Ecosystem-Driven Design of In-Home Terminals Based on Open Platform for the

Abstract—In-home healthcare services based on the Internet-of-Things (IoT) have great business potentials. To turn it into reality, a business ecosystem should be established first. Technical solutions should therefore aim for a cooperative ecosystem by meeting the interoperability, security, and system integration requirements. In this paper, we propose an ecosystem-driven design strategy and apply it in the design of an open-platform-based in-home healthcare terminal. A cooperative business ecosystem is formulated by merging the traditiona

The trans-ancestral genomic architecture of glycemic traits

Glycemic traits are used to diagnose and monitor type 2 diabetes and cardiometabolic health. To date, most genetic studies of glycemic traits have focused on individuals of European ancestry. Here we aggregated genome-wide association studies comprising up to 281,416 individuals without diabetes (30% non-European ancestry) for whom fasting glucose, 2-h glucose after an oral glucose challenge, glycated hemoglobin and fasting insulin data were available. Trans-ancestry and single-ancestry meta-analyses identified 242 loci (99 novel; P < 5 x 10(-8)), 80% of which had no significant evidence of between-ancestry heterogeneity. Analyses restricted to individuals of European ancestry with equivalent sample size would have led to 24 fewer new loci. Compared with single-ancestry analyses, equivalent-sized trans-ancestry fine-mapping reduced the number of estimated variants in 99% credible sets by a median of 37.5%. Genomic-feature, gene-expression and gene-set analyses revealed distinct biological signatures for each trait, highlighting different underlying biological pathways. Our results increase our understanding of diabetes pathophysiology by using trans-ancestry studies for improved power and resolution. A trans-ancestry meta-analysis of GWAS of glycemic traits in up to 281,416 individuals identifies 99 novel loci, of which one quarter was found due to the multi-ancestry approach, which also improves fine-mapping of credible variant sets.Peer reviewe

[[alternative]]The Development of Community Empowerment Process Scale(CEPS)--A Study of Elder Community Participation in Taiwan

