853 research outputs found
Kernel Spectral Clustering and applications
In this chapter we review the main literature related to kernel spectral
clustering (KSC), an approach to clustering cast within a kernel-based
optimization setting. KSC represents a least-squares support vector machine
based formulation of spectral clustering described by a weighted kernel PCA
objective. Just as in the classifier case, the binary clustering model is
expressed by a hyperplane in a high dimensional space induced by a kernel. In
addition, the multi-way clustering can be obtained by combining a set of binary
decision functions via an Error Correcting Output Codes (ECOC) encoding scheme.
Because of its model-based nature, the KSC method encompasses three main steps:
training, validation, testing. In the validation stage model selection is
performed to obtain tuning parameters, like the number of clusters present in
the data. This is a major advantage compared to classical spectral clustering
where the determination of the clustering parameters is unclear and relies on
heuristics. Once a KSC model is trained on a small subset of the entire data,
it is able to generalize well to unseen test points. Beyond the basic
formulation, sparse KSC algorithms based on the Incomplete Cholesky
Decomposition (ICD) and , , Group Lasso regularization are
reviewed. In that respect, we show how it is possible to handle large scale
data. Also, two possible ways to perform hierarchical clustering and a soft
clustering method are presented. Finally, real-world applications such as image
segmentation, power load time-series clustering, document clustering and big
data learning are considered.Comment: chapter contribution to the book "Unsupervised Learning Algorithms
Recommended from our members
Observations of Past Lunar Landing Sites by the D-CIXS X-Ray Spectrometer on SMART-1
D-CIXS initial observations show a first unambiguous remote sensing of calcium in the lunar regolith. Data obtained are broadly consistent with current understanding of mare and highland composition. Ground truth is provided by the returned Apollo and Luna sample sets
Self‐consistent modeling of the large‐scale distortions in the geomagnetic field during the 24–27 September 1998 major magnetic storm
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/94715/1/jgra17531.pd
Corporate Governance, Opaque Bank Activities, and Risk/Return Efficiency: Pre- and Post-Crisis Evidence from Turkey
Does better corporate governance unambiguously improve the risk/return efficiency of banks? Or does either a re-orientation of banks' revenue mix towards more opaque products, an economic downturn, or tighter supervision create off-setting or reinforcing effects? The authors relate bank efficiency to shortfalls from a stochastic risk/return frontier. They analyze how internal governance mechanisms (CEO duality, board experience, political connections, and education profile) and external governance mechanisms (discipline exerted by shareholders, depositors, or skilled employees) determine efficiency in a sample of Turkish banks. The 2000 financial crisis was a wakeup call for bank efficiency and corporate governance. As a result, better corporate governance mechanisms have been able to improve risk/return efficiency when the economic, regulatory, and supervisory environments are more stable and bank products are more complex.corporate governance;bank risk;noninterest income;crisis;frontier
Key Features Relevant to Select Antigens and TCR From the MHC-Mismatched Repertoire to Treat Cancer
Adoptive transfer of T cells transgenic for tumor-reactive T-cell receptors (TCR) is an attractive immunotherapeutic approach. However, clinical translation is so far limited due to challenges in the identification of suitable target antigens as well as TCRs that are concurrent safe and efficient. Definition of key characteristics relevant for effective and specific tumor rejection is essential to improve current TCR-based adoptive T-cell immunotherapies. We here characterized in-depth two TCRs derived from the human leukocyte antigen (HLA)-mismatched allogeneic repertoire targeting two different myeloperoxidase (MPO)-derived peptides presented by the same HLA-restriction element side by side comprising state of the art biochemical and cellular in vitro, in vivo, and in silico experiments. In vitro experiments reveal comparable functional avidities, off-rates, and cytotoxic activities for both TCRs. However, we observed differences especially with respect to cytokine secretion and cross-reactivity as well as in vivo activity. Biochemical and in silico analyses demonstrate different binding qualities of MPO-peptides to the HLA-complex determining TCR qualities. We conclude from our biochemical and in silico analyses of peptide-HLA-binding that rigid and high-affinity binding of peptides is one of the most important factors for isolation of TCRs with high specificity and tumor rejection capacity from the MHC-mismatched repertoire. Based on our results, we developed a workflow for selection of such TCRs with high potency and safety profile suitable for clinical translation
