistema a pastoreo de Entre Ríos (Argentina)

Se planteó como objetivo evaluar distintos genotipos lecheros durante su primera lactancia, en un sistema a pastoreo con suplementación de la cuenca lechera de Entre Ríos, Argentina. Se analizaron datos retrospectivos de lactancias de vacas primíparas pertenecientes a cinco genotipos lecheros: Holstein (H), H x Jersey (F1), F1 x Pardo Suizo (P), F1 x Guernsey (G) y retrocruza de las vacas triple cruza con H (R). Las vacas presentaron diferentes pesos al parto en los años 2007 y 2010, en tanto la edad al primer parto mostró diferencias en la F1 en 3 de los 4 años. El G aparece como uno de los genotipos con menor y más constante intervalo parto-concepción (ipc) en todos los años, en tanto F1 mostró los menores valores para ese parámetro en los últimos tres períodos y H siempre mostró los mayores, confirmando que mayores producciones se asocian a peores indicadores reproductivos. El número de servicios por preñez y los días en lactancia acompañaron en general la tendencia del ipc, pero revelaron una alta variabilidad dentro de cada genotipo, rotando la performance de los genotipos según el año. La producción de leche estuvo por encima de 6.000 litros en todos ellos, destacándose H cuando las condiciones ambientales y de alimentación se lo permitieron. La producción de grasa butirosa y proteína total se presentó muy variable entre genotipos y años, siendo H y G los de mayor producción en todos los años. Puede concluirse que las variaciones dentro de cada genotipo analizado y las diferentes respuestas que cada uno de ellos produjo, no permiten explicar adecuadamente la posible adaptación o no de los animales al ambiente y manejo del sistema durante el período considerado, aunque podría afirmarse que los genotipos F1 y G son los más estables en producción y con mejores respuestas reproductivas para estas condiciones