Real World Effectiveness of fixed combination of glargine 100 U/ml and lixisenatide therapy in outpatients with Type 2 Diabetes: A Retrospective Cohort Study SOLO

Background: The effectiveness and safety of a fixed combination of insulin glargine 100 ME/ml and lixisenatide for treatment of patients with type 2 diabetes (T2DM) has been demonstrated in randomized clinical trials, but there are still not enough data of it`s usage of it real clinical practice.Aim: To describe the baseline characteristics of patients with T2DM who started treatment with a fixed ratio combination of insulin glargine 100 ME/ml and lixisenatide in the period from November 2018 to July 2020, and to evaluate the effectiveness of using fixed combination of insulin glargine 100 ME/ml and lixisenatide in for 6–12 months of therapy in a real outpatient practice.Materials and methods: SOLO was a retrospective cohort multicentre study conducted in Russia, Moscow. Adults (≥18 years) with T2DM and HbA1c≥7% in case of availability of medical records during ≥180 days before and ≥1 HbA1c level during 150–210 days after start of treatment with Soliqua SoloStar® were eligible.Results: A total of 383 people with T2DM were included. Baseline characteristics were the following (mean±SD): age 59.9±8.3 years; BMI 36.4±6.3 kg/m2; proportion of patients with BMI≥35 kg/m2 — 52.2%; HbA1c 9.14±1.08%. 65% of patients received oral antidiabetic drugs (OAD) before start of treatment with fixed combination of insulin glargine 100 ME/ml and lixisenatide ; 31.3% of patients were switched from combination of OAD with basal insulin, 1.04% of patients received other therapy (GLP-1 RA, basal-bolus insulin treatment, basal insulin monotherapy), and 2.61% of patients did not receive any hypoglycemic therapy. HbA1c level was 7.78±0.8% after 6 months of treatment and 7.4±0.61% after 12 months. There was a significant decrease of body weight from the baseline value 101.62±20.64 kg by 1.96±4.03 kg at month 6 and by 3.13±4.71 kg at month 12 (p<0.001) Overall, 4 patients (1.04%) reported symptomatic hypoglycemia (glycemia ≤3.9 mmol/L); no episodes of severe hypoglycemia were registered.Conclusion: In a real-life setting in Russia, initiation of a fixed combination of insulin glargine 100 ME/ ml and lixisenatide in people with T2DM uncontrolled on OADs or combination of OADs with basal insulin resulted resulted in an improved glycemic control and body weight change with low risk of hypoglycemia compared to baselin

Psychological status and features of gestation in women of late reproductive age

The reasons for the significant increase in the number of women who decide to give birth after the age of 35 are the rapidly changing conditions of modern life. In recent decades, the number of births in women over 35 years of age has in-creased by 44% in Russia. In the 90s, if the pregnancy occurred in the late repro-ductive age, it was taken as a mistake in family planning. Over the past few years, attitudes have changed. Domestic and foreign scientists agree on the need for special attention to pregnant women over 35 years due to the high risk of various complications of gestation.Причины для существенного увеличения числа женщин, которые решаются родить ребенка после 35 лет, это стремительно меняющиеся условия современной жизни. В последние десятилетия на территории России численность родов у женщин старше 35 лет увеличилось на 44%. В 90-е года если беременность наступила в позднем репродуктивном возрасте, то это принимали за ошибку в вопросе планирования семьи. За последние несколько лет отношение к данной проблеме изменилась. отечественные и зарубежные ученые сходятся в едином мнении о необходимости особого внимания к беременным старше 35 лет из-за высокого риска различных осложнений гестации

The role of lipoproteins in the bone metabolism in postmenopausal women against the background of obesity

The aim of this article was to study the effect of lipoproteins on bone mass in postmenopausal women against the background of obesity. The study included 165 women, who were postmenopausal. The 1st group included 87 women with abdominal obesity, the 2nd group - 78 women without obesity. In group 124 (27.8%) patients had normal values of bone mineral density, the osteopenia was defined in 48 (55.4%) patients and osteoporosis was defined in 15 (16.8%) patients. 2 It was noted that in the second group 22 (28.4%) patients had normal values of bone mineral density, 37 (47.7%) had osteopenia and 19 (23.9%) had osteoporosis. It can be assumed that the atherogenic changes in the lipid profile may be one of the risk factors in the formation of osteopenic syndrome in postmenopausal women against the background of obesity.Целью данного исследования явилось изучение влияния липопротеидов на костную массу женщин в постменопаузальном периоде на фоне ожирения. В исследование было включено 165 женщин в период постменопаузы. В 1-ю группу включены 87 женщин с абдоминальным типом ожирения, во 2-ю группу - 78 женщины без ожирения. В 1 группе 24 (27,8%) пациентки имели нормальные показатели минеральной плотности костной ткани, у 48 (55,4%) пациенток определялась остеопения и у 15 (16,8%) - остеолороз. Во 2 же группе отмечено, что у 22 (28,4%) пациентов имелись нормальные показатели минеральной плотности костной ткани, у 37 (47,7%) - остеопения и у 19 (23,9%) - остеопороз. Можно предположить, что атерогенные изменения в липидном профиле могут являться одним из факторов риска формирования остеоленического синдрома в постменопаузе на фоне ожирения

