Hubungan Antara Pemakaian Alat Kontrasepsi Dalam Rahim Dengan Kejadian Kandidiasis Vulvovaginalis Di Rsud Dr. Moewardi

Latar Belakang: Kandidiasis vulvovaginalis (KVV) adalah infeksi jamur pada saluran kelamin, vulva, dan vagina pada perempuan yang disebabkan oleh spesies Candida. Beberapa penelitian melaporkan bahwa AKDR dapat berperan penting dalam menyebabkan KVV. Tujuan: Penelitian ini bertujuan untuk mempelajari dan menganalisis hubungan antara pemakaian alat kontrasepsi dalam rahim dengan kejadian kandidiasis vulvovaginalis. Metode: Desain penelitian yang digunakan adalah metode observasional dengan rancangan penelitian cross sectional. Besar sampel 92 pasien. Sampel yang digunakan adalah pasien dengan umur 18-60 tahun yang menderita leukorea di RSUD Dr. Moewardi Surakarta. Pengambilan sampel menggunakan teknik purposive sampling. Hubungan antara pemakaian AKDR dengan kejadian kandidiasis vulvovaginalis ini dianalisis menggunakan Chi-Square dengan menggunakan program SPSS versi 21.0 for windows. Hasil: Terdapat hubungan yang signifikan secara statistik pasien yang menggunakan AKDR dan mengalami KVV berjumlah 43 orang (46,7%) dan yang tidak mengalami KVV berjumlah 12 orang (13,1%). Sedangkan pasien yang tidak menggunakan AKDR dan mengalami KVV berjumlah 21 orang (22,8%) dan yang tidak menderita KVV berjumlah 16 orang (17,4%). Hasil uji hipotesis Chi-square didapatkan significancy 0,029 dimana p < 0,05. Kesimpulan: Terdapat hubungan antara pemakaian alat kontrasepsi dalam rahim dengan kejadian kandidiasis vulovaginalis di RSUD Dr. Moewardi Surakarta yang signifikan secara statistik

DEVELOPMENT OF INNOVATIVE MULTI-DRUG APPROACHES TO COUNTERACT ILLICIT DRUG ABUSE IN THE UAE POPULATION

The abuse of addictive substances is on the rise in the United Arab Emirates (UAE) population. Consequently, the UAE government spends about Dhs 5.5 billion annually on the rehabilitation of drug addicts. Blood, urine, and hair tests can reveal signs of sporadic or chronic drug use. Given the list of banned chemicals in the UAE, our main objective in this work was to develop a novel analytical method to identify and measure banned substances, especially prescription and over-the-counter drugs in the UAE. We developed and validated a rapid, sensitive and reliable liquid chromatography-mass spectrometry/mass spectrometry (LC-MS/MS) approach for the targeted analysis of 42 commonly consumed drugs in blood, urine, and hair matrices of the UAE population. Among the substances studied were seventeen benzodiazepines (BZDs), seventeen opioid drugs (OPI), and eight combined acid drugs (CAD). In the UAE, 1,300 samples were collected from suspects at various police stations and these were analyzed according to the established procedures. The result was that 302 urine samples, 283 blood samples, and 248 hair samples were positive. Each sample tested positive for one or up to five different substances. About 26 different drugs were found in all three matrices. The results suggested that in addition to blood and urine, hair samples should also be considered in drug testing to effectively combat the growing drug problem in the UAE population. These innovative, sensitive, reliable, robust, and state-of-the-art analytical methods will help forensic laboratories examine the different types of drugs used and addicts in the UAE. Following the results of this study, it is critical that relevant authorities advise forensic laboratories to use hair testing as a complementary additional evidence of drug use, and criminal courts may also consider hair testing as trustworthy evidence

