206 research outputs found
Да ли мали град са туристичком функцијом има демографски потенцијал?
This research is conducted to determine impacts of tourism development on the
demographic image of selected small towns in Serbia. Analyzing the following indicators —
tourism potential, the share of inhabitants employed in the tourism industry, tourist turnover, and
tradition in tourism, the group of 23 small towns is singled out. Further, the selected small towns
with dominant tourism function are observed within four tourism clusters. Demographic
characteristics of these urban settlements are analyzed through population indicators: total
population increase/decrease, age and sex structure, economic activity, education structure, etc.,
according to the latest available data. The level of local population involvement in tourism is
examined, as well as the influence of these small towns on the immediate rural surroundings. The
results of conducted analysis show that tourism has an important impact on demographic
development in several observed small towns. In the case of other selected small towns, the
tourism influence on population increase or migration is stagnating. Despite that, increasing
number of employed in the tourism industry is recorded, which implies that tourism is recognized
within local community as an activity that could contribute to the development of small towns in
Serbia
DOES SMALL TOWN WITH TOURISTIC FUNCTION HAVE DEMOGRAPHIC POTENTIAL?
This research is conducted to determine impacts of tourism development on the demographic image of selected small towns in Serbia. Analyzing the following indicators – tourism potential, the share of inhabitants employed in the tourism industry, tourist turnover, and tradition in tourism, the group of 23 small towns is singled out. Further, the selected small towns with dominant tourism function are observed within four tourism clusters. Demographic characteristics of these urban settlements are analyzed through population indicators: total population increase/decrease, age and sex structure, economic activity, education structure, etc., according to the latest available data. The level of local population involvement in tourism is examined, as well as the influence of these small towns on the immediate rural surroundings. The results of conducted analysis show that tourism has an important impact on demographic development in several observed small towns. In the case of other selected small towns, the tourism influence on population increase or migration is stagnating. Despite that, increasing number of employed in the tourism industry is recorded, which implies that tourism is recognized within local community as an activity that could contribute to the development of small towns in Serbia.
Mutational Polymorphism in the Bacterial Topoisomerase Genes Driven by Treatment with Quinolones
Fostering Internationalization in Adult Education Graduate Programs in the United States: Opportunities for Growth
Internationalization is a key element of higher education missions to prepare learners for the global dimensions of their lives and work, which are increasingly integrated. In the United States, adult education graduate programs play a vital role in the wider educational landscape, particularly because of their interconnectedness with diverse disciplines and a working learner student population. Although student and scholar mobility remain important to fostering connections, adult education graduate programs can broaden the scope of internationalization aims. This paper proposes three main opportunities for internationalization growth within adult education graduate programs: incorporating intercultural literacy in formal curricula, emphasizing a continuing professional education approach, and integrating the formal – nonformal – informal education continuum in programs. Conceptualizing efforts within these opportunity sectors can spur innovation central to internationalization initiatives
Hydrothermal synthesis of LiFePO4
Poster presented at the 11th Conference of the Materials Research Society of Serbia - YUCOMAT 2009, Herceg Novi, Montenegro, August 31 – September 4, 2009
The importance of biomarkers and specific diagnostic procedures in the early detection and different phenotypes of Takayasu arteritis
Uvod: Takajaši arteritis (TA) je idiopatska, zapaljenska bolest hroničnog toka,
koja se karakteriše granulomatoznim zapaljenjem aorte i njenih grana. Određeni
genetički faktori mogu imati značaja u nastanku TA. Sekundarni antifosfolipidni
sindrom (AFS) se može javiti u sklopu TA i karakteriše se vaskularnim i/ili
komplikacijama u vezi sa trudnoćom i/ili porođajem, u prisustvu antifosfolipidnih (AF)
antitela. U dijagnostici i praćenju ovih bolesnika se primenjuje ehosonografski (EHO)
Doppler pregled krvnih sudova, kompjuterizovana tomografija sa kontrastnom
angiografijom (CTA) i poslednjih godina, poziciona emisiona tomografija u kombinaciji
sa niskorezolutivnom komjuterizovanom tomografijom uz primenu radioobeleživača -
fluorodeoksiglukoze (18FDG PET-CT). Za procenu aktivnosti bolesti se najčešće koriste
klinički skor NIH (National Institute of Health) i Indijski skor aktivnosti TA (Indian
Takayasu’s Arteritis score, ITAS2010). Progresija bolesti se može indirektno proceniti i
primenom skorova: Indeksa ošećenja kod vaskulitisa (Vasculitis Damage Index, VDI),
Indeksa oštećenja za pacijente sa TA (Takayasu Arteritis Damage Score, TADS) i
Kombinovanog skora oštećenja kod pacijenata sa arteritisom (Combined Arteritis
Damage Score, CARDS). Pouzdani serumski biomarkeri vaskularnog i/ili sveukupno
oštećenja do sada nisu identifikovani.
