Germylene-β-sulfoxide hemilabile ligand in coordination chemistry

The use of transition-metal germylenes complexes in catalysis remains sporadic, with olny a few recent reports. In this context, we described the synthesis of a germylene-β-sulfoxide ligand and its abilities in coordination chemistry . We characterized transition metal complexes by X-ray diffraction

Stannylenes and Germylenes Stabilized by Tetradentate Bis(amidine) Ligands with a Rigid Naphthalene Backbone

International audienceAn unusual series of germylenes and stannylenes stabilized by new tetradentate bis(amidine) ligands RNC(R ′)N-linker-NC(R ′)NR with a rigid naphthalene backbone has been prepared by protonolysis reaction of Lappert's metallylenes [M(HMDS) 2 ] (M = Ge or Sn). Germylenes and stannylenes were fully characterized by NMR spectroscopy and X-ray diffraction analysis. DFT calculations have been performed to clarify the structural and electronic properties associated with tetradentate bis(amidine) ligands. Stannylene L 1 Sn shows reactivity through oxidation, oxidative addition, and transmetalation reactions, affording the corresponding gallium and aluminum derivatives

Design, chemical synthesis of 3-(9H-fluoren-9-yl)pyrrolidine-2,5-dione derivatives and biological activity against enoyl-ACP reductase (InhA) and Mycobacterium tuberculosis.

We report here the discovery, synthesis and screening results of a series of 3-(9H-fluoren-9-yl)pyrrolidine-2,5-dione derivatives as a novel class of potent inhibitors of Mycobacterium tuberculosis H37Rv strain as well as the enoyl acyl carrier protein reductase (ENR) InhA. Among them, several compounds displayed good activities against InhA which is one of the key enzymes involved in the type II fatty acid biosynthesis pathway of the mycobacteria cell wall. Furthermore, some exhibited promising activities against M. tuberculosis and multi-drug resistant M. tuberculosis strains

Trinuclear manganese complexes of unsymmetrical polypodal diamino N 3O3 ligands with an unusual [Mn3(μ-OR) 4]5+ triangular core: Synthesis, characterization, and catalase activity

Two new tri-MnIII complexes of general formula [Mn 3L2(μ-OH)(OAc)]ClO4 (H3L = 1-[N-(2-pyridylmethyl),N-(2-hydroxybenzyl)amino]-3-[N′-(2-hydroxybenzyl), N′-(4-X-benzyl)amino]propan-2-ol; 1ClO4, X = Me; 2ClO 4, X = H) have been prepared and characterized. X-ray diffraction analysis of 1ClO4 reveals that the complex cation possesses a Mn 3(μ-alkoxo)2(μ-hydroxo)(μ-phenoxo)4+ core, with the three Mn atoms bound to two fully deprotonated N 3O3 chelating L3-, one exogenous acetato ligand, and one hydroxo bridge, the structure of which is retained upon dissolution in acetonitrile or methanol. The three Mn atoms occupy the vertices of a nearly isosceles triangle (Mn1···Mn3 = 3.6374(12) Å, Mn2···Mn3 3.5583(13) Å, and Mn1···Mn2 3.2400(12) Å), with one substitution-labile site on the apical Mn ion occupied by terminally bound monodentate acetate. Temperature-dependent magnetic susceptibility studies indicate the presence of predominant antiferromagnetic intramolecular interactions between Mn III ions in 1ClO4. Complexes 1ClO4 and 2ClO4 decompose H2O2 at comparable rates upon initial binding of peroxide through acetate substitution, with retention of core structure during catalysis. Kinetic and spectroscopic studies suggest that these complexes employ the [Mn-(μ-oxo/aquo)-Mn]4+ moiety to activate peroxide, with the additional (μ-alkoxo)(μ-phenoxo)Mn(μ- alkoxo) metallobridge carrying out a structural function.Fil: Ledesma, Gabriela Nanci. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Química Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Química Rosario; ArgentinaFil: Anxolabéhère-Mallart, Elodie. Université Paris Diderot - Paris 7; FranciaFil: Rivière, Eric. Université Paris Sud; FranciaFil: Mallet-Ladeira, Sonia. Université Paul Sabatier; FranciaFil: Hureau, Christelle. Université Paul Sabatier; FranciaFil: Signorella, Sandra Rosanna. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Química Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Química Rosario; Argentin