Technology development of obtaining essential fatty acids from hydrobionts hydrolyzates

Articleɷ-3, 6-fatty acids from hydrobiontsare a minor component in the nutrition of European countries population. This causes a number of diseases, such as cardiovascular ones, cancer etc. There is a task of concentrating these acids in oil due to the fact that to meet their daily needs it is problematic to use large quantities of fish oil-from 15 to 20 g. Particularly rich in ɷ-3, 6-acids are wastes from the cutting of hydrobionts, containing muscle tissue and skin. Protein hydrolysates were obtained from rainbow trout (Oncorhynchusmykiss) and Atlantic herring (Clupeaharengus) wastes by the electrochemical method using electrolyzers of the original design which are allowed to be used in food industry. A technological scheme of separating of lipids from protein hydrolyzates has been developed and experimental batches of oil samples have been developed. To concentrate the fatty acids the cryoconcentration method was used. The phase transitions of the obtained lipids were studied after their cryoconcentration in the temperature range from + 15 °C to minus 40 °C in the environment of calcium chloride using a low-temperature refrigeration unit. To analyze phase transitions the plant was used, which is a container with a solution of calcium chloride cooled by a low-temperature refrigeration machine. The properties of 5 fractions of lipids formed at the time of lipid phase transitions have been identified and studied (the fractional composition, acid, iodine numbers, the content of polyunsaturated fatty acids (PUFAs), vitamin D3 and A). It was established that as cryoconcentration increases the concentration of PUFAs, reaching values close to 90%, which allows the resulting product to be attributed to biologically active food additives (BAA). By calculation, it was shown that to create functional food products on fish base from fish of the Gadidae family it is enough to inject 4 grams of BAA to 100 grams of the product. Organoleptic properties of food products from low-fat fish species were improved

Acceleration and transport of ions in turbulent current sheets: formation of non-maxwelian energy distribution

The paper is devoted to particle acceleration in turbulent current sheet (CS). Our results show that the mechanism of CS particle interaction with electromagnetic turbulence can explain the formation of power law energy distributions. We study the ratio between adiabatic acceleration of particles in electric field in the presence of stationary turbulence and acceleration due to electric field in the case of dynamic turbulence. The correlation between average energy gained by particles and average particle residence time in the vicinity of the neutral sheet is discussed. It is also demonstrated that particle velocity distributions formed by particle-turbulence interaction are similar in essence to the ones observed near the far reconnection region in the Earth's magnetotail

Variability of Cerebral Deep Venous System in Preterm and Term Neonates Evaluated on MR SWI Venography

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Production and Investigation of Biological and Photocatalytic Activit Multimodal Nanopowders Produced by Pulsed Electron Beam Evaporation in Vacuum

Nanopowders doped with silver were produced by the methode pulsed electron beam evaporation. © Journal of Physics: Conference Series 2021.The study was carried out with the financial support of RFFI and the Sverdlovsk region as part of the scientific project No. 20-48-660019. For assistance in research, we thank students of the Ural Federal University Troshina Anastasia and Tairov Yevgeny

Oxidative stress as a primary risk factor for brain damage in preterm newborns

The risk of oxidative stress is high in preterm newborns. Room air exposure of an organism primed to develop in a hypoxic environment, lacking antioxidant defenses, and subjected to hyperoxia, hypoxia, and ischemia challenges the newborn with oxidative stress production. Free radicals can be generated by a multitude of other mechanisms, such as glutamate excitotoxicity, excess free iron, inflammation, and immune reactions. Free radical-induced damage caused by oxidative stress appears to be the major candidate for the pathogenesis of most of the complications of prematurity, brain being especially at risk, with short to long-term consequences. We review the role of free radical oxidative damage to the newborn brain and propose a mechanism of oxidative injury, taking into consideration the particular maturation-dependent vulnerability of the oligodendrocyte precursors. Prompted by our observation of an increase in plasma Adenosine concentrations significantly associated with brain white matter lesions in some premature infants, we discuss a possible bioenergetics hypothesis, correlated to the oxidative challenge of the premature infant. We aim at explaining both the oxidative stress generation and the mechanism promoting the myelination disturbances. Being white matter abnormalities among the most common lesions of prematurity, the use of Adenosine as a biomarker of brain damage appears promising in order to design neuroprotective strategies