Ciljevi istraživanja: Identifikacija biomarkera i dijagnostičkih procedura od
značaja za postavljanje dijagnoze i praćenje toka TA; analiza genetičkih faktora i
biomarkera koji bi mogli da se dovedu u vezu sa različitom fenotipskom ekspresijom,
statusom aktivnosti, odgovorom na primenjene različite modalitete lečenja i pojavom
komplikacija bolesti.
Pacijenti i metode: Ovom studijom preseka obuhvaćeno je 33 pacijenata sa TA;
dijagnoza je postavljena na osnovu klasifikacionih kriterijuma Američkog koledža za
reumatologiju (American College of Rheumathology, ACR) iz 1990. godine za adultne
pacijente, i kriterijuma EULAR/PRINTO/PRES za pedijatrijski uzrast. DNK je izolovana
iz periferne krvi korišćenjem automatizovanog sistema Maxwell 16 Purification Kit.
Tipizacija humanih leukocitnih antigena (Human Leucocyte Antigens, HLA) je učinjena
korišćenjem oligonukleotidnih proba koje su specifične za sekvencu (Sequence-specific
oligonucleotide, SSO). Dobijena p vrednost je korigovana primenom Benjamini-
Hochberg metoda. Polimorfizam TNF (Tumor necrosis factor) gena (rs1800692) je
ispitivan TaqMan metodom sa komercijalno dostupnom smešom (#C__514879_10).
Koncentracije aminoterminalnog propeptida prokolagena tipa III (Aminoterminal
propeptide of procollagen type III, PIIINPI), hijaluronske kiseline (Hyaluronic acid, HA),
i tkivnog inhibitora matriksne metaloproteinaze-1 (Tissue Inhibitor of Matrix
Metalloproteinase-1, TIMP-1) su analizirane pomoću imunoeseja ADVIACentaur®, a
skor ELF (Enchanced Liver Fibrosis) je automatski izračunavan prema proizvođačkoj
specifikaciji. Takođe, analizirani su rezultati imidžing dijagnostike, antikardiolipinskih
(AclA), antitela protiv β2 glikoproteina 1 (β2GPI), lupus antikoagulansa (LA) i rutinskih
biohumoralnih parametara.
Rezultati: Ispitanike je činilo 93,9% osoba ženskog pola. Prosečna starost
iznosila je 43,9±16,3 godina, uz medijanu kašnjenja u postavljanju dijagnoze od 2 (1-
4,5) godine, u odnosu na pojavu prvih simptoma...Introduction: Takayasu arteritis (TA) is a chronic, idiopathic, inflammatory
disease, characterized by granulomatous inflammation of the aorta and its branches.
Certain genetic factors may play an important role in the development of TA. Secondary
antiphospholipid syndrome (APS) may occur in patients with TA and it is characterized
by vascular and/or complications related to pregnancy and/or delivery, in the presence
of antiphospholipid (AP) antibodies. Echosonographic (ECHO) Doppler examination,
computed tomography with contrast angiography (CTA), and the positional emission
tomography combined with a low-resolution computed tomography using the
fluorodeoxyglucose (18FDG PET-CT), can be used for diagnosis and monitoring in
patients with TA. The NIH (National Institute of Health) clinical score and the Indian
Takayasu’s Arteritis score (ITAS2010) are used the most often for assessing disease
activity. Disease progression can be assessed using the Vasculitis Damage Index (VDI),
Takayasu Arteritis Damage Score (TADS) and Combined Arteritis Damage Score
(CARDS). Serum biomarkers reflecting vascular and/or overall progression of the
disease have not been identified so far.
