A utilização do ácido hialurónico na periodontite

Dissertação para obtenção do grau de Mestre no Instituto Universitário Egas MonizNos últimos anos tem havido um aumento considerável na pesquisa da molécula de Ácido Hialurónico (AH). O Ácido Hialurónico é um glicosaminoglicano não sulfatado de alto peso molecular encontrado no tecido conjuntivo de vertebrados. O AH é o glicosaminoglicano mais abundante da matriz extracelular dos tecidos periodontais moles. Devido às suas propriedades físico-químicas únicas e aos seus efeitos de não imunogenicidade, o Hialuronano tem mostrado ter algumas vantagens em várias aplicações médicas e no tratamento de condições inflamatórias. O AH pode ser injetado intradermicamente ou pode ser utilizado topicamente e é utilizado para enchimento dérmico na área da dermatologia cosmética; na formação de cicatrizes em procedimentos ciúrgicos; em ortopedia para o tratamento da artrose do joelho e artrite reumatoide; em oftalmonologia para o tratamento de cataratas e também tem sido explorado no campo de engenharia de tecidos. Mais recentemente, o AH foi investigado como um agente farmacológico para tratamentos em Medicina Dentária devido às suas propriedades anti-inflamatórias e anti-bacterianas.Recently there has been an increase in the research of Hyaluronic Acid (HA). Hyaluronic acid is a non-sulfated, high molecular weight glycosaminoglycan found in the connective tissue of vertebrates. HA is the most abundant glycosaminoglycan of extracellular matrix of soft periodontal tissues. Due to its unique physiochemical properties and its non-immunogenicity, hyaluronan has been proved to have some advantages in various medical applications and in the treatment of inflammatory conditions. HA can be injected intradermally or can be used topically and it has been used as a dermal filler for cosmetic dermatology; in formation of scars in surgical procedures; in orthopedics for the treatment of osteoarthritis; in ophthalmology for the treatment of cataracts and it has also been explored in the field of tissue engineering. More recently, HA has been investigated as a pharmacological agent for treatments in Dentistry due to its anti-inflammatory and anti-bacterial properties

The Quest for Biomarkers from Acute Disease to Disease Resolution

Background: Acute pancreatitis (AP) is an inflammatory disease of the pancreas with incompletely known pathogenic mechanisms. This study aimed to explore the temporal changes in serum cytokines in patients with AP and to assess the association of these changes with disease severity. Methods: Fifty patients hospitalized with AP were enrolled, and their serum cytokine levels were analyzed at four different time points. A healthy control (HC) group of 30 outpatients was included. Results: AP patients showed increased levels of interleukin (IL)-6, IL-8, IL-10, vascular endothelial growth factor (VEGF), tumor necrosis factor (TNF)-alpha, and monocyte chemoattractant protein (MCP)-1 at admission when compared with HC. IL-6, VEGF, and EGF remained elevated 1 month after hospitalization and 6 months after discharge. Conclusions the Bedside Index of Severity in Acute Pancreatitis (BISAP) and severity classification of the revised Atlanta classification system, IL-6 and VEGF, determined 48 h after hospitalization, were the two cytokines consistently elevated in the most severe patients. Increased levels of IL-4, IL-6, IL-10, and TNF-alpha at admission and MCP-1 48 h after admission are also related to the length of hospital stay. Conclusions: Our study highlights the role cytokines play in the pathogenesis of AP and can be useful in the development of future drug trials for AP.publishersversionpublishe

a transdisciplinaridade como metametodologia no Design de Comunicação

Tese de mestrado, Design de comunicação e novos media, Universidade de Lisboa, Faculdade de Belas Artes, 2013Based on the proposal for a critical research laboratory in communication design, we propose a theoretical and projectual model acting in the various extensions of design in the context of the network culture. Assuming that the network culture is the exponent of contemporary communication, this paper seeks to examine the extent in which transdisciplinarity contributes to the widening of the field of action and research of communication desig

