Some rheological properties of new and used mineral lubricant and biolubricant for tractors

ArticleIt is important to know physical characteristics of lubricating oils to ensure the highest reliability for operation of device. The use of ecological lubricants depends on their characteristics; the most important are density and viscosity, protection against wear and tear, corrosion resistance etc. The objective of this work was to find changes of the rheological properties of the synthetic oil and bio lubricant. We compared two different oils in our measurements. One sample was synthetic oil and the other was mineral oil (bio lubricant). Both oils are universal oils for tractors. Further, comparison of new and used sample after million cycles was performed. The density and the dynamic viscosity show strong exponentially decreasing dependence. With the increasing temperature, values of the both properties, decreased. It can be also observed that used samples have lower viscosity and density. The results presented in this article can be important when putting ecological lubricants into operation

Glasgow Coma Scale score at intensive care unit discharge predicts the 1-year outcome of patients with severe traumatic brain injury

OBJECTIVE: To analyse the association between the Glasgow Coma Scale (GCS) score at intensive care unit (ICU) discharge and the 1-year outcome of patients with severe traumatic brain injury (TBI). DESIGN: Retrospective analysis of prospectively collected observational data. PATIENTS: Between 01/2001 and 12/2005, 13 European centres enrolled 1,172 patients with severe TBI. Data on accident, treatment and outcomes were collected. According to the GCS score at ICU discharge, survivors were classified into four groups: GCS scores 3–6, 7–9, 10–12 and 13–15. Using the Glasgow Outcome Scale (GOS), 1-year outcomes were classified as “favourable” (scores 5, 4) or “unfavourable” (scores <4). Factors that may have contributed to outcomes were compared between groups and for favourable versus unfavourable outcomes within each group. MAIN RESULTS: Of the 538 patients analysed, 308 (57 %) had GCS scores 13–15, 101 (19 %) had scores 10–12, 46 (9 %) had scores 7–9 and 83 (15 %) had scores 3–6 at ICU discharge. Factors significantly associated with these GCS scores included age, severity of trauma, neurological status (GCS, pupils) at admission and patency of the basal cisterns on the first computed tomography (CT) scan. Favourable outcome was achieved in 74 % of all patients; the rates were significantly different between GCS groups (93, 83, 37 and 10 %, respectively). Within each of the GCS groups, significant differences regarding age and trauma severity were found between patients with favourable versus unfavourable outcomes; neurological status at admission and CT findings were not relevant. CONCLUSION: The GCS score at ICU discharge is a good predictor of 1-year outcome. Patients with a GCS score <10 at ICU discharge have a poor chance of favourable outcome

