Prevalence and risk factors for mast cell tumours in dogs in England

BACKGROUND: Mast cell tumour (MCT) appears to be a frequent tumour type in dogs, though there is little published in relation to its frequency in dogs in the UK. The current study aimed to investigate prevalence and risk factors for MCTs in dogs attending English primary-care veterinary practices. METHODS: Electronic patient records from practices participating in the VetCompass animal surveillance project between July 2007 and June 2013 were searched for MCT diagnosis. Various search terms and standard diagnostic terms (VeNom codes) identified records containing MCT diagnoses, which were evaluated against clinical criteria for inclusion to the study. MCT prevalence for the entire dataset and specific breed types were calculated. Descriptive statistics characterised MCT cases and multivariable logistic regression methods evaluated risk factors for association with MCT (P < 0.05). RESULTS: Within a population of 168,636 dogs, 453 had MCT, yielding a prevalence of 0.27% (95% confidence interval (CI) 0.24% - 0.29%). The highest breed type specific prevalences were for the Boxer at 1.95% (95% CI 1.40% - 2.51%), Golden Retriever at 1.39% (0.98% - 1.81%) and Weimaraner at 0.85% (95% CI 0.17% to 1.53%). Age, insurance status, neuter status, weight and breed type were associated with MCT diagnosis. Of dogs of specific breed type, the Boxer, Pug and Staffordshire Bull Terrier showed greater odds of MCT diagnosis compared with crossbred dogs. Conversely, the German Shepherd Dog, Border Collie, West Highland White Terrier, Springer Spaniel and Cocker Spaniel had reduced odds of MCT diagnosis compared with crossbred dogs. No association was found between MCT diagnosis and sex. CLINICAL SIGNIFICANCE: This study highlights a clinically significant prevalence of MCT and identifies specific breed types with predisposition to MCT, potentially aiding veterinarian awareness and facilitating diagnosis

Data analysis of continuous gravitational wave: Fourier transform-II

In this paper we obtain the Fourier Transform of a continuous gravitational wave. We have analysed the data set for (i) one year observation time and (ii) arbitrary observation time, for arbitrary location of detector and source taking into account the effects arising due to rotational as well as orbital motion of the earth. As an application of the transform we considered spin down and N-component signal analysis.Comment: Accepted in MNRAS, 14 pages, 4 figure

Modelling combined intravenous thrombolysis and mechanical thrombectomy in acute ischaemic stroke: Understanding the relationship between stent retriever configuration and clot lysis mechanisms

Background: Combined intravenous thrombolysis and mechanical thrombectomy (IVT-MT) is a common treatment in acute ischaemic stroke, however the interaction between IVT and MT from a physiological standpoint is poorly understood. In this pilot study, we conduct numerical simulations of combined IVT-MT with various idealised stent retriever configurations to evaluate performance in terms of complete recanalisation times and lysis patterns. Methods: A 3D patient-specific geometry of a terminal internal carotid artery with anterior and middle cerebral arteries is reconstructed, and a thrombus is artificially implanted in the MCA branch. Various idealised stent retriever configurations are implemented by varying stent diameter and stent placement, and a configuration without a stent retriever provides a baseline for comparison. A previously validated multi-level model of thrombolysis is used, which incorporates blood flow, drug transport, and fibrinolytic reactions within a fibrin thrombus. Results: Fastest total recanalisation was achieved in the thrombus without a stent retriever, with lysis times increasing with stent retriever diameter. Two mechanisms of clot lysis were established: axial and radial permeation. Axial permeation from the clot front was the primary mechanism of lysis in all configurations, as it facilitated increased protein binding with fibrin fibres. Introducing a stent retriever channel allowed for radial permeation, which occurred at the fluid-thrombus interface, although lysis was much slower in the radial direction because of weaker secondary velocities. Conclusions: Numerical models can be used to better understand the complex physiological relationship between IVT and MT. Two different mechanisms of lysis were established, providing a basis towards improving the efficacy of combined treatments

PSR J1016-5857: a young radio pulsar with possible supernova remnant, X-ray, and gamma-ray associations

We report the discovery of a young and energetic pulsar in the Parkes multibeam survey of the Galactic plane. PSR J1016-5857 has a rotation period of 107 ms and period derivative of 8e-14, implying a characteristic age of 21 kyr and spin-down luminosity of 2.6e36 erg/s. The pulsar is located just outside, and possibly interacting with, the shell supernova remnant G284.3-1.8. Archival X-ray data show a source near the pulsar position which is consistent with emission from a pulsar wind nebula. The pulsar is also located inside the error box of the unidentified EGRET source 3EG J1013-5915, for which it represents a plausible counterpart.Comment: 5 pages, 3 included figures, accepted for publication by ApJ Letter

