Quantitative genetics of growth traits in the edible snail, Helix aspersa Müller

Genetic parameters of adult weight, age at maturity (adult age), weight after hibernation and relative loss of weight during hibernation were estimated in a population of edible snails (Helix aspersa Müller). Eight thousand four hundred and eighthy three animals were sampled from 143 pairs for adult weight, 4 333 from 87 pairs for adult age and 2 256 from 123 pairs for traits after hibernation. An animal model taking into account all the relationships was used to estimate genetic parameters. Estimates were also computed from the covariances between full-sibs and parent offspring regressions to assess possible non-additive genetic effects. Heritabilities were high except for relative loss of weight during hibernation. Estimates from the animal model were 0.48 ± 0.04 for adult weight, 0.40 ± 0.05 for adult age, 0.40 ± 0.05 for weight after hibernation and 0.12 ± 0.03 for relative loss of weight during hibernation. Adult weight and adult age were neither phenotypically nor genetically correlated (0.05 and 0.003 ± 0.07, respectively). A substantial maternal effect, especially on adult weight was found.Les paramètres génétiques de plusieurs caractères de croissance ont été estimés dans une population d’escargots Petit-Gris (Helix aspersa Müller). Il s’agit du poids adulte, de l’âge à maturité (âge adulte), du poids après hibernation et de la perte relative de poids lors de l’hibernation. Le nombre d’observations collectées se répartit ainsi : 8 483 animaux issus de 143 couples pour le poids adulte, 4 333 issus de 87 couples pour l’âge adulte et 2 256 issus de 123 couples pour les caractères mesurés après hibernation. Afin de tenir compte de toutes les relations de parenté, nous avons utilisé un modèle animal pour estimer les paramètres génétiques. Ils ont également été estimés à partir des covariances entre plein-frères et de la régression parents-descendants. Cela nous a permis de discuter des effets génétiques non additifs. Tous les caractères sauf la perte de poids relative lors de l’hibernation révèlent des héritabilités élevées. Les estimations issues du modèle animal sont de 0,48 ± 0,04 pour le poids adulte, 0,40 ± 0,05 pour l’âge adulte, 0,40 ± 0,05 pour le poids après hibernation et 0, 12 ± 0 03 pour la perte relative de poids lors de l’hibernation. Il n’y a pas de corrélation (ni phénotypique, ni génétique) significative entre le poids et l’âge adultes (0,05 et 0,003 ± 0,07, respectivement). Nous avons également mis en évidence un effet maternel important, en particulier sur le poids adulte

The effect of interpolation methods in temperature and salinity trends in the Western Mediterranean

Temperature and salinity data in the historical record are scarce and unevenly distributed in space and time and the estimation of linear trends is sensitive to different factors. In the case of the Western Mediterranean, previous works have studied the sensitivity of these trends to the use of bathythermograph data, the averaging methods or the way in which gaps in time series are dealt with. In this work, a new factor is analysed: the effect of data interpolation. Temperature and salinity time series are generated averaging existing data over certain geographical areas and also by means of interpolation. Linear trends from both types of time series are compared. There are some differences between both estimations for some layers and geographical areas, while in other cases the results are consistent. Those results which do not depend on the use of interpolated or non-interpolated data, neither are influenced by data analysis methods can be considered as robust ones. Those results influenced by the interpolation process or the factors analysed in previous sensitivity tests are not considered as robust results

Guest Artists: Manley Mallard, Guitar and Elizabeth Barnabe, Soprano

Kemp Recital Hall Wednesday Evening February 24, 1999 8:00p.m

Inference by belief propagation in composite systems

We devise a message passing algorithm for probabilistic inference in composite systems, consisting of a large number of variables, that exhibit weak random interactions among all variables and strong interactions with a small subset of randomly chosen variables; the relative strength of the two interactions is controlled by a free parameter. We examine the performance of the algorithm numerically on a number of systems of this type for varying mixing parameter values

Experimental investigation of planar ion traps

Chiaverini et al. [Quant. Inf. Comput. 5, 419 (2005)] recently suggested a linear Paul trap geometry for ion trap quantum computation that places all of the electrodes in a plane. Such planar ion traps are compatible with modern semiconductor fabrication techniques and can be scaled to make compact, many zone traps. In this paper we present an experimental realization of planar ion traps using electrodes on a printed circuit board to trap linear chains of tens of 0.44 micron diameter charged particles in a vacuum of 15 Pa (0.1 torr). With these traps we address concerns about the low trap depth of planar ion traps and develop control electrode layouts for moving ions between trap zones without facing some of the technical difficulties involved in an atomic ion trap experiment. Specifically, we use a trap with 36 zones (77 electrodes) arranged in a cross to demonstrate loading from a traditional four rod linear Paul trap, linear ion movement, splitting and joining of ion chains, and movement of ions through intersections. We further propose an additional DC biased electrode above the trap which increases the trap depth dramatically, and a novel planar ion trap geometry that generates a two dimensional lattice of point Paul traps.Comment: 11 pages, 20 figure

A proportion of mutations fixed in the genomes of in vitro selected isogenic drug-resistant Mycobacterium tuberculosis mutants can be detected as minority variants in the parent culture.

We studied genomic variation in a previously selected collection of isogenic Mycobacterium tuberculosis laboratory strains subjected to one or two rounds of antibiotic selection. Whole genome sequencing analysis identified eleven single, unique mutations (four synonymous, six non-synonymous, one intergenic), in addition to drug resistance-conferring mutations, that were fixed in the genomes of six monoresistant strains. Eight loci, present as minority variants (five non-synonymous, three synonymous) in the genome of the susceptible parent strain, became fixed in the genomes of multiple daughter strains. None of these mutations are known to be involved with drug resistance. Our results confirm previously observed genomic stability for M. tuberculosis, although the parent strain had accumulated allelic variants at multiple locations in an antibiotic-free in vitro environment. It is therefore likely to assume that these so-called hitchhiking mutations were co-selected and fixed in multiple daughter strains during antibiotic selection. The presence of multiple allelic variations, accumulated under non-selective conditions, which become fixed during subsequent selective steps, deserves attention. The wider availability of 'deep' sequencing methods could help to detect multiple bacterial (sub)populations within patients with high resolution and would therefore be useful in assisting in the detailed investigation of transmission chains

Spontaneous Transition of Turbulent Flames to Detonations in Unconfined Media

Deflagration-to-detonation transition (DDT) can occur in environments ranging from experimental and industrial systems to astrophysical thermonuclear (type Ia) supernovae explosions. Substantial progress has been made in explaining the nature of DDT in confined systems with walls, internal obstacles, or pre-existing shocks. It remains unclear, however, whether DDT can occur in unconfined media. Here we use direct numerical simulations (DNS) to show that for high enough turbulent intensities unconfined, subsonic, premixed, turbulent flames are inherently unstable to DDT. The associated mechanism, based on the nonsteady evolution of flames faster than the Chapman-Jouguet deflagrations, is qualitatively different from the traditionally suggested spontaneous reaction wave model, and thus does not require the formation of distributed flames. Critical turbulent flame speeds, predicted by this mechanism for the onset of DDT, are in agreement with DNS results.Comment: 4 pages, 3 figures; accepted to Physical Review Letter