Efficient Simulation Of A Simple Evolutionary System

An infinite population model is considered for diploid evolution under the influence of crossing over and mutation. The evolution equations show how Vose’s haploid model for Genetic Algorithms extends to the diploid case, thereby making feasible simulations which otherwise would require excessive resources. This is illustrated through computations confirming the convergence of finite diploid population short-term behaviour to the behaviour predicted by the infinite diploid model. The results show the distance between finite and infinite population evolutionary trajectories can decrease in practice like the reciprocal of the square root of population size. Under necessary and sufficient conditions (NS) concerning mutation and crossover, infinite populations show oscillating behavior. We explore whether finite populations can also exhibit oscillation or approximate oscillation. Simulation results confirm that approximate finite population oscillation is possible when NS are satisfied. We also investigate the robustness of finite population oscillation. We show that when the part of NS concerning mutation is violated, the Markov chain which models finite population evolution is regular, and perfect oscillation should not occur. However, our simulation results show finite population approximate oscillation can occur even though the Markov chain is regular. Finite populations can also exhibit approximate oscillating behavior when the part of NS concerning crossover is violated

Grain Yield Stability of Quality Protein Maize Genotypes across Diverse Environments of Terai and Mid Hills in Nepal

Maize is produced in diverse environmental conditions in Nepal. National Maize Research Program regularly tests maize genotypes for their grain yield stability in highly diverse environments. The objective of this paper is to estimate grain yield stability of quality protein maize genotypes across different environments. Two quality protein maize genotypes namely Poshilo Makai-1 and S99TLYQ-HG-B along with Farmer’s variety were tested at nine different locations of Nepal in four consecutive years before 2013 under farmer’s fields. Alpha-lattice design with two replications was used. The results of these studies revealed that S99TLYQ-HG-B was more stable followed by Poshilo Makai-1 as compare to Farmer’s variety. The overall higher mean grain yield and regression coefficient (b) near to unity showed that S99TLYQ-HG-B is the most adaptive genotype across the tested environments. However, more than unity regression coefficient (b) indicates that Poshilo Makai-1 could be the recommended variety for better environments under farmers’ management

A study on the lipid ratios and inflammatory markers in pre-diabetic and diabetic patients

Background: One of the leading causes of diabetic mortality is cardiovascular disease. Diabetes progression is preceded by pre-diabetic phase which is also at higher cardiovascular risk. Both hyperglycemia and atherosclerotic processes are inflammatory phenomenon. Keeping this in view, it was aimed to evaluate atherogenic indices and correlate them with inflammatory mediators.Methods: This study included 80 controls, 80 pre-diabetic and 80 diabetic patients. Anthropometric parameters (BMI, WHR) and blood parameters like fasting glucose, HbA1c, lipid profile (cholesterol, HDL, LDL TG, VLDL), adiponectin, IL-6, CRP, fibrinogen and uric acid were analysed.Results: Significantly high atherogenic indices were observed in pre-diabetic and diabetic subjects compared to healthy controls. The indices were also significantly correlated with BMI, fasting sugar, HbA1c, cholesterol, HDL, TG and LDL. The correlation with HDL was negative and with other parameters, the correlation was positive. In pre-diabetic patients, adiponectin showed significant negative correlation while fibrinogen and CRP showed significant positive correlation with cardiac risk indices. IL-6 was positively correlated only with AIP while correlation of uric acid with these indices was insignificant. In case of diabetic patients, the cardiac risk indices were significantly correlated with adiponectin, IL-6, CRP, fibrinogen and uric acid. The correlation with adiponectin was negative.Conclusions: The altered atherogenic indices and their significant association with inflammatory markers signify the direct association of inflammation with CVD risks. Thus, there is requirement of novel approaches that can retard inflammatory responses and arrest unwanted cardiac health outcomes

Risk of publication in worthless journals

oai:nepjol:article/22217Implementing research and publishing results is a crucial for a professional development, scientific communication and collaboration of any academicians, scholars, and researchers in science around the world. The timely dissemination of knowledge and scientific information in the global scientific community helps the development of science and worldwide recognition. The researchers working on scientific community cannot appreciate the value of evidence generated without publishing their work in right and quality journals. Therefore, authors should be careful about predatory or fake journals/publishers for communicating their scientific works. The objective of this study is to raise awareness on predatory or fake publishers/journals and of their dishonest publishing practices. In general, the predatory journal publishes without peer review and true editorial board, often publish mediocre or even worthless papers on charging high publication cost, citing fake and non-existing impact factors and mostly focused on private business motives. On the other hand, publishing in a high impact quality journals undoubtedly enhances the future career prospects, communication ability of authors and deliver concise research messages in the scientific field. Researcher of various disciplines and academic experience should aware with the lists of predatory journals/publishers which are available on Beall’s list in internet before publishing any research articles. Therefore, publishing in predatory/fake journals not only spoil or degrade academic reputations but also waste the time, resources and research message too

Strengthening emergency contraception in Nepal

A national workshop on emergency contraception was organized in Nepal by the Family Health Division within the Ministry of Health in 2004, with technical assistance provided by the FRONTIERS program of the Population Council. Among many conclusions from the workshop, one recommendation was that emergency contraceptive pills (ECP) should be introduced through the government family planning program to assist in reducing unwanted pregnancies. Based on the Population Council’s past experiences with introducing and mainstreaming ECP services in Bangladesh and India, a phase-wise introduction of ECP in Nepal was recommended. The project findings suggest that Nepalese women continue to face an unmet need for ECP, and expansion of the program to additional regions within Nepal is necessary. In addition, there is an urgent need for capacity-building among providers, given their consistently weak supervision and monitoring by the health system