Quantum phase transitions in impurity models and percolating lattices

This thesis investigates the influence of random disorder and dissipation on zero-temperature quantum phase transitions. Both phenomena can fundamentally change the character of the phases of a quantum many-particle system and of the transitions between them. If dissipation and disorder occur simultaneously in a system undergoing a quantum phase transition, particularly strong effects can be expected. In the first paper reproduced in this thesis, we study a single quantum rotor coupled to a sub-Ohmic dissipative bath. We find that this system undergoes a quantum phase transition from a delocalized phase to a localized phase as the dissipation strength is increased. We determine the exact critical behavior of this transition; it agrees with that of the corresponding long-range interacting classical model. Therefore, the quantum-to-classical mapping is valid for the sub-Ohmic rotor model. In the second paper, we investigate the influence of sub-Ohmic dissipation on randomly diluted quantum Ising and rotor models. We find that the zero-temperature quantum phase transition across the lattice percolation threshold separates an unusual super-paramagnetic cluster phase from an inhomogeneous ferromagnetic phase. We determine the low-temperature thermodynamic behavior in both phases, and we relate our results to the smeared transition scenario for disordered quantum phase transitions. In the last paper, the influence of Ohmic dissipation on the random transverse-field Ising chain is studied by means of large-scale Monte-Carlo simulations. Our simulations show that Ohmic dissipation destroys the infinite-randomness quantum critical point of the dissipationless system. Instead, the quantum phase transition between the paramagnetic and ferromagnetic phases is smeared, as predicted by a recent strong-disorder renormalization group approach --Abstract, page iv

Fully Stable Banach Algebra Module

The object of this paper is to introducea class of module which is a fully stable Banach Algebra module.

Redox-active molecules and polymers with photovoltaic applications

The study presented in this thesis provides details regarding the synthesis and characterization of different redox active molecules which can be applied to form the active layer of photovoltaic devices. For example in chapter two, star-shaped thiophene based molecules are described and their electronic and optical properties have been investigated. In chapter three, oligomers featuring bipyridinium units with different thienyl moieties have been successfully synthesized. Preliminary electropolymerization studies are achieved. In chapter four, two different series of powerful push-pull systems containing dimethyaniline DMA moieties as a strong donating group and TCNE or TCNQ as electron accepting groups have been prepared. These series feature quinone and oligothiophene units as supporting acceptor and donor unit. In chapter five, two different series of powerful organic dyes that could improve the efficiency of DSSCs by modulating the absorption of light towards the near-IR region are achieved. The influence of π-conjugated spacers on the optical and physical properties of synthesized dyes has been investigated. Preliminary DSSCs have been fabricated from some of these systems and their properties have been compared to dye N719

Microbial Degradation of Various Organic Pollutants Using Bacteria Isolated From Petroleum Sludge

Intensification of agriculture and manufacturing industries has resulted in increased release of a wide range of xenobiotic compounds to the environment. The extensive discharge of hazardous waste in industrial wastewater and the recalcitrant nature of some of these organic pollutants have fueled a strong interest in exploring efficient and environmentally friendly approaches for wastewater remediation. Bioremediation approaches can provide efficient, inexpensive and environmentally safe cleanup tools. In the present study, our main objective was to isolate novel bacterial strains from UAE petroleum sludge and to examine their abilities to degrade various aromatic pollutants, including azo dyes and emerging pollutants. We report here on the isolation and purification of novel bacterial strains from petroleum sludge that were capable of efficiently degrading various classes of aromatic dyes. Of these 12 isolates, extensive biochemical and optimization studies were carried out with the most promising strain, MA1. The optimum culture conditions of MA1 strain were found to be at pH 7, with 100 ppm dye concentration, and under aerobic condition. DNA sequencing of the 16S rRNA gene was carried out for the 12 bacterial strains and the data showed that the isolates belonged to two different bacterial species: Bacillus cereus and Pseudomonas guariconensis. Confirmation of the degradation of the aromatic compounds by the chosen bacterial strains was done using HPLC and LC-MS/MS analyses. This novel strain, MA1, was able to efficiently degrade aromatic dyes (e.g. Toluidine Blue, Ponceau BS, Reactive Black 5 and Congo Red) and more importantly various emerging pollutants of human concern such as sulfamethoxazole, prometryn, and fluometuron

Is collagenase-3 (MMP-13) expression in chondrosarcoma of the jaws a true marker for tumor aggressiveness?

