Squashed entanglement in one-dimensional quantum matter

Squashed entanglement and its universal upper bound, the quantum conditional mutual information, are faithful measures of bipartite quantum correlations defined in terms of multipartitions. As such, they are sensitive to the fine-grain structure of quantum systems. Building on this observation, we introduce the concept of quantum conditional mutual information between the edges of quantum many-body systems. We show that this quantity characterizes unambiguously one-dimensional topological insulators and superconductors, being equal to Bell-state entanglement in the former and to half Bell-state entanglement in the latter, mirroring the different statistics of the edge modes in the two systems. The edge-to-edge quantum conditional mutual information is robust in the presence of disorder or local perturbations, converges exponentially with the system size to a quantized topological invariant, even in the presence of interactions, and vanishes in the trivial phase. We thus conjecture that it coincides with the edge-to-edge squashed entanglement in the entire ground-state phase diagram of symmetry-protected topological systems, and we provide some analytical evidence supporting the claim. By comparing them with the entanglement negativity, we collect further indications that the quantum conditional mutual information and the squashed entanglement provide a very accurate characterization of nonlocal correlation patterns in one-dimensional quantum matter.Comment: 13 pages, 8 figures, revised and expanded versio

Resilience of topological superconductivity under particle current

We investigate the robustness of topological superconductors under the perturbing influence of a finite charge current. To this aim, we introduce a modified Kitaev Hamiltonian parametrically dependent on the quasiparticle momentum induced by the current. Using different quantifiers of the topological phase, such as the Majorana polarization and the edge state quantum conditional mutual information, we prove the existence of a finite critical value of the quasiparticle momentum below which edge modes and topological superconductivity survive. We also discuss how a finite current breaks time reversal symmetry and changes the topological class in the Altland-Zirnbauer classification scheme compared to the case of isolated systems. Our findings provide a nontrivial example of the interplay between topology and the nonequilibrium physics of open quantum systems, a relation of crucial importance in the quest to a viable topological quantum electronics.Comment: 8 pages, 3 figures, regular pape

Open Source Interactive Map of Albania Cultural Heritage

AbstractICTs represent strategic resources for Cultural Heritage (CH) projects. Anyway, several conditions put the success of promotion projects at risk, especially if carried out at the local level. Firstly, local scale amplifies the weight of budget constraints on the priorities of public administrations, compelled to allocate funds to the physical conservation of heritage rather than to software and training. Secondly, proprietary SW, often sophisticated and complex in procedures, fails to integrate precious unformalized knowledge from local stakeholders and communities, particularly in the field of cultural tourism. Finally, a changing demand for cultural tourism, with potential visitors frequently searching for information directly on the Web before moving, requires a higher interactivity in tools and systems. The paper illustrates the work carried out at the Construction Technologies Institute for delivering procedures and SW specifically designed to simplify the publication of geo-referenced information and reduce the need for specialized skills and equipments. The described results were achieved along different research programs focusing on the Albanian CH with a learning-by-doing approach

Hallmarks of non-trivial topology in Josephson junctions based on oxide nanochannels

We investigate the topological properties of a Josephson junction obtained by constraining a two-dimensional electron gas at oxide interface to form a quasi-1D conductor. We reveal an anomalous critical current behaviour with a magnetic field applied perpendicular to the Rashba spin-orbit one. We relate the observed critical current enhancement at small magnetic fields with a non-trivial topology, accompanied by Majorana bound states (MBSs) pinned at the edges of the superconducting leads. Signatures of MBSs also include a sawtooth profile in the current-phase relation. Our findings allow to recognize fingerprints of topological superconductivity in non-centrosymmetric materials and confined systems with Rashba spin-orbit interaction, and to explain recent experimental observations for which a microscopic description is still lacking.Comment: 10 pages, 8 figures, pape

A universal bioluminescence resonance energy transfer sensor design enables high-sensitivity screening of GPCR activation dynamics

