Realistic Simulation of BM@N GEM Detectors: Model Implementation and Testing

The Lorentz shift of electrons in a magnetic field is taken into account with simulating the response of a GEM detector for the BM@N experiment. Dependences of the determined coordinate x on the track angle, the values of the Lorentz shift of electrons and its dispersion for the gas mixture ArC4H10 were obtained. The momentum resolution was obtained as a function of the momentum for the deuteron-carbon (dC) process, and the invariant mass of the Λ-hyperon was determined. The obtained results are close to the first results of experimental data collected in the technical run in interactions of the deuteron beam of 4 AGeV with different targets

On Question about Conditions of Development of Creativity in Senior Pupils of Secondary Schools

The issue of creating the conditions in school for development of creative potential of students is considered. It is noted that the development of creative thinking of senior pupils is the basis for the formation of innovative potential of the future specialist, therefore, currently this is one of the main tasks of school education. The results of search of conditions for development of creative potential of senior pupils are presented, using a modified technique by George Guildford, subtext “Use items,” offering the task on listing the most complete set of options for the use of any object. The author reveals the conditions that promote the creative potential of senior students, among which there are support of visual-figurative thinking in the process of creative activities and use of tasks focused on the development of visual-figurative thinking associated with creative expression, imagination, manifestation of personality, internal motivation, interest, goal, conversion, research, creation of the new. It is indicated that the development of creativity contributes to the rejection of rigid guidelines for the students that allows them to express individuality. It is noted that the development of creative potential of students can be carried out on sectarian activities. It is shown that the result of the experiment will allow to improve the forms of organization of extra-curricular clubs and classes, and creative homework

The BM@N Experiment at JINR: Status and Physics Program

BM@N (Baryonic Matter at Nuclotron) is the first experiment to be realized at the accelerator complex of NICA-Nuclotron at JINR (Dubna, Russia). The aim of the experiment is to study interactions of relativistic heavy ion beams with energy up to of strange mesons, multi-strange hyperons and light hyper-nuclei which are produced in nucleus-nucleus collisions close to the kinematic threshold. The BM@N set-up, the experimental program and first results of technical runs are presented

Comparative Analysis of Peculiarities of Thinking of Urban and Rural Schoolchildren

The results of the comparative analysis of the peculiarities of thinking of urban and rural schoolchildren of primary and senior levels of education are presented. In order to identify differences in the levels of formation of individual characteristics of thinking linked, inter alia, with the characteristics of social, physical and physiological development of students in urban and rural schools, a number of works were studied on the comparison of functional indicators of hemodynamics, psycho-emotional stability, verbal and logical thinking and characteristics of educational and cognitive activity among urban and rural schoolchildren. The results of the interpretation of the data obtained during the experiment conducted by the authors (54 respondents, 27 rural and urban high school students) are presented. It is concluded that rural pupils are characterized by higher level of development of abilities and qualities of the personality, providing them successful performance of the main types of mathematical activity: low level of psychoemotional tension, qualitative analysis of visual and visually-spatial information, logical conclusions, generalization of information, interest in the correct solution of a problem, etc. In the future, it is expected to find out possible reasons for “lagging” of urban schoolchildren from rural ones in terms of individual indicators of formation of mathematical thinking operations

Inflammatory biomarkers associated with developing critical state of Covid-19: a meta-analysis

COVID-19, a novel coronavirus has been responsible for millions of cases of deaths worldwide. Infected patients progress to critical severe state which required high-flow oxygen support, compromising the availability of health resources. Critical group experienced more multiorgan damage which was partially induced by direct attack of SARS-CoV-2. Among these patients, the most often detected high level of pro-inflammatory markers (PCT, WBS, and CRP). Thus, early finding and laboratory markers diagnostics have a certain extent of positive effect on the prognosis and prevent negative outcomes in a timely manner

RNA polymerase II clusters form in line with surface condensation on regulatory chromatin

It is essential for cells to control which genes are transcribed into RNA. In eukaryotes, two major control points are recruitment of RNA polymerase II (Pol II) into a paused state, and subsequent pause release toward transcription. Pol II recruitment and pause release occur in association with macromolecular clusters, which were proposed to be formed by a liquid–liquid phase separation mechanism. How such a phase separation mechanism relates to the interaction of Pol II with DNA during recruitment and transcription, however, remains poorly understood. Here, we use live and super-resolution microscopy in zebrafish embryos to reveal Pol II clusters with a large variety of shapes, which can be explained by a theoretical model in which regulatory chromatin regions provide surfaces for liquid-phase condensation at concentrations that are too low for canonical liquid–liquid phase separation. Model simulations and chemical perturbation experiments indicate that recruited Pol II contributes to the formation of these surface-associated condensates, whereas elongating Pol II is excluded from these condensates and thereby drives their unfolding