Inclusive charged hadron elliptic flow in Au + Au collisions at = 7.7 - 39 GeV
A systematic study is presented for centrality, transverse momentum ()
and pseudorapidity () dependence of the inclusive charged hadron elliptic
flow () at midrapidity() in Au+Au collisions at
= 7.7, 11.5, 19.6, 27 and 39 GeV. The results obtained with
different methods, including correlations with the event plane reconstructed in
a region separated by a large pseudorapidity gap and 4-particle cumulants
(), are presented in order to investigate non-flow correlations and
fluctuations. We observe that the difference between and
is smaller at the lower collision energies. Values of , scaled by
the initial coordinate space eccentricity, , as a function
of are larger in more central collisions, suggesting stronger collective
flow develops in more central collisions, similar to the results at higher
collision energies. These results are compared to measurements at higher
energies at the Relativistic Heavy Ion Collider ( = 62.4 and 200
GeV) and at the Large Hadron Collider (Pb + Pb collisions at =
2.76 TeV). The values for fixed rise with increasing collision
energy within the range studied (). A comparison to
viscous hydrodynamic simulations is made to potentially help understand the
energy dependence of . We also compare the results to UrQMD
and AMPT transport model calculations, and physics implications on the
dominance of partonic versus hadronic phases in the system created at Beam
Energy Scan (BES) energies are discussed.Comment: 20 pages, 12 figures. Version accepted by PR
Measurements of and Production in + Collisions at = 200 GeV
We report measurements of charmed-hadron (, ) production cross
sections at mid-rapidity in + collisions at a center-of-mass energy of
200 GeV by the STAR experiment. Charmed hadrons were reconstructed via the
hadronic decays , and their charge conjugates,
covering the range of 0.62.0 GeV/ and 2.06.0 GeV/ for
and , respectively. From this analysis, the charm-pair production cross
section at mid-rapidity is = 170 45
(stat.) (sys.) b. The extracted charm-pair cross section is
compared to perturbative QCD calculations. The transverse momentum differential
cross section is found to be consistent with the upper bound of a Fixed-Order
Next-to-Leading Logarithm calculation.Comment: 15 pages, 16 figures. Revised version submitted to Phys. Rev.
Observation of the antimatter helium-4 nucleus
High-energy nuclear collisions create an energy density similar to that of
the universe microseconds after the Big Bang, and in both cases, matter and
antimatter are formed with comparable abundance. However, the relatively
short-lived expansion in nuclear collisions allows antimatter to decouple
quickly from matter, and avoid annihilation. Thus, a high energy accelerator of
heavy nuclei is an efficient means of producing and studying antimatter. The
antimatter helium-4 nucleus (), also known as the anti-{\alpha}
(), consists of two antiprotons and two antineutrons (baryon
number B=-4). It has not been observed previously, although the {\alpha}
particle was identified a century ago by Rutherford and is present in cosmic
radiation at the 10% level. Antimatter nuclei with B < -1 have been observed
only as rare products of interactions at particle accelerators, where the rate
of antinucleus production in high-energy collisions decreases by about 1000
with each additional antinucleon. We present the observation of the antimatter
helium-4 nucleus, the heaviest observed antinucleus. In total 18
counts were detected at the STAR experiment at RHIC in 10 recorded Au+Au
collisions at center-of-mass energies of 200 GeV and 62 GeV per nucleon-nucleon
pair. The yield is consistent with expectations from thermodynamic and
coalescent nucleosynthesis models, which has implications beyond nuclear
physics.Comment: 19 pages, 4 figures. Submitted to Nature. Under media embarg
Studies of di-jet survival and surface emission bias in Au+Au collisions via angular correlations with respect to back-to-back leading hadrons
We report first results from an analysis based on a new multi-hadron
correlation technique, exploring jet-medium interactions and di-jet surface
emission bias at RHIC. Pairs of back-to-back high transverse momentum hadrons
are used for triggers to study associated hadron distributions. In contrast
with two- and three-particle correlations with a single trigger with similar
kinematic selections, the associated hadron distribution of both trigger sides
reveals no modification in either relative pseudo-rapidity or relative
azimuthal angle from d+Au to central Au+Au collisions. We determine associated
hadron yields and spectra as well as production rates for such correlated
back-to-back triggers to gain additional insights on medium properties.Comment: By the STAR Collaboration. 6 pages, 2 figure
- …