Discovery of the grave and identification of the remains of Matteo Maria Boiardo in Saint Mary's church, Scandiano (Reggio Emilia)

According to the documentary information and to the prospectings performed by means of the georadar, beneath the floor of the Church of Santa Maria of Scandiano (RE), it has been possible to locate the sepulchral crypts where the poet Matteo Maria Boiardo and other members of his family, such as his father Giovanni, his grandfather Feltrino and maybe his wife Taddea Gonzaga and one of his sons, Camillo, must have been buried. The exploration of these sepulchral crypts has led to the recovery of the skeletal remains belonging altogether to at least 20 persons (adults and children). Among them, 3 have been discovered into a sepulchral room and the rest into an adjacent tomb. Among the first ones, a person, with the same sex, age of death, sturdiness, height and physical characteristics of the poet Boiardo, has been identified. As confirmation of this probable identity, the genetic profile of this man, got from the nuclear dna sample taken from his body, has come out to be compatible with a possible father/child relationship, this result has been compared to the one gotten from the find found into the adjacent room where the poet's father and grandfather had to be buried. The body of a second person, of female sex and well on in years, with a genetic profile different from the previous ones, could be identified with Boiardo's wife. For what regards the body of the third man, besides it is not possible to exclude that it belongs to Camillo, the poet's son dead when he was very young, it has not been possible yet, to get enough proofs able to confirm this theory

Flow Characterization of a Pulsating Heat Pipe through the Wavelet Analysis of Pressure Signals

Pulsating Heat Pipes are two phase passive heat transfer devices characterized by a thermally induced two phase oscillating flow. The correct detection of the dominant frequencies of such oscillations is fundamental to fully characterize the device thermofluidic operation but the studies available in the literature are very heterogenous and results are often discordant. In this work, the concept of dominant frequency in Pulsating Heat Pipes is thoroughly discussed and defined analytically. The wavelet transform is used to characterize the fluid pressure signal in the frequency domain varying the heat power input at the evaporator and in the condenser zone of a full-scale Pulsating Heat Pipe tested in microgravity conditions. During the slug-plug flow regime, the dominant frequencies falls in the range 0.6–0.9 Hz, showing an increasing trend with the heat load input. The Cross-Correlation reveals that the two signals at the evaporator and at the condenser are very similar. Finally, the instantaneous angle of phase is calculated and lies between 310 and 360 deg. This value can be physically interpreted as a repeatable time shift between the two signals that can be used to evaluate the flow local mean velocity (0.09–0.13 m/s) constituting a valuable alternative to the visualization techniques

Population Data for Y-Chromosome Haplotypes Defined by AmpFlSTR YFiler PCR Amplification Kit in North Sardinia (Italy)

The 17 Y-chromosomal short tandem repeats (STRs) included in the AmpFlSTR YFiler Amplification Kit (AB Applied Biosystems) (DYS19, DYS389I, DYS389II, DYS390, DYS391, DYS392, DYS393, DYS385, DYS437, DYS438, DYS439, DYS448, DYS456, DYS458, DYS635 and GATA H4.1) were typed in 100 samples from North Sardinia (Italy). A total of 91 different haplotypes were found, where 9 haplotypes were shared by two individuals. The overall haplotype diversity (HD) was 0.9982. DYS458 non-consensus alleles were found in one samples, and one in the DYS438. We found a double peak in one sample for the DYS19 with alleles 15/16. Population comparisons with available 10 YSTR loci data in Mediterranean Basin samples were undertaken, significant differences were observed between our sample and all the compared populations, except for a entire sample from Sardinia. Prediction of haplogroups showed I2a1 was found to be the most frequent haplogroup (33%) in our sample. Testing high-resolution Y-chromosome data sets it is useful in autochthonous population and micro-population studies to highlight the most informative loci for evolutionary aims

Start-Up and Operation of a 3D Hybrid Pulsating Heat Pipe on Board a Sounding Rocket