Objectives: This study aimed to identify serum biomarkers and diagnostic
procedures relevant for diagnosis and disease monitoring; analysis of genetic factors
and biomarkers that might be related to different phenotypic expression, disease
activity status, response to different treatment and disease related complications.
Patients and methods: This cross-sectional study included 33 patients with TA;
the diagnosis was made according to the 1990 American College of Rheumatology
(ACR) classification criteria for adults, and the EULAR/PRINTO/PRES criteria for
pediatric patients. DNA was isolated from peripheral blood using the automated
Maxwell 16 Purification Kit. Human Leukocyte Antigens (HLA) typing was performed
using the sequence-specific oligonucleotide (SSO) probes; p values were corrected using
the Benjamini-Hochberg method. TNF (Tumor necrosis factor) gene polymorphism
(rs1800692) was examined using the TaqMan method with a commercially available
mixture (# C__514879_10). Concentrations of Aminoterminal Propeptide Procollagen
Type II (PIIINPI), Hyaluronic Acid (HA), and Tissue Inhibitor of Matrix
Metalloproteinase-1 (TIMP-1) were analyzed using the ADVIACentaur®, and the ELF
(Enhanced Liver Fibrosis) score is automatically calculated according to the
manufacturer's specification. The results of imaging procedures, routine serology
parameters and AP antibodies: anticardiolipin (AclA), antibodies against β2
glycoprotein 1 (β2GPI) and lupus anticoagulants (LA) were also analyzed.
Results: Of all patients, 93.9% were females with an average age of 43.9 ± 16.3
years, and a median delay in diagnosis of 2 (1-4.5) years from the appearance of the first
symptoms. The HLA-B*52, HLA-A*32, HLA-B*15, HLA-B*57, and HLA-C*03 alleles, and
DRB1*15:02-DQB1*05 haplotype were more frequent in TA than controls, although
only HLA-B*52 remained significance after the statistical correction. HLA-B*52 allele in
the TA group was 10% (5/50), while it was present in 1.2% controls (46/3984) (p =
0.0004, padj = 0.011). Carriage of HLA-B*52 was associated with a significantly earlier
disease onset and more severe clinical presentations. Carriers of HLA-C*03 experienced
a milder clinical form of the disease..
Eko-turizam Ovčarsko-kablarske klisure - stanje i perspektive
Eko-turizam predstavlja selektivni vid turizma, čiji je cilj očuvanje prirode, osiguranje dobrobiti
lokalnog stanovništva i edukacija turista o problemima zagađenja životne sredine. Na taj ovaj način se nastoji da se podigne svest ljudi o značaju očuvanja životne sredine, kako zbog sadašnjih tako i budućih generacija. Područje Ovčarsko-kablarske klisure je proučavano zato što je proglašeno Predelom izuzetnih odlika, nalazi se na IBA listi i deo je EMERALD mreže u Srbiji. Pored potencijala za razvoj eko-turizma, klisura poseduje raznovrsne prirodne i antropogene turističke potencijale. Posmatrajući klisuru kao kompleksan turistički motiv, analizirano je trenutno stanje i buduće perspektive razvoja eko-turizma Ovčarsko-kablarske klisure.Eco-tourism represents selective type of tourism which has a goal: protection of nature, ensuring
well-being of local population and tourists education about environmental pollution. By this representation, main intention is increasing the awareness about importance of environmental protection for both current and future generations. Area of the Ovcar-Kablar gorge has been studied because it was announced as “Area of exceptional quality”, it exists in a IBA list and it is part of Serbia EMERALD network. Besides ecotourism growing potential, this gorge owns various natural and anthropogenic tourist potentials. Looking at the gorge as a complex tourist motive, this paper analyzes current state and future eco-tourism development directions of the Ovcar-Kablar gorge.Konferencija je organizovana u saradnji sa Katedrom za životnu sredinu Geografskog Fakulteta Univerziteta u Beogradu
The influence of the high intra-abdominal pressure concerning intra-abdominal hypertension on a mortality rate at the intensive care unit.
