614 research outputs found

    Comparative analysis of safety and efficacy of cefotaxime/sulbactam verses piperacillin/tazobactam combinations in the treatment of complicated urinary tract infections

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    Background: Complicated UTIs (cUTIs) are leading causes of the gram negative bacteraemia. The objective of this study was to compare efficacy and safety Cefotaxime/ Sulbactam (CTS) and Piperacillin/ Tazobactam (PT) combinations in complicated Urinary Tract Infections.Methods: Total 80 patients admitted in the hospital due to cUTI were enrolled. 31 patients were given CTS while 49 patients were given PT. Clinical symptoms were registered and scored as mild (1) moderate (2) or severe (3). The follow-up of were done daily till the patient is discharged. Thereafter, one follow up visit was done within 4 to 9 days of after discharge, termed as test of cure (TOC), and, one late follow up visit after 6 to 8 weeks was done, known as late follow up visit (LFU). Clinical assessments and microbiological analysis were done at the time of TOC and LFU.Results: At TOC visit, in CTS and PT groups, clinical scores were 1.25±3.47 and 0.86±2.35, respectively (p<0.005). Rate of clinical improvement at TOC visit was 92.00% and 92.68% while microbiological clearance was 84.00% and 87.80% with CTS and PT groups respectively. At LFU visit, clinical scores CTS and PT in groups were 1.30±3.56 and 1.32±3.37, respectively, suggesting significant improvement from baseline (p<0.005). Clinical cure rate at LFU visit was 88.00% and 87.80% while microbiological cure rate at LFU visit was 76.00% and 82.91% in CTS and PT groups respectively.Conclusions: Results suggest that both regimens have no significant difference for the treatment of cUTI. CTS and PT both are equally efficacious in treatment of cUTI

    Development and Validation of Analytical methods for estimation of Simvastatin and Fenofibrate

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    The present work describes Stability indicating RP-HPLC and First order derivative UV spectrophotometric method for the quantitative determination of Simvastatin and Fenofibrate. Materials and methods: The parameters Specificity, linearity, accuracy, precision, detection limit, quantitation limit, Robustness and system suitability tests were studied and their results were compiled to ICH guideline Q2 (R2).&nbsp; Chromatography was carried out by reverse phase technique on an RP-18 with mobile phase composed of Acetonitrile: Water (90:10; %v/v) adjusted to pH 3.3 with 10% orthophosphoric acid) with flow rate 1 ml/min. Both drugs were eluted, isocratically using detection wavelength 230 nm. Methanol was used as a solvent, the spectrum was recorded between 200-400 nm wavelengths, and all the zero-order spectrum (D0) were converted to first-order derivative spectrum (D1) using delta lambda 2.0 and scaling factor 4. 240 nm (zero crossing point of Fenofibrate) and 306 nm (zero crossing point of Simvastatin) were used for determination of Simvastatin and Fenofibrate, respectively. Regression analysis of UV-Spectrophotometric method showed good linearity r2 = 0.9991 at 240 nm of Simvastatin 1-5 µg/ml and r2 = 0.9998 at 306 nm of Fenofibrate 10-50 µg/ml. For proposed methods, the linearity for both methods were obtained in the concentration range of 1-5 μg/ml for Simvastatin and 10-50 μg/ml for Fenofibrate. Statistical analysis by student’s t-test showed no significance difference between the results obtained by these two methods.&nbsp; Results: The suitability of method for the quantitative determination of Simvastatin and Fenofibrate was proved by validation. Conclusion: The proposed methods and its results had been successfully applied and validated statistically to the simultaneous estimation of Simvastatin and Fenofibrate in their combination for quality analysi

    Experimental observations of topologically guided water waves within non-hexagonal structures

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    We investigate symmetry-protected topological water waves within a strategically engineered square lattice system. Thus far, symmetry-protected topological modes in hexagonal systems have primarily been studied in electromagnetism and acoustics, i.e. dispersionless media. Herein, we show experimentally how crucial geometrical properties of square structures allow for topological transport that is ordinarily forbidden within conventional hexagonal structures. We perform numerical simulations that take into account the inherent dispersion within water waves and devise a topological insulator that supports symmetry-protected transport along the domain walls. Our measurements, viewed with a high-speed camera under stroboscopic illumination, unambiguously demonstrate the valley-locked transport of water waves within a non-hexagonal structure. Due to the tunability of the energy's directionality by geometry, our results could be used for developing highly-efficient energy harvesters, filters and beam-splitters within dispersive media

    A Novel Approach for Development and Evaluation of LiDAR Navigated Electronic Maize Seeding System Using Check Row Quality Index.

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    Crop geometry plays a vital role in ensuring proper plant growth and yield. Check row planting allows adequate space for weeding in both direction and allowing sunlight down to the bottom of the crop. Therefore, a light detection and ranging (LiDAR) navigated electronic seed metering system for check row planting of maize seeds was developed. The system is comprised of a LiDAR-based distance measurement unit, electronic seed metering mechanism and a wireless communication system. The electronic seed metering mechanism was evaluated in the laboratory for five different cell sizes (8.80, 9.73, 10.82, 11.90 and 12.83 mm) and linear cell speed (89.15, 99.46, 111.44, 123.41 and 133.72 mm·s-1). The research shows the optimised values for the cell size and linear speed of cell were found to be 11.90 mm and 99.46 mm·s-1 respectively. A light dependent resistor (LDR) and light emitting diode (LED)-based seed flow sensing system was developed to measure the lag time of seed flow from seed metering box to bottom of seed tube. The average lag time of seed fall was observed as 251.2&nbsp;±&nbsp;5.39 ms at an optimised linear speed of cell of 99.46 mm·s-1 and forward speed of 2 km·h-1. This lag time was minimized by advancing the seed drop on the basis of forward speed of tractor, lag time and targeted position. A check row quality index (ICRQ) was developed to evaluate check row planter. While evaluating the developed system at different forward speeds (i.e., 2, 3 and 5 km·h-1), higher standard deviation (14.14%) of check row quality index was observed at forward speed of 5 km·h-1

    The Management of Talar Osteochondral Lesions - Current Concepts

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    Osteochondral lesions of the talus (OLTs) are a common complication following trauma, involving both the articular cartilage and the underlying subchondral bone, with variable aetiologies and often presenting with non-specific symptoms. Diagnosis of OLTs requires a combination of clinical assessment and imaging and despite many different treatment options, there is no generalised consensus regarding which option is the most effective. Left untreated, OLTs risk progressing to osteoarthritis. Acute non-displaced OLTs can be treated non-operatively. However, OLTs refractory to non-surgical care for three to six months may be suitable for surgical care. In these cases, conservative treatments are often unsuccessful, particularly for larger and more severe defects and so the majority require surgical intervention. Although bone marrow stimulation techniques remain the “gold standard” for lesions <150 mm2, there still requires a need for better long term clinical data and cost-benefit analyses compared with other treatment options. Biological attempts at either regenerating or replacing the articular cartilage are however demonstrating some promising results, but each with their own advantages and disadvantages. In this review, we summarise the clinical management of OLTs and present the current concepts of different treatment regimes
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