[[abstract]]本研究旨在發展一份適合測試國內社區參與之權能激發過程量表，並且探討個人背景變項、個人內外在因素及社區參與情形與權能激發之關係。首先就十二位積極參與台北市士林區「社區健康營造研究計畫」之社區人士，進行質性訪談資料分析，建構「社區權能激發過程量表」的架構與題目，並檢定量表之信效度。再以宜蘭縣溪南地區三個社區共313名65歲以上民眾作為正式施測對象，以探討社區老人人口學變項、社區參與狀況、與權能激發程度之關係。 本研究結果顯示「社區權能激發過程量表」總量表之Cronbach’s alpha值為0.897 ; 而權能激發動力（內在特質與外在激力），權能激發結果（認知權能激發,情緒權能激發和行為權能激發）等五個次量表的Cronbach’s alpha 值依序為0.88，0.87，0.85，0.87和0.90。在驗證性因素分析方面，權能激發動力部分的兩個因素（內在特質與外在激力）解釋力達59%，權能激發結果部分的三個因素（認知、情緒與行為）解釋力則達82.16%。以皮爾遜積差相關分析發現權能激發動力與結果的五項因素間均存在高度相關。透過階層複迴歸分析，證實兩項權能激發動力（內在特質與外在激力）為權能激發結果之重要預測因子，兩者對權能激發結果的總解釋力高達79%。 研究對象參與社區活動以受鄰居影響為多（佔42.7%），且多為社區活動固定成員(58.14%)。以獨立樣本t檢定分析法發現老人「參加社區活動的頻率」、「是否為活動固定成員」、及「是否為社團幹部」對其認知、情緒及行為權能激發程度均有顯著影響，即參加頻率愈高、是活動固定成員、及擔任社團幹部者的權能激發分數明顯地愈高。 本研究中已建立「社區權能激發過程量表」初步的信效度，亦有實際應用之研究結果，並依之提出了對社區護理實務、護理教育、及護理研究等方面的建議，期能提供社區適才適性激勵老人參與社區活動之參考，使老人由社區參與活動中藉由自身權能激發程度之提升來改善其生活品質。 關鍵字：老人、社區參與、權能激發、量表[[abstract]]The purpose of this study was to develop a Community Empowerment Process Scale (CEPS) and to explore the motivation and effectiveness of elders’ community Participation in Taiwan I-Lan Area. The structure and items of CEPS were derived from a qualitative analysis of 12 active members’ interviews, those who deeply involved in a “Community Health City Program” in Shih-Lin district of Taipei. After being verified the validity and reliability, the CEPS was used to explore the relationships among epidemiological data, community participation and empowerment effectiveness of the elderly, by testing 313 elders living in three different communities of I-Lan County. The results reveal: 1)The total Cronbach’s alpha of CEPS is 0.897. In which, the Cronbach’s alpha of 5 subscales are: “Internal Characteristics”─0.88; “External Inducers”─0.87; “Cognition Empowerment”─0.85; “Emotion Empowerment”─0.87; and “Behavior Empowerment”─0.90. 2)By factor analysis, the “Internal Characteristics” and “External Inducers” can explain 59% factors of empowerment motives; the “Cognition Empowerment”, “Emotion Empowerment”, and “Behavior Empowerment” can totally explain 82.16% factors of empowerment effectiveness. 3)By Pearson’s product correlation, two empowerment motives factors and three empowerment effectiveness factors have highly inter-relationships. 4)By regression analysis, “Internal Characteristics” and “External Inducers” are two vital predictors of empowerment effectiveness. Their prediction power is up to 79%. 5)The action of participating community activities of most elders were initiated by their neighbors (42.7%) and most of them were active members in community activities (58.14%). 6)Elders who participated in activities more often, being active members and being board members of activities had higher level of empowerment effectiveness. This research develops a “Community Empowerment Process Scale”, which possesses good validity and reliability. More application issues in nursing practice, education, and future are discussed. Keywords: elder, community participation, empowerment, scal

[[alternative]]A Conceptual Analysis of the Process of Empowering the Elderly at the Community Level

[[abstract]]WHO在1986年的Ottawa宣言(WHO/Europe, 2005, April 18)中曾指出『社區』為健康促進活動的「最佳介入點」，而倡導權能激發亦被視為現代健康促進活動的主軸，即健康促進必須靠有效與創新的社區行動(community action)來達成；而社區的權能激發(community empowerment)為社區行動的三大要素之一，故我們相信透過社區場域的人事物互動，可以使老年人力資源有所應用，使老人們更有能力感，且此方式其本身將是促使老人社會參與、發揮自我效能的最佳策略。本文藉由文獻回顧與整理介紹權能激發之定義、概念發展、重要內涵，並列舉實徵性研究與測量工具加以分析探討，除檢視老人社區參與及權能激發的運作情形及成效外，更對社區老人照護相關議題提出建議。[[abstract]]The World Health Organization's 1986 Ottawa Declaration (WHO/Europe, 2005, April 18) named the community as the best level at which to initiate health promotion activities and recognized ”empowerment” as a main focus of modern health promotion activities. This implies that the success of health promotion initiatives relies on effective and creative community action, of which community empowerment is one of the three major influencing factors. Empowerment is a manner by which the resources of senior citizens can be reorganized and an awareness of their own capabilities cultivated. Moreover, empowerment is the best strategy to encourage senior citizen participation in the community as well as self-efficacy. Based on a review of the literature, this article introduces the definitions, concept development and vital components of community empowerment. Evidence-based research and examination instruments for the concept of empowerment are critically reviewed as well. In addition to discussing the application and effectiveness of senior citizen community participation and empowerment, this paper provides suggestions related to current community nursing care issues

Erratum to: Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (Autophagy, 12, 1, 1-222, 10.1080/15548627.2015.1100356

non present