A Novel 3-Hydroxysteroid Dehydrogenase That Regulates Reproductive Development and Longevity

A multidisciplinary approach identifies novel biochemical activities involved in the synthesisof C. elegans bile acid-like steroids, which act as hormones that regulate sterol metabolism and longevity

Опыт успешного комплексного лечения пациента с диабетической нейроостеоартропатией среднего отдела стопы в стадии гнойных осложнений

The article presents a clinical case of the successful complex treatment of a patient L., 58 years old, with diabetic neuroosteoarthropathy in the middle part of the foot (Charcot's foot), complicated by a deep plantar phlegmon. The strategy of complex treatment, perioperative management and rehabilitation is described in detail. The long-term relapse-free observation period for a patient is more than 5 years.В статье представлено клиническое наблюдение успешного комплексного лечения пациента Л., 58 лет, с диабетической нейроостеоартропатией среднего отдела стопы (стопа Шарко), осложненной глубокой флегмоной подошвенной поверхности. Подробно описана стратегия комплексного лечения, периоперационное ведение и реабилитация. Отдаленный безрецидивный период наблюдения за больным составляет более 5 лет

ART in Europe, 2017: results generated from European registries by ESHRE

© The Author(s) 2021. Published by Oxford University Press on behalf of European Society of Human Reproduction and Embryology. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.Study question: What are the data on ART and IUI cycles, and fertility preservation (FP) interventions reported in 2017 as compared to previous years, as well as the main trends over the years? Summary answer: The 21st ESHRE report on ART and IUI shows the continual increase in reported treatment cycle numbers in Europe, with a decrease in the proportion of transfers with more than one embryo causing an additional slight reduction of multiple delivery rates (DR) as well as higher pregnancy rates (PR) and DR after frozen embryo replacement (FER) compared to fresh IVF and ICSI cycles, while the number of IUI cycles increased and their outcomes remained stable. What is known already: Since 1997, ART aggregated data generated by national registries, clinics or professional societies have been gathered and analyzed by the European IVF-monitoring Consortium (EIM) and communicated in a total of 20 manuscripts published in Human Reproduction and Human Reproduction Open. Study design size duration: Data on European medically assisted reproduction (MAR) are collected by EIM for ESHRE on a yearly basis. The data on treatments performed between 1 January and 31 December 2017 in 39 European countries were provided by either National Registries or registries based on personal initiatives of medical associations and scientific organizations. Participants/materials setting methods: Overall, 1382 clinics offering ART services in 39 countries reported a total of 940 503 treatment cycles, including 165 379 with IVF, 391 379 with ICSI, 271 476 with FER, 37 303 with preimplantation genetic testing (PGT), 69 378 with egg donation (ED), 378 with IVM of oocytes, and 5210 cycles with frozen oocyte replacement (FOR). A total of 1273 institutions reported data on 207 196 IUI cycles using either husband/partner's semen (IUI-H; n = 155 794) or donor semen (IUI-D; n = 51 402) in 30 countries and 25 countries, respectively. Thirteen countries reported 18 888 interventions for FP, including oocyte, ovarian tissue, semen and testicular tissue banking in pre- and postpubertal patients. Main results and the role of chance: In 21 countries (20 in 2016) in which all ART clinics reported to the registry, 473 733 treatment cycles were registered for a total population of approximately 330 million inhabitants, allowing a best-estimate of a mean of 1435 cycles performed per million inhabitants (range: 723-3286).Amongst the 39 reporting countries, the clinical PR per aspiration and per transfer in 2017 were similar to those observed in 2016 (26.8% and 34.6% vs 28.0% and 34.8%, respectively). After ICSI the corresponding rates were also similar to those achieved in 2016 (24% and 33.5% vs 25% and 33.2% in 2016). When freeze all cycles were removed, the clinical PRs per aspiration were 30.8% and 27.5% for IVF and ICSI, respectively.After FER with embryos originating from own eggs the PR per thawing was 30.2%, which is comparable to 30.9% in 2016, and with embryos originating from donated eggs it was 41.1% (41% in 2016). After ED the PR per fresh embryo transfer was 49.2% (49.4% in 2016) and per FOR 43.3% (43.6% in 2016).In IVF and ICSI together, the trend towards the transfer of fewer embryos continues with the transfer of 1, 2, 3 and ≥4 embryos in 46.0%, 49.2%, 4.5% and in 0.3% of all treatments, respectively (corresponding to 41.5%, 51.9%. 6.2% and 0.4% in 2016). This resulted in a reduced proportion of twin DRs of 14.2% (14.9% in 2016) and stable triplet DR of 0.3%. Treatments with FER in 2017 resulted in a twin and triplet DR of 11.2% and 0.2%, respectively (vs 11.9% and 0.2% in 2016).After IUI, the DRs remained similar at 8.7% after IUI-H (8.9% in 2016) and at 12.4% after IUI-D (12.4.0% in 2016). Twin and triplet DRs after IUI-H were 8.1% and 0.3%, respectively (in 2016: 8.8% and 0.3%) and 6.9% and 0.2% after IUI-D (in 2016: 7.7% and 0.4%). Amongst 18 888 FP interventions in 13 countries, cryopreservation of ejaculated sperm (n = 11 112 vs 7877 from 11 countries in 2016) and of oocytes (n = 6588 vs 4907 from eight countries in 2016) were the most frequently reported. Limitations reasons for caution: As the methods of data collection and levels of reporting vary amongst European countries, interpretation of results should remain cautious. Some countries were unable to deliver data about the number of initiated cycles and deliveries. Wider implications of the findings: The 21st ESHRE report on ART, IUI and FP interventions shows a continuous increase of reported treatment numbers and MAR-derived livebirths in Europe. Being already the largest data collection on MAR in Europe, efforts should continue to optimize data collection and reporting with the perspective of improved quality control, transparency and vigilance in the field of reproductive medicine. Study funding/competing interests: The study has received no external funding and all costs are covered by ESHRE. There are no competing interests.info:eu-repo/semantics/publishedVersio