<p>Abstract</p> <p>Background</p> <p>Matrix metalloproteinases (MMPs) play an important role in the modeling and remodeling of the extracellular matrix in both physiologic and pathologic states and thus plays an important role in tumor progression. Human collagenase-3 (MMP-13) is a member of matrix metalloproteinase family of enzymes that was originally identified in breast carcinomas and subsequently detected during fetal ossification and in arthritic processes.</p> <p>Aim</p> <p>The present study was designed to investigate the expression MMP-13 and to correlate its expression with clinicopathological parameters in chondrosarcoma of the jaws.</p> <p>Methods</p> <p>Archival tumor tissues from 11 patients with chondrosarcoma of the jaws were analyzed by immunohistochemistry for the expression of MMP-13. Clinical information was obtained through the computerized retrospective database from the tumor registry between 1998 to 2006.</p> <p>Results</p> <p>Eight of 11 cases (72.8 %) of chondrosarcomas showed a positive reaction for MMP-13, whereas two cases of normal cartilage were negative for this collagenase. As regard the clinicopathological parameters, there was no correlation between MMP-13 expression and sex, age and tumor site. While, there were significant associations between MMP-13 expression and both of mitotic counts and necrosis. On the other hand, there was a significant difference between low and high grade tumors (P < 0.05) regarding MMP-13 expression. Also, there was no significant correlation between MMP-13 expression in primary lesions and their local recurrence.</p> <p>Conclusion</p> <p>MMP-13 is expressed in the majority of chondrosarcoma of the jaws. It is also noteworthy that the expression of MMP-13 may be related to tumor biological aggressiveness and used to aid in predicting patient's poor prognosis.</p

Percolation transition in quantum Ising and rotor models with sub-Ohmic dissipation

We investigate the influence of sub-Ohmic dissipation on randomly diluted quantum Ising and rotor models. The dissipation causes the quantum dynamics of sufficiently large percolation clusters to freeze completely. As a result, the zero-temperature quantum phase transition across the lattice percolation threshold separates an unusual super-paramagnetic cluster phase from an inhomogeneous ferromagnetic phase. We determine the low-temperature thermodynamic behavior in both phases which is dominated by large frozen and slowly fluctuating percolation clusters. We relate our results to the smeared transition scenario for disordered quantum phase transitions, and we compare the cases of sub-Ohmic, Ohmic, and super-Ohmic dissipation.Comment: 9 pages, 2 figure

Impact of Scenario – Based Educational Intervention about Central Venous Catheter Care on Nurses’ Knowledge and Practice

Scenario based education (SBE) is a methodology, which aims to promote learning by involving participants in realistic situations. It can improve critical care nurses’ (CCN) knowledge and skills in management of nursing procedures especially central venous catheter (CVC) which is widely used and consider lifesaving. Aim of the study: to examine the impact of SBE on the nurses' knowledge and practices about care of CVC. Research design: A quasi-experimental design “one group, pre – posttest” was utilized in this study. Research hypotheses: 1) CCN “baccalaureate degree” who will receive SBE about care of CVC will have higher mean knowledge score as compared to their pre- implementation mean knowledge score. 2) CCN “diploma degree” who will receive SBE about care of CVC will have higher mean knowledge score as compared to their pre- implementation mean knowledge score. 3) CCN “baccalaureate degree” who will receive SBE about care of CVC will have higher mean practice score as compared to their pre- implementation mean practice score. 4) CCN “baccalaureate degree” who will receive SBE about care of CVC will have higher mean practice score as compared to their pre- implementation mean practice score.Setting: Adult intensive care unit (ICU) at Damietta chest disease hospital.Sample: A convenient samples “All nurses” working in the adult ICU Tools of data collection: Two tools was utilized 1) Pre/ post- test interview questionnaire schedule.2) CCNs observational checklist. Results: There was statistically significant difference in total knowledge score pre SBE, immediately after and two months later of both bachelor nurses (F= 53.206, P =.000) and diploma nurses (F= 58.613, P =.000). Also, there was statistically significant difference in total practice score pre SBE, immediately after and two months later of both bachelor nurses (F = 691.310, P =.000) and diploma nurses (F = 42.34, P =.000). Conclusion: Utilizing innovative educational methods such as SBE can have a significant influence on enhancing the nurses’ knowledge and skills. Recommendations: Continuous training sessions for nurses by innovative educational methods and further studies needed to be carried out to examine the effect of SBE on a larger probability sample, Keywords:  Scenario based education, Central venous catheter, Intensive care uni