222 research outputs found
Development of catheter techniques to treat native and acquired stenoses in congenital heart disease
Aim: To describe innovative uses of catheter based treatment in a variety of native and
post surgical stenoses in children and young adults with congenital heart disease.
Background: Cardiac catheterization in man was first described 1929 and since then
there has been a drive to develop endovascular techniques to investigate and treat both
congenital and acquired heart disease. Many of the advances are being made in
congenital heart disease.
Methods: A number of congenital cardiac stenotic lesions were studied including baffle
obstruction after atrial switch for transposition of the great arteries, aortic stenosis in
infants, coarctation of the aorta, peripheral pulmonary artery stenosis and superior vena
caval obstruction. The use of angioplasty balloons, cutting balloons, stents and
alternative catheter approaches were investigated for these lesions.
Results: Following atrial redirection surgery for transposition of the great arteries
balloon angioplasty improved baffle haemodynamics. The technique of anterograde
balloon dilation of the aortic valve was developed and had superior outcomes in terms
of aortic insufficiency compared to a retrograde approach in neonates with severe aortic
valve stenosis. In an animal model of peripheral pulmonary arterial stenosis, the
application of cutting balloon angioplasty produced effective relief in a controlled
fashion. Balloon mounted stents were used in patients with native and post surgical
coarctation of the aorta with significant relief of stenosis and relief of hypertension.
Finally, a group of patients with superior vena obstruction syndrome after surgical
repair of partial anomalous pulmonary venous drainage had successful treatment using
balloon mounted stents.
Conclusions: Catheter based treatment of congenital and post surgical vascular stenoses
of the heart and great arteries using angioplasty balloons, cutting balloons and balloon
mounted stents is safe and appears to be effective in the short and medium term. It may
represent a useful alternative to surgery and will reduce the number of surgical
procedures required over a lifetime. Future directions will include bio-absorbable stents
and hybrid techniques involving surgery
The Ursinus Weekly, November 14, 1974
15 U.C. seniors named to Who\u27s who • Puzzle solved • Letter to the Editor • Part two: The Legend of the three doors • Growth of the Greeks: Green and gold - KDK • Library metamorphosis • Rebuilding Bears lose to Dickinson • Only one game lost • Alumna corner: First foreign student • Pages from Ursinus past: Freshmen regulations • Photo reviewhttps://digitalcommons.ursinus.edu/weekly/1025/thumbnail.jp
Lindsay Anderson and the Legacy of Free Cinema
Accepting that Free Cinema’s legacy has been found on British cinema and television screens in the work of directors other than Lindsay Anderson, this article investigates whether Anderson’s own films and television programmes made after the mid-1970s (including not only those that were released but others that were not completed) reveal a continuing commitment to what he liked to call the Free Cinema ‘tradition’ of film-making. In so doing it draws critical attention to Anderson’s lesser known later works such as The Old Crowd, Is That All There Is?, In Celebration, The Whales of August and Glory! Glory! as well as to unmade projects such as The Grand Babylon Hotel, Dress Gray, Vile Bodies, Empire and If (2). . .
