The relationship of aging, complete tooth loss, and having a dental visit in the last 12 months

OBJECTIVES: To evaluate the extent to which dental health care visits in the past year differed among older adults with and without edentulism. MATERIAL AND METHODS: We conducted a cross-sectional study using the 2017 Medical Expenditure Panel Survey among participants aged \u3e /=50 years (n = 10,480, weighted = 112,116,641). Two self-reported outcome variables were used: loss of all teeth from upper and lower jaws (yes/no) and dental visit in the last 12 months (yes/no). Logistic models were used to estimate adjusted odds ratios (aOR) and 95% confidence intervals (CI). RESULTS: Overall, 11.4% of the non-institutionalized U.S. population aged \u3e /=50 years were edentulous; the prevalence was higher in those with advanced age. Adherence to annual oral health visits was 16% among those with edentulism, 52% among those without. The prevalence of dental care visits in the past year was higher among those with advanced age without edentulism, but for those with edentulism, the odds of visiting a dental care provider was lower in all age groups compared to those 50-59 years ((60-69 years): aOR: 0.58, CI:0.36-0.95; (70-79 years): aOR: 0.51, CI: 0.30-0.88; ( \u3e /= 80 years): aOR: 0.45, CI: 0.26-0.80)). CONCLUSION: Although the prevalence of edentulism was higher in those with advanced age, oral health visits during the last 12 months were less frequent in older adults with edentulism. Interventions to improve adherence to dental care recommendations in the growing aging population are warranted

The Associative Field Of The Lexemes "Work" In Russian And Tatar Language Consciousness

At present time, one of the most important directions in linguistics is the study of the linguistic consciousness of man, the tradition of research of which goes back to the ideas of W. von Humboldt about the link between the language and the spirit of the people. Among the methods of research of linguistic consciousness, one distinguishes an associative experiment, which is a survey of the informants united by some commonality (language, profession, territory of residence, etc.) for revealing their associations-reactions to a certain stimulus. The following methods of linguistic analysis were used in the paper: generalization and systematization, analytical method, descriptive, comparative methods, and also the method of association experiment, etc.The association experiments with 500 students of the city of Kazan, the native speakers of the Tatar language,were conductedIn the course of the research. The results were compared with the materials of the “The Slavic Associative Dictionary” (2004).This paper analyzes and identifies the general and specific features of the associative fields of the lexemes “Ñш”in the Tatar language and “работа”/“work” in the Russian language. An analysis of the responses received by the respondents showed that the associative fields of the lexemes “Ñш” in Tatar and“работа”/“work” in Russian coincided in general. However, Tatar native speakers have more associations with the components of the meaning “Ñ‚Ñжелый”/ “heavy”, “трудноÑÑ‚ÑŒ”/“difficulty”, etc., often characterizing physical labour. Russian-speaking young people more often associate their future with comfortable mental work indoors.The associations of Russian speakers are distinguished by a wide variety of associates with negative connotations, reduced stylistic characteristics, and the use of answers of paremiological origin.Thus, the association experiment allows of revealing the content systemacyof thetypeofconsciousness behind the word in different languages, and confirms the uniqueness, the inimitability of the image of the world of each culture. The research to have been carried out has practical significance, since the obtained results are a valuable and sufficiently reliable material for studying certain fragments of linguistic consciousness, national-specific phenomena, knowledge, value orientations, and so on.

Stemness Features in Liver Cancer

Heterogeneity is a cardinal hallmark of cancer, including primary liver cancer (PLC), and occurs at different layers including putative cell-of-origin. Current evidence suggests that within cellular subpopulations in PLC there are stem-like cells, the cancer stem cells (CSCs). The CSC concept has been recently proposed as an explanation of such intra-tumor heterogeneity. According to this model, CSCs are responsible for tumor initiation, recurrence, metastasis as well as drug-resistance. However, although the CSC hypothesis is intriguing and supported by a large number of experimental studies, there are still open questions regarding the origin of putative CSCs. Since chemo-resistance and recurrence represent major issues in PLC treatment, the development of new therapeutic strategies is needed, for which a good understanding of tumor behavior and in particular of CSCs biology is an imperative prerequisite. In this review we summarize the regulatory pathways that support CSC features in PLC. Moreover, we highlight the key features of hepatic CSC, in terms of enhanced drug-resistance, increased metastatic potential and metabolic rearrangement. Knowledge of the molecular mechanisms underlying CSC biology may provide novel options for PLC combination therapies

English language proficiency, complete tooth loss, and recent dental visits among older adults in the United States

Objectives: This study sought to provide population-based estimates of complete tooth loss and recent dental visits among older adults in the United States by English language proficiency. Methods: We conducted a cross-sectional analysis of the 2017 Medical Expenditure Panel Survey among participants 50 years of age (n = 10,452, weighted to represent 111,895,290 persons). Five categories of language proficiency were created based on self-reported English language ability and language spoken at home (Spanish, Other). Results: The prevalence of complete tooth loss was higher among those with limited English proficiency (Spanish speaking: 13.7%; Other languages: 16.9%) than those proficient in English (Spanish speaking: 5.0%; Other languages: 6.0%, English only: 12.0%). Complete tooth loss was less common among participants for whom Spanish was their primary language, with limited English proficiency relative to English only (adjusted odds ratio: 0.56; 95% confidence interval: 0.42-0.76). Among those without complete tooth loss, dental visits in the past year were less common among participants with primary language other than English as compared to those who only speak English. Conclusions: Complete tooth loss varied by English language proficiency among adults aged 50 years in the United States. Suboptimal adherence to annual dental visits was common, more so in those with complete tooth loss, and varied by English language proficiency

Ultrasonographic evaluation of the eyes' posterior segment of diabetic and non-diabetic dogs with cataracts