Laboratory testing for COVID 19 (SARS cov 2): current situation and trend in Ukraine

Finally, we showed that interest of Ukrainian Google users to coronavirus laboratory testing was almost comparable in time to quarantine restrictions. These finding was demonstrated that the number of performed laboratory detection and cases of laboratory-confirmed COVID-19 infection is currently actual and could possibly serve as an important basis for the selection and creation of effective algorithms and strategies for laboratory testing in public health

ДІАГНОСТИКА ЕНДОТЕЛІАЛЬНОЇ ДИСФУНКЦІЇ У ХВОРИХ НА АУТОІМУННИЙ ТИРЕОЇДИТ ЗА НАЯВНОСТІ АТЕРОСКЛЕРОТИЧНОГО УРАЖЕННЯ СУДИН

Поширеність аутоімунного тиреоїдиту(АІТ) в Україні за останні 10 років зросла на 68 %.АІТ є найчастішою причиною гіпотиреозу (70–80 % випадків). Ендотеліальна дисфункція (ЕД),що формується в умовах запального процесу, насьогодні розцінюється як основний патогенетич-ний чинник формування атеросклеротичногоураження судин, яке є морфологічною основоюішемічної хвороби серця (ІХС). Тому пошук пока-зових маркерів ЕД як при АІТ, так і при атероскле-розі (АС), є актуальним для оптимізації діагности-ки, оцінки перебігу та ефективності лікувальнихзаходів

Analysis of involvement of nanoparticles fullerene C60 in regulation innate and adaptive immune reactions

Background: Nanoparticles fullerene C60 (FC60) have offered new hope for detection, prevention, and treatment in modern medicine due to their key properties, small size, enhanced permeability, surface modification and retention effects. However, the effects of nanoparticle properties on the immune system are still being explored. The main purpose of this investigation was to assess the influence of FCl on functional activity of the phagocytic cells in vitro, production of hemagglutinins, hemolysins and level activity of complement during the primary immune response in vivo. Materials and methods: Peripheral blood (PB) from 10 healthy donors was obtained. FC60 was added at 0,01 and 0,1 pM/1 to PB and incubated for 10 min at 37°C. Level of phagocytosis, Nitroblue Tetrazolium (NBT)-test, level of myeloperoxidase activity, zimozan-induced chemiluminescence was assayed. Peripheral blood mononuclear cells were incubated with PE-conjugated mAb to CD54 and analyzed by flow cytometry. Balb/c mice were immunized by 2% suspensions of ram red blood cells for induction of the primary immune response. Mice were treated i.p. with 50 ng of FC6I| during 1, 3 and 6 days after induction of the primary immune response. Titre of hemagglutinins was determined by reaction of hemagglutination, litre of hemolysins - by reaction of immune lysis, activity of complement - by immune hemolysis. Results: The results demonstrated that FC60 did not affect the phagocytic activity of neutrophils at any doses. FC significantly decreased level of myeloperoxiase activity in neutrophils in doses 0,01 and 0,1 pM/1. FCf significantly increased the indices of the NBT-test in neutrophils in dose 0,01 pM/1. Addition of FC6 to peripheral blood suppressed zimozan-induced chemiluminescence in doses 0,01 and 0,1 pM/1. Moreover, FCf strongly reduced level of expression CD54 on lymphocytes and monocytes in doses 0,01 and 0,1 pM/1, but did not effect on neutrophils. The study revealed that FC( induced the production of hemagglutinins and hemolysins, especially in initial and maximum phase of the generation antibodies during induction of the primary immune response. Additionally, FC60 induced the complement system activation and enlarged its activity after induction of the primary immune response. Conclusion: The studies showed that FCtn can influence on immune reactions via different mechanisms. FC6|| negatively alter phagocytic activity of immune cells in vitro, but it positively influence on production of hemagglutinins and hemolysins, level activity of complement during the primary immune response in Balb/c mice in vivo. Thus, FC60 provides a potential perspective medical application because it can display immunomodulatory properties which are directed on the innate (phagocytosis and complement system) and adaptive mechanisms (production antibodies) of immune system