EFFECTIVE MANAGEMENT OF ODONTOGENIC INFECTIONS THROUGH CONTROLLED FASHION BY POLYMERIC DEVICE CONTAINING MOXYFLOXACIN

Objective: Present work demonstrates the use of film that releases the drug at a pre-programmed manner. Several methods have been explored for management of moxifloxacin in dealing of Odontogenic infections which are mainly caused by necrotic pulp or by bacterial invasion from the periodontal tissue. These are usually mixed bacterial infections, and they penetrate mostly into the soft and bony oromaxillofacial tissues to produce submucosal infiltrates and abscesses.Methods: The films were developed with the intention to minimize the dose of a drug, to deliver definite concentration and to preserve dosage at its site for a longer period by this means gets a better patient compliance. Moxifloxacin films were prepared by solvent casting technique using gellan gum at different concentrations and PEG 400 as plasticizers. Compatibility study such as FT-IR and DSC also performed to check the interaction between drug and excipients used. The formulations were evaluated for their thickness, weight uniformity, folding endurance, content uniformity, surface pH, In vitro drug release. Optimized formulations were subjected to in vitro antibacterial activity and stability studies to assess the effectiveness of the formulations.Results: Formulations shown the good uniformity of drug content, there was no any kind of effect on moisture loss test. Weight and thickness of the films were found to be uniform. Plasticizer like PEG400 was found to influence their effect on drug release as well as characteristics of films.Conclusion: In vitro studies revealed that the formulations provide the best alternative to prolong drug release at the end of 10 h and formulations remained stable with intact at ambient conditions.Â

Performance and Stability of an Agile Tail-less MAV with Flexible Articulated Wings

This paper considers the problems of (a) modelling the ight mechanics of a tail-less MAV equipped with exible articulated wings, and (b) the analysis of its turning performance. The wings are assumed to have two degrees of freedom - heave and twist. They are assumed to be actuated from the root, which is the abstraction of an experimental control mechanism being developed by the authors. The dihedral and twist angles at the wing root are controlled. A novel actuator concept of axial tension to control wing stiffness has been explored in this paper. It is shown that axial tension in the wing has a significant effect on the turning performance of the aircraft, although the effect is not uniformly beneficial in nature. The effect of exibility on the steady state turning performance of the aircraft has been demonstrated by comparing it with that of a rigid aircraft, and with that of a similar aircraft possessing a wing with different elastic properties

Synthesis and biological evaluation of novel 3-aryl-4-methoxy N-alkyl maleimides

473-478In the present investigation, a series of 3-aryl-4-methoxy N-alkyl maleimide 5a-l have been synthesized and screened for their antimicrobial activity against one Gram positive bacteria (S. aureus), one Gram negative bacteria (E. coli) and fungal strains (C. albicans, C. tropicalis,  A. niger and A. clavatus). The structures of the compounds have been substantiated by their IR, NMR, mass and elemental analysis. The minimum inhibitory concentrations (MICs) of synthesized maleimides have been determined by broth microdilution method. Of the newly synthesized maleimides, compounds 5c, 5f, 5h, 5i, 5k and 5l registered significant activity against the tested microorganisms

Circle of Willis variation in a complex stroke presentation: a case report

BACKGROUND: The impact of circle of Willis anatomical variation upon the presentation of stroke is probably underrecognised. CASE PRESENTATION: A 63-year-old right-handed woman developed a left hemiparesis and right leg weakness sequentially following a road traffic accident (RTA). Despite initial concern about the possibility of cervical spinal cord injury, the final diagnosis was bilateral artery-to-artery embolic cerebral infarction with dominant right internal carotid artery. CONCLUSION: The case illustrates the complex presentation of stroke as a pseudo-cervical cord lesion and the impact of circle of Willis anatomical variation upon the expression of large vessel cerebrovascular disease

The prognostic significance of immune microenvironment in breast ductal carcinoma in situ

BackgroundThe role of different subtypes of tumour infiltrating lymphocytes (TILs) in breast ductal carcinoma in situ (DCIS) is still poorly defined. This study aimed to assess the prognostic significance of B and T lymphocytes and immune checkpoint proteins expression in DCIS.MethodsA well characterised DCIS cohort (n = 700) with long-term follow-up comprising pure DCIS (n = 508) and DCIS mixed with invasive carcinoma (IBC; n = 192) were stained immunohistochemically for CD20, CD3, CD4, CD8, FOXP3, PD1 and PDL1. Copy number variation and TP53 mutation status were assessed in a subset of cases (n = 58).ResultsCD3+ lymphocytes were the predominant cell subtype in the pure DCIS cohort, while FOXP3 showed the lowest levels. PDL1 expression was mainly seen in the stromal TILs. Higher abundance of TILs subtypes was associated with higher tumour grade, hormone receptor negativity and HER2 positivity. Mutant TP53 variants were associated with higher levels of stromal CD3+, CD4+ and FOXP3+ cells. DCIS coexisting with invasive carcinoma harboured denser stromal infiltrates of all immune cells and checkpoint proteins apart from CD4+ cells. Stromal PD1 was the most differentially expressed protein between DCIS and invasive carcinoma (Z = 5.8, p

Venous thromboembolism in COVID-19 patients and prediction model: a multicenter cohort study

