Risk Quotient of Airborne Paraquat Exposure Among Workers in Palm Oil Plantation

Paraquat is the herbicide widely used at palm oil plantations, although usage it in some countries has been banned and restricted. Paraquat spraying was not appropriate procedure could be polluted the environment and lead to health disorders workers. Paraquat could enter the body through inhalation, dermal and ingestion, one of frequent routes through inhalation during spraying weeds in plantation areas. This study aimed was to analyze potential inhalation dose and Risk Quotient to workers at palm oil plantation. This research was a descriptive study with cross sectional design and analysis of environmental health risk methods. Airborne Paraquat residue was collected from 8 workers with occupational activity as a supervisor and sprayer. Airborne Paraquat residue was measured for 25 minutes during spraying by using personal air sampler at worker's breathing zone. Airborne Paraquat residue was detected by High Performance Liquid Chromatography (HPLC) with NIOSH 5003 methods. The average of airborne Paraquat residue was 0.0125 mg/m3, it values was less than the Threshold Limit Value (0.05 mg/m3) of American Conference of Government Industrial Hygienists, but the average of potential inhalation dose was 0.001 mg/kg/day for worker's weight 55 kg, it was value higher than Acceptable Operator Exposure Limit (0.0005 mg/kg/day) and the calculation of Risk Quotient (RQ) was more than 1, it conditions was unacceptable for workers. Although, airborne Paraquat residue were safe, but potential inhalation dose and Risk Quotient (RQ) were unsafe for workers, cause it can be lead to lung function disorders. Therefore, for further studies it was necessary to assess the lung function of workers and the use of personal protective equipment must be completely and standard

Food Hygiene and Sanitation in Six Food Providers at University X, South Sumatra

Food provider at university is one of places that needs to implement standards of food hygiene and sanitation (FHS). This study aimed to evaluate and analyze practices of FHS based on Regulation of Health Minister No. 1098 of 2003 and best practices in six food providers at University X. This study used mixed method evaluation with sequential explanatory design through two stages. Stage I was in forms of assessment on six food providers, food handlers and laboratoryexamination on food and beverage samples as well as on eating utensils. Stage II was in form of focus group discussion (FGD) to deepen findings atstage I. Results of this study showed that 100% of food providers had not yet met the government's regulation. As much as 67% of eating utensils and 83% of food were contaminated with bacteria. Based on food handler examination results, 100% of food handlers were not yet to get medical checkups and training. FGD results indicated that findings at stage I were associated with a lack of knowledge among food handlers and the absence of special unit to oversee FHS at campus. In conclusion, six food providers in the study area have not met the regulation

A study of Microbial composition and Lignocellulose degradation in the mound soil of Macrotermes bellicosus Smeathman.

Mound soil samples of Macrotermes bellicosus Smeathman and the adjacent soils were examined for total heterotrophic bacteria, yeasts, moulds, actinomycetes, nitrogen fixers and cellulose decomposers. There were higher populations of the various microbial groups in the mound soil than in the adjacent soils with the exception of yeasts. In the mound soil were Klebsiella, Micrococcus, Aeromonas, Flavobacterium, and Bacillus. The yeasts were Candida, Rhodororula and Torulopsis, whilst the moulds were capable of utilizing lignin and cellulosic substrates for growth with the production of cellulolytic enzymes. Growth of Aspergillus oryzae and Mycelia sterilia on wood dust resulted in substantial weight loss, carbohydrate and lignin depletion of the wood residues. The significance of fungal delignification in relation to termite nutrition is emphasized and discussed

Water Quality and Water Borne Diseases in Lowland Ecosystem of Banyuasin, South Sumatra, Indonesia

Water quality and quantity is always an important issue in lowland ecosystem of Banyuasin. Low domestic water supply sanitation is considered as having an important contribution on the high frequency of waterborne diseases in the area. The study aims at recording water borne diseases and the water quality in the lowland area of Banyuasin District. This field research was conducted using a cross-sectional method. Total samples were 210 households in Telang which were observed during July through August 2011. Six water samples were measured for their physical and chemical properties, in addition to 1 water sample for bacteriological test. All respondents used river water for sanitary purposes and 41.4% of them also have dug wells. Those who used river water for sanitation, 68.5 % also consumed purified water for drinking purpose. All water samples are acidic (pH 5,68-6,19) and contain high Iron (1-26,269 Mg/L). Water has yellowish color. The major disease are diarrhea and skin diseases. In the lowland area with the estuarine ecosystem water quality and scarcity are serious problems. This in turn causes the high prevalent of waterborne diseases such as diarea. Low level of education and socio-economic status make it difficult for the local people to overcome these problems. Outside intervention especially government so as to improve the condition is neede

From C-3PO to HAL: Opening The Discourse About The Dark Side of Multi-Modal Social Agents

The increasing prevalence of communicative agents raises questions about human-agent communication and the impact of such interaction on people's behavior in society and human-human communication. This workshop aims to address three of those questions: (i) How can we identify malicious design strategies - known as dark patterns - in social agents?; (ii) What is the necessity for and the effects of present and future design features, across different modalities and social contexts, in social agents?; (iii) How can we incorporate the findings of the first two questions into the design of social agents? This workshop seeks to conjoin ongoing discourses of the CUI and wider HCI communities, including recent trends focusing on ethical designs. Out of the collaborative discussion, the workshop will produce a document distilling possible research lines and topics encouraging future collaborations