CIRI-CIRI AKUSTIK KONTRAS PENYUARAAN BUNYI FRIKATIF ARAB BERASASKAN PARAMETER TEMPOH FRIKASI

Latar Belakang dan Tujuan: Makalah ini bertujuan menyerlahkan perbezaan penyuaraan bunyi frikatif Arab bersuara dan tak bersuara yang dihasilkan oleh penutur Melayu. Kajian lepas membuktikan bahawa penutur Melayu sering melakukan kesalahan pertuturan faringealisasi Arab. &nbsp; Metodologi: Analisis ciri-ciri akustik bunyi frikatif Melayu dan Arab di awal kata menggunakan parameter tempoh frikasi, justeru, dilaksanakan bagi menyerlahkan persamaan dan perbezaan bunyi konsonan berkenaan. Kaedah analisis spektrograf menerusi perisian Praat dimanfaatkan bagi membolehkan pengkaji memindahkan data rakaman ujaran dalam bentuk spektrogram dan melakukan penelitian akustik. Hasil dapatan analisis akustik dimanipulasikan menerusi SPSS (Statistical Package for Social Sciences). Data spektogram sebanyak 2960 diperoleh daripada rakaman ujaran subjek kajian seramai 24 orang pelajar ijazah Sarjana Muda Pengajian Bahasa Arab dan Tamadun Islam Universiti Kebangsaan Malaysia. Proses rakaman terlebih dahulu dijalankan di studio rakaman Fakulti Sains Sosial dan Kemanusiaan, UKM menggunakan alat perakam TASCAM MP3/WAV. Senarai perkataan mengandungi bunyi frikatif di awal kata bagi kedua-dua bahasa dibaca oleh subjek kajian dengan keadaan tahap pertuturan yang selesa, iaitu tidak terlalu perlahan dan tidak terlalu laju. Subjek diminta mengulangi perkataan tersebut sebanyak lima kali. &nbsp; Dapatan Kajian: Hasil kajian ini mendapati bahawa bunyi frikatif tak bersuara /s/ adalah lebih panjang berbanding bunyi bersuara /z/. Dapatan kajian juga menunjukkan bahawa tiada hubungan signifikan antara bunyi /س/ dan /sˤ/ dan /ز/ dan /zˤ/. Secara khususnya, kajian ini mengesahkan bahawa tidak semua bunyi faringealisasi Arab dipengaruhi bahasa ibunda. Bunyi ini mampu juga dikuasai oleh bukan penutur natif Arab. &nbsp; Implikasi: Kajian ini memberi implikasi signifikan terhadap pembelajaran bahasa Arab sebagai bahasa kedua di Malaysia serta perkembangan ilmu fonetik akustik di Malaysia khususnya bagi menambah baik sebutan frikatif Arab dalam kalangan penutur natif Melayu. &nbsp; Kata kunci: Akustik, bahasa Arab, gangguan bahasa, pemindahan bahasa, tempoh frikasi. &nbsp; Abstract &nbsp; Background and Purpose: This paper aims to highlight the voicing contrast of Arabic and Malay fricatives produced by Malay native speakers. Previous studies show that Malay speakers often make mistakes on Arabic pharyngealisation. &nbsp; Methodology: This study, thus, analysed the frication duration characteristics of Malay and Arabic fricatives in initial word position and highlight their similarities and differences. The spectrographic analysis method via Praat software was utilized to enable the researcher to transfer speech recording data into a spectrogram and analysed acoustically. A total of 2960 spectrograms was obtained from the recording of 24 subjects’ utterences. The subjects are undergraduate students of Arabic Studies and Islamic Civilization of the Universiti Kebangsaan Malaysia. The recording process was performed in the Faculty of Social Sciences and Humanities, UKM recording studio using TASCAM MP3 / WAV recorder. A word list that contains the fricative sound at the beginning of each word in both languages was ​​read by subjects with comfortable speech level, i.e. neither slow nor too fast. Subjects were asked to repeat the word five times. &nbsp; Findings: The result of the acoustic analysis was manipulated using Statistical Package for Social Sciences. This study found that the fricative sound / s / is longer than the sound / z / for both languages. The findings also show that there is no significant relationship between sound / س / and / sˤ / and / ز / and / zˤ /. In particular, this study confirms that not all Arabic pharyngealisation are influenced by their native language. It can be mastered also by non-native speakers of Arabic. &nbsp; Contributions: This study provides significant implications for learning Arabic as a second language in Malaysia as well as the development of acoustic phonetics, particularly, in improving the fricative pronunciation of Arabic among native speakers of Malay. &nbsp; Keywords: Acoustic, Arabic, frication duration, language interference, language transfer. &nbsp; Cite as: Shahidi A. H., Radzi, M. P., Aman, R., CheLaeh, M., &amp; Anwar, O. D. (2020). Ciri-ciri akustik kontras penyuaraan bunyi frikatif Arab berasaskan parameter tempoh frikasi [The acoustic properties of Arabic fricative voicing contrast based on the frication duration parameter]. Journal of Nusantara Studies, 5(1), 143-168. http://dx.doi.org/10.24200/jonus.vol5iss1pp143-16

The burden of injury in Central, Eastern, and Western European sub-region: a systematic analysis from the Global Burden of Disease 2019 Study

Bill and Melinda Gates FoundationpublishedVersio

The burden of injury in Central, Eastern, and Western European sub-region: a systematic analysis from the Global Burden of Disease 2019 Study

Abstract: Background: Injury remains a major concern to public health in the European region, particularly among adults younger than 49 years. Previous iterations of the Global Burden of Disease (GBD) study showed wide variation in injury death and disability adjusted life year (DALY) rates across Europe, indicating injury inequality gaps between sub-regions and countries. The objectives of this study were to: 1) compare GBD 2019 estimates on injury mortality and DALYs across European sub-regions and countries by cause-of-injury category and sex; 2) examine changes in injury DALY rates over a 20 year-period by cause-of-injury category, sub-region and country; and 3) assess inequalities in injury mortality and DALY rates across the countries. Methods: We performed a secondary database descriptive study using the GBD 2019 results on injuries in 44 European countries from 2000 to 2019. Inequality in DALY rates between these countries was assessed by calculating the DALY rate ratio between the highest-ranking country and lowest-ranking country in each year. Results: In 2019, in Eastern Europe 80 [95% uncertainty interval (UI): 71 to 89] people per 100,000 died from injuries; twice as high compared to Central Europe (38 injury deaths per 100,000; 95% UI 34 to 42) and three times as high compared to Western Europe (27 injury deaths per 100,000; 95%UI 25 to 28). The injury DALY rates showed less pronounced differences between Eastern (5129 DALYs per 100,000; 95% UI: 4547 to 5864), Central (2940 DALYs per 100,000; 95% UI: 2452 to 3546) and Western Europe (1782 DALYs per 100,000; 95% UI: 1523 to 2115). Injury DALY rate was lowest in Italy (1489 DALYs per 100,000) and highest in Ukraine (5553 DALYs per 100,000). The difference in injury DALY rates by country was larger for males compared to females. The DALY rate ratio was highest in 2005, with DALY rate in the lowest-ranking country (Russian Federation) 6.0 times higher compared to the highest-ranking country (Malta). After 2005, the DALY rate ratio between the lowest- and the highest-ranking country gradually decreased to 3.7 in 2019. Conclusions: Injury death and DALY rates were highest in Eastern Europe and lowest in Western Europe, although differences in injury DALY rates decline rapidly, particularly in the past decade. The injury DALY rate ratio of highest- and lowest-ranking country declined from 2005 onwards, indicating declining inequalities in injuries between European countries

