Relating CP divisibility of dynamical maps with compatibility of channels

The role of CP-indivisibility and incompatibility as valuable resources for various information-theoretic tasks is widely acknowledged. This study delves into the intricate relationship between CP-divisibility and channel compatibility. Our investigation focuses on the behaviour of incompatibility robustness of quantum channels for a pair of generic dynamical maps. We show that the incompatibility robustness of channels is monotonically non-increasing for a pair of generic CP-divisible dynamical maps. We have explicitly studied the behaviour of incompatibility robustness with time for some specific dynamical maps and found non-monotonic behaviour in the CP-indivisible regime. Additionally, we propose a measure of CP-indivisibility based on the incompatibility robustness of quantum channels. Our investigation provides valuable insights into the nature of quantum dynamical maps and their relevance in information-theoretic applications.Comment: 10 pages, 5 figure

The E-cadherin/AmotL2 complex organizes actin filaments required for epithelial hexagonal packing and blastocyst hatching

Epithelial cells connect via cell-cell junctions to form sheets of cells with separate cellular compartments. These cellular connections are essential for the generation of cellular forms and shapes consistent with organ function. Tissue modulation is dependent on the fine-tuning of mechanical forces that are transmitted in part through the actin connection to E-cadherin as well as other components in the adherens junctions. In this report we show that p100 amotL2 forms a complex with E-cadherin that associates with radial actin filaments connecting cells over multiple layers. Genetic inactivation or depletion of amotL2 in epithelial cells in vitro or zebrafish and mouse in vivo, resulted in the loss of contractile actin filaments and perturbed epithelial packing geometry. We further showed that AMOTL2 mRNA and protein was expressed in the trophectoderm of human and mouse blastocysts. Genetic inactivation of amotL2 did not affect cellular differentiation but blocked hatching of the blastocysts from the zona pellucida. These results were mimicked by treatment with the myosin II inhibitor blebbistatin. We propose that the tension generated by the E-cadherin/AmotL2/actin filaments plays a crucial role in developmental processes such as epithelial geometrical packing as well as generation of forces required for blastocyst hatching.Peer reviewe

Collective Cell Migration Drives Morphogenesis of the Kidney Nephron

Tissue organization in epithelial organs is achieved during development by the combined processes of cell differentiation and morphogenetic cell movements. In the kidney, the nephron is the functional organ unit. Each nephron is an epithelial tubule that is subdivided into discrete segments with specific transport functions. Little is known about how nephron segments are defined or how segments acquire their distinctive morphology and cell shape. Using live, in vivo cell imaging of the forming zebrafish pronephric nephron, we found that the migration of fully differentiated epithelial cells accounts for both the final position of nephron segment boundaries and the characteristic convolution of the proximal tubule. Pronephric cells maintain adherens junctions and polarized apical brush border membranes while they migrate collectively. Individual tubule cells exhibit basal membrane protrusions in the direction of movement and appear to establish transient, phosphorylated Focal Adhesion Kinase–positive adhesions to the basement membrane. Cell migration continued in the presence of camptothecin, indicating that cell division does not drive migration. Lengthening of the nephron was, however, accompanied by an increase in tubule cell number, specifically in the most distal, ret1-positive nephron segment. The initiation of cell migration coincided with the onset of fluid flow in the pronephros. Complete blockade of pronephric fluid flow prevented cell migration and proximal nephron convolution. Selective blockade of proximal, filtration-driven fluid flow shifted the position of tubule convolution distally and revealed a role for cilia-driven fluid flow in persistent migration of distal nephron cells. We conclude that nephron morphogenesis is driven by fluid flow–dependent, collective epithelial cell migration within the confines of the tubule basement membrane. Our results establish intimate links between nephron function, fluid flow, and morphogenesis

Interaction of Chandipura Virus N and P Proteins: Identification of Two Mutually Exclusive Domains of N Involved in Interaction with P