Uvod. Pritisak unutar trbušne duplje normalno je nešto iznad atmosferskih vrednosti. Samo malo povećanje intraabdominalnog pritiska može dovesti do niza štetnih posledica u funkciji respiratornog, kardiovaskularnog, bubrežnog, centralnog i gastrointestinalnog sistema. Intraabdominalni pritisak se može meriti direktno invazivnim metodama i indirektno kroz kateter plasiran u mokraćnu bešiku. Indirektni način merenja je jeftin, jednostavan i daje iste rezultate kao i direktno merenje. Znatno povećanje intraabdominalnog pritiska se stalno sreće kod pacijenata u jedinicu intenzivnog lečenja, kod rupture aneurizme abdominalne aorte, abdominalne traume i akutnog pankreatitisa. Abdominalni kompartment sindrom predstavlja kombinaciju povećanog intraabdominalnog pritiska i multiorganske disfunkcije. Ovaj sindrom ima visok stepen smrtnosti, najviše zbog razvoja sepse i multiorganoskog oštećenja organa. Dijagnoza abdominalnog kompartment sindroma zahteva brižljivu identifikaciju pacijenata sa rizikom, redovno merenje intraabdominalnog pritiska, adekvatnu nadoknadu tečnosti i hiruršku dekompresiju. Danas, preporučljiv i ispravan vid lečenja, kod razvijenog abdominalnog kompartment sindroma je hirurška dekompresija.
Ciljevi istraživanja. Rano prepoznavanje promena osnovnih vitalnih funkcija kod pacijenata sa povećanim IAP, prognostički faktori vezani za IAP koji utiču na evoluciju patološkog poremećaja, uticaj IAP na stopu smrtosti kod pacijenata suspektnih na IAH
Materijal i metod rada. Prospektivna studija je sprovedena kod 100 pacijenta suspektnih na postojanje IAH i ACS u jedinici hirurške intenzivne nege i lečenja u Kliničko bolničkom Centru (KBC) “Zvezdara“ u Beogradu, u periodu januar 2014. do decembra 2015. godine. Rizična grupa pacijenata obuhvatala je pacijente koji imaju faktore rizika za smanjenje komplijanse trbušnog zida (akutno respiratorno oštećenje sa povećanim intratorakalnim pritiskom, abdominalna operacija sa čvrstim fascijalnim zatvaranjem), porast intraluminalnog sadržaja (gastropareza, ileus, pseudo-obstrukcija kolona), porast abdominalnog sadržaja (hemoperitoneum, pneumoperitoneum, ascites, poremećaj funkcije jetre, pankreatitis, peritonitis) i prekomernu nadoknadu tečnosti ili kapilarno krvarenje (acidoza (pH < 7,2), hipotenzija,
masivna nadoknada tečnosti (> 5 l /24 sata), oligurija, sepsa). Studija nije obuhvatala pacijente koji su imali traumu, opekotine ili su bili prethodno operisani.
Svi pacijenti su podeljeni na osnovu izmerenih vrednosti..
Influence of diabetes on stent thrombosis in patients with implanted first generation drugeluting stents
Cilj ovog istraživanja je bio da se odredi nivo pojava trombotičkih komlikacija kod
pacijenata kod kojih su implantirani stentovi prve generacije obloženi lekom (drugeluting stentovi) u zavisnosti od postojanja šećerne bolesti. U skladu sa ovim osnovnim
ciljem definisani su konkretni zadaci:
1. analiza učestalosti pojave akutnih, subakutnih, udaljenih i vrlo udaljenih tromboza
u zavisnosti od postojanja šećerne bolesti kod pacijenata kod kojih su implantirani
stentovi prve generacije obloženi lekom (drug-eluting stentovi).