A large tube may still behave, to a certain extent, as a capillary in a micro-gravity environment. This very basic concept is here applied to a two-phase passive heat transfer device to obtain a new family of hybrid wickless heat pipes. Indeed, a Loop Thermosyphon, which usually consists of a large tube, closed end to end in a loop, evacuated and partially filled with a working fluid and intrinsically gravity assisted, may become a capillary tube in space condition and turn its thermo-fluidic behavior into a Pulsating Heat Pipe. This work presents the results obtained on such a hybrid device heated at 200 W both on board a sounding rocket (ESA REXUS 22, microgravity period ~120 s), and on ground in vertical and anti-gravity orientation. Since no steady state occurred in microgravity conditions, the comparison between flight and ground data focuses on the startup phenomenon, whereas the thorough ground test campaign describes the limits and performances of the device working in thermosyphon mode. The expected thermal behavior in microgravity conditions is between that of a purely conductive tube in anti-gravity conditions on ground and that of a gravity assisted thermosyphon. Since a microgravity period of approximately 120 s is not enough to reach a pseudo steady state regime, further investigation on a longer-term weightless condition is mandatory

Wavelet Analysis of the Pressure Signal in a Pulsating Heat Pipe

Thermally induced oscillations in two phase slug flow may largely affect the design heat transfer in microchannel heat exchangers and in passive wickless two-phase systems, i.e. Pulsating Heat Pipes (PHPs). The occurrence of flow instabilities and how and when possible dominant frequencies appear during the device operation are still open issues in the scientific community and, most important, are not known a priori, neither can be derived only from physical and analytical considerations. In the literature, studies about different types of time-frequency analyses on the fluid pressure, the fluid and wall temperature, the liquid slug velocity and the vapor plugs displacement signals can be found. The results are incomplete because the link between frequencies and device performance is still not clear. In this work the time-frequency analysis has been applied to the evaporator and condenser pressure signals of a Pulsating Heat Pipe and individually analyzed to investigate the existence of dominant frequencies. Data recording is performed varying the heat power input at the evaporator zone, ranging from 68 W to 146 W. To characterize the signal in the frequency domain and identify the time interval in which the dominant frequency occurs the selected tool is the Wavelet Transform, a good compromise between resolution and complexity of implementation. During the slug-plug flow regime, the results show that the dominant frequencies always fall in the range 0.6 - 0.9 Hz, with an increasing trend with the heat input level. Moreover, the two signals at the evaporator and at the condenser were compared through the Wavelet Cross-Correlation, identifying the dominant frequency common to both signals and the phase angle 〖10〗^o 〖-20〗^o. The understanding of the complex phenomena related to the thermally induced oscillations is essential for the development of reliable heat transfer models and robust design tools for Pulsating heat pipes

Population Data for Y-Chromosome Haplotypes Defined by AmpFlSTR YFiler PCR Amplification Kit in North Sardinia (Italy)

The 17 Y-chromosomal short tandem repeats (STRs) included in the AmpFlSTR YFiler Amplification Kit (AB Applied Biosystems) (DYS19, DYS389I, DYS389II, DYS390, DYS391, DYS392, DYS393, DYS385, DYS437, DYS438, DYS439, DYS448, DYS456, DYS458, DYS635 and GATA H4.1) were typed in 100 samples from North Sardinia (Italy). A total of 91 different haplotypes were found, where 9 haplotypes were shared by two individuals. The overall haplotype diversity (HD) was 0.9982. DYS458 non-consensus alleles were found in one samples, and one in the DYS438. We found a double peak in one sample for the DYS19 with alleles 15/16. Population comparisons with available 10 YSTR loci data in Mediterranean Basin samples were undertaken, significant differences were observed between our sample and all the compared populations, except for a entire sample from Sardinia. Prediction of haplogroups showed I2a1 was found to be the most frequent haplogroup (33%) in our sample. Testing high-resolution Y-chromosome data sets it is useful in autochthonous population and micro-population studies to highlight the most informative loci for evolutionary aims

Peri-operative red blood cell transfusion in neonates and infants: NEonate and Children audiT of Anaesthesia pRactice IN Europe: A prospective European multicentre observational study