Clinical characteristics of Polish patients with ANCA-associated vasculitides-retrospective analysis of POLVAS registry

Objective Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitides (AAV) are rare small to medium-size vessel systemic diseases. As their clinical picture, organ involvement, and factors influencing outcome may differ between countries and geographical areas, we decided to describe a large cohort of Polish AAV patients coming from several referral centers-members of the Scientific Consortium of the Polish Vasculitis Registry (POLVAS). Methods We conducted a systematic multicenter retrospective study of adult patients diagnosed with AAV between Jan 1990 and Dec 2016 to analyze their clinical picture, organ involvement, and factors influencing outcome. Patients were enrolled to the study by nine centers (14 clinical wards) from seven Voivodeships populated by 22.3 mln inhabitants (58.2% of the Polish population). Results Participating centers included 625 AAV patients into the registry. Their distribution was as follows: 417 patients (66.7%) with GPA, 106 (17.0%) with MPA, and 102 (16.3%) with EGPA. Male-to-female ratios were almost 1:1 for GPA (210/207) and MPA (54/52), but EGPA was twice more frequent among women (34/68). Clinical manifestations and organ involvement were analyzed by clinical phenotype. Their clinical manifestations seem very similar to other European countries, but interestingly, men with GPA appeared to follow a more severe course than the women. Fifty five patients died. In GPA, two variables were significantly associated with death: permanent renal replacement therapy (PRRT) and respiratory involvement (univariate analysis). In multivariate analysis, PRRT (OR = 5.3; 95% confidence interval (CI) = 2.3–12.2), respiratory involvement (OR = 3.2; 95% CI = 1.06–9.7), and, in addition, age > 65 (OR = 2.6; 95% CI = 1.05–6.6) were independently associated with death. In MPA, also three variables were observed to be independent predictors of death: PRRT (OR = 5.7; 95% CI = 1.3–25.5), skin involvement (OR = 4.4; 95% CI = 1.02– 19.6), and age > 65 (OR = 6.3; 95% CI = 1.18–33.7). Conclusions In this first multicenter retrospective study of the Polish AAV patients, we have shown that their demographic characteristics, disease manifestations, and predictors of fatal outcome follow the same pattern as those from other European countries, with men possibly suffering from more severe course of the disease

Global, regional, and national comparative risk assessment of 79 behavioural, environmental and occupational, and metabolic risks or clusters of risks, 1990-2015: a systematic analysis for the Global Burden of Disease Study 2015