Productivity of maize (Zea mays L.) as affected by varieties and sowing dates

Genotypic yield potential of maize varieties is greatly affected by sowing dates. In order to investigate the effects of sowing dates and varieties on the grain yield of maize, the field experiment was carried out at research field of National Maize Research Program (NMRP), Rampur, Chitwan, Nepal from April 2009 to March 2010.  Three varieties namely Rampur Composite, Arun-2 and Gaurav were sown at every week. The results of experiment showed that interaction effect of variety and sowing date on grain yield of maize was significant. Rampur Composite produced highest grain yield (6.1 t/ha) in August and lowest yield (2.6 t/ha) in May. Similarly Arun-2 produced highest yield (4.6 t/ha) in August and lowest yield (2.1 t/ha) in May. Gaurav produced highest grain yield (5.1 t/ha) in September followed by 4.9, 4.8 and 4.6 t/ha in February, July and August respectively and lowest yield (1.5 t/ha) in November. The sowing date was highly significant on grain production. The highest grain production was 5.1 t/ha in August followed by in February (4.9 t/ha), September (4.6 t/ha) and March (4.4 t/ha) respectively. The lowest grain yield was produced in May (2.4 t/ha). Therefore it was concluded that August planting was best for higher grain production of maize varieties (Rampur Composite, Arun-2 and Gaurav) in terai region of Nepal

Effect of introducing an \u27afternoon pay clinic\u27 on service utilization and cost recovery (Nepal)

An operations research study was initiated with financial and technical assistance from the FRONTIERS program to examine whether introducing an afternoon clinic at the Chhetrapati Family Welfare Center (CFWC) in Nepal with a substantially higher registration fee could improve cost recovery by adding more to program revenues than to program costs. The study showed, however, that premium pricing of afternoon services generated very little additional demand for services. Even with a premium price, the afternoon clinic could reach its cost recovery goal only if the volume of afternoon clients were to increase significantly. However, client perceptions about the ability of CFWC providers to provide non-family planning services needs to change in order for the utilization of the CFWC afternoon clinic to increase. Among the report’s conclusions is that family planning program sustainability without external support would not be feasible in the near future

Evaluation of pro-vitamin A enriched maize hybrids for fighting hidden hunger in Nepal

Prevailing vitamin A deficiency is a malnutrition repercussing retarded growth, weak immune system and night-blindness in human beings. Pro-vitamin A enriched maize hybrids could be a strategy for combating vitamin A deficiency, mostly prevailing in children and women of Nepal. With the objective to investigate superior pro-vitamin A enriched ‘bio-fortified’ maize cultivars, twice replicated experiments were laid out in α-lattice design over two consecutive growing seasons of 2019 and 2019/20 at the National Maize Research Program (NMRP), Rampur, Chitwan, Nepal. The results revealed that the difference among tested hybrids was glaring for all agro-morphological, yield, and yield components traits. Among the evaluated traits, days to 50% anthesis and silking, plant and ear height, numbers of kernel rows per cob, grains per row, and grain yield varied significantly among the tested maize hybrids. Effect of planting season was significant for grain yield where winter maize produced 32% higher grain yield than spring maize. HPO16-2, HPO49-3, HPO49-5, and HPO49-2 were the 38-61% high yielding ‘bio-fortified’ maize genotypes than normal hybrid check. Therefore, these hybrids might be the potential higher-yielding future pro-vitamin A enriched maize hybrids to resolve food insecurity, malnutrition, trade deficit on maize grains and specially to combat vitamin A deficiency in Nepal

Barriers and facilitators to the implementation of a national multisectoral action plan for the prevention and control of noncommunicable diseases in Nepal:perspectives of stakeholders

BACKGROUND: Nepal adopted the Multisectoral Action Plan for the Prevention and Control of Non-Communicable Diseases (MSAP) in 2014. Implementation of the plan has been challenging, with limited participation from non-health sectors. OBJECTIVES: The overall aim of the study was to gain the perspectives of key stakeholders involved in the Nepal MSAP on the barriers and facilitators to its implementation, through the participation of relevant sectors in the plan. METHODS: We held face-to-face semi-structured interviews with 12 stakeholders working in sectors involved in the MSAP. These sectors included the Office of the Prime Minister and Council of Ministries; Ministry of Health and Population (MOHP); Ministry of Education, Science and Technology; Ministry of Forest and Environment; academia; and professional organizations. Thematic analysis of transcripts was used to identify themes on awareness of NCDs, awareness of the MSAP, and barriers and facilitators to participation in the MSAP. RESULTS: Participants recognised NCDs as a growing and major burden in Nepal. However, a number of participants were not familiar with the MSAP, identifying a lack of leadership and poor dissemination. Political and systemic transformation, since the adoption of the MSAP, was seen as a key barrier to implementation. International commitments to develop multisectoral action made by the Government of Nepal were identified as drivers. The recent establishment of a separate section for NCDs and Mental Health within the Department of Health Services of MOHP and the promotion of a Health in All Policies (HiAP) approach in recent national documents, were both considered to support implementation. CONCLUSIONS: The establishment of permanent multisectoral or multistakeholder mechanisms has been challenging despite strong political calls for their development. Moving beyond 2020, multisectoral action plans should engage with stakeholders from federal, provincial and local governments in order to develop costed action plans with specific roles and responsibilities for each sector