Robust epidemic aggregation under churn

In large-scale distributed systems data aggregation is a fundamental task that provides a global synopsis over a distributed set of data values. Epidemic protocols are based on a randomised communication paradigm inspired by biological systems and have been proposed to provide decentralised, scalable and fault-tolerant solutions to the data aggregation problem. However, in epidemic aggregation, nodes failure and churn have a detrimental effect on the accuracy of the local estimates of the global aggregation target. In this paper, a novel approach, the Robust Epidemic Aggregation Protocol (REAP), is proposed to provide robustness in the presence of churn by detecting three distinct phases in the aggregation process. An analysis of the impact of each phase over the estimation accuracy is provided. In particular, a novel mechanism is introduced to improve the phase that is most critical for the protocol accuracy. REAP is validated by means of simulations and is shown to achieve convergence with a good level of accuracy for a reasonable range of node churn rates

Leiomyosarcome Du Cordon Spermatique

Introduction: Leiomyosarcoma of the spermatic cord is a rare tumor, develops from the mesenchymal tissues of the spermatic cord, epididymis and  testicular tunics. Its incidence is 0.05 to 0.1% and the occurrence in the testis is rare. In the literature, the testicular leiomyosarcoma (LST) is reported as sporadic cases or as a very limited series. In adults, most testicular sarcomas are the result of a sarcomatous transformation of germ cell tumors (GCT) especially teratomas and spermatocytic sarcomas.Observation: We report on a pure paratesticular leiomyosarcoma and we present the histological, therapeutic and prognostic aspects of this rare tumor

Localisation Intravésicale d’une Broche d’ostéosynthèse (A Propos D’un Cas)

La variété de corps étrangers introduits dans l’appareil génito- urinaire défie l’imagination et peut confronter l’urologue aux difficultés de leur extraction. Si leur présence relève souvent d’une pratique douteuse d’origine psychiatrique, il faut noter la possibilité d’une migration à partir des espaces perivésicaux lors d’une chirurgie de voisinage ainsi qu’une introduction accidentelle durantune intervention transvésicale. Les symptômes du bas appareil urinaire, non spécifiques, sont les circonstances fortuites de découverte de corps étrangers intravésicaux. Bien que le pronostic vital ne soit pas engagé, l’extractionchirurgicale ou endoscopique s’avère nécessaire du fait de l’inflammation sévère associée aux dommages vésicaux secondaires à ce corps étranger.Nous rapportons le cas d’un jeune patient admis aux urgences chez qui on trouve une broche d’ostéosynthèse compliquée d’une lithiase située dans la vessie

Proposal for an ecofriendly and economic strategy for efficient radioiodination of coumarin derivatives

Combination of the calculation of reactivity descriptors and the cold iodine test for some coumarin derivatives was used in order to optimize the radioiodination reaction. The strongly nucleophilic predicted coumarins were subjected to the action of cold iodine. With two coumarins substituted at 3 by the 2-hydroxybenzoyl group, iodination did not occur but a product of intramolecular heterocyclization was obtained. This strategy is useful for economic and environmentally friendly radioiodination.publishe

Biodiversité et dynamique de la végétation dans la subéraie de la Maâmora (Maroc), effet de la durée de clôture.

La subéraie de la Maâmora au Maroc, abrite une flore très riche et variée. Elle subit cependant de nombreuses contraintes, notamment anthropiques. Cette étude sur l'évolution de la biodiversité permet la comparaison très précises de parcelles clôturées et non clôturées, afin d'évaluer le rôle de la mise en défens sur l'évolution de la végétation

Shear band dynamics from a mesoscopic modeling of plasticity

The ubiquitous appearance of regions of localized deformation (shear bands) in different kinds of disordered materials under shear is studied in the context of a mesoscopic model of plasticity. The model may or may not include relaxational (aging) effects. In the absence of relaxational effects the model displays a monotonously increasing dependence of stress on strain-rate, and stationary shear bands do not occur. However, in start up experiments transient (although long lived) shear bands occur, that widen without bound in time. I investigate this transient effect in detail, reproducing and explaining a t^1/2 law for the thickness increase of the shear band that has been obtained in atomistic numerical simulations. Relaxation produces a negative sloped region in the stress vs. strain-rate curve that stabilizes the formation of shear bands of a well defined width, which is a function of strain-rate. Simulations at very low strain-rates reveal a non-trivial stick-slip dynamics of very thin shear bands that has relevance in the study of seismic phenomena. In addition, other non-stationary processes, such as stop-and-go, or strain-rate inversion situations display a phenomenology that matches very well the results of recent experimental studies.Comment: 10 pages, 10 figure