2. analiza uticaja kvaliteta glikoregulacije na pojavu tromboze stenta
3. utvrđivanje incidence značajnih srčanih događajaThe main goal of the research is to determine the level of thrombotic complications in patients
with implanted first-generation stents coated with a drug (drug-eluting stents), depending on the
existence of diabetes. In accordance with this basic goal, specific tasks are defined:
1. analysis of the frequency of acute, subacute, distant and very distant thrombosis depending
on the existence of diabetes in patients in whom first-generation stents coated with the drug
(drug-eluting stents) were implanted.
2. analysis of the influence of the quality of glycoregulation on the occurrence of stent
thrombosis
3. determining the incidence of significant cardiac event
Environmental reporting – normative and accounting aspects
Companies are part of society in which they are performing their business
activities, so, in addition to achieving their economic goals, they must take into account the
impact of their activities on the environment and society as well, which means that, it is
necessary to act in a socially responsible and acceptable way, and thus accomplish certain
benefits. Due to the obvious changes in the natural environment (e.g. climate change and its
consequences, water shortages, air pollution, degradation of ecosystems and ozone layer
depletion) and the material effect of the global “life-style” on the environment, there has been
an increasing awareness in a lot of countries and societies that the environment and its
resources are the major elements that are crucially necessary for the future of mankind. This
growing awareness has led on the one hand to the regulatory activities of national and
international institutions and on the other hand to the public concerns about environmental
issues. As a consequence the concept of “sustainable development” of society was broadly
and globally accepted as a core of national and international policy in the early 90-ies of the
last century. This more or less global commitment and conviction has, besides other aspects,
also drawn attention to the impact of companies` business activities on the environment and
the society and has led to the concept that the value of a company should not only be
measured according to its financial performance but also to its environmental and social
performance of the business, including the positive and negative impacts on the natural and
social environment. This performance concept is referred to as the triple bottom line
performance and is increasingly considered by the major stakeholders of companies (such as
capital provider, suppliers, customers and society in general). Companies need to respond to
the expectations of their stakeholders so that they will include the impacts of their business
activities on the environment and society in their strategic and operative management
systems, as well as their decision making process and their system of external financial and
non-financial reporting. Including of these effects in the system of external financial and nonfinancial
reporting, i.e. the expansion of the traditional model of external financial reporting
with non-financial information is of particular importance, because corporate reporting is
crucial for the evaluation of the company by its stakeholders and therefore for its future
(financial) success. Information about environmental aspects of the business were firstly
disclosed as a part of the annual report, then shortly as a part of the so-called social reporting,
then in the form of a standalone environmental report, sustainability report, and recently
within an integrated report. In order to define content and form of the above mentioned
reports a number of guidelines and regulatory requirements for reporting have been
developed by European and international organizations and institutions. At the EU level
particularly important are Eco-Management and Audit Scheme (EMAS) established by the
European Commission, European Commission Recommendation on the recognition,
measurement and disclosure of environmental issues in the annual accounts and annual
reports of companies, certain Directives of the European Commission as well as Proposal of
an environmental reporting framework issued by Federation of European Accountants, while
at the global level Sustainability Reporting Guidelines established by Global Reporting
Initiative (GRI) and International Integrated Reporting Framework issued by International
Integrated Reporting Council (IIRC) are the most comprehensive guidelines for
sustainaibility reporting. In order to improve credibility and quality of disclosed information
about environmental (and wider social) aspects of the business, it is important to conduct an
audit or assurance of sustainability reports depending on the reporting form, which also
caused the development of certain standards such as International Auditing Practice
Statement 1010, International Standard on Assurance Engagements (ISAE) 3000 and
AA1000 Assurance Standard. While at the EU level and around the world a lot has already
been done regarding this matter, and the sustainability reporting level in the world is
constantly increasing, for companies which are operating in the Republic of Serbia this
reporting concept is the relative novelty, considering that the most of our companies are still
trying to find their interest in this area and to become familiar with the sustainability
reporting guidelines, reporting methods as well as with the significance of the assurance
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