The nucleocapsid protein (N) and the phosphoprotein (P) of nonsegmented negative-strand (NNS) RNA viruses interact with each other to accomplish two crucial events necessary for the viral replication cycle. First, the P protein binds to the aggregation prone nascent N molecules maintaining them in a soluble monomeric (N0) form (N0-P complex). It is this form that is competent for specific encapsidation of the viral genome. Second, the P protein binds to oligomeric N in the nucleoprotein complex (N-RNA-P complex), and thereby facilitates the recruitment of the viral polymerase (L) onto its template. All previous attempts to study these complexes relied on co-expression of the two proteins in diverse systems. In this study, we have characterised these different modes of N-P interaction in detail and for the first time have been able to reconstitute these complexes individually in vitro in the chandipura virus (CHPV), a human pathogenic NNS RNA virus. Using a battery of truncated mutants of the N protein, we have been able to identify two mutually exclusive domains of N involved in differential interaction with the P protein. An unique N-terminal binding site, comprising of amino acids (aa) 1–180 form the N0-P interacting region, whereas, C-terminal residues spanning aa 320–390 is instrumental in N-RNA-P interactions. Significantly, the ex-vivo data also supports these observations. Based on these results, we suggest that the P protein acts as N-specific chaperone and thereby partially masking the N-N self-association region, which leads to the specific recognition of viral genome RNA by N0

How the Atmosphere over Eastern Himalaya, India is Polluted with Carbonyl Compounds? Temporal Variability and Identification of Sources

A study was conducted on atmospheric carbonyl compounds for the first time over a Himalayan atmosphere in India. Samples were collected from a high altitude hill station, Darjeeling (27.01°N, 88.15°E, 2200 masl) during June 2012 to May 2013. Temporal variation, meteorological influence, source apportionment and ozone formation potential etc were studied for acetaldehyde, formaldehyde, acetone, butanaldehyde, propanaldehyde, benzaldehyde, crotonaldehyde, valeraldehyde, isovaleraldehyde, hexanaldehyde, p-tolualdehyde and o-tolualdehyde. High concentration of Acetone (81.6 ± 63.5 µg m–3) was observed which could be due to the higher photochemical production from its precursor volatile organic compounds emitted from tea plants and tea processing units. The concentration of acetaldehyde (20.7 ± 47.6 µg m–3) and formaldehyde (11.6 ± 16.3 µg m–3) were found to be comparable with metro cities of India and world. The average annual concentration of total carbonyl compounds was 174.2 ± 184.6 µg m–3 with maximum during postmonsoon (456.9 ± 199.5 µg m–3) and minimum during winter season (72.2 ± 42.9 µg m–3). Meteorological parameters like temperature and surface reaching solar radiative flux played the major roles for the seasonal variation of the carbonyl concentration over the hill station. The average ratio of formaldehyde to acetaldehyde over Darjeeling was found to be 1.64 ± 1.43 well representing a typical urban atmosphere at this part of Himalaya. Positive matrix factorization model showed that the biogenic emissions from tea plants and vehicular emissions were the major sources of carbonyl compounds over the hill station

Thermally assisted and magnetic field driven isostructural distortion of spinel structure and occurrence of polar order in CoCr2S4\mathrm{CoCr_2 S_4}

We report appearance of polar order with a ordering temperature (T$_{C}$) at 28 K, which is well below the ferrimagnetic order at 225 K (T$_{N}$) for CoCr$_{2}$S$_{4}$. Intriguingly, the value of spontaneous electric polarization (P) is ~ 122μC/m$_{2}$ at 15 K, which is the second largest value in Cr octahedra-based spinels after CdCr$_{2}$S$_{4}$. Incidentally, the P value is ~60 times larger than the value of Pfr the oxide counterpart CoCr$_{2}$S$_{4}$. The significant magnetoelectric coupling is verified from the magnetodielectric response and magnetic field dependent enhancement of P. We note that the field-dependent dielectric permittivity scales linearly to the squared magnetization in the low field regime below ~10 kOe as described by the Ginzburg-Landau theory. Synchrotron diffraction studies over a wide temperature range, 15–300 K, illustrate strong magnetoelastic coupling at T$_{N}$ and isostructural distortion at T$_{C}$. Analyses of the diffraction patterns reveal that the occurrence of polar order involves expansion of Co tetrahedra and contraction of Cr octahedra of the spinel structure and these distortions are further enhanced driven by the magnetic field. The delicate interplay between magnetoelastic, magnetoelectric, and electroelastic couplings in CoCr$_{2}$S$_{4}$ proposes the system as a potential candidate in multiferroics