Rotating Neutron Stars in a Chiral SU(3) Model

We study the properties of rotating neutron stars within a generalized chiral SU(3)-flavor model. The influence of the rotation on the inner structure and the hyperon matter content of the star is discussed. We calculate the Kepler frequency and moments of inertia of the neutron star sequences. An estimate for the braking index of the associated pulsars is given.Comment: 14 pages, 9 figure

Quark Matter in Neutron Stars: An apercu

The existence of deconfined quark matter in the superdense interior of neutron stars is a key question that has drawn considerable attention over the past few decades. Quark matter can comprise an arbitrary fraction of the star, from 0 for a pure neutron star to 1 for a pure quark star, depending on the equation of state of matter at high density. From an astrophysical viewpoint, these two extreme cases are generally expected to manifest different observational signatures. An intermediate fraction implies a hybrid star, where the interior consists of mixed or homogeneous phases of quark and nuclear matter, depending on surface and Coulomb energy costs, as well as other finite size and screening effects. In this brief review article, we discuss what we can deduce about quark matter in neutron stars in light of recent exciting developments in neutron star observations. We state the theoretical ideas underlying the equation of state of dense quark matter, including color superconducting quark matter. We also highlight recent advances stemming from re-examination of an old paradigm for the surface structure of quark stars and discuss possible evolutionary scenarios from neutron stars to quark stars, with emphasis on astrophysical observations.Comment: 15 pages, 1 figure. Invited review for Modern Physics Letters

Gravitational wave detection using pulsars: status of the Parkes Pulsar Timing Array project

The first direct detection of gravitational waves may be made through observations of pulsars. The principal aim of pulsar timing array projects being carried out worldwide is to detect ultra-low frequency gravitational waves (f ~ 10^-9 to 10^-8 Hz). Such waves are expected to be caused by coalescing supermassive binary black holes in the cores of merged galaxies. It is also possible that a detectable signal could have been produced in the inflationary era or by cosmic strings. In this paper we review the current status of the Parkes Pulsar Timing Array project (the only such project in the Southern hemisphere) and compare the pulsar timing technique with other forms of gravitational-wave detection such as ground- and space-based interferometer systems.Comment: Accepted for publication in PAS

Australia Telescope Compact Array Observations of the OH Star Roberts 22: Resolved Images of OH Emission

We have imaged the unusual OH/IR object G 284-0.8 (Roberts 22) in the OH transitions at 1612, 1665 and 1667 MHz using the Australia Telescope Compact Array in Narrabri, NSW, Australia. The angular resolution of the OH images we present here is 6 arcsec (12000 AU at a distance of 2 kpc). We find OH emission, of extent 1.5 arcsec (2800 AU), located inside the optical bipolar flow region (size 8 arcsec) discovered by Allen et al. (1980) and imaged recently by Sahai et al. (1999) with the Hubble Space Telescope. We present astrometry of Roberts 22, providing registration of the OH and Hubble Space Telescope images to within ~0.35 arcsec. We describe the OH velocity field in Roberts 22 and discuss the kinematic properties of the source and its evolutionary status.Comment: 6 pages, 8 figures, tables. Accepted for AJ, tentatively scheduled for the May 2001 issu

First principles modelling of magnesium titanium hydrides

Mixing Mg with Ti leads to a hydride Mg(x)Ti(1-x)H2 with markedly improved (de)hydrogenation properties for x < 0.8, as compared to MgH2. Optically, thin films of Mg(x)Ti(1-x)H2 have a black appearance, which is remarkable for a hydride material. In this paper we study the structure and stability of Mg(x)Ti(1-x)H2, x= 0-1 by first-principles calculations at the level of density functional theory. We give evidence for a fluorite to rutile phase transition at a critical composition x(c)= 0.8-0.9, which correlates with the experimentally observed sharp decrease in (de)hydrogenation rates at this composition. The densities of states of Mg(x)Ti(1-x)H2 have a peak at the Fermi level, composed of Ti d states. Disorder in the positions of the Ti atoms easily destroys the metallic plasma, however, which suppresses the optical reflection. Interband transitions result in a featureless optical absorption over a large energy range, causing the black appearance of Mg(x)Ti(1-x)H2.Comment: 22 pages, 9 figures, 4 table