2H-Pyran-2-one-3-carbothioamide derivatives: Synthesis and reaction with hydrazine hydrate

N-Aryl-4-hydroxy-6-methyl-2H-pyran-2-one-3-carbothiamides and N-aryl-4-hydroxycoumarin-3-carbothiamides were synthesized by the reaction of arylisothiocyanates with 4-hydroxy-6-methylpyran-2-one and 4-hydroxycoumarin, respectively. Novel products 3-[bis(arylamino)methylene]-6-methyl-2H,4H-pyran-2,4-diones and N,N′-diaryl-4-hydroxycoumarin-3-carboximidamides have also been obtained in the same reactions. Novel 4-acetoacetyl-3-phenylamino-4,5-dihydro-5H-pyrazol-5-ones were synthesized from the reaction of N-aryl-4-hydroxy-6-methyl-2H-pyran-2-one-3-carbothiamides with an excess of hydrazine. The structure of all compounds was established by NMR and mass spectra

Monotherapy with pixantrone in histologically confirmed relapsed or refractory aggressive B-cell non-Hodgkin lymphoma: post-hoc analyses from a phase III trial.

This post hoc analysis of a phase 3 trial explored the effect of pixantrone in patients (50 pixantrone, 47 comparator) with relapsed or refractory aggressive B-cell non-Hodgkin lymphoma (NHL) confirmed by centralized histological review. Patients received 28-d cycles of 85 mg/m(2) pixantrone dimaleate (equivalent to 50 mg/m(2) in the approved formulation) on days 1, 8 and 15, or comparator. The population was subdivided according to previous rituximab use and whether they received the study treatment as 3rd or 4th line. Median number of cycles was 4 (range, 2-6) with pixantrone and 3 (2-6) with comparator. In 3rd or 4th line, pixantrone was associated with higher complete response (CR) (23·1% vs. 5·1% comparator, P = 0·047) and overall response rate (ORR, 43·6% vs. 12·8%, P = 0·005). In 3rd or 4th line with previous rituximab (20 pixantrone, 18 comparator), pixantrone produced better ORR (45·0% vs. 11·1%, P = 0·033), CR (30·0% vs. 5·6%, P = 0·093) and progression-free survival (median 5·4 vs. 2·8 months, hazard ratio 0·52, 95% confidence interval 0·26-1·04) than the comparator. Similar results were found in patients without previous rituximab. There were no unexpected safety issues. Pixantrone monotherapy is more effective than comparator in relapsed or refractory aggressive B-cell NHL in the 3rd or 4th line setting, independently of previous rituximab

Comparison of thermo-hydraulic performance among different 3D printed periodic open cellular structures

As additive manufacturing of periodic open cellular structures (POCS) is gaining interest in structured catalytic reactor research, this work seeks to thermohydraulically compare the well-known Kelvin lattice structure with the lesser-researched BCC and gyroid lattice structures. Using a combined CFD (Computational Fluid Dynamic) and experimental approach, the selected POCS are fabricated through Laser Powder Bed Fusion (LPBF), characterized, and subsequently subjected to numerical analysis. From the manufacturability point of view, the 3D printed samples closely matched their CAD designs, showing a maximum porosity deviation of 15% below design values. A CFD model, validated through pressure drop experiment, was employed to compare the POCS designs on shared geometric attributes such as specific surface area and porosity. While all structures exhibited comparable performance in term of heat and momentum transfer, our findings suggest that the Gyroid lattice may provide the optimal balance between momentum and heat transfer rates in low-velocity region. Conversely, the BCC configuration may be more favourable at higher velocity. An Ergun-like correlation was also developed and validated for each lattice type, with a Mean Absolute Percentage Error (MAPE) below 10%. Our pressure drop results align quite well with existing literature correlations, showing a MAPE under 20%. Concerning heat transfer, the values forecasted in this research show a reasonable alignment with literature's results, though they tend to be on the lower spectrum.</p