G-protein-coupled receptors (GPCRs) represent one of the most important classes of drug targets. The discovery of new GCPR therapeutics would greatly benefit from the development of a generalizable high-throughput assay to directly monitor their activation or de-activation. Here we screened a variety of labels inserted into the third intracellular loop and the C-terminus of the α-adrenergic receptor and used fluorescence (FRET) and bioluminescence resonance energy transfer (BRET) to monitor ligand-binding and activation dynamics. We then developed a universal intramolecular BRET receptor sensor design to quantify efficacy and potency of GPCR ligands in intact cells and real time. We demonstrate the transferability of the sensor design by cloning β-adrenergic and PTH1-receptor BRET sensors and monitored their efficacy and potency. For all biosensors, the Z factors were well above 0.5 showing the suitability of such design for microtiter plate assays. This technology will aid the identification of novel types of GPCR ligands

Improving Homecare Risk Management and Patient Safety

Background: Risk management in the domiciliary healthcare setting is a harder challenge than in a hospital environment. Many, not always predictable, variables related to the patient, the caregiver, the health professionals and the home environment make it impossible to guarantee complete safety in homecare. The first aim of the study was to verify that the Electrical Medical Devices (EMD) and medical Consumables Supplies (CS) provided to mechanically ventilated and artificially fed patients at home comply with requirements for safe homecare.  Methods: We conducted a Failure Modes, Effects and Criticality Analysis (FMECA) on two processes, mechanical ventilation and artificial feeding at home, and defined a local institutional list of the requirements for safe home healthcare; a checklist containing all the items in the list was administered to ventilated and artificially fed patients at home.  Results: The checklist was used for 92 home patients, sex M/F=52/40, mean age 59,8±22 years (range 2÷102 years). Many failures were highlighted when the checklist was applied and problems affecting AMBU resuscitator bags, tracheostomy tubes, ventilators in patients being mechanically ventilated around-the-clock and ventilator circuits were identified as the most critical potential vulnerabilities for homecare patients.  Conclusion: The checklist is a simple and valid tool for implementing proactive clinical risk management initiatives in homecare. Although it is impossible to guarantee complete safety in any healthcare environment, scheduling periodic checks with checklists to assess the quantitative and qualitative adequacy of EMD and CS provided to the patient could contribute to the homecare risk reduction.&nbsp

cardio ankle vascular index is associated with diabetic retinopathy in younger than 70 years patients with type 2 diabetes mellitus

Abstract Aims This study aimed to investigate the relationship between cardio-ankle vascular index (CAVI) and diabetic retinopathy (DR) in Caucasian patients with type 2 Diabetes Mellitus (T2DM). Methods This was a cross-sectional study of 299 T2DM patients admitted to Endocrine Unit of Foggia. DR was diagnosed using the International Clinical Disease Severity Scale of American Academy of Ophthalmology. The VaSera VS-1500N was used to measure CAVI. Because age is the most powerful determinant of arterial stiffness and affects the progression of DR, we divided the whole sample into two subgroups: above (older) and below (younger) 70 years. Results The mean age of patients was 60.4 ± 12.6 years and the mean CAVI value was 8.6 ± 1.7. In the whole population DR was diagnosed in 74 (24.7%) patients. CAVI value was clearly higher in patients with DR (9.5 ± 1.6) than in those without (8.7 ± 1.7) ( P =0.001) although this difference was not any more significant when adjusted by age and gender (P=0.067). In the multivariate model taking into account several possible confounders, the correlation between DR and CAVI remained significant only in younger subjects. In the same subgroup we found a significant association between the stages of DR and CAVI (p=0.019 adjusted by age and gender). Conclusions This study shows that CAVI is significantly higher in younger patients with DR than in those without, with a relationship between the stages of DR and CAVI in the same subgroup. Physicians should pay attention to sub-clinical macroangiopathy in younger T2DM patients who have DR

LASER SCANNER AND CAMERA-EQUIPPED UAV ARCHITECTURAL SURVEYS

ABSTRACT: The paper reports the workflow of 3D modelling and photorealistic texture mapping based on close range imagery acquired through a terrestrial laser scan and a camera mounted on a mini Unmanned Aerial Vehicle (UAV). The 3D models of the same architectural object -a watchtower named "Torre Pelosa" (Bari, Italy) -were compared in order to evaluate strengths and weaknesses of the used instruments and methods. The evaluated parameters where geo-referencing capability, manageability, manoeuvrability, operational constraint, survey completeness and costs. Despite a lower accuracy of the results, the use of a UAV mounted camera is essential to obtain a whole representation of the tower