BACKGROUND: Patients with COVID-19 infection are commonly reported to have an increased risk of venous thrombosis. The choice of anti-thrombotic agents and doses are currently being studied in randomized controlled trials and retrospective studies. There exists a need for individualized risk stratification of venous thromboembolism (VTE) to assist clinicians in decision-making on anticoagulation. We sought to identify the risk factors of VTE in COVID-19 patients, which could help physicians in the prevention, early identification, and management of VTE in hospitalized COVID-19 patients and improve clinical outcomes in these patients. METHOD: This is a multicenter, retrospective database of four main health systems in Southeast Michigan, United States. We compiled comprehensive data for adult COVID-19 patients who were admitted between 1st March 2020 and 31st December 2020. Four models, including the random forest, multiple logistic regression, multilinear regression, and decision trees, were built on the primary outcome of in-hospital acute deep vein thrombosis (DVT) and pulmonary embolism (PE) and tested for performance. The study also reported hospital length of stay (LOS) and intensive care unit (ICU) LOS in the VTE and the non-VTE patients. Four models were assessed using the area under the receiver operating characteristic curve and confusion matrix. RESULTS: The cohort included 3531 admissions, 3526 had discharge diagnoses, and 6.68% of patients developed acute VTE (N = 236). VTE group had a longer hospital and ICU LOS than the non-VTE group (hospital LOS 12.2 days vs. 8.8 days, p \u3c 0.001; ICU LOS 3.8 days vs. 1.9 days, p \u3c 0.001). 9.8% of patients in the VTE group required more advanced oxygen support, compared to 2.7% of patients in the non-VTE group (p \u3c 0.001). Among all four models, the random forest model had the best performance. The model suggested that blood pressure, electrolytes, renal function, hepatic enzymes, and inflammatory markers were predictors for in-hospital VTE in COVID-19 patients. CONCLUSIONS: Patients with COVID-19 have a high risk for VTE, and patients who developed VTE had a prolonged hospital and ICU stay. This random forest prediction model for VTE in COVID-19 patients identifies predictors which could aid physicians in making a clinical judgment on empirical dosages of anticoagulation

Porosity Reduction in the High-Speed Processing of Glass-Fiber Composites by Resin Transfer Molding (RTM)

High-speed processing is essential to achieve lower production cost in the fabrication of fiber-reinforced composites with the current liquid molding practices. A major consequence of increasing the resin injection velocity is the formation of defects such as voids and dry regions that decrease the load-bearing capability of the composite. Void formation mechanisms and analytical predictions of the detrimental effect of porosity on the structural integrity of molded parts have been studied extensively. In contrast, knowledge of void removal strategies is very limited. In this investigation, various postfill pressure levels were applied to disk-shaped random-mat glass/epoxy parts molded at high volumetric flow rates as a method to reduce their voidage content. Quantitative image analysis over cross-sections cut from these composites revealed that significant changes in porosity concentration take place with the postfill pressure. For instance, overall void content dropped more than 70% with the application of a postfill pressure as low as 300 kPa. Other important void morphometry characteristics such as void shape, size, and spatial distribution could also be manipulated by this method. As the packing pressure increases, large voids gradually disappear, and at the same time, the small circular voids are mobilized towards radial locations near the vents. In addition to this spatial voidage gradient in the radial direction, voidage gradient also exists through the specimen thickness. It seems that higher front velocities promote the appearance of secondary flow phenomena inside the mold cavity (e.g. microfountain flow), which may explain why more voids tend to concentrate at the surface of the specimen irrespective of the postfill pressure level reached inside the mold.Yeshttps://us.sagepub.com/en-us/nam/manuscript-submission-guideline

Preliminary evaluation of turmeric (Curcuma longa L.) varieties at Konkan region of Maharashtra

The performance of 21 varieties of turmeric (Curcuma longa) for rhizome characters, yield and curcumin content was studied at Konkan region (Maharashtra). Salem was found to be the best variety, which recorded significantly higher weight of primary fingers (208.92 g), secondary fingers (243.75 g), yield plot' (11.99 kg) and yield hectare" (44,395 kg). The curcumin content was significantly higher in CA-71 (4.87%). The phenotypic and genotypic coefficient of variation, heritability and genetic advance on mean basis were appreciably high for yield and curcumin content. The magnitude for environmental coefficient of variation was very low

The `Friction' of Vacuum, and other Fluctuation-Induced Forces

The static Casimir effect describes an attractive force between two conducting plates, due to quantum fluctuations of the electromagnetic (EM) field in the intervening space. {\it Thermal fluctuations} of correlated fluids (such as critical mixtures, super-fluids, liquid crystals, or electrolytes) are also modified by the boundaries, resulting in finite-size corrections at criticality, and additional forces that effect wetting and layering phenomena. Modified fluctuations of the EM field can also account for the `van der Waals' interaction between conducting spheres, and have analogs in the fluctuation--induced interactions between inclusions on a membrane. We employ a path integral formalism to study these phenomena for boundaries of arbitrary shape. This allows us to examine the many unexpected phenomena of the dynamic Casimir effect due to moving boundaries. With the inclusion of quantum fluctuations, the EM vacuum behaves essentially as a complex fluid, and modifies the motion of objects through it. In particular, from the mechanical response function of the EM vacuum, we extract a plethora of interesting results, the most notable being: (i) The effective mass of a plate depends on its shape, and becomes anisotropic. (ii) There is dissipation and damping of the motion, again dependent upon shape and direction of motion, due to emission of photons. (iii) There is a continuous spectrum of resonant cavity modes that can be excited by the motion of the (neutral) boundaries.Comment: RevTex, 2 ps figures included. The presentation is completely revised, and new sections are adde