Early Pain Exposure Influences Functional Brain Connectivity in Very Preterm Neonates

Background: Early exposure to nociceptive events may cause brain structural alterations in preterm neonates, with long-lasting consequences on neurodevelopmental outcome. Little is known on the extent to which early pain may affect brain connectivity. We aim to evaluate brain functional connectivity changes in preterm neonate that underwent multiple invasive procedures during the postnatal period, and to correlate them with the neurodevelopmental outcome at 24 months. Methods: In this prospective case-control study, we collected information about exposure to painful events during the early postnatal period and resting-state BOLD-fMRI data at term equivalent age from two groups of preterm neonate: 33 subjected to painful procedures during the neonatal intensive care (mean gestational age 27.9 \ub1 1.8 weeks) and 13 who did not require invasive procedures (average gestational age 31.2 \ub1 2.1 weeks). A data-driven principal-component-based multivariate pattern analysis (MVPA) was used to investigate the effect of early pain exposure on brain functional connectivity, and the relationship between connectivity changes and neurodevelopmental outcome at 24 months, assessed with Griffiths, Developmental Scale-Revised: 0\u20132. Results: Early pain was associated with decreased functional connectivity between thalami and bilateral somatosensory cortex, and between the right insular cortex and ipsilateral amygdala and hippocampal regions, with a more evident effect in preterm neonate undergoing more invasive procedures. Functional connectivity of the right thalamocortical pathway was related to neuromotor outcome at 24 months (P = 0.003). Conclusion: Early exposure to pain is associated with abnormal functional connectivity of developing networks involved in the modulation of noxious stimuli in preterm neonate, contributing to the neurodevelopmental consequence of preterm birth

Integrative Neuropsychological Characteristics of Subcortical-Frontal Brain Regions as a Schizophrenia Liability Factor

Para estudiar las características de las regiones cerebrales subcórtico-frontal, se investigaron la función y la evaluación de su relación con la vulnerabilidad a la esquizofrenia en 59 pacientes y 23 controles, empleando los métodos neuropsicológicos de Luria. El análisis estableció anormalidades bilaterales de la función de las zonas lobulares prefrontal y frontal profunda en pacientes comparados con los controles. Estas anormalidades eran más predominantes en el hemisferio izquierdo. Las coeficientes de correlación punto-biserial de algunos indicadores neuropsicológicos integrativos con la vulnerabilidad a la esquizofrenia eran de 0,39 ± 0,11 y 0,28 ± 0,09, respectivamente. Los datos obtenidos llevan a la discusión de los indicadores neuropsicológicos integrativos de regiones subcortical-frontales del cerebro que se revelan como marcadores potenciales de vulnerabilidad a la esquizofrenia y confirma el papel de la asimetría estructural y funcional del cerebro en la patogénesis de la esquizofrenia.In order to study neuropsychological characteristics of subcortical-frontal brain regions function and assessment of their relation with vulnerability to schizophrenia 59 patients and 23 controls were investigated using Luria’s neuropsychological methods. The analysis established bilateral abnormalities of the function of prefrontal and profound frontal lobe zones in patients as compared with controls. These abnormalities were more predominate in the left hemisphere. Point biserial correlation coefficients of determined integrative neuropsychological indicators with liability to schizophrenia were 0.39 ± 0.11 and 0.28 ± 0.09, for the left and right brain zones respectively. The obtained data permits discussion of the integrative neuropsychological indicators of subcorticalfrontal brain regions as potential markers of liability to schizophrenia and confirms the role of structural and functional brain asymmetry in the pathogenesis of schizophrenia