BACKGROUND: Little is known about current clinical practice concerning peri-operative red blood cell transfusion in neonates and small infants. Guidelines suggest transfusions based on haemoglobin thresholds ranging from 8.5 to 12 g dl-1, distinguishing between children from birth to day 7 (week 1), from day 8 to day 14 (week 2) or from day 15 (≥week 3) onwards. OBJECTIVE: To observe peri-operative red blood cell transfusion practice according to guidelines in relation to patient outcome. DESIGN: A multicentre observational study. SETTING: The NEonate-Children sTudy of Anaesthesia pRactice IN Europe (NECTARINE) trial recruited patients up to 60 weeks' postmenstrual age undergoing anaesthesia for surgical or diagnostic procedures from 165 centres in 31 European countries between March 2016 and January 2017. PATIENTS: The data included 5609 patients undergoing 6542 procedures. Inclusion criteria was a peri-operative red blood cell transfusion. MAIN OUTCOME MEASURES: The primary endpoint was the haemoglobin level triggering a transfusion for neonates in week 1, week 2 and week 3. Secondary endpoints were transfusion volumes, 'delta haemoglobin' (preprocedure - transfusion-triggering) and 30-day and 90-day morbidity and mortality. RESULTS: Peri-operative red blood cell transfusions were recorded during 447 procedures (6.9%). The median haemoglobin levels triggering a transfusion were 9.6 [IQR 8.7 to 10.9] g dl-1 for neonates in week 1, 9.6 [7.7 to 10.4] g dl-1 in week 2 and 8.0 [7.3 to 9.0] g dl-1 in week 3. The median transfusion volume was 17.1 [11.1 to 26.4] ml kg-1 with a median delta haemoglobin of 1.8 [0.0 to 3.6] g dl-1. Thirty-day morbidity was 47.8% with an overall mortality of 11.3%. CONCLUSIONS: Results indicate lower transfusion-triggering haemoglobin thresholds in clinical practice than suggested by current guidelines. The high morbidity and mortality of this NECTARINE sub-cohort calls for investigative action and evidence-based guidelines addressing peri-operative red blood cell transfusions strategies. TRIAL REGISTRATION: ClinicalTrials.gov, identifier: NCT02350348

A Qualitative Exploration of the Use of Contraband Cell Phones in Secured Facilities

Offenders accepting contraband cell phones in secured facilities violate state corrections law, and the possession of these cell phones is a form of risk taking behavior. When offenders continue this risky behavior, it affects their decision making in other domains where they are challenging authorities; and may impact the length of their incarceration. This qualitative phenomenological study examined the lived experience of ex-offenders who had contraband cell phones in secured correctional facilities in order to better understand their reasons for taking risks with contraband cell phones. The theoretical foundation for this study was Trimpop\u27s risk-homeostasis and risk-motivation theories that suggest an individual\u27s behaviors adapt to negotiate between perceived risk and desired risk in order to achieve satisfaction. The research question explored beliefs and perceptions of ex-offenders who chose to accept the risk of using contraband cell phones during their time in secured facilities. Data were collected anonymously through recorded telephone interviews with 8 male adult ex-offenders and analyzed using thematic content analysis. Findings indicated participants felt empowered by possession of cell phones in prison, and it was an acceptable risk to stay connected to family out of concern for loved ones. The study contributes to social change by providing those justice system administrators, and prison managers responsible for prison cell phone policies with more detailed information about the motivations and perspectives of offenders in respect to using contraband cell phones while imprisoned in secured facilities

Sentience, Moral Relevance of

Present adress for Alessandro Blasimme: INSERM UMR 1027, Université de Toulouse 3-Paul SabatierSentience is a capacity that only some organisms have. It is often assumed that this capacity has moral significance and should have a prominent role in moral thinking. The commonsense notion of sentience (as indicated by the etymology, from the Latin sentiens which means "capable of feeling") suggests that sentience is a capacity to be in certain kinds of mental states. In the ethical literature, the term "sentience" is often used to refer to the ability to feel pain and pleasure. More generally, sentience can be said to be the capacity to have feelings or sensations, which include pain and pleasure but also visual and auditory sensations, hunger, sadness, and so on