Bem-estar subjetivo de adeptos de futebol durante a interdição de público nos estádios devido à pandemia COVID-19

A pandemia de COVID-19 trouxe a necessidade da tomada de medidas com vista à promoção da saúde pública e à prevenção do contágio. Todos os espetáculos desportivos, incluindo jogos de futebol, foram interditados de acesso por parte do público, realizando-se sem adeptos nas bancadas. O presente estudo exploratório, de abordagem quantitativa e qualitativa, teve como objetivo conhecer a forma como os adeptos de futebol percecionaram o impacto que a interdição de público nos estádios de futebol teve no seu bem-estar. Participaram nesta investigação 431 adeptos de futebol (71% homens) residentes em Portugal, com idades entre os 18 e os 74 anos. Os dados foram recolhidos através de questionário online, que incluiu questões de caracterização sociodemográfica e de caracterização do tipo de adepto; escalas Positive and Negative Affect Scale (PANAS) e Mental Health Continnum Short Form (MHCF-SF), adaptadas para avaliar o bem-estar subjetivo neste contexto particular, bem como algumas questões abertas. Concluiu-se que a interdição de público nos estádios de futebol teve um impacto negativo no bem-estar subjetivo dos adeptos, sobretudo em participantes com elevado grau de afeição ao clube. As temáticas emergentes do processo de análise de conteúdo comprovaram os efeitos negativos no bem-estar subjetivo, evidenciando as áreas em que o mesmo foi mais sentido, nomeadamente na alteração e quebra de rotinas, aos sentimentos e emoções percecionados e à impossibilidade de manifestar apoio à equipa. As implicações do estudo remetem para a importância que assistir presencialmente aos jogos de futebol tem no bem-estar subjetivo dos respetivos adeptos. Investigações futuras são necessárias no sentido de sustentar estes resultados, estudando de forma mais aprofundada o impacto que o futebol assume no bem-estar junto dos seus adeptos, independentemente do contexto pandémico que emoldurou a nossa investigação.The COVID-19 pandemic brought the need to take measures to promote public health and prevent contagion. All sports shows, including football matches, were banned from access by the public, taking place without fans in the stands. This exploratory study, with a quantitative and qualitative approach, aimed to know how football fans perceived the impact that the ban on the public in football stadiums had on their well-being. A total of 431 football fans (71% men) living in Portugal, aged between 18 and 74 years old, participated in this investigation. Data were collected through an online questionnaire, which included questions on sociodemographic characterization and characterization of the type of supporter; Positive and Negative Affect Scale (PANAS) and Mental Health Continnum Short Form (MHCF-SF), adapted to assess subjective well-being in this context, as well as some open-ended questions. It was concluded that the ban on the public in football stadiums had a negative impact on the subjective well-being of supporters, especially on participants with a high degree of affection for the club. The themes emerging from the content analysis process proved the negative effects on subjective well-being, highlighting the areas in which it was most felt, namely in the change and break of routines, the perceived feelings and emotions and the impossibility of expressing support for the team. The implications of the study refer to the importance that attending football matches in person has on the subjective well-being of the respective supporters. Future investigations are necessary to support these results, studying in more depth the impact that football has on the well-being of its fans, regardless of the pandemic context that framed our investigation

Value creation wheel applied to Jerónimo Martins Distribuição de Produtos de Consumo and Whymob

This thesis focuses on the application of the Value Creation Wheel (VCW), a dynamic tool that enables companies to solve problems and create value while encouraging the participation of multiple stakeholders, both internal and external (Lages, 2016). First, literature is revisited to gain insight about the concepts being explored in this thesis. Then, it is introduced DIANA, VCW’s theoretical framework, and its main contributions to the fields of strategic management, innovation management, and value creation. Finally, are presented the findings from the application of TIAGO VCW’s practical tool at Jerónimo Martins Distribuição de Produtos de Consumo (JMD) and Whymob