ANALYSIS OF LIVING FORMS OF GROUND BUTTES OF STEPPE REGIONS OF THE SOUTH RUSSIA AND NORTH-EAST OF AZERBAIJAN

The analysis of living forms of Carabidae of steppes of South Russia and North-East Azerbaijan is given in the work

IDENTIFICATION OF AIR RADAR TARGETS USING THE DOPPLER EFFECT FROM A HEATED JET ENGINE

Objectives The aim of the study is to develop a methodology for identifyingaircraft by the deflections of an electromagnetic radar beam by a heated jet engine. Methods Atoms of the crystal lattice of the metallic parts of the operating jet engine will be in a state of chaotic Brownian motion due to heating. The electromagnetic beam, falling on these atoms, will change its frequency in accordance with the Doppler effect, by means of which the spectral electromagnetic radiation component will expand in direct proportion to the magnitude of the engine temperature. When determining the width of the spectral line of the direction-finding radio emission, it is possible to accurately identify the temperature of the aircraft in order to avoid false targets.Results When locating aircraft having a working jet engine, it is possible not only to determine the coordinates of the target, but also to identify the heated engine. Due to the use of high-precision methods for identifying heated sections, the direction-finding targets may be classified, the spatial orientation of both the aircraft itself and its control planes to be determinedand the direction of the thrust vector control of the jet engine calculated.Conclusion The application of an innovative technique for direction-finding air targets will allow the radar targets to be identified with high accuracy against the background of active and passive interferences. In addition, when analysing the information on the magnitude and direction of the jet engine thrust and the position of the aircraft controls, it is possible to determine not only the coordinates of the direction-finding object, but also to proactively identify the manoeuvres to be performed

Computer stabilometry for evaluation of the habilitation effectiveness of children with movement disorders in their first twelve months of life

Objective: To develop new objective criteria for assessing the effectiveness of medical habilitation for children aged 3—6 months with movement disorders based on a dynamic quantitative assessment of the ability to maintain the first antigravity postures.Characteristics of children and research methods. 85 children aged 3—6 months underwent clinical and functional examination, including neurological examination and computer stabilometry according to our methodology. The test group consisted of 69 children with movement disorders after moderate and severe perinatal lesions of the central nervous system. The control group consisted of 16 children without neurological pathology. The children of the test group underwent a dynamic examination, before and after a course of medical habilitation. In a retrospective analysis, they were divided into 2 subgroups depending on the dynamics of movement disorders: Group I — children with positive dynamics (n=50), Group II — children without positive dynamics ((n=19).Results and conclusion. The authors found that on the background of the treatment activities the dynamics of computer stabilometry was associated with the dynamics of neurological disorders. The authors described a new method for assessing the effectiveness of medical habilitation in children aged six months with movement disorders using the computer stabilometry. This method is characterized by a high diagnostic significance

SPECIES STRUCTURE AND GEOGRAPHICAL DISTRIBUTION OF GROUND BEETLES OF GENUS BEMBIDION OF DAGHESTAN REPUBLIC.

The species structure of Bembidion ground beetles of Daghestan is studies in the work 86 species of 31 subgenus are revealed