Image analysis as an adjunct to manual HER-2 immunohistochemical review: a diagnostic tool to standardize interpretation
Dobson L, Conway C, Hanley A, Johnson A, Costello S, O’Grady A, Connolly Y, Magee H, O’Shea D, Jeffers M & Kay E (2010) Histopathology57, 27–38 Image analysis as an adjunct to manual HER-2 immunohistochemical review: a diagnostic tool to standardize interpretatio
Repeat Organ Transplantation in the United States, 1996–2005
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/72698/1/j.1600-6143.2007.01786.x.pd
Patient Selection and Volume in the Era Surrounding Implementation of Medicare Conditions of Participation for Transplant Programs
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/110882/1/hesr12188.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/110882/2/hesr12188-sup-0001-AuthorMatrix.pd
The GstLAL Search Analysis Methods for Compact Binary Mergers in Advanced LIGO's Second and Advanced Virgo's First Observing Runs
After their successful first observing run (September 12, 2015 - January 12,
2016), the Advanced LIGO detectors were upgraded to increase their sensitivity
for the second observing run (November 30, 2016 - August 26, 2017). The
Advanced Virgo detector joined the second observing run on August 1, 2017. We
discuss the updates that happened during this period in the GstLAL-based
inspiral pipeline, which is used to detect gravitational waves from the
coalescence of compact binaries both in low latency and an offline
configuration. These updates include deployment of a zero-latency whitening
filter to reduce the over-all latency of the pipeline by up to 32 seconds,
incorporation of the Virgo data stream in the analysis, introduction of a
single-detector search to analyze data from the periods when only one of the
detectors is running, addition of new parameters to the likelihood ratio
ranking statistic, increase in the parameter space of the search, and
introduction of a template mass-dependent glitch-excision thresholding method.Comment: 12 pages, 7 figures, to be submitted to Phys. Rev. D, comments
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Intragenic sequences in the trophectoderm harbour the greatest proportion of methylation errors in day 17 bovine conceptuses generated using assisted reproductive technologies
Abstract Background Assisted reproductive technologies (ART) are widely used to treat fertility issues in humans and for the production of embryos in mammalian livestock. The use of these techniques, however, is not without consequence as they are often associated with inauspicious pre- and postnatal outcomes including premature birth, intrauterine growth restriction and increased incidence of epigenetic disorders in human and large offspring syndrome in cattle. Here, global DNA methylation profiles in the trophectoderm and embryonic discs of in vitro produced (IVP), superovulation-derived (SOV) and unstimulated, synchronised control day 17 bovine conceptuses (herein referred to as AI) were interrogated using the EmbryoGENE DNA Methylation Array (EDMA). Pyrosequencing was used to validate four loci identified as differentially methylated on the array and to assess the differentially methylated regions (DMRs) of six imprinted genes in these conceptuses. The impact of embryo-production induced DNA methylation aberrations was determined using Ingenuity Pathway Analysis, shedding light on the potential functional consequences of these differences. Results Of the total number of differentially methylated loci identified (3140) 77.3 and 22.7% were attributable to SOV and IVP, respectively. Differential methylation was most prominent at intragenic sequences within the trophectoderm of IVP and SOV-derived conceptuses, almost a third (30.8%) of the differentially methylated loci mapped to intragenic regions. Very few differentially methylated loci were detected in embryonic discs (ED); 0.16 and 4.9% of the differentially methylated loci were located in the ED of SOV-derived and IVP conceptuses, respectively. The overall effects of SOV and IVP on the direction of methylation changes were associated with increased methylation; 70.6% of the differentially methylated loci in SOV-derived conceptuses and 57.9% of the loci in IVP-derived conceptuses were more methylated compared to AI-conceptuses. Ontology analysis of probes associated with intragenic sequences suggests enrichment for terms associated with cancer, cell morphology and growth. Conclusion By examining (1) the effects of superovulation and (2) the effects of an in vitro system (oocyte maturation, fertilisation and embryo culture) we have identified that the assisted reproduction process of superovulation alone has the largest impact on the DNA methylome of subsequent embryos
The GstLAL template bank for spinning compact binary mergers in the second observation run of Advanced LIGO and Virgo
We describe the methods used to construct the aligned-spin template bank of
gravitational waveforms used by the GstLAL-based inspiral pipeline to analyze
data from the second observing run of Advanced LIGO and Virgo. The bank expands
upon the parameter space covered during the first observing run, including
coverage for merging compact binary systems with total mass between 2
and 400 and mass ratios between 1 and
97.989. Thus the systems targeted include merging neutron star-neutron star
systems, neutron star-black hole binaries, and black hole-black hole binaries
expanding into the intermediate-mass range. Component masses less than 2
have allowed (anti-)aligned spins between while
component masses greater than 2 have allowed
(anti-)aligned between . The bank placement technique combines a
stochastic method with a new grid-bank method to better isolate noisy
templates, resulting in a total of 677,000 templates.Comment: 9 pages, 13 figure
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