SummaryBackground The Global Burden of Diseases, Injuries, and Risk Factors Study 2015 provides an up-to-date synthesis of the evidence for risk factor exposure and the attributable burden of disease. By providing national and subnational assessments spanning the past 25 years, this study can inform debates on the importance of addressing risks in context. Methods We used the comparative risk assessment framework developed for previous iterations of the Global Burden of Disease Study to estimate attributable deaths, disability-adjusted life-years (DALYs), and trends in exposure by age group, sex, year, and geography for 79 behavioural, environmental and occupational, and metabolic risks or clusters of risks from 1990 to 2015. This study included 388 risk-outcome pairs that met World Cancer Research Fund-defined criteria for convincing or probable evidence. We extracted relative risk and exposure estimates from randomised controlled trials, cohorts, pooled cohorts, household surveys, census data, satellite data, and other sources. We used statistical models to pool data, adjust for bias, and incorporate covariates. We developed a metric that allows comparisons of exposure across risk factors—the summary exposure value. Using the counterfactual scenario of theoretical minimum risk level, we estimated the portion of deaths and DALYs that could be attributed to a given risk. We decomposed trends in attributable burden into contributions from population growth, population age structure, risk exposure, and risk-deleted cause-specific DALY rates. We characterised risk exposure in relation to a Socio-demographic Index (SDI). Findings Between 1990 and 2015, global exposure to unsafe sanitation, household air pollution, childhood underweight, childhood stunting, and smoking each decreased by more than 25%. Global exposure for several occupational risks, high body-mass index (BMI), and drug use increased by more than 25% over the same period. All risks jointly evaluated in 2015 accounted for 57·8% (95% CI 56·6–58·8) of global deaths and 41·2% (39·8–42·8) of DALYs. In 2015, the ten largest contributors to global DALYs among Level 3 risks were high systolic blood pressure (211·8 million [192·7 million to 231·1 million] global DALYs), smoking (148·6 million [134·2 million to 163·1 million]), high fasting plasma glucose (143·1 million [125·1 million to 163·5 million]), high BMI (120·1 million [83·8 million to 158·4 million]), childhood undernutrition (113·3 million [103·9 million to 123·4 million]), ambient particulate matter (103·1 million [90·8 million to 115·1 million]), high total cholesterol (88·7 million [74·6 million to 105·7 million]), household air pollution (85·6 million [66·7 million to 106·1 million]), alcohol use (85·0 million [77·2 million to 93·0 million]), and diets high in sodium (83·0 million [49·3 million to 127·5 million]). From 1990 to 2015, attributable DALYs declined for micronutrient deficiencies, childhood undernutrition, unsafe sanitation and water, and household air pollution; reductions in risk-deleted DALY rates rather than reductions in exposure drove these declines. Rising exposure contributed to notable increases in attributable DALYs from high BMI, high fasting plasma glucose, occupational carcinogens, and drug use. Environmental risks and childhood undernutrition declined steadily with SDI; low physical activity, high BMI, and high fasting plasma glucose increased with SDI. In 119 countries, metabolic risks, such as high BMI and fasting plasma glucose, contributed the most attributable DALYs in 2015. Regionally, smoking still ranked among the leading five risk factors for attributable DALYs in 109 countries; childhood underweight and unsafe sex remained primary drivers of early death and disability in much of sub-Saharan Africa. Interpretation Declines in some key environmental risks have contributed to declines in critical infectious diseases. Some risks appear to be invariant to SDI. Increasing risks, including high BMI, high fasting plasma glucose, drug use, and some occupational exposures, contribute to rising burden from some conditions, but also provide opportunities for intervention. Some highly preventable risks, such as smoking, remain major causes of attributable DALYs, even as exposure is declining. Public policy makers need to pay attention to the risks that are increasingly major contributors to global burden. Funding Bill & Melinda Gates Foundation

Developmental axon pruning mediated by BDNF-p75NTR–dependent axon degeneration

The mechanisms that regulate the pruning of mammalian axons are just now being elucidated. Here, we describe a mechanism by which, during developmental sympathetic axon competition, winning axons secrete brain-derived neurotrophic factor (BDNF) in an activity-dependent fashion, which binds to the p75 neurotrophin receptor (p75NTR) on losing axons to cause their degeneration and, ultimately, axon pruning. Specifically, we found that pruning of rat and mouse sympathetic axons that project to the eye requires both activity-dependent BDNF and p75NTR. p75NTR and BDNF are also essential for activity-dependent axon pruning in culture, where they mediate pruning by directly causing axon degeneration. p75NTR, which is enriched in losing axons, causes axonal degeneration by suppressing TrkA-mediated signaling that is essential for axonal maintenance. These data provide a mechanism that explains how active axons can eliminate less-active, competing axons during developmental pruning by directly promoting p75NTR-mediated axonal degeneration

Antibodies against cyclic citrullinated peptide don’t decrease after 6 months of infliximab treatment in refractory rheumatoid arthritis

Anti-citrullinated peptide antibodies (ACPA) and the rheumatoid factor (RF) are well-established serological markers for rheumatoid arthritis (RA). ACPA are very useful in the diagnosis of RA, especially at the early stages of the disease when ACPA have a greater diagnostic value than RF. The aim of the study was to assess the influence of infliximab treatment on RF IgM and ACPA serum levels and RA activity during 6 months of treatment. Thirty-two patients with refractory RA were treated with infliximab during a 6-month period. At baseline, 3 and 6 months of treatment the patients were examined for the number swollen and tender joints out of 28 (SJC, TJC) and the visual analogue scale of arthritis activity according to the patient (VAS). Serum samples were tested for erythrocyte sedimentation rate (ESR), C-reactive protein level (CRP), ACPA and RF IgM. The disease activity score (DAS-28) parameter was also calculated at the same time. During the course of our study, we observed statistically significant improvement in ESR, CRP, TJC, SJC, VAS DAS-28, and RF IgM after 3 and 6 months of infliximab treatment when compared to the baseline, whereas the ACPA level remained unchanged after 3 and 6 months of treatment (P = 0.96 and P = 0.85). The changes in the ACPA level are not a factor for evaluation of successful infliximab treatment but the changes in RF IgM are. According to different behavior of these antibodies during infliximab treatment, we suggest that the roles of ACPA and RF in the pathogenesis of RA are different