Phenotypic and Genotypic Characterization and Treatment of a Cohort with Familial Tumoral Calcinosis/Hyperostosis-Hyperphosphatemia Syndrome

Familial tumoral calcinosis (FTC)/hyperostosis-hyperphosphatemia syndrome (HHS) is a rare disorder caused by mutations in the genes encoding fibroblast growth factor-23 (FGF23), N-acetylgalactosaminyltransferase 3 (GALNT3), or KLOTHO. The result is functional deficiency of, or resistance to, intact FGF23 (iFGF23), causing hyperphosphatemia, increased renal tubular reabsorption of phosphorus (TRP), elevated or inappropriately normal 1,25-dihydroxyvitamin D3 (1,25D), ectopic calcifications and/or diaphyseal hyperostosis. Eight subjects with FTC/HHS were studied and treated. Clinical manifestations varied, even within families, ranging from asymptomatic to large, disabling calcifications. All subjects had hyperphosphatemia, increased TRP, and elevated or inappropriately normal 1,25D. C-terminal FGF23 was markedly elevated while iFGF23 was comparatively low, consistent with increased FGF23 cleavage. Radiographs ranged from diaphyseal hyperostosis to massive calcification. Two subjects with severe calcifications also had overwhelming systemic inflammation and elevated C-reactive protein (CRP). GALNT3 mutations were identified in 7 subjects; no causative mutation was found in the eighth. Biopsies from 4 subjects showed ectopic calcification and chronic inflammation, with areas of heterotopic ossification observed in 1 subject. Treatment with low phosphate diet, phosphate binders, and phosphaturia-inducing therapies was prescribed with variable response. One subject experienced complete resolution of a calcific mass after 13 months of medical treatment. In the 2 subjects with systemic inflammation, interleukin-1 (IL-1) antagonists significantly decreased CRP levels with resolution of calcinosis cutis and peri-lesional inflammation in one subject and improvement of overall well-being in both subjects. This cohort expands the phenotype and genotype of FTC/HHS and demonstrates the range of clinical manifestations despite similar biochemical profiles and genetic mutations. Overwhelming systemic inflammation has not been described previously in FTC/HHS; the response to IL-1 antagonists suggests that anti-inflammatory drugs may be useful adjuvants. In addition, this is the first description of heterotopic ossification reported in FTC/HHS, possibly mediated by the adjacent inflammation

HLA Class I and Class II Associations in Dengue Viral Infections in a Sri Lankan Population

BACKGROUND: HLA class I and class II alleles have been shown to be associated with the development of dengue hemorrhagic fever (DHF)/dengue shock syndrome (DSS) in different populations. However, the majority of studies have been based on limited numbers of patients. In this study we aimed to investigate the HLA-class I and class II alleles that are positively and negatively associated with the development of DSS in a cohort of patients with DHF and also the alleles associated with development of DHF during primary dengue infections in a Sri Lankan population. METHODOLOGY/PRINCIPAL FINDINGS: The allele frequencies of HLA class I and class II alleles were compared in 110 patients with DHF and 119 individuals from the population who had never reported a symptomatic dengue infection at the time of recruitment. We found that HLA-A*31 (corrected P = 0.01) and DRB1*08 (corrected P = 0.009) were associated with susceptibility to DSS when infected with the dengue virus, during secondary dengue infection. The frequency of DRB1*08 allele was 28.7 times higher than in the normal population in patients with DSS. HLA-A*31 allele was increased 16.6 fold in DHF who developed shock when compared to those who did not develop shock. A*24 (corrected P = 0.03) and DRB1*12 (corrected P = 0.041) were strongly associated with the development of DHF during primary dengue infection. CONCLUSIONS/SIGNIFICANCE: These data suggest that certain HLA alleles confer susceptibility/protection to severe dengue infections. As T cell epitope recognition depend on the HLA type of an individual, it would be now important to investigate how epitope specific T cells associate with primary and secondary dengue infections and in severe dengue infections

Affective Guide with Attitude

The Affective Guide System is a mobile context-aware and spatial-aware system, offering the user with an affective multimodal interaction interface. The system takes advantage of the current mobile and wireless technologies. It includes an ‘affective guide with attitude’ that links its memories and visitor’s interest to the spatial location so that stories are relevant to what can be immediately seen. This paper presents a review of related work, the system in detail, challenges and the future work to be carried out

The evolving SARS-CoV-2 epidemic in Africa: insights from rapidly expanding genomic surveillance

Investment in SARS-CoV-2 sequencing in Africa over the past year has led to a major increase in the number of sequences generated, now exceeding 100,000 genomes, used to track the pandemic on the continent. Our results show an increase in the number of African countries able to sequence domestically, and highlight that local sequencing enables faster turnaround time and more regular routine surveillance. Despite limitations of low testing proportions, findings from this genomic surveillance study underscore the heterogeneous nature of the pandemic and shed light on the distinct dispersal dynamics of Variants of Concern, particularly Alpha, Beta, Delta, and Omicron, on the continent. Sustained investment for diagnostics and genomic surveillance in Africa is needed as the virus continues to evolve, while the continent faces many emerging and re-emerging infectious disease threats. These investments are crucial for pandemic preparedness and response and will serve the health of the continent well into the 21st century