Industrial Urbanism

This thesis presents the history of urbanism through the point of view of theevolution of the productive process history from the irst Industrial Revolution (1760-1840) to today, as well as a proposal for a development of an area in Trelleborg,Sweden that includes also manufacturing, based on Europan Competition’s 2017theme of “Productive City”. In the irst part it presents the history of the industrial erastarting from the 18th century until today though a chronological diagram, includingpolitical, social and technological events, as well as important urban planning ideasand innovative factories. Then proceeds to a more extended presentation of industrialurbanism theory based on theoretical approaches and realized examples. The inalpart of the thesis presents a case study of the “productive city”, which includes themasterplan of the area, diagrams for the location of manufacturing and ideas for thetypes of manufacturing that could be included in the urban block. It concludes withinal consideration about production and the role it can play for a better future

Industrial Urbanism

This thesis presents the history of urbanism through the point of view of theevolution of the productive process history from the irst Industrial Revolution (1760-1840) to today, as well as a proposal for a development of an area in Trelleborg,Sweden that includes also manufacturing, based on Europan Competition’s 2017theme of “Productive City”. In the irst part it presents the history of the industrial erastarting from the 18th century until today though a chronological diagram, includingpolitical, social and technological events, as well as important urban planning ideasand innovative factories. Then proceeds to a more extended presentation of industrialurbanism theory based on theoretical approaches and realized examples. The inalpart of the thesis presents a case study of the “productive city”, which includes themasterplan of the area, diagrams for the location of manufacturing and ideas for thetypes of manufacturing that could be included in the urban block. It concludes withinal consideration about production and the role it can play for a better future

Industrial Urbanism

This thesis presents the history of urbanism through the point of view of theevolution of the productive process history from the irst Industrial Revolution (1760-1840) to today, as well as a proposal for a development of an area in Trelleborg,Sweden that includes also manufacturing, based on Europan Competition’s 2017theme of “Productive City”. In the irst part it presents the history of the industrial erastarting from the 18th century until today though a chronological diagram, includingpolitical, social and technological events, as well as important urban planning ideasand innovative factories. Then proceeds to a more extended presentation of industrialurbanism theory based on theoretical approaches and realized examples. The inalpart of the thesis presents a case study of the “productive city”, which includes themasterplan of the area, diagrams for the location of manufacturing and ideas for thetypes of manufacturing that could be included in the urban block. It concludes withinal consideration about production and the role it can play for a better future

alpha v beta 5 integrin sustains growth of human pre-B cells through an RGD-independent interaction with a basic domain of the CD23 protein

CD23 is a type II transmembrane glycoprotein synthesized by hematopoietic cells that has biological activity in both membrane-bound and freely soluble forms, acting via a number of receptors, including integrins. We demonstrate here that soluble CD23 (sCD23) sustains growth of human B cell precursors via an RGD-independent interaction with the alpha v beta 5 integrin. The integrin recognizes a tripeptide motif in a small disulfide-bonded loop at the N terminus of the lectin head region of CD23, centered around Arg(172), Lys(173), and Cys(174) (RKC). This RKC motif is present in all forms of sCD23 with cytokine-like activity, and cytokine activity is independent of the lectin head, an "inverse RGD" motif, and the CD21 and IgE binding sites. RKC-containing peptides derived from this region of CD23 bind alpha v beta 5 and are biologically active. The binding and activity of these peptides is unaffected by inclusion of a short peptide containing the classic RGD sequence recognized by integrins, and, in far-Western analyses, RKC-containing peptides bind to the beta subunit of the alpha v beta 5 integrin. The interaction between alpha v beta 5 and sCD23 indicates that integrins deliver to cells important signals initiated by soluble ligands without the requirement for interactions with RGD motifs in their common ligands. This mode of integrin signaling may not be restricted to alpha v beta 5