Grand Unification from Gauge Theory on M4×ZNM_4 \times Z_N

The SU(5) grand unified theory (GUT) is derived from the geometrical point of view of gauge theory on three-sheeted space-time, i.e., $M_4 \times Z_3$ manifold without recourse to noncommutative geometry. A derivation of SO(10) GUT is also discussed in the same point of view.Comment: 11 pages, 7 figures, style changed to revtex, added reference to section 1, corrected typo

Seismic Performance of Isolated Bridges Considering Long-term Deterioration of Isolators

Mechanical properties of natural rubber seismic isolators are varied due to aging deterioration. It is needed that seismic performance of isolated bridges are maintained considering aging deterioration of isolators over their lifetime. In this study, seismic failure modes and seismic safety of isolated bridges were evaluated considering uncertainties in the material and mechanical properties and aging deterioration of isolators. It was shown that seismic safety of the isolated bridges is mainly controlled by the rupture strain of the isolator if the ultimate capacity ratio between the isolator and the column is low and that adequate capacity ratio is needed to enhance seismic safety and reparability of isolated bridges

The diagnostic ability of SPECT/CT fusion imaging for gastrointestinal bleeding : a retrospective study

Background Blood loss from the gastrointestinal tract can be an acute and life-threatening event. For the treatment of gastrointestinal bleeding, it is important to accurately detect gastrointestinal bleeding and to localize the sites of bleeding. The purpose of this study was to retrospectively assess the capabilities of SPECT/CT in the diagnosis of gastrointestinal bleeding by a comparison with planar imaging alone as well as planar and SPECT. Methods We conducted a retrospective analysis of 20 patients (21 examinations) who underwent gastrointestinal bleeding scintigraphy in the past 7 years and in whom the bleeding site was identified by endoscopy or capsule endoscopy, or in whom no evidence of gastrointestinal bleeding was identified during the clinical course. Five patients (5 examinations) were diagnosed by planar imaging (planar group). Eight patients (9 examinations) were diagnosed by planar imaging and SPECT (planar + SPECT group). Seven patients (7 examinations) were diagnosed by planar imaging and SPECT/CT (planar + SPECT/CT group). We calculated the diagnostic ability of each method in detecting the presence of bleeding, as well as the ability of each method to identify the sites of bleeding. The sensitivity, specificity, and accuracy of the methods were compared. Results The diagnostic ability of the three imaging methods in detecting the presence of gastrointestinal bleeding was as follows. Planar imaging showed 100% sensitivity (3/3), 100% specificity (2/2), and 100% accuracy (5/5). Planar + SPECT imaging showed 85.7% sensitivity (6/7), 100% specificity (2/2), and 88.9% accuracy (8/9). Planar + SPECT/CT imaging showed 100% sensitivity (6/6), 100% specificity (1/1), and 100% accuracy (7/7). The diagnostic ability of the three modalities in detecting the site of bleeding was as follows: planar, 33.3% (1/3); planar + SPECT, 71.4% (5/7); and planar + SPECT/CT, 100% (6/6). Conclusions All 3 imaging methods showed good accuracy in detecting the presence of gastrointestinal bleeding. The addition of SPECT or SPECT/CT made the anatomical position of the uptake clear and contributed to the localization of the site of gastrointestinal bleeding. Planar + SPECT/CT imaging therefore showed the highest diagnostic ability for detecting the site of gastrointestinal bleeding

Parallel Verification of Serial MAC and AE Modes

A large number of the symmetric-key mode of operations, such as classical CBC-MAC, have serial structures. While a serial mode gives an implementation advantage in terms of required memory or footprint compared to the parallel counterparts, it wastes the capability of parallel process even when it is available. The problem is becoming more relevant as lightweight cryptography is going to be deployed in the real world. In this article, we propose an alternative implementation strategy for serial MAC modes and serial authenticated encryption (AE) modes that allows 2-block parallel operation for verification/decryption. Our proposal maintains the original functionality and security. It is simple yet novel, and generally applicable to a wide range of existing modes including two NIST recommendations, CMAC and CCM. We demonstrate the effectiveness of our proposal by showing several case studies with software implementations

Neutrino Masses, Dark Matter and B-L Symmetry at the LHC

We establish a hybrid seesaw mechanism to explain small neutrino masses and predict cold dark matter candidate in the context of the B-L gauge symmetry extension of the Standard Model. In this model a new scalar doublet and two new fermion singlets are introduced at loop-level beyond the minimal Type I seesaw. The lightest particle inside the loop can be dark matter candidate. We study in detail the constraints from neutrino oscillation data, lepton flavor violating processes and cosmological observation. We also explore the predictions of the decays of the new charged scalars in each spectrum of neutrino masses and show the most optimistic scenarios to distinguish the spectra. We consider the pair production of the stable fermion associated with two observable SM charged leptons at the LHC, which occurs in a two-step cascade decay of the new gauge boson Z' and the new charged scalars stand as intermediate particles. The masses of missing dark matter and its parent particle can be well-determined in such production topology.Comment: 20 pages, 9 figures and 2 tables, revised version accepted for publication in Nucl. Phys.

Preclinical Evaluation of MicroRNA-34b/c Delivery for Malignant Pleural Mesothelioma

The microRNA-34s (miR-34s) have p53 response elements in their 5ʼ-flanking regions and demonstrate tumor-suppressive functions. In malignant pleural mesothelioma (MPM), we previously reported that expression of miR-34b and miR-34c (miR-34b/c) was frequently downregulated by methylation in MPM cell lines and primary tumors. The forced overexpression of miR-34b/c showed significant antitumor effects with the induction of apoptosis in MPM cells. In this study, we examined the in vivo antitumor effects of miR-34b/c using adenovirus vector on MPM. We subcutaneously transplanted NCI-H290, a human MPM cell line, into BALB/C mice and injected adenovirus vector expressing miR-34b/c, luciferase driven by the cytomegalovirus promoter (Ad-miR-34b/c or Ad-Luc), or PBS control into tumors over 5mm in diameter. A statistically significant growth inhibition of the tumor volume was observed in the Ad-miR-34b/c group from day 6 onward compared to the Ad-Luc group. The inhibition rate of Ad-miR-34b/c, compared to the tumor volume treated with Ad-Luc, was 58.6% on day 10 and 54.7% on day13. Our results indicate that adenovirus-mediated miR-34b/c gene therapy could be useful for the clinical treatment of MPM