Cataracts jeopardize the light penetration into the eye and may restrain direct exam of eye structures. It is necessary to identify very early any eye disease that could cause the failure of cataract surgery. The ocular ultrasonography or echography is a safe, non invasive, inexpensive and easy procedure that complements ocular examination. Two hundred and twenty five eyes of 123 dogs were evaluated using a 10 Mhz linear transducer ultrasound. The dogs were divided into three groups, as there is Group 1: 36 healthy control dogs; Group 2: 52 non diabetic dogs with cataracts; and Group 3: 35 diabetic dogs with cataracts; all of them were patients of the Veterinary Teaching Hospital, University of São Paulo. The ultrasonographic findings were in Group 1: vitreous degeneration in 43%, posterior vitreous detachment in 7.7%, asteroid hyalosis in 4.6% of the eyes; in Group 2: vitreous degeneration in 58.9%, posterior vitreous detachment in 8.4%, asteroid hyalosis in 2.1%, inflammatory or haemorrhagic process in 2.1%, retinal detachment in 4.3% of the eyes; and in Group 3: vitreous degeneration in 50.7%, posterior vitreous detachment in 13.8%, asteroid hyalosis in 12.3%, inflammatory or haemorrhagic process in 3.1%, retinal detachment in 3.1% of the eyes. It could be concluded that (1) diabetic dogs, mainly the ones with diabetes for more than 2 years, have greater chances to develop asteroid hyalosis; (2) there were no significant differences in retinal detachment frequencies for the diabetic and non diabetic dogs; and (3) the ocular ultrasonography is a safe, effective and important exam for the pre-operatory evaluation of dogs with cataracts.A catarata impossibilita a passagem de luz dentro do olho, dificultando o exame físico direto das estruturas oculares. É necessária a identificação prévia de quaisquer alterações oculares que contra-indiquem a cirurgia de catarata. A ultra-sonografia, ou ecografia ocular, é um exame seguro, de baixo custo, não invasivo, de fácil realização, que completa o exame oftálmico. Foi realizada avaliação ultra-sonográfica, com transdutor linear, freqüência de 10 MHz, de 225 olhos de 123 cães, sendo cães controle (Grupo 1), 52 cães não diabéticos portadores de catarata (Grupo 2) e 35 cães diabéticos portadores de catarata (Grupo 3), todos eles atendidos no Hospital Veterinário da Universidade de São Paulo. Foram encontradas as seguintes alterações ultra-sonográficas no Grupo 1: degeneração vítrea em 43%, descolamento de vítreo posterior em 7,7%, hialose asteróide em 4,6% dos olhos; no Grupo 2: degeneração vítrea em 58,9%, descolamento de vítreo posterior em 8,4%, hialose asteróide em 2,1%, processo inflamatório e/ou hemorrágico em 2,1% e descolamento de retina em 4,3% dos olhos; e no Grupo 3: degeneração vítrea em 50,7%, descolamento de vítreo posterior em 13,8%, hialose asteróide em 12,3%, processo inflamatório e/ou hemorrágico em 3,1% e descolamento de retina em 3,1% dos olhos. Concluiu-se, que (1) cães diabéticos, principalmente os que apresentam a doença há mais de 2 anos, tem maior predisposição para o desenvolvimento de hialose asteróide; (2) não houve diferença entre a freqüencia de descolamento de retina encontrada em cães diabéticos e não diabéticos; e (3) a ultra-sonografia ocular é em exame seguro, eficaz e importante na avaliação pré-operatória de cães portadores de catarata.Universidade de São Paulo Departamento de Cirurgia da Faculdade de Medicina Veterinária e ZootecniaUniversidade Federal de São Paulo (UNIFESP) Escola Paulista de Medicina Departamento de OftalmologiaUSP Hospital Veterinário Serviço de OftalmologiaUSP FMVZ Departamento de CirurgiaUNIFESP, EPM, Depto. de OftalmologiaSciEL

Early TBI-Induced Cytokine Alterations are Similarly Detected by Two Distinct Methods of Multiplex Assay

Annually, more than a million persons experience traumatic brain injury (TBI) in the US and a substantial proportion of this population develop debilitating neurological disorders, such as, paralysis, cognitive deficits, and epilepsy. Despite the long-standing knowledge of the risks associated with TBI, no effective biomarkers or interventions exist. Recent evidence suggests a role for inflammatory modulators in TBI-induced neurological impairments. Current technological advances allow for the simultaneous analysis of the precise spatial and temporal expression patterns of numerous proteins in single samples which ultimately can lead to the development of novel treatments. Thus, the present study examined 23 different cytokines, including chemokines, in the ipsi and contralateral cerebral cortex of rats at 24 h after a fluid percussion injury (FPI). Furthermore, the estimation of cytokines were performed in a newly developed multiplex assay instrument, MAGPIX (Luminex Corp), and compared with an established instrument, Bio-Plex (Bio-Rad), in order to validate the newly developed instrument. The results show numerous inflammatory changes in the ipsi and contralateral side after FPI that were consistently reported by both technologies

Developing a Measure of Safety Data Culture

Safety is a critical concern for many organizations, especially those in construction and manufacturing. A newer approach to improving an organization’s decision making involves the use of data analytics. In regard to safety, the use of data analytics would allow for detecting and tracking risk factors such as behaviors, environmental contingencies, production, procedures, and hazards that are associated with workplace injuries. However, many organizations do not have a culture involving the use and measurement of relevant variables on an ongoing basis. Accordingly, the purpose of the study is to develop a measure of safety culture with a specific emphasis on the extent to which data is being utilized for management of safety in an organization. This measure of safety culture and analytics will assist in determining the extent to which an organization is